Article
Oncology
I-Wen Song, Henry Hiep Vo, Ying-Shiuan Chen, Mehmet A. Baysal, Michael Kahle, Amber Johnson, Apostolia M. Tsimberidou
Summary: Precision oncology is the targeted use of anticancer drugs to inhibit the function of specific oncogenic proteins in a patient's tumor. Molecular technologies and targeted therapies have significantly advanced precision oncology, leading to favorable clinical outcomes in selected cancer patients.
Review
Medicine, General & Internal
Jason Weatherald, Athenais Boucly, Anthony Peters, David Montani, Krishna Prasad, Mitchell A. Psotka, Faiez Zannad, Mardi Gomberg-Maitland, Vallerie McLaughlin, Gerald Simonneau, Marc Humbert
Summary: Despite advancements in pulmonary arterial hypertension treatment, prognosis remains poor. Novel therapies targeting vascular remodeling and innovative clinical trial designs are needed to improve outcomes.
Review
Oncology
Hanna H. Kakish, Fasih Ali Ahmed, Mohamedraed Elshami, Alexander W. Loftus, Richard S. Hoehn, John B. Ammori, Lee M. Ocuin, Jordan M. Winter, Jeremy S. Bordeaux, Ankit Mangla, Luke D. Rothermel
Summary: In recent years, there has been an increasing focus on clinical trial investment in melanoma therapy, particularly in exploring novel drug mechanisms like immunotherapy and vaccines. Results indicate that ongoing trials may offer new treatment strategies for melanoma patients.
Article
Oncology
Melissa M. de Meza, Willeke A. M. Blokx, Han J. Bonenkamp, Cristian U. Blank, Maureen J. B. Aarts, Franchette W. P. J. van den Berkmortel, Marye J. Boers-Sonderen, Jan Willem B. de Groot, John B. Haanen, Geke A. P. Hospers, Ellen W. Kapiteijn, Olivier J. van Not, Djura Piersma, Rozemarijn S. van Rijn, Marion A. Stevense-Den A. Boer, Astrid A. M. van Der Veldt, Gerard Vreugdenhil, Alfons J. M. van den Eertwegh, Karijn P. M. Suijkerbuijk, Michel W. J. M. Wouters
Summary: This study examines the adjuvant systemic therapy of in-transit melanoma (ITM) patients and compares the outcomes of different patient groups. The results indicate that ITM-only patients have similar recurrence-free survival and overall survival rates to non-ITM patients, while patients with both ITM and nodal disease have lower rates.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Review
Oncology
Shuai Zhang, Jiaran Zhang, Jun Guo, Lu Si, Xue Bai
Summary: Mucosal melanoma differs from cutaneous melanoma in terms of epidemiology, clinical features, and molecular landscape, and has poorer response to systemic therapy. However, recent advancements in targeted therapy options and combination treatments have provided promising prospects for improving clinical outcomes.
CURRENT ONCOLOGY REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Ivan Y. Y. Filin, Yuri P. P. Mayasin, Chulpan B. B. Kharisova, Anna V. Gorodilova, Kristina V. V. Kitaeva, Daria S. S. Chulpanova, Valeriya V. V. Solovyeva, Albert A. A. Rizvanov
Summary: Melanoma is a highly aggressive and therapy-resistant cancer, with increasing incidence rates. Conventional methods of treatment often result in relapse. Adjuvant therapies, such as cell-based immunotherapy, can be used to reduce recurrence risk by mobilizing the immune system to kill cancer cells. This review discusses the advantages, challenges, and ongoing clinical trials of cell-based therapy for adjuvant treatment of melanoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Vivian Chua, Jane Mattei, Anna Han, Lauren Johnston, Kyleigh LiPira, Sara M. Selig, Richard D. Carvajal, Andrew E. Aplin, Sapna P. Patel
Summary: Uveal melanoma, a rare cancer in adults, poses a challenging treatment due to lack of effective options. However, ongoing clinical trials and novel targets show promise in improving treatment outcomes, highlighting the high interest and unmet needs in this field.
CLINICAL CANCER RESEARCH
(2021)
Review
Gastroenterology & Hepatology
Elliot B. Tapper, Marina Serper, David S. Goldberg
Summary: Patients with chronic liver disease can benefit from pragmatic trial designs, which aim to provide evidence for the adoption of interventions in real-world clinical practice. The efficiency of identifying, recruiting, and following patients, the resemblance of interventions and design to usual clinical care, and the importance of outcomes to patients are key factors in determining the pragmatism of a trial. This review focuses on the promise, trade-offs, and purpose of pragmatic trials in hepatology.
Review
Pharmacology & Pharmacy
Javier Ros, Nadia Saoudi, Francesc Salva, Iosune Baraibar, Guzman Alonso, Josep Tabernero, Elena Elez
Summary: Molecular profiling has improved survival in metastatic colorectal cancer patients. Circulating tumor DNA has reshaped the prognosis of local CRC. Clinical guidelines recommend testing for multiple biomarkers to guide treatment.
EXPERT OPINION ON INVESTIGATIONAL DRUGS
(2022)
Editorial Material
Oncology
Gretchen M. Alicea, Jessie Villanueva, Marie R. Webster, Vito W. Rebecca
Summary: On the 20th Anniversary of the Society for Melanoma Research, five melanoma patients shared their stories, highlighting the health inequities in melanoma care. These stories serve as a reminder to focus on the diagnosis, treatment, and prevention of melanoma, as well as the importance of resources in communities of color and low socioeconomic status.
