Article
Plant Sciences
Zsolt Gulyas, Blanka Moncsek, Kamiran Aron Hamow, Pal Straner, Zoltan Tolnai, Eszter Badics, Norbert Incze, Eva Darko, Valeria Nagy, Andras Perczel, Laszlo Kovacs, Vilmos Soos
Summary: This study characterizes D27-LIKE1 in Arabidopsis and highlights its important physiological and enzymatic functions related to carotenoids. The results show that D27-LIKE1 has multi-substrate specificity and may regulate carotenoid cis pools and the biosynthesis pathways of strigolactones and ABA.
Article
Chemistry, Multidisciplinary
Shutaro Karashima, Xincheng Miao, Akio Kanayama, Yo-ichi Yamamoto, Junichi Nishitani, Nikita Kavka, Roland Mitric, Toshinori Suzuki
Summary: In this study, we discovered the ultrafast ring closure reaction of gaseous cis-St for the first time using extreme ultraviolet time-resolved photoelectron spectroscopy. Previous computational simulations predicted a quantum yield of only 0.04 for the formation of 4a,4b-dihydrophenanthrene (DHP) from cis-St, but our results showed a different branching ratio of 0.55:0.41:0.04 for cis-St:DHP:trans-St.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Applied
Jolanta Konieczkowska, Mariola Siwy
Summary: This work investigates the thermal cis-trans isomerization in solid-state for poly(ether imide)s and poly(ester imide)s with azobenzene or azo pyridine moieties. The study explores the relationship between various material aspects such as polyimide structure, molar mass, azo dye content, d-spacing value, polymer film thickness, and thermal cis-trans isomerization. The reversibility of the trans-cis-trans reaction was studied using different irradiation wavelengths. This is the first comprehensive article on solid-state cis-trans isomerization for azo polyimides.
Article
Physics, Fluids & Plasmas
Izabela Sliwa, Pavel Maslennikov, Alex Zakharov
Summary: A molecular model is proposed to describe the effective anchoring energy of a liquid crystal system. The model explains the mechanism behind the anchoring transition caused by structural changes in the photosensitive azobenzene layer.
Article
Polymer Science
Yujin Cha, JiHyeon Hwang, Luis Ramos, Huina Lin, Tianyu Zhu, Chuanbing Tang
Summary: The synthesis of cyclic cobaltocenium and its application in the synthesis of high-performance copolymers have been reported.
Article
Chemistry, Multidisciplinary
Zhao Gao, Fei Yan, Lulu Shi, Yifei Han, Shuai Qiu, Juan Zhang, Feng Wang, Si Wu, Wei Tian
Summary: Photoisomeric supramolecular assemblies have been a hot topic in recent years. In general, the photoisomerization process from irregular aggregates to regular assemblies leads to the destruction of assemblies. However, through the conversion from planar to nonplanar photoisomer, a converse sol-to-gel transition has been achieved. A well-designed acylhydrazone-linked monomer, with imine for trans-cis interconversion and amide for intermolecular hydrogen bonding, is used to drive the photoisomerization-induced self-assembly. The counterintuitive sol-to-gel transition is attributed to the partial trans->cis photoisomerization of acylhydrazone, which changes the stacking mode of monomers. This reversible phase transition also holds potential for miniature materials, as demonstrated in the formation of in situ valves in microfluidic devices.
Article
Chemistry, Applied
Ke-Xin Wang, Bo -Wen Yin, Pei-Ke Jia, Teng-Shuo Zhang, Ganglong Cui, Bin-Bin Xie
Summary: In this work, electronic structure calculations and dynamics simulations were conducted to investigate the photoinduced ring-opening, relaxation, and isomerization of spirooxazine. The results revealed the important role of conical intersections in the nonadiabatic transitions and identified the reaction pathways involving bonded and unbonded conical intersections. The simulations provided mechanistic insights into spirooxazine-based photochromic materials.
