Article
Multidisciplinary Sciences
Jianfeng Wu, Kang Yang, Shaowei Cai, Xiaohan Zhang, Lichen Hu, Fanjia Lin, Su-qin Wu, Changchun Xiao, Wen-Hsien Liu, Jiahuai Han
Summary: This study highlights the important role of p38 alpha kinase in B cell differentiation, affecting plasma cell differentiation through regulating the transcriptional program by BLIMP1. This finding is crucial for understanding the mechanism of plasma cell differentiation.
NATURE COMMUNICATIONS
(2022)
Article
Clinical Neurology
Jae-Hong Kim, Ri Jin Kang, Seung Jae Hyeon, Hoon Ryu, Hyejin Joo, Youngmin Bu, Jong-Heon Kim, Kyoungho Suk
Summary: Reactive glial cells play a role in brain injury, but their contribution to secondary inflammatory pathology and neurological deficits is poorly understood. This study investigates the role of Lipocalin-2 (LCN2) in neuroinflammation following brain injury. LCN2 expression is high in the mouse brain after controlled cortical impact (CCI) and photothrombotic stroke (PTS) injury. It is also significantly higher in patients with chronic traumatic encephalopathy (CTE). Astrocytes are the major source of LCN2 in the injured brain. Deficiency of LCN2 or injection of an LCN2 neutralizing antibody reduces brain lesions, behavioral deficits, and neuroinflammation. In cultured glial cells, LCN2 enhances proinflammatory cytokine gene expression and inhibits neurotropic factors expression. Overall, LCN2 mediates secondary damage response to traumatic and ischemic brain injury by promoting neuroinflammation and suppressing the expression of neurotropic factors.
Article
Neurosciences
Cui Liu, Song Han, Jiayin Zheng, Hongyu Wang, Shujuan Li, Junfa Li
Summary: Ischemic stroke leads to white matter injury and neurobehavioral dysfunction, and there is a lack of effective therapies to inhibit demyelination or promote remyelination. EphA4 promotes the proliferation of oligodendrocyte precursor cells but reduces the numbers of mature oligodendrocytes and the levels of myelin-associated proteins. EphA4 regulates white matter remyelination after ischemic stroke through the Ephexin-1/RhoA/ROCK signaling pathway. EphA4 may provide a novel therapeutic target in the clinical practice of ischemic stroke.
Article
Biochemistry & Molecular Biology
Beatrice Richter, Tamar Kapanadze, Nina Weingaertner, Stefanie Walter, Isabel Vogt, Andrea Grund, Jessica Schmitz, Jan Hinrich Braesen, Florian P. Limbourg, Dieter Haffner, Maren Leifheit-Nestler
Summary: High phosphate intake may lead to progressive kidney injury and represents an underestimated health problem for kidney health.
Article
Pharmacology & Pharmacy
Zhuanghua Liu, Zhaopeng Zhou, Pu Ai, Chunlei Zhang, Junhui Chen, Yuhai Wang
Summary: This study demonstrates the significant role of ferroptosis in subarachnoid hemorrhage and reveals that Astragaloside IV inhibits ferroptosis by activating the Nrf2/HO-1 pathway, providing neuroprotection.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Dermatology
Qinqin Meng, Mei Bai, Meiliang Guo, Zhengxiao Li, Wanwen Liu, Xiaojing Fan, Rui Sun, Xinrong Yang, Dingfen Yuan, Yuling Shi, Hui Deng
Summary: The regulatory role of SGK1 in psoriasis and its underlying molecular mechanism are not well understood. This study found that SGK1 expression was decreased in macrophages from psoriasis patients. Moreover, SGK1 inhibition enhanced toll-like receptor 7/8 activation and proinflammatory cytokine production.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Fisheries
Yuehong Zhao, Xiaoli Zhang, Xiaona Zhang, Guoqing Shen, Weiwei Li, Qun Wang
Summary: This study found that integrin01 regulates the survival of Chinese mitten crab hemocytes by activating the FAK/ERK signaling cascade, and reducing the phosphorylation of ERK can enhance apoptosis.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Materials Science, Biomaterials
Siqi Song, Xianglin Hou, Weiwei Zhang, Xinyu Liu, Wei Wang, Xiaoya Wang, Wenxuan Cao, Yujun Xia, Wei Chen, Chunying Shi
Summary: In this study, a targeted delivery system called KIT-bFGF was found to attenuate renal tubule damage and fibrosis, promote functional recovery, and protect against ischemic injury in the kidney by activating the ERK1/2 and Akt signaling pathways.
