Article
Cardiac & Cardiovascular Systems
Christopher A. Hanson, Edwin Lu, Saad S. Ghumman, Michelle L. Ouellette, Adrian I. Loffler, George A. Beller, Jamieson M. Bourque
Summary: In a cohort of patients undergoing ICA evaluation, those with obstructive CAD had significantly decreased survival rates compared to those with NNCA or nonobstructive CAD. There were no significant differences in event rates between NNCA and nonobstructive CAD patients. Increased use of aspirin, lipid lowering therapy, and beta-blockers post ICA may explain the low incidence of subsequent cardiac events.
CLINICAL CARDIOLOGY
(2021)
Article
Peripheral Vascular Disease
Daniel Kosuta, Borut Jug, Zlatko Fras
Summary: The presence of nonobstructive and obstructive CAD on CCTA is associated with an increased risk of coronary events, with patients having nonobstructive CAD showing a 2-fold increase in risk compared to those with no CAD.
Article
Cardiac & Cardiovascular Systems
Jana Taron, Borek Foldyna, Thomas Mayrhofer, Michael T. Osborne, Nandini Meyersohn, Daniel O. Bittner, Stefan B. Puchner, Hamed Emami, Michael T. Lu, Maros Ferencik, Neha J. Pagidipati, Pamela S. Douglas, Udo Hoffmann
Summary: This study developed a risk prediction model for patients with nonobstructive CAD and found that advanced coronary plaque features have incremental value in discriminating clinical events in low-risk stable chest pain patients. ASCVD risk, degree of stenosis, and presence of HRP features independently predicted composite events in patients with nonobstructive CAD, improving model fit significantly. Patients with ASCVD >= 7.5%, any HRP, and mild/moderate stenosis had significantly higher rates of events compared to those who did not meet those criteria.
JACC-CARDIOVASCULAR IMAGING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mahmoud Mohamed, Maria Bosserdt, Viktoria Wieske, Benjamin Dubourg, Hatem Alkadhi, Mario J. Garcia, Sebastian Leschka, Elke Zimmermann, Abbas A. Shabestari, Bjarne L. Norgaard, Matthijs F. L. Meijs, Kristian A. Ovrehus, Axel C. P. Diederichsen, Juhani Knuuti, Bjrn A. Halvorsen, Vladymir Mendoza-Rodriguez, Yung-Liang Wan, Nuno Bettencourt, Eugenio Martuscelli, Ronny R. Buechel, Hans Mickley, Kai Sun, Simone Muraglia, Philipp A. Kaufmann, Bernhard A. Herzog, Jean-Claude Tardif, Georg M. Schuetz, Michael Laule, David E. Newby, Stephan Achenbach, Matthew Budoff, Robert Haase, Federico Biavati, Aldo Vasquez Mezquita, Peter Schlattmann, Marc Dewey
Summary: Combining coronary computed tomography angiography (CCTA) with coronary artery calcium (CAC) score can significantly improve the diagnosis of coronary artery disease (CAD). The addition of CAC score is particularly beneficial when CCTA alone is inconclusive.
EUROPEAN RADIOLOGY
(2023)
Article
Endocrinology & Metabolism
Yipu Ding, Zinuan Liu, Guanhua Dou, Xia Yang, Xi Wang, Dongkai Shan, Bai He, Jing Jing, Yundai Chen, Junjie Yang
Summary: The study investigated the prognostic value of atherosclerotic extent shown by CCTA in diabetic patients with nonobstructive CAD, revealing an association between atherosclerotic extent and adverse cardiac events. This highlights the importance of better risk stratification and management in these patients.
JOURNAL OF DIABETES RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Harmony R. Reynolds, Ariel Diaz, Derek D. Cyr, Leslee J. Shaw, G. B. John Mancini, Jonathon Leipsic, Matthew J. Budoff, James K. Min, Cameron J. Hague, Daniel S. Berman, Bernard R. Chaitman, Michael H. Picard, Sean W. Hayes, Marielle Scherrer-Crosbie, Raymond Y. Kwong, Renato D. Lopes, Roxy Senior, Sudhanshu K. Dwivedi, Todd D. Miller, Benjamin J. W. Chow, Ramesh de Silva, Gregg W. Stone, William E. Boden, Sripal Bangalore, Sean M. O'Brien, Judith S. Hochman, David J. Maron
Summary: This study investigated the prevalence of ischemia with nonobstructive coronary arteries (INOCA) among patients with at least moderate ischemia and the relationship between ischemia severity and non-obstructive atherosclerosis severity. The results showed that the prevalence of INOCA was 13% and there was no significant association between the severity of ischemia and the severity of nonobstructive atherosclerosis. Female sex was identified as an independent predictor of INOCA.