Review
Agriculture, Multidisciplinary
Clemens Lamberth
Summary: Ring closing and opening manipulations of molecular scaffolds are important for scaffold hopping. Analogues derived from biologically active compounds through these strategies often show similar potency due to similar shape and physicochemical properties. This review demonstrates how various ring closure techniques, such as replacing carboxylic functions with cyclic peptide mimics, incorporating double bonds into aromatic rings, and tying back ring substituents, as well as ring opening, have led to the discovery of highly active agrochemicals.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Xia Yu, Yuzhang Meng, Hao Zhang, Junbo Guo, Shixian Wang, Hui Li, Jun Hu, Min-Hui Li
Summary: This study synthesized and characterized two pure stereoisomers, trans- and cis-TPE-2GA, which exhibited different aggregation-induced emission, self-assembly properties, and crystallinity. The cis-TPE-2GA showed mechano-chromic properties and a lower energy gap, higher quantum yield, and longer lifetime compared to trans-TPE-2GA, explaining their differences in fluorescence and mechano-chromic properties.
Article
Chemistry, Multidisciplinary
Timothy H. Vo, Rafal Korlacki, Alexander Sinitskii
Summary: The isomerization of dimethyl 2,3-dibromofumarate in chloroform solutions was studied using NMR and DFT calculations. The bromination reaction initially produces the trans isomer, which converts into the more stable cis isomer. The conversion from trans to cis is spontaneous and is greatly accelerated by light.
Article
Biochemistry & Molecular Biology
Kritika Kumari, Marina Warepam, Aniket Kumar Bansal, Tanveer Ali Dar, Vladimir N. Uversky, Laishram Rajendrakumar Singh
Summary: TMAO is a significant metabolite derived from various organic compounds, with diverse biological functions in humans. Studies have shown its crucial impact on protein folding and cell cycle, potentially leading to protein misfolding and the development of related diseases.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Polymer Science
Aysenur Vardar, Ozden Erdebil, Olcay Mert, Serap Mert
Summary: In this study, a variety of squaramide organocatalysts with different structures were synthesized, and the ring-opening polymerizations of asymmetrically substituted glycolides were successfully achieved. The trans-DACH-based catalysts showed higher polymerization activity towards IBG, IBMG, and IBEG monomers compared to the cis-DACH-based derivatives. The presence of different substituents in the monomers also affected the polymerization selectivity.
Article
Biochemistry & Molecular Biology
Huan-Hua Xu, Liang Yang, Ming-Xia Tang, An-Ping Ye, Bo-Dan Tu, Zhen-Hong Jiang, Jian-Feng Yi
Summary: This study found that the degree of isomerization of lobeline has a significant impact on its respiratory excitatory effects. The respiratory excitatory effect was significantly reduced with the administration of trans-lobeline injections compared to cis-lobeline injections. The study also discovered that isomerization is a one-way reaction catalyzed by temperature, with pH as the key factor. Lobeline, as a nonselective antagonist with high affinity for nicotinic acetylcholine receptors, has shown potential in the treatment of addiction and nervous system disorders.
Article
Chemistry, Multidisciplinary
Arui Huang, Jie Hu, Mengmeng Han, Kangwei Wang, Jian Long Xia, Jiajia Song, Xuelian Fu, Kai Chang, Xiaocong Deng, Siwei Liu, Qianqian Li, Zhen Li
Summary: This study demonstrated multiple photodeformable processes in anil-poly(ethylene terephthalate) systems utilizing excited-state intramolecular proton transfer and trans-cis isomerization as microscopic molecular motions under light stimulus. The doping films were able to achieve light-driven contraction and bending angle during a simple stretching process. The internal mechanism and relationship between molecular structure and photocontrolled motion were investigated through transient absorption spectra, theoretical calculations, and crystal analysis.
ADVANCED MATERIALS
(2021)
Article
Food Science & Technology
Chongyun He, Likang Qin, Jianmei Yang, Yong Zhu
Summary: The regularity of cis-trans isomerization of unsaturated fatty acids in camellia oil under heating was explored through fatty acid profile evolution and reaction kinetics. The temperatures for generating mono-trans linoleic acids and linolelaidic acid were significantly higher than that of elaidic acid. The total trans fatty acids content increased with heating temperature. The study also calculated the activation energy of the cis-trans isomerization reactions, which provides valuable information for inhibiting trans fatty acid formation during camellia oil processing.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Luis Cruz, Nuno Basilio, Nuno Mateus, Victor de Freitas, Fernando Pina
Summary: Flavylium compounds are a diverse family of plant pigments that contribute to a wide range of colors. There is growing interest in synthesizing different flavylium compounds with various substitution patterns for industrial applications. This Review provides an overview of the chemistry, synthetic and enzymatic approaches, and properties of flavylium-based compounds.