REGENERATIVE BIOMATERIALS
(2022)
Review
Medicine, Research & Experimental
Chun-Lin Xiao, Wen-Chao Yin, Yan-Chun Zhong, Jia-Quan Luo, Lu-Lin Liu, Wu-Yang Liu, Kai Zhao
Summary: Spinal cord injury is a severe central nervous system injury that leads to sensory and motor dysfunction. The PI3K/Akt signaling pathway plays a key role in the pathological processes and neuronal recovery of spinal cord injury, and its activation can promote neurological function recovery by reducing cell apoptosis.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Rong Chen, Wei Li, Zhen Qiu, Qin Zhou, Yuan Zhang, Wen-yuan Li, Ke Ding, Qing-tao Meng, Zhong-yuan Xia
Summary: Intestinal mucosal barrier dysfunction induced by myocardial ischemia reperfusion (IR) injury can lead to adverse cardiovascular outcomes after myocardial infarction. Myocardial ischemic postconditioning (IPo) has a protective effect on intestinal barrier injury induced by myocardial IR, potentially mediated by the DJ-1/Nrf2 pathway.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Cell Biology
Na Zhang, Gang Wang, Gengyun Sun
Summary: This study revealed that IQGAP1 is significantly upregulated in LPS-induced models of acute lung injury, promoting barrier dysfunction and ICAM-1 upregulation in pulmonary microvascular endothelial cells by affecting the Rap1/Src signaling pathway. Knockdown of IQGAP1 can protect the barrier function of cells from LPS-induced damage.
CELLULAR SIGNALLING
(2021)
Article
Pharmacology & Pharmacy
Li Han, Chenhui Ma, Zhitao Wu, Huiming Xu, Hai Li, Guoyu Pan
Summary: Inhibition of Aryl hydrocarbon receptor (AhR) attenuates hepatic ferroptosis, improving survival and therapeutic effects of human MSCs (hMSCs) in mouse models of liver disease.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Hua Miao, Xia-Qing Wu, Yan-Ni Wang, Dan-Qian Chen, Lin Chen, Nosratola D. Vaziri, Shougang Zhuang, Yan Guo, Wei Su, Shi-Xing Ma, Huan-Qiao Zhang, You-Quan Shang, Xiao-Yong Yu, Yan-Long Zhao, Jia-Rong Mao, Ming Gao, Jin-Hua Zhang, Jin Zhao, Yuan Zhang, Li Zhang, Ying-Yong Zhao, Gang Cao
Summary: This study identified the role of 1-hydroxypyrene in mediating renal fibrosis in patients with chronic kidney disease. The findings suggest that targeting the aryl hydrocarbon receptor may be an alternative therapeutic strategy for CKD progression.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jia-Wei Wu, Hao Hu, Jin-sheng Hua, Li-Kun Ma
Summary: IF1 plays a cardioprotective role in myocardial I/R injury by activating AMPK signaling, thus improving cardiac function and pathological development.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Bingchuan Geng, Xiaoliang Wang, Ki Ho Park, Kyung Eun Lee, Jongsoo Kim, Peng Chen, Xinyu Zhou, Tao Tan, Chunlin Yang, Xunchang Zou, Paul M. Janssen, Lei Cao, Lei Ye, Xuejun Wang, Chuanxi Cai, Hua Zhu
Summary: In this study, it was found that UCHL1 plays a protective role in myocardial infarction (MI) by stabilizing HIF-1α and promoting HIF-1α signaling. The absence of UCHL1 makes cardiomyocytes more susceptible to hypoxia/re-oxygenation induced injury.