PIGMENT CELL & MELANOMA RESEARCH
(2023)
Review
Engineering, Biomedical
Ke Nie, Ying Xiao
Summary: Biomarkers are biological measures of disease behavior, and radiomics is a new quantitative imaging analysis approach that can extract advanced imaging features to predict disease behavior and treatment response. However, radiomics faces challenges in clinical applications that need to be addressed.
PHYSICS IN MEDICINE AND BIOLOGY
(2023)
Review
Oncology
Russell G. Witt, Derek J. Erstad, Jennifer A. Wargo
Summary: The treatment of malignant melanoma has undergone significant changes in recent years, including the use of immune checkpoint blockade, targeted therapy, and intralesional therapy. Despite improvements in patient response rates, there remains a subset of high-risk patients with surgically resectable disease. Neoadjuvant therapy offers several advantages for this high-risk group, including a stronger immune response, the ability to assess treatment response, and increased disease resectability.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2022)
Editorial Material
Biochemistry & Molecular Biology
Claus Garbe, Reinhard Dummer, Teresa Amaral, Rodabe N. Amaria, Paolo A. Ascierto, Elizabeth M. Burton, Brigitte Dreno, Alexander M. M. Eggermont, Axel Hauschild, Christoph Hoeller, Roland Kaufmann, Celeste Lebbe, Mario Mandala, Alexander M. Menzies, David Moreno, Olivier Michielin, Paul Nathan, Sapna P. Patel, Caroline Robert, Dirk Schadendorf, Paul C. Lorigan, Richard A. Scolyer, Hussein A. Tawbi, Bart A. van de Wiel, Christian Blank, Georgina V. Long
Summary: Individuals with cutaneous melanoma who receive neoadjuvant immunotherapy demonstrate significant improvement, which should be included in standard care.
Article
Integrative & Complementary Medicine
Joyce K. Anastasi, Bernadette Capili, Jessica Neumaier, Londa Hackett
Summary: The delivery of acupuncture in a clinical trial differs significantly from its delivery in real-world clinical settings. Traditional Chinese medicine-trained acupuncturists often need to set aside traditional care principles when participating in research, which can lead to mixed feelings. This article reviews the subjective experiences of research acupuncturists and suggests the need for a specialized training program to address their concerns and improve the design and execution of acupuncture studies.
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2023)
Article
Medicine, Research & Experimental
Paolo A. Ascierto, Christian Blank, Reinhard Dummer, Marc S. Ernstoff, Soldano Ferrone, Bernard A. Fox, Thomas F. Gajewski, Claus Garbe, Patrick Hwu, Pawel Kalinski, Michelle Krogsgaard, Roger S. Lo, Jason J. Luke, Bart Neyns, Michael A. Postow, Sergio A. Quezada, Michele W. L. Teng, Giorgio Trinchieri, Alessandro Testori, Corrado Caraco, Iman Osman, Igor Puzanov, Magdalena Thurin
Summary: Advances in immune checkpoint therapy and targeted therapy have improved overall survival for patients with advanced melanoma, but challenges remain in patient classification, therapy selection, and prediction of treatment response. Understanding tumor microenvironment, immunity, and therapy response drives translational and clinical research in melanoma.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Review
Oncology
Rui Wang, Aashiq Hussain, Quanquan Guo, Meimei Ma
Summary: DNA is highly immunogenic and can activate the cGAS-STING pathway, which plays a crucial role in the pathogenesis and progression of neoplastic diseases. The modulation of cGAS-STING signaling holds great promise for cancer therapy, although there are disagreements on whether to activate or inhibit this pathway.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2024)
Review
Oncology
Ali Zarezadeh Mehrabadi, Faezeh Shahba, Hossein Khorramdelazad, Nazanin Aghamohammadi, Milad Karimi, Kowsar Bagherzadeh, Majid Khoshmirsafa, Ramin Massoumi, Reza Falak
Summary: IL-1 receptor accessory protein (IL-1RAP) plays a crucial role in inflammatory conditions and tumorigenesis in the tumor microenvironment. It is involved in the progression, metastasis, and angiogenesis of solid tumors and hematological malignancies.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2024)
Review
Oncology
Xiao Tang, Yujie Niu, Jinli Jian, Yuancheng Guo, Yin Wang, Yu Zhu, Bei Liu
Summary: Ferroptosis is an iron-dependent form of cell death that promotes tumor cell death by causing cell membrane rupture and accumulation of lipid peroxides. Extensive research has been conducted to explore the mechanism of ferroptosis inducers, but its role in hematological tumors is still limited.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2024)
Review
Oncology
Tanwei Yuan, Dominic Edelmann, Jakob N. Kather, Ziwen Fan, Katrin E. Tagscherer, Wilfried Roth, Melanie Bewerunge-Hudler, Alexander Brobeil, Matthias Kloor, Hendrik Blaeker, Barbara Burwinkel, Hermann Brenner, Michael Hoffmeister
Summary: The study aimed to analyze and validate previously published CpG-methylation-based prognostic biomarkers and prediction models for colorectal cancer (CRC) prognosis. The results showed that the discrimination ability of the models was insufficient and lacked clinical relevance.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2024)
Review
Oncology
Zhihui Duan, Dandan Yang, Ping Yuan, Xiaoming Dai, Guodong Chen, Daichao Wu
Summary: This article provides a comprehensive overview of therapeutic cancer vaccines, including their classification, clinical application, efficacy, and combination strategies with other therapies. It offers a valuable theoretical basis for the future clinical application and development of therapeutic cancer vaccines.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2024)