Article
Chemistry, Applied
Fernando Pina, Nuno Basilio, A. J. Parola, Maria J. Melo, Joana Oliveira, Victor de Freitas
Summary: Blue was the last color to be spread in Nature by anthocyanins, and the last color to be managed by Humans in Anthropocene. It took a long time for humanity to figure out how to reproduce and use blue, but plants developed strategies like intramolecular copigmentation and metalloanthocyanins to achieve the color. Blue was absent in early cave paintings and came later than red and green in LEDs and LASERs. It was only in the late 20th century that genetic engineering created blue flowers and blue remains sought after as a natural alternative to synthetic colorants. Despite being second-rate in the West, blue is now the preferred color in many countries.
Article
Biochemistry & Molecular Biology
Oscar H. Martinez-Costa, Laura Rodrigues-Miranda, Sofia M. Clemente, Antonio Jorge Parola, Nuno Basilio, Alejandro K. Samhan-Arias
Summary: Cytochrome b(5) reductase (Cb5R) is a flavoprotein that participates in redox reactions and generates superoxide anion. Previous studies have shown that different flavonoids can inhibit Cb5R. This study aims to investigate the molecular mechanism of interaction between flavonoids and Cb5R using flavylium salts as dynamic inhibitors.
Article
Chemistry, Analytical
Liliana J. Gomes, Joao P. Carrilho, Pedro M. Pereira, Artur J. Moro
Summary: This study presents a new Near InfraRed (NIR) fluorescent chemosensor that can detect metal ions and anions. The sensor is based on a synthetic analogue of the natural anthocyanin family and has a metal chelating unit. It shows high sensitivity to Zn2+ and has selectivity towards ATP and ADP. The sensor also exhibits strong luminescence in bacterial and mammalian cells, suggesting potential applications in intracellular labeling.
Article
Chemistry, Multidisciplinary
Ana Pinheiro, Andreia Ruivo, Joao Rocha, Marta Ferro, Joana Vaz Pinto, Jonas Deuermeier, Tiago Mateus, Ana Santa, Manuel J. J. Mendes, Rodrigo Martins, Sandra Gago, Cesar A. T. Laia, Hugo Aguas
Summary: The present study aims to enhance the performance of solar cells by developing advanced luminescent down-shifting using encapsulated nanostructured perovskite materials. Thin films of CsPbBr3 perovskite nanocrystal luminophores were synthesized and encapsulated with parylene type C to protect and stabilize the films. The results showed that this encapsulation technique significantly improved the current generation and spectral response of the photovoltaic cells.
Article
Chemistry, Multidisciplinary
Joana N. Martins, Beatriz Raimundo, Alicia Rioboo, Yeray Folgar-Camean, Javier Montenegro, Nuno Basilio
Summary: In this study, photoswitchable calixarenes were introduced to activate the transport of cationic peptide cargos across lipid membranes. The calixarenes, equipped with a hydrophobic azobenzene arm, can recognize cationic peptide sequences at the nanomolar range. The activation of membrane peptide transport was confirmed in synthetic vesicles and living cells by using calixarene activators with the azobenzene arm in the E configuration. This method allows the modulation of transmembrane transport of peptide cargos through the Z-E photoisomerization of functionalized calixarenes using 500 nm visible light.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Analytical
Roberto Pizzoferrato, Ramanand Bisauriya, Simonetta Antonaroli, Marcello Cabibbo, Artur J. Moro
Summary: Fluorescent nitrogen and sulfur co-doped carbon dots were synthesized through a simple one-step hydrothermal method and showed selective dual optical response to Cu(II) in water. The response was attributed to the formation of cuprammonium complexes or the oxidation of residual o-phenylenediamine bound to NSCDs. The NSCDs were successfully incorporated into a hydrogel agarose matrix for easier handling and sensing application.