JACC-CARDIOVASCULAR IMAGING
(2023)
Article
Multidisciplinary Sciences
Caroline A. Berge, Ingeborg Eskerud, Elise B. Almeland, Terje H. Larsen, Eva R. Pedersen, Svein Rotevatn, Mai Tone Lonnebakken
Summary: This study aimed to investigate the association between hypertension and extensive non-obstructive coronary artery disease (CAD) in patients with symptomatic chronic coronary syndrome (CCS). The results showed that hypertension was associated with extensive non-obstructive CAD in CCS patients, independent of factors such as sex, age, smoking, diabetes, statin treatment, obesity, and calcium score.
Article
Multidisciplinary Sciences
Zengfa Huang, Beibei Cao, Xinyu Du, Mei Li, Jiong Huang, Zuoqin Li, Jianwei Xiao, Xiang Wang
Summary: We aimed to predict the risk of major adverse cardiovascular events (MACE) in patients with suspected non-obstructive coronary artery disease (CAD) by exploring classifications based on coronary computed tomography angiography (CTA). We compared these classifications with traditional non-obstructive CAD (NOCAD) classification, Duke prognostic NOCAD index, and Non-obstructive coronary artery disease reporting and data system (NOCAD-RADS). 4378 consecutive non-obstructive CAD patients were assessed, and the SPI classification, which focused on proximal involvement of plaques, provided important prognostic information for MACE prediction.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Jeremy Boyer, Axel Bartoli, Pierre Deharo, Antoine Vaillier, Jerome Ferrara, Pierre-Antoine Barral, Nicolas Jaussaud, Pierre Morera, Alizee Porto, Frederic Collart, Alexis Jacquier, Thomas Cuisset
Summary: Computed coronary tomography angiography (CCTA) is an efficient alternative to invasive coronary angiography (ICA) for coronary artery disease (CAD) screening before transcatheter aortic valve implantation (TAVI) in patients without known CAD.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Javier Lopez-Pais, Barbara Izquierdo Coronel, Sergio Raposeiras-Roubin, Leyre Alvarez Rodriguez, Oscar Vedia, Manuel Almendro-Delia, Alessandro Sionis, Agustin C. Martin-Garcia, Aitor Uribarri, Emilia Blanco, Irene Martin de Miguel, Emad Abu-Assi, David Galan Gil, Manuela Sestayo Fernandez, Maria Jesus Espinosa Pascual, Rosa Maria Agra-Bermejo, Diego Lopez Otero, Jose Maria Garcia Acuna, Joaquin Jesus Alonso Martin, Jose Ramon Gonzalez-Juanatey, Miguel Angel Perez de Juan Romero, Ivan J. Nunez-Gil
Summary: Compared to other MINOCAs, Takotsubo syndrome presents different patient characteristics and a more aggressive acute phase. However, its long-term cardiovascular prognosis is better.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Seung Hun Lee, Doosup Shin, Joo Myung Lee, Tim P. van de Hoef, David Hong, Ki Hong Choi, Doyeon Hwang, Coen K. M. Boerhout, Guus A. de Waard, Ji-Hyun Jung, Hernan Mejia-Renteria, Masahiro Hoshino, Mauro Echavarria-Pinto, Martijn Meuwissen, Hitoshi Matsuo, Maribel Madera-Cambero, Ashkan Eftekhari, Mohamed A. Effat, Tadashi Murai, Koen Marques, Joon-Hyung Doh, Evald H. Christiansen, Rupak Banerjee, Hyun Kuk Kim, Chang-Wook Nam, Giampaolo Niccoli, Masafumi Nakayama, Nobuhiro Tanaka, Eun-Seok Shin, Steven A. J. Chamuleau, Niels van Royen, Paul Knaapen, Bon Kwon Koo, Tsunekazu Kakuta, Javier Escaned, Jan J. Piek
Summary: In stable patients with nonobstructive coronary stenoses, a diagnosis of INOCA based only on abnormal NIT did not identify patients with higher risk of long-term cardiovascular events. Incorporating intracoronary physiologic assessment to NIT information in patients with nonobstructive disease allowed identification of patient subgroups with up to 4-fold difference in long-term cardiovascular events.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Review
Medicine, Research & Experimental
H. R. Reynolds, N. R. Smilowitz
Summary: Myocardial infarction with nonobstructive coronary arteries (MINOCA) is a subtype of myocardial infarction (MI) that occurs in a certain percentage of spontaneous MI patients who undergo coronary angiography. The pathogenesis of MINOCA is more variable than MI with obstructive coronary artery disease (MI-CAD), and the management varies depending on the underlying mechanism. Therefore, systematic approaches to diagnosis are recommended.
