Article
Urology & Nephrology
Nicolas Vamour, Anis Gasmi, Xavier Leroy, Philippe Puech, Mohamed Koussa, Arnauld Villers, Jean-Christophe Fantoni, Nicolas Doumerc, Karim Bensalah, Jonathan Olivier, Zine-Eddine Khene
Summary: This study evaluated the impact of positive vascular margins (PVMs) following surgical resection of non-metastatic renal cell carcinoma (RCC) with inferior vena cava (IVC) tumor thrombus. Results indicated that PVMs were associated with a higher risk of local recurrence, but did not have a significant impact on systemic recurrence or overall mortality.
WORLD JOURNAL OF UROLOGY
(2022)
Article
Urology & Nephrology
Joana B. Neves, Leyre Vanaclocha Saiz, Yasmin Abu-Ghanem, Marta Marchetti, My-Anh Tran-Dang, Soha El-Sheikh, Ravi Barod, Christian Beisland, Umberto Capitanio, David Cullen, Tobias Klatte, Borje Ljungberg, Faiz Mumtaz, Prasad Patki, Grant D. Stewart, Saeed Dabestani, Maxine G. B. Tran, Axel Bex
Summary: Recurrence and death after surgically resected chRCC are rare, with excellent prognosis for completely excised lesions <= pT2a without coagulative necrosis or sarcomatoid features. Patients meeting these criteria should be reassured and have reduced follow-up intensity.
WORLD JOURNAL OF UROLOGY
(2021)
Article
Gastroenterology & Hepatology
Tao Wei, Xu-Feng Zhang, Fabio Bagante, Francesca Ratti, Hugo P. Marques, Silvia Silva, Olivier Soubrane, Vincent Lam, George A. Poultsides, Irinel Popescu, Razvan Grigorie, Sorin Alexandrescu, Guillaume Martel, Aklile Workneh, Alfredo Guglielmi, Tom Hugh, Yi Lv, Luca Aldrighetti, Timothy M. Pawlik
Summary: The study found that setting the time point for recurrence at 8 months is beneficial for distinguishing early from late recurrence, with early recurrence patients typically having shorter survival time and post-recurrence survival, as well as less likely to receive curative treatment. Curative-intent retreatment for late recurrence patients is associated with similar overall survival compared to patients without recurrence.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Urology & Nephrology
Haruyuki Ohsugi, Chisato Ohe, Takashi Yoshida, Junichi Ikeda, Motohiko Sugi, Hidefumi Kinoshita, Tadashi Matsuda
Summary: Perinephric fat invasion, sarcomatoid or rhabdoid component, and necrosis are independent predictors of recurrence-free survival in patients with pT3a-predominant renal cell carcinoma. Patients with more than two of these predictors have poor oncological outcomes.
INTERNATIONAL JOURNAL OF UROLOGY
(2021)
Article
Gastroenterology & Hepatology
Charlotte Costentin, Etienne Audureau, Young Nyun Park, Serena Langella, Eric Vibert, Alexis Laurent, Francois Cauchy, Olivier Scatton, Mircea Chirica, Rami Rhaiem, Emmanuel Boleslawski, Luca di Tommaso, Alessandro Ferrero, Hirohisa Yano, Jun Akiba, Matteo Donadon, Martina Nebbia, Olivier Detry, Pierre Honore, Marcello Di Martino, Lilian Schwarz, Louise Barbier, Jean-Charles Nault, Hyungjin Rhee, Chetana Lim, Raffaele Brustia, Valerie Paradis, Catherine Guettier, Brigitte Le Bail, Shinya Okumura, Jean-Frederic Blanc, Julien Calderaro
Summary: This study aimed to develop and validate a simple scoring system to predict 2-year recurrence after surgical resection (SR) for hepatocellular carcinoma (HCC). By studying 2359 HCC patients who underwent SR in 17 centers, variables associated with 2-year recurrence were identified and used to create the Early Recurrence Score (ERS). The ERS is a user-friendly staging system that can help design personalized surveillance strategies and adjuvant therapy trials.
LIVER INTERNATIONAL
(2023)
Article
Medicine, General & Internal
Mauro Giuffre, Enrico Zuliani, Alessia Visintin, Paola Tarchi, Paola Martingano, Riccardo Pizzolato, Deborah Bonazza, Flora Masutti, Rita Moretti, Lory Saveria Croce
Summary: This study aims to determine factors associated with early recurrence of hepatocellular carcinoma (HCC). The results indicate that male gender and larger tumor nodules are the main risk factors for early HCC recurrence.
