The plaque hypothesis: understanding mechanisms of plaque progression and destabilization, and implications for clinical management

COMBINED HIGH-RISK PLAQUE VARIABLES LOW ENDOTHELIAL SHEAR STRESS, HIGH ENDOTHELIAL SHEAR STRESS GRADIENT AND HIGH PLAQUE STRUCTURAL STRESS COLOCALIZE IN CORONARY PLAQUES RESPONSIBLE FOR MAJOR ADVERSE CARDIAC EVENTS

(2023) Mona Engy Suzan Ahmed et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Endothelial shear stress computed from coronary computed tomography angiography: A direct comparison to intravascular ultrasound

(2023) Diaa Hakim et al.   Journal of Cardiovascular Computed Tomography

The role of endothelial shear stress, shear stress gradient, and plaque topography in plaque erosion

(2023) Diaa Hakim et al.   ATHEROSCLEROSIS

AI-Guided Quantitative Plaque Staging Predicts Long-Term Cardiovascular Outcomes in Patients at Risk for Atherosclerotic CVD

(2023) Nick S. Nurmohamed et al.   JACC-Cardiovascular Imaging

The Global Burden of Cardiovascular Diseases and Risk

(2022) Muthiah Vaduganathan et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Fundamental Pathobiology of Coronary Atherosclerosis and Clinical Implications for Chronic Ischemic Heart Disease Management—The Plaque Hypothesis

(2022) Peter H. Stone et al.   JAMA Cardiology

Association of coronary artery calcium score with qualitatively and quantitatively assessed adverse plaque on coronary CT angiography in the SCOT-HEART trial

(2021) Maia Osborne-Grinter et al.   European Heart Journal-Cardiovascular Imaging

Acute Myocardial Infarction in Young Individuals

(2020) Rajiv Gulati et al.   MAYO CLINIC PROCEEDINGS

Initial Invasive or Conservative Strategy for Stable Coronary Disease

(2020) David J. Maron et al.   NEW ENGLAND JOURNAL OF MEDICINE

High Spatial Endothelial Shear Stress Gradient Independently Predicts Site of Acute Coronary Plaque Rupture and Erosion

(2020) Vikas Thondapu et al.   CARDIOVASCULAR RESEARCH

Coronary 18F-sodium fluoride PET detects high-risk plaque features on optical coherence tomography and CT-angiography in patients with acute coronary syndrome

(2020) Kamran Majeed et al.   ATHEROSCLEROSIS

Coronary Artery Plaque Characteristics Associated With Adverse Outcomes in the SCOT-HEART Study

(2019) Michelle C. Williams et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Superior Risk Stratification With Coronary Computed Tomography Angiography Using a Comprehensive Atherosclerotic Risk Score

(2019) Alexander R. van Rosendael et al.   JACC-Cardiovascular Imaging

Heart Disease and Stroke Statistics—2019 Update: A Report From the American Heart Association

(2019) Emelia J. Benjamin et al.   CIRCULATION

Heterogeneity of Plaque Structural Stress Is Increased in Plaques Leading to MACE

(2019) Charis Costopoulos et al.   JACC-Cardiovascular Imaging

Relationship between coronary plaque morphology of the left anterior descending artery and 12 months clinical outcome: the CLIMA study

(2019) Francesco Prati et al.   EUROPEAN HEART JOURNAL

Identification of patients and plaques vulnerable to future coronary events with near-infrared spectroscopy intravascular ultrasound imaging: a prospective, cohort study

(2019) Ron Waksman et al.   LANCET

Coronary Atherosclerotic Precursors of Acute Coronary Syndromes

(2018) Hyuk-Jae Chang et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Role of Low Endothelial Shear Stress and Plaque Characteristics in the Prediction of Nonculprit Major Adverse Cardiac Events

(2018) Peter H. Stone et al.   JACC-Cardiovascular Imaging

Plaque Rupture in Coronary Atherosclerosis Is Associated With Increased Plaque Structural Stress

(2017) Charis Costopoulos et al.   JACC-Cardiovascular Imaging

Plaque Structural Stress Estimations Improve Prediction of Future Major Adverse Cardiovascular Events After Intracoronary ImagingCLINICAL PERSPECTIVE

(2016) Adam J. Brown et al.   Circulation-Cardiovascular Imaging

Role of biomechanical forces in the natural history of coronary atherosclerosis

(2016) Adam J. Brown et al.   Nature Reviews Cardiology

Near-Infrared Spectroscopy Predicts Cardiovascular Outcome in Patients With Coronary Artery Disease

(2014) Rohit M. Oemrawsingh et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Red blood cell, hemoglobin and heme in the progression of atherosclerosis

(2014) Viktória Jeney et al.   Frontiers in Physiology

In vivo detection of high-risk coronary plaques by radiofrequency intravascular ultrasound and cardiovascular outcome: results of the ATHEROREMO-IVUS study

(2013) Jin M. Cheng et al.   EUROPEAN HEART JOURNAL

Prediction of Progression of Coronary Artery Disease and Clinical Outcomes Using Vascular Profiling of Endothelial Shear Stress and Arterial Plaque Characteristics

(2012) Peter H. Stone et al.   CIRCULATION

Coronary Artery Wall Shear Stress Is Associated With Progression and Transformation of Atherosclerotic Plaque and Arterial Remodeling in Patients With Coronary Artery Disease

(2011) Habib Samady et al.   CIRCULATION

Characterization of the differential response of endothelial cells exposed to normal and elevated laminar shear stress

(2011) Stephen J. White et al.   JOURNAL OF CELLULAR PHYSIOLOGY

A Prospective Natural-History Study of Coronary Atherosclerosis

(2011) Gregg W. Stone et al.   NEW ENGLAND JOURNAL OF MEDICINE

Association Between IVUS Findings and Adverse Outcomes in Patients With Coronary Artery Disease

(2011) Patrick A. Calvert et al.   JACC-Cardiovascular Imaging

High shear stress induces a strain increase in human coronary plaques over a 6-month period

(2011) Frank J.H. Gijsen et al.   EuroIntervention