ANNUAL REVIEW OF MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Qingya Xie, Lingling Zhou, Ying Li, Ruizhe Zhang, Han Wei, Gaoxiang Ma, Yuping Tang, Pingxi Xiao
Summary: This study aimed to explore the effects of using invasive coronary angiography (ICA) or coronary computed tomography angiography (CCTA) as an initial examination on the incidence of major adverse cardiovascular events (MACEs) and major operation-related complications in patients with stable coronary artery disease. The analysis of six included studies revealed that among patients with stable coronary artery disease, an initial examination with ICA was significantly associated with a higher risk of MACEs, all-cause death, and major procedure-related complications compared to CCTA.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Toshimitsu Tsugu, Kaoru Tanaka, Dries Belsack, Yuji Nagatomo, Mayuko Tsugu, Jean-Francois Argacha, Bernard Cosyns, Nico Buls, Michel De Maeseneer, Johan De Mey
Summary: In non-obstructive coronary artery disease, the decline of CT-derived fractional flow reserve (FFRCT) depends not only on vessel length but also on the lumen volume. A new marker, the ratio of lumen volume to vessel length (V/L ratio), was found to be the strongest predictor of distal FFRCT.
EUROPEAN RADIOLOGY
(2023)
Article
Biology
Chen Zhao, Aviral Vij, Saurabh Malhotra, Jinshan Tang, Haipeng Tang, Drew Pienta, Zhihui Xu, Weihua Zhou
Summary: An automatic method was developed using deep learning to segment coronary arteries and detect arterial stenosis with high accuracy and sensitivity. The promising results could advance to clinical use and provide auxiliary suggestions for CAD diagnosis and treatment.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
Article
Cell Biology
Zhen Wang, Hong Zhou, Huaping Zheng, Xikun Zhou, Guobo Shen, Xiu Teng, Xiao Liu, Jun Zhang, Xiaoqiong Wei, Zhonglan Hu, Fanlian Zeng, Yawen Hu, Jing Hu, Xiaoyan Wang, Shuwen Chen, Juan Cheng, Chen Zhang, Yiyue Gui, Song Zou, Yan Hao, Qixiang Zhao, Wenling Wu, Yifan Zhou, Kaijun Cui, Nongyu Huang, Yuquan Wei, Wei Li, Jiong Li
Summary: This study reveals a novel autophagy mechanism in the pathogenesis of psoriasis, indicating the pivotal role of HMGB1-associated autosecretion in cutaneous inflammation.
Article
Cardiac & Cardiovascular Systems
Xiaoqiong Wei, Song Zou, Zhonghui Xie, Zhen Wang, Nongyu Huang, Zhifu Cen, Yan Hao, Chengxin Zhang, Zhenyu Chen, Fulei Zhao, Zhonglan Hu, Xiu Teng, Yiyue Gui, Xiao Liu, Huaping Zheng, Hong Zhou, Shuwen Chen, Juan Cheng, Fanlian Zeng, Yifan Zhou, Wenling Wu, Jing Hu, Yuquan Wei, Kaijun Cui, Jiong Li
Summary: The study demonstrates the important role of EDIL3 in cardiac remodeling after myocardial infarction. EDIL3 deficiency improves adverse cardiac healing mainly through the mechanism of neutrophil extracellular trap-mediated pro-inflammatory macrophage polarization.