Article
Oncology
Josiah An, Vignesh T. Packiam, Adithya Chennamadhavuni, Jordan Richards, Jayanshu Jain, Sarah L. Mott, Rohan Garje
Summary: This study assessed the incidence and survival outcomes of non-clear cell renal cell carcinoma (ccRCC) subtypes compared to ccRCC. The results showed that the survival rate was not significantly different between papillary RCC and ccRCC, while collecting duct and sarcomatoid subtypes had poorer survival outcomes. Further studies are needed to evaluate the role of neoadjuvant and adjuvant systemic therapies in improving oncologic outcomes for these subtypes.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Sung Han Kim, Boram Park, Eu Chang Hwang, Sung-Hoo Hong, Chang Wook Jeong, Cheol Kwak, Seok Soo Byun, Jinsoo Chung
Summary: This study compared the cancer-specific survival and overall survival of patients with non-metastatic renal cell carcinoma who experienced disease recurrence in different scenarios. The findings indicated that the group with local recurrence had the worst survival outcomes compared to the other groups.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Haiyang Yang, Xiang Dong, Xinghe Pan, Wenliang Ma, Jun Pan, Hongqian Guo, Weidong Gan
Summary: TFE3-rearranged renal cell carcinoma is a rare subtype of renal tumor that primarily affects young women and is characterized by early metastasis and a poor prognosis. This case study reports a 29-year-old woman with TFE3-rearranged RCC, who initially presented with painless gross hematuria, and achieved favorable treatment outcomes.
FRONTIERS IN ONCOLOGY
(2023)
Article
Surgery
Wei-Feng Li, Yi-Hao Yen, Yueh-Wei Liu, Chih-Chi Wang, Chee-Chien Yong, Chih-Che Lin, Yu-Fan Cheng, Jing-Houng Wang, Sheng-Nan Lu
Summary: This study aimed to predict early recurrence of hepatocellular carcinoma after liver resection by assessing preoperative image tumor characteristics and alpha-fetoprotein levels. The study identified AFP level, tumor size, vascular invasion, and multiple tumors as predictive factors for early recurrence. A simple diagnostic model was developed to successfully predict early recurrence.
AMERICAN JOURNAL OF SURGERY
(2022)
Article
Oncology
Dongsub Jeon, Won-Mook Choi, Jin-Sun Kim, Yusun Jung, Su-Yeon Lee, Haeng Ran Seo, Kang Mo Kim
Summary: This study found that serum sorbitol dehydrogenase (SORD) levels were associated with the length of recurrence-free survival after surgical resection for HCC, with higher SORD levels (>= 15 ng/mL) being linked to a shorter recurrence-free survival. When combined with AFP levels, SORD levels could better predict the prognosis in HCC patients.
Article
Surgery
Haili Zhang, Fei Liu, Ningyuan Wen, Bo Li, Yonggang Wei
Summary: This study found that intrahepatic recurrence was still the most common pattern after LLR for HCC, with most recurrences occurring within 2 years. There were no significant differences in recurrence patterns, timing, or treatment between LLR and OLR, with independent risk factors for recurrence including ALBI grade, postoperative alpha-fetoprotein levels, tumor size, surgical margins, and multiple tumors.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Gastroenterology & Hepatology
Yuxin Guo, Yun Le Linn, Ye Xin Koh, Ek Khoon Tan, Jin Yao Teo, Peng Chung Cheow, Prema Raj Jeyaraj, Pierce K. H. Chow, London L. P. J. Ooi, Alexander Y. F. Chung, Chung Yip Chan, Brian K. P. Goh
Summary: In this study, preoperative predictors of early recurrence in patients who underwent liver resection for multifocal hepatocellular carcinoma (HCC) were evaluated. Hepatitis B/C aetiology, >= 3 nodules, and elevated AFP >= 200 ng/ml were identified as significant independent predictors of early recurrence. The presence of these predictors can help in better patient selection and resource allocation.
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Article
Gastroenterology & Hepatology
Filippo Pelizzaro, Franco Trevisani, Vittorio Simeon, Alessandro Vitale, Umberto Cillo, Fabio Piscaglia, Gabriele Missale, Angelo Sangiovanni, Francesco G. Foschi, Giuseppe Cabibbo, Eugenio Caturelli, Maria Di Marco, Francesco Azzaroli, Maurizia R. Brunetto, Giovanni Raimondo, Gianpaolo Vidili, Maria Guarino, Antonio Gasbarrini, Claudia Campani, Gianluca Svegliati-Baroni, Edoardo G. Giannini, Andrea Mega, Alberto Masotto, Gian Ludovico Rapaccini, Donatella Magalotti, Rodolfo Sacco, Gerardo Nardone, Fabio Farinati
Summary: This study evaluated the incidence and predictors of non-transplantable recurrence in patients with single hepatocellular carcinoma (HCC) <= 5 cm treated with liver resection (LR). The results showed that HCC size >= 4 cm and high alpha-fetoprotein (AFP) level at the time of LR were independent predictors of recurrence beyond established criteria. Microvascular invasion and microsatellite lesions were identified as additional independent risk factors for non-transplantable recurrence.
LIVER INTERNATIONAL
(2023)
Article
Oncology
Yao Huang, Hengkai Chen, Yongyi Zeng, Zhiqiang Liu, Handong Ma, Jingfeng Liu
Summary: A machine learning prognostic model was developed to identify high-risk patients after surgical resection, with variable importance reviewed in different time intervals. Tumor characteristics contribute more to HCC relapse in 0 to 1 year, while HBV infection and smoking largely affect patients' outcome in 3 to 5 years.
FRONTIERS IN ONCOLOGY
(2021)