Editorial Material
Oncology
Jack Bowden
Summary: MR-PHeWAS is a powerful new design for discovering causal mechanisms between a disease and its candidate risk factors, with great potential in cancer research when utilizing powerful and principled statistical approaches.
BRITISH JOURNAL OF CANCER
(2021)
Article
Clinical Neurology
Brittany L. Mitchell, Santiago Diaz-Torres, Svetlana Bivol, Gabriel Cuellar-Partida, Zachary F. Gerring, Nicholas G. Martin, Sarah E. Medland, Katrina L. Grasby, Dale R. Nyholt, Miguel E. Renteria
Summary: This study explores the genetic relationship between migraine risk and brain morphometry using genome-wide association studies. The researchers found a negative genetic correlation between migraine risk and intracranial volume, and identified shared genomic regions between migraine and various brain structures. Additionally, evidence of a causal relationship between smaller brain volumes and increased migraine risk was discovered. These findings contribute to the understanding of the genetic basis for migraine and potential therapeutic targets.
Article
Cardiac & Cardiovascular Systems
Yaozhong Liu, Biao Li, Yingxu Ma, Yunying Huang, Feifan Ouyang, Qiming Liu
Summary: This study identified genes and DNAm sites potentially causally associated with AF through integrating GWAS with eQTL and mQTL studies, highlighting potential mechanisms in genetic regulation of transcription through DNAm that mediates the effect of genetic variants on AF. Further validation is needed for clinical translation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cell Biology
Shizheng Qiu, Peigang Cao, Yu Guo, Haoyu Lu, Yang Hu
Summary: Through genome-wide association study and Mendelian randomization analysis, the study found a significant correlation between hypothyroidism and NAFLD, with hypothyroidism patients at significantly higher risk of developing NAFLD.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Genetics & Heredity
Hong Wu, Tianjun Ma, Dongli Li, Mei He, Hui Wang, Ying Cui
Summary: This study investigated the causal relationship between circulating VEGF and different types of cancer using genome-wide association studies (GWASs) data. A causal relationship was found between circulating VEGF and colorectal cancer, but no causal relationship was found for other types of cancer.
FRONTIERS IN GENETICS
(2022)
Article
Endocrinology & Metabolism
Mengyuan Dai, Weijie Guo, San Zhu, Guidong Gong, Mei Chen, Zhuoling Zhong, Junling Guo, Yaoyao Zhang
Summary: This study conducted a Two-sample Mendelian randomization (MR) study and found that strict type 2 diabetes mellitus (T2DM) may not be significantly associated with a higher genetic risk of abnormal spermatozoa in Europeans. More comprehensive and larger samples are needed to further investigate the relationship and potential mechanism between T2DM and abnormal spermatozoa.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yu Min, Xiaoyuan Wei, Zheran Liu, Zhigong Wei, Yiyan Pei, Ruidan Li, Jing Jin, Yongllin Su, Xiaolin Hu, Xingchen Peng
Summary: Based on GWAS data, a two-sample Mendelian randomization analysis was conducted to investigate the causal effects of statin use on cancer risks. The results suggest that statin use may increase the risk of colorectal cancer and decrease the risk of bile duct cancer, but no significant effects were observed for other types of cancer. The findings highlight the controversy surrounding the use of statins for cancer prevention.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Yuning Zhang, Shouzheng Liu, Yunwen Wang, Yue Wang
Summary: This study assessed the causal association between PM2.5 concentrations and the risk of hypothyroidism using two-sample Mendelian randomization. The results showed that increased PM2.5 concentrations are associated with an increased risk of hypothyroidism.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Immunology
Mengmeng Xiang, Yilun Wang, Zhanyan Gao, Jie Wang, Qian Chen, Zhan Sun, Jun Liang, Jinhua Xu
Summary: This study used Mendelian randomization to assess the causal correlations between 41 inflammatory cytokines and systemic lupus erythematosus (SLE). The results suggested that CTACK and IL-17 may be associated with the risk of SLE, while several other inflammatory cytokines may be consequences of SLE development.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Huahua Zhong, Kexin Jiao, Xiao Huan, Rui Zhao, Manqiqige Su, Li-Ying Goh, Xueying Zheng, Zhirui Zhou, Sushan Luo, Chongbo Zhao
Summary: This study used Mendelian randomization analysis to investigate the causal relationship between T cell biomarkers and MG, identifying HVEM and other T cell subtypes as protective factors for MG risk. These findings were validated in different populations, highlighting the potential role of HVEM as a novel molecular factor in modulating MG risk.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Health Care Sciences & Services
Yaoyao Nie, Houpu Liu, Jing Wang, Ye Yang, Wenxia Zhao, Dingwan Chen, Yingjun Li
Summary: This study aimed to analyze the causal relationship between osteoarthritis (OA) and asthma. Through meta-analysis and bidirectional two-sample Mendelian randomization (MR) analysis, it was found that patients with asthma have a higher prevalence of OA, but there is no causal relationship between asthma and all OA or site-specific OA.
