Article
Cell Biology
Kuan-Ju Chiang, Li-Cheng Chiu, Yi-No Kang, Chiehfeng Chen
Summary: This study aimed to assess the effects of ASCT on LECWs and found that patients receiving ASCT had significantly higher complete healing rates. CD34+ is an important cell marker for potential wound healing. However, more extensive and well-designed studies are needed to explore the details of ASCT and chronic wound healing.
Review
Medicine, General & Internal
Sarah Park, Ada Tang, Courtney Pollock, Brodie M. Sakakibara
Summary: This paper describes the protocol of a systematic review and meta-analysis that aims to evaluate the clinical outcomes of lower extremity-focused telerehabilitation interventions for stroke patients.
Review
Dermatology
Tassia Lima Bomfim, Isla Alcantara Gomes, Daniele de Vasconcelos Cerqueira Meneses, Adriano Antunes de Souza Araujo
Summary: Through a systematic literature review, it was found that topical ozone therapy can have a healing effect on lower limb ulcers and no adverse effects were reported. Further controlled and randomized clinical trials are needed to determine the effectiveness of ozone therapy in wound healing.
ADVANCES IN SKIN & WOUND CARE
(2021)
Review
Immunology
Jia-ming Chen, Qiao-yi Huang, Wei-hong Chen, Shu Lin, Qi-yang Shi
Summary: This study compared the safety and efficacy of autologous and allogeneic stem cell treatments for intrauterine adhesions (IUAs). The results showed that autologous stem cell therapy had a better effect in improving endometrial thickness and pregnancy rate.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Physiology
Bowen Liu, Jinlong Wu, Qiuqiong Shi, Fengwei Hao, Wen Xiao, Jingxuan Yu, Fengyu Yu, Zhanbing Ren
Summary: The results of this study suggest that lower extremity stiffness is negatively correlated with running economy, indicating that greater lower extremity stiffness leads to poorer running economy. In addition, maximum oxygen uptake and speed will determine the extent to which lower extremity stiffness affects running economy.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Endocrinology & Metabolism
Bernardo Meza-Torres, Fabrizio Carinci, Christian Heiss, Mark Joy, Simon de Lusignan
Summary: Specific organizational arrangements, such as dedicated teams, care pathways, and multidisciplinary teams, can significantly reduce the risk of lower extremity amputations in individuals with diabetes and foot ulcers. Further research is needed to assess the cost-effectiveness and identify barriers to implementation.
ACTA DIABETOLOGICA
(2021)
Review
Cell Biology
Yuxin Wang, Xinyue Wu, Xinhua Hu, Yu Yang
Summary: The aim of this study was to estimate the pooled prevalence of frailty in patients with lower extremity PAD. The results showed that the prevalence of frailty was higher in patients with lower extremity PAD, suggesting frailty is a common condition. There were differences in the prevalence of frailty among different genders and severity of PAD.
AGEING RESEARCH REVIEWS
(2022)
Review
Clinical Neurology
Mingze Zhou, Yang Tu, Jiarui Cui, Ping Gao, Ting Yi, Jun Wang, Qinghong Hao, Hui Li, Tianmin Zhu
Summary: This systematic review comprehensively studies the effectiveness of Constraint-Induced Movement Therapy (CIMT) in treating lower extremity motor dysfunction in stroke patients. The results indicate that CIMT effectively improves lower extremity motor function in post-stroke patients, especially when devices are used. The eligible studies showed high heterogeneity.
FRONTIERS IN NEUROLOGY
(2022)
Review
Sport Sciences
Anna C. Davis, Nicholas P. Emptage, Dana Pounds, Donna Woo, Robert Sallis, Manuel G. Romero, Adam L. Sharp
Summary: Neuromuscular warmups show significant protective effects for preventing lower extremity injuries among basketball players. While most studies are underpowered, the evidence supports the effectiveness of neuromuscular warmups as a preventative measure.
SPORTS MEDICINE-OPEN
(2021)
Review
Surgery
Syed H. Mufarrih, Nada Q. Qureshi, Rayaan A. Yunus, Anastasia Katsiampoura, Ibrahim Quraishi, Aidan Sharkey, Feroze Mahmood, Robina Matyal
Summary: The aim of this study was to assess the effects of regional anesthesia vs general anesthesia on postoperative complications in patients undergoing lower extremity amputation (LEA). The meta-analysis of 10 retrospective observational studies revealed that general anesthesia was associated with a higher rate of respiratory failure and sepsis compared with regional anesthesia, while no significant differences were found in other complications.
JOURNAL OF VASCULAR SURGERY
(2023)
Review
Endocrinology & Metabolism
Rongqi Liu, Brian J. Petersen, Gary M. Rothenberg, David G. Armstrong
Summary: This study analyzed data from 205 articles to determine the reamputation rates, particularly among diabetic patients who had undergone initial amputations. The results showed high incidence rates of reamputation to both limbs and the contralateral limb, with no significant changes in reamputation rates over a period of at least two decades.
BMJ OPEN DIABETES RESEARCH & CARE
(2021)
Review
Dermatology
Gianluca Melotto, Thanaporn Tunprasert, Jacqueline Rachel Forss
Summary: This paper reviewed the effects of electrical stimulation (ES) in combination with standard wound care (SWC) compared to SWC alone in the treatment of diabetic foot ulceration. The findings suggest that ES may lead to higher healing rates among diabetic ulcers, but the reliability of these findings is limited by small sample sizes and risk of bias in the studies. Currently, there is insufficient evidence to support the systematic use of ES in the treatment of diabetic foot ulcers.
INTERNATIONAL WOUND JOURNAL
(2022)
Review
Neurosciences
Keya Li, Xinyue Li, Guiying Shi, Xuepei Lei, Yiying Huang, Lin Bai, Chuan Qin
Summary: Animal models studies indicate that ADSC transplantation shows long-lasting therapeutic effects in Parkinson's disease animal models, possibly through neurogenesis and neuroprotective effects. Standardized induction of neural form of transplanted ADSCs may have potential for future clinical application.
TRANSLATIONAL NEURODEGENERATION
(2021)
Review
Oncology
Beatriz Regina Lima de Aguiar, Eliete Neves Silva Guerra, Ana Gabriela Costa Normando, Carolina Castro Martins, Paula Elaine Diniz dos Reis, Elaine Barros Ferreira
Summary: PBMT shows some effectiveness in preventing and treating radiation dermatitis (RD) in breast cancer patients, especially in preventing grade 3 RD. Further randomized clinical trials are needed to confirm the promising effect of PBMT in RD.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Review
Dermatology
Qianting Zhang, Ling Lu, Jia lin Song, Lu Wang
Summary: This study conducted a systematic review of eight randomized control trials to examine the effects of exercise on venous leg ulcer healing and exercise adherence. The findings showed that exercise has positive effects on the healing rate and range of ankle mobility, and patients tend to adhere well to exercise regimens.
INTERNATIONAL WOUND JOURNAL
(2023)