CARDIOVASCULAR RESEARCH
(2022)
Article
Allergy
Xiaoting Tong, Huan Tong, Ling Gao, Yuqin Deng, Rong Xiang, Ruixiang Cen, Yan Zhao, Pengju Wang, Guo Li, Jingqiu Shen, Bisheng Xu, Benchao He, Yonggang Kong, Zezhang Tao, Yu Xu
Summary: The prevalence of allergic rhinitis in school children in Hubei Province varies significantly between different cities, and is positively correlated with the regional GDP per capita. Risk factors for allergic rhinitis in children include male gender, family history of allergy, food and drug allergies, and environmental factors such as exposure to dust. Strategies to reduce the risk of allergic rhinitis should consider both genetic and environmental influences.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Haiguang Li, Xiaochao Wu, Pengju Wang, Qingkui Li, Tao Zhang, Kaijun Yang, Jun Wang, Kunming Pan, Zhimin Huang, Jilin He
Summary: This research investigated the structural stability, deoxidation characteristics, and sintering behaviors of activated Mo-10%Nb solid-solution powders. The results showed that the activated powders exhibited good stability in terms of crystal structure and composition. The oxygen content was mainly concentrated at the surface and could be significantly decreased through a deoxidation process. Using the activated powders, the density of the sintered billet increased, and the homogeneity of composition and microstructure was greatly improved.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2022)
Review
Cardiac & Cardiovascular Systems
Yi Zhang, Tian-Yuan Xiong, Yi-Ming Li, Yi-Jun Yao, Jing-Jing He, Hao-Ran Yang, Zhong-Kai Zhu, Fei Chen, Yuanweixiang Ou, Xi Wang, Qi Liu, Xi Li, Yi-Jian Li, Yan-Biao Liao, Fang-Yang Huang, Zhen-Gang Zhao, Qiao Li, Xin Wei, Yong Peng, Sen He, Jia-Fu Wei, Wen-Xia Zhou, Ming-Xia Zheng, Yun Bao, Xuan Zhou, Hong Tang, Wei Meng, Yuan Feng, Mao Chen
Summary: This study aimed to compare the clinical adverse events in patients undergoing transcatheter aortic valve replacement (TAVR) with bicuspid aortic valve (BAV) versus tricuspid aortic valve (TAV) anatomy, as well as the efficacy of balloon-expandable (BE) versus self-expanding (SE) valves in the BAV population. The findings showed that patients with BAV had higher risks of complications such as the need for a second valve or permanent pacemaker implantation, compared to patients with TAV. However, TAVR remains a viable option for selected patients with severe BAV and the newer generation devices demonstrated better outcomes in terms of reducing complications.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Oncology
Yijie Sun, Zhe Zhang, Chenglin Zhang, Na Zhang, Pengju Wang, Yongchao Chu, Louisa S. Chard Dunmall, Nicholas R. Lemoine, Yaohe Wang
Summary: Glioblastoma is the most common malignant brain tumor with limited response to immunotherapeutic strategies. The use of a new generation of vaccinia virus enhances immune control over the tumor and results in tumor growth control and long-term survival in mice models. The upregulation of stem cell memory T cells after virus treatment contributes to the strong and durable anti-tumor activity.
MOLECULAR THERAPY-ONCOLYTICS
(2022)
Correction
Biotechnology & Applied Microbiology
Han Hsi Wong, Guozhong Jiang, Rathi Gangeswaran, Pengju Wang, Jiwei Wang, Ming Yuan, Hexiao Wang, Vipul Bhakta, Heike Mueller, Nicholas R. Lemoine, Yaohe Wang
Article
Emergency Medicine
Bao-tao Huang, Yi-heng Cheng, Bo-sen Yang, Yi-ke Zhang, Fang -yang Huang, Yong Peng, Xiao-bo Pu, Mao Chen
Summary: This study investigated whether pressure injury risk mediates the association between left ventricular ejection fraction (LVEF) and all-cause death in patients aged 80 years or older with acute myocardial infarction (AMI). The results showed that reduced LVEF was associated with an increased risk of all-cause death only in the high-risk group of pressure injury, with significant interactions between pressure injury risk and LVEF. Incorporating pressure injury risk assessment into AMI care management improved the classification of older patients for therapy and prognosis assessment.
WORLD JOURNAL OF EMERGENCY MEDICINE
(2023)
Article
Materials Science, Multidisciplinary
Pengju Wang, Yazhou Sun, Ziyang Ma, Liwei Diao, Haitao Liu, V. Prasad Shastri
Summary: Conventional methods for creating gradient tissue structures using extrusion-based 3D printing systems involve using mixers to create homogeneous materials. However, commercially available mixers can generate high fluid pressure and shear force that harm cells. Hence, a new mixer-integrated print-head was developed, inspired by stirring-rod-assisted mixing processes. The as-designed mixing system was validated through computational fluid dynamics simulations.
