期刊
CHEMICAL COMMUNICATIONS
卷 51, 期 41, 页码 8652-8655出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc00513b
关键词
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资金
- Ministry of Science and Technology, Taiwan [NSC 100-2113-M-001-013-MY2, NSC 102-2113-M-001-007]
- Nano Science and Technology Program of Academia Sinica
We identify a new amyloidogenic peptide from the glutamine/asparagine-rich region of the FTLD-related protein (TDP-43), which can seed both the full-length and N-terminus-truncated TDP-43. Through the microinjection and real-time fluorescence imaging, we also found that this novel peptide could trigger cell apoptosis and initiate TDP-43 aggregation in the cytosol.
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