Article
Humanities, Multidisciplinary
Tiago Veiga, Artur J. Moro, Paula Nabais, Marcia Vilarigues, Vanessa Otero
Summary: This paper investigates the 19th-century manufacture of red lake pigments obtained from madder by Winsor & Newton (W&N). Three main synthesis methods were identified and reproduced, revealing three main steps. The pigments were characterized using various analytical techniques. The study aims to contribute new knowledge towards the identification and preservation of W&N's 19th-century madder colors in heritage objects.
Article
Polymer Science
Bernardo Monteiro, Joao Avo, Artur J. Moro, Claudia C. L. Pereira
Summary: In this study, emissive polysulfone thin films doped with tetracoordinated Tb3+ and Eu3+ complexes were successfully prepared. The emission of these films was regulated by simultaneous excitation light and heat, allowing for controllable emissive patterns. The addition of specific complexes promoted increased emission in the blue region, resulting in a dynamic irreversible generation of emissive color from green to cyan. Under a commercial 366 nm UV lamp, the selected pre-chosen pattern emitted brighter light in the blue region compared to non-irradiated films. A simple methodology was presented to prepare fingerprint emission profiles based on an unusual interaction between polysulfone, an aromatic polymer with intrinsic luminescence, and highly fluorinated lanthanide complexes for advanced anticounterfeiting technologies.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Chemistry, Physical
Dmitriy Moreira, Oren Regev, Nuno Basilio, Eduardo F. Marques
Summary: This study develops a delivery system based on dual light and pH responsive vesicles, which can achieve precise drug release. By adjusting the acid and base conditions and UV irradiation, the release of the drug is successfully controlled, demonstrating the potential application of vesicles as nano-carriers in acidic environments such as tumors.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Andreia Forte, Sandra Gago, Celso Alves, Joana Silva, Joana Alves, Rui Pedrosa, Cesar A. T. Laia, Isabel M. Marrucho, Luis C. Branco
Summary: This study explores the formulation of magnetic ionic liquids (MILs) or organic salts based on lanthanides as anions. A set of choline-family-based salts, along with two other cation families, were combined with Gadolinium(III) and Terbium(III) anions. The magnetic moments of the lanthanides were found to be correlated with the structural features of the cation, and most of the prepared compounds were non-toxic to cells.
Article
Pharmacology & Pharmacy
Luis Filipe, Telma de Sousa, Dario Silva, Miguel M. Santos, Manuela Ribeiro Carrott, Patricia Poeta, Luis C. Branco, Sandra Gago
Summary: The combination of active pharmaceutical ingredients in the form of ionic liquids or organic salts (API-OSILs) with mesoporous silica nanoparticles (MSNs) as drug carriers can enhance the capabilities of current antibiotics, especially against resistant strains of bacteria. In this study, three nanomaterials based on the modification of MSN surface with different ionic liquids coupled with anionic ciprofloxacin were prepared. These materials showed no cytotoxicity and exhibited improved antibacterial activity against both resistant and sensitive strains of K. pneumoniae. One particular nanomaterial, [MSN-Chol][Cip], showed significant enhancement with a tenfold decrease in MIC against sensitive strains. The importance of this study is rated at 8 out of 10 for its potential application in combating antibiotic resistance.
Article
Chemistry, Multidisciplinary
Jialei Chen-Wu, Patricia Maximo, Patricia Remon, A. Jorge Parola, Nuno Basilio, Uwe Pischel
Summary: The tailored design of a light-triggered supramolecular cascade allows for the transduction of photons into chemical communication and the release of a neurotransmitter, reminiscent of crucial steps in natural vision process.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Physical
Paula Araujo, Joana Oliveira, Nuno Basilio, A. Jorge Parola, Victor de Freitas, Fernando Pina
Summary: The thermodynamics and kinetics of compound 7-diethylamino-4 '-dimethylaminoflavylium were studied in various solvents and in the presence of micelles. Different pH domains and photochemical reactions were observed in different solvents and micelles.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2022)
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)