MATERIALS & DESIGN
(2023)
Article
Materials Science, Multidisciplinary
Pengju Wang, Yazhou Sun, Dekai Li, Ziyang Ma, Bohan Zhang, Liwei Diao, Haitao Liu
Summary: This study proposes a new approach for preparing structured inks for extrusion-based 3D printing (E3DP), which controls the material distribution before printing. The feasibility is verified through ink preparation and process parameter optimization, using a combination of casting and 3D printing. Computational fluid dynamics (CFD) simulation is employed to analyze the ink flow, and the geometric parameters are determined by analyzing the cross section of the extruded fibers. This approach enriches E3DP and facilitates the fabrication of heterogeneous tissue structures.
MATERIALS & DESIGN
(2023)
Review
Immunology
Yangyang Jia, Yanru Wang, Louisa S. Chard Dunmall, Nicholas R. Lemoine, Pengju Wang, Yaohe Wang
Summary: Cancer immunotherapy (CIT) is a promising new approach to cancer treatment, but the overall response rate is still unsatisfactory. Therefore, an ideal preclinical animal model for evaluating CIT is urgently needed. Syrian hamsters show similarities to humans in terms of their anatomy, physiology, and pathology, making them an ideal model for studying CIT. This article reviews current tumor models in Syrian hamsters and the latest progress in using them to develop and assess CIT for human cancer treatments, as well as the challenges involved.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Junteng Zhou, Geer Tian, Yue Quan, Qihang Kong, Fangyang Huang, Junli Li, Wenchao Wu, Yong Tang, Zhichao Zhou, Xiaojing Liu
Summary: Cardiac fibrosis is a detrimental process in cardiovascular disease, leading to reduced cardiac compliance and ultimately heart failure. In this study, the key long noncoding RNA (lncRNA) THBS1-AS1 was identified as positively associated with cardiac fibrosis. Functional studies demonstrated that THBS1-AS1 could regulate cardiac fibroblast activation through miR-221/222 and TGFBR1. In vivo knockdown of THBS1-AS1 alleviated cardiac fibrosis, suggesting it as a potential therapeutic target for cardiac fibrosis treatment.
Article
Cardiac & Cardiovascular Systems
Bao-Tao Huang, Lu Yang, Bo-Sen Yang, Fang-Yang Huang, Qian-Feng Xiao, Xiao-Bo Pu, Yong Peng, Mao Chen
Summary: The interaction between body fat percentage and left ventricular hypertrophy (LVH) affects the risk of all-cause death in patients with coronary artery disease (CAD). The study found that patients with higher body fat percentage and LVH had the highest mortality rate, while patients with lower body fat percentage and no LVH had the lowest mortality rate.
JOURNAL OF GERIATRIC CARDIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zhen Wang, Fan-lian Zeng, Ya-wen Hu, Xiao-yan Wang, Fu-lei Zhao, Pei Zhou, Jing Hu, Yuan-yuan Xiao, Zhong-lan Hu, Ming-feng Guo, Xiao-qiong Wei, Xiao Liu, Nong-yu Huang, Jun Zhang, Shu-wen Chen, Juan Cheng, Hua-ping Zheng, Hong Zhou, Qi-xiang Zhao, Chen Zhang, Yan Hao, Song Zou, Yi-yue Gui, Jia-dong Yu, Lin-na Gu, Cheng-cheng Yue, Hao-zhou Zhang, Wen-ling Wu, Yi-fan Zhou, Xi-kun Zhou, Guo-bo Shen, Xiu Teng, Jiong Li
Summary: Interleukin-37b (IL-37) is a crucial inhibitor of natural and acquired immunity. Research has shown that IL-37 increases the risk of colitis-associated colorectal cancer (CAC) and dampens the immune response mediated by cytotoxic T cells. IL-37 has little effect on intestinal mutagenesis, CRC cell proliferation, apoptosis, and migration. Additionally, IL-37 levels are significantly increased in CRC patients, positively correlated with serum CRC biomarker CEA levels, but negatively correlated with CD8(+) T cell infiltration.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2022)
Review
Engineering, Biomedical
Pengju Wang, Yazhou Sun, Xiaoquan Shi, Huixing Shen, Haohao Ning, Haitao Liu
Summary: Tissue engineering is a novel approach to address tissue repair and organ replacement in regenerative medicine. Recent advances in 3D printing have facilitated the fabrication of vascular scaffolds, leading to promising prospects for tissue vascularization. The review highlights the importance of scaffold-based tissue engineering for vascular regeneration and discusses emerging trends in 3D printing of tissue engineering vascular scaffolds.
BIO-DESIGN AND MANUFACTURING
(2021)