Article
Medicine, General & Internal
Yan Li, Hongyan Liu, Shuting Ye, Bumei Zhang, Xiaopei Li, Jiapei Yuan, Yongrui Du, Jianmei Wang, Yang Yang
Summary: Endometriosis is a complex gynecological disorder that affects 6-10% of reproductive-aged women. This study used GWAS summary statistics to examine the causal relationship between coagulation factors and the risk of endometriosis.
Article
Medicine, General & Internal
Jaeyoon Chung, Viha Vig, Xinyu Sun, Xudong Han, George T. O'Connor, Xuejing Chen, Margaret M. DeAngelis, Lindsay A. Farrer, Manju L. Subramanian
Summary: Age-related macular degeneration (AMD) is a risk factor for severe consequences from COVID-19. Genetic analysis shows a significant correlation between AMD and COVID-19, and identified novel genetic associations between the two diseases.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Virology
Ancha Baranova, Hongbao Cao, Fuquan Zhang
Summary: Genetic correlation and Mendelian randomization analyses showed that severe COVID-19 may contribute to the development of Alzheimer's disease, while mild cases of COVID-19 do not increase the risk. The influence of COVID-19 on Alzheimer's disease may be mediated by immunity-related pathways acting predominantly in the lung and brain.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Cell Biology
Jiahui Zhang, Mingai Sun, Yuanyuan Zhao, Guannan Geng, Yang Hu
Summary: Periodontal diseases have a significant impact on children and adolescents, with studies identifying candidate genes related to gingivitis and developing a data integration method to identify these genes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Medicinal
Bozhi Ye, Xudong Chen, Shanshan Dai, Jibo Han, Xiaohe Liang, Shuang Lin, Xueli Cai, Zhouqing Huang, Weijian Huang
DRUG DESIGN DEVELOPMENT AND THERAPY
(2019)
Article
Physiology
Xudong Chen, Haiyan Li, Kangwei Wang, Xiaohe Liang, Weiqi Wang, Xiaokang Hu, Zhouqing Huang, Yonghua Wang
FRONTIERS IN PHYSIOLOGY
(2019)
Article
Cell Biology
Xudong Chen, Shuang Lin, Shanshan Dai, Jibo Han, Peiren Shan, Weiqi Wang, Zhouqing Huang, Bozhi Ye, Weijian Huang
Summary: Trimetazidine can protect cardiomyocytes from ischemia/reperfusion injury by inhibiting inflammation. This research is of great significance for the development of alternative treatments for myocardial I/R injury.
INFLAMMATION RESEARCH
(2022)
Article
Plant Sciences
Bozhi Ye, Xudong Chen, Yanghao Chen, Wante Lin, Diyun Xu, Zimin Fang, Nipon Chattipakorn, Weijian Huang, Xu Wang, Gaojun Wu, Guang Liang
Summary: This study demonstrates that Costunolide (Cos) can improve obesity cardiomyopathy by inhibiting inflammation. Through molecular docking, we confirmed that Cos targets TAK1 and inhibits NF-kappa B pathway activation by blocking the formation of the TAK1/TAB2 complex, thereby reducing inflammatory cytokine release and improving myocardial inflammation. Moreover, Cos effectively reduces cardiac hypertrophy and fibrosis caused by obesity, leading to improved cardiac function against obesity cardiomyopathy.
Review
Cardiac & Cardiovascular Systems
Lei Huang, Jiacheng Rong, Cheng Fang, Xudong Chen, Chaokun Hong
Summary: This study aimed to examine the occurrence of immediate and long-term adverse outcomes in individuals with elevated levels of uric acid following a diagnosis of myocardial infarction (MI). The study included a large sample size of 225,600 MI patients and found that patients diagnosed with hyperuricemia had significantly increased rates of short-term mortality and incidence of major adverse cardiovascular events. These individuals also experienced higher rates of long-term all-cause mortality and incidence of major adverse cardiovascular events.
BMC CARDIOVASCULAR DISORDERS
(2023)
Article
Cardiac & Cardiovascular Systems
Lingfeng Zhong, Jibo Han, Xiaoxi Fan, Zhouqing Huang, Lan Su, Xueli Cai, Shuang Lin, Xudong Chen, Weijian Huang, Shanshan Dai, Bozhi Ye
Summary: The study identified a new drug (GI-Y1) for treating cardiac disorders by targeting GSDMD, and discovered a new tool compound for pyroptosis research.
BASIC RESEARCH IN CARDIOLOGY
(2023)