期刊
MEDICINE
卷 95, 期 36, 页码 -出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MD.0000000000004803
关键词
-aminobutyric acid; cognition; glutamate; magnetic resonance spectroscopy; type 2 diabetes mellitus
资金
- VENI from The Netherlands Organization for Scientific Research (NWO) [916.11.059]
- Netherlands Organization for Health Research and Development (ZonMw)
- Stichting de Weijerhorst foundation
- NIH [R01 EB016089, P41 EB015909]
Type 2 diabetes mellitus is associated with accelerated cognitive decline. The underlying pathophysiological mechanisms still remain to be elucidated although it is known that insulin signaling modulates neurotransmitter activity, including inhibitory -aminobutyric acid (GABA) and excitatory glutamate (Glu) receptors. Therefore, we examined whether levels of GABA and Glu are related to diabetes status and cognitive performance.Forty-one participants with type 2 diabetes and 39 participants without type 2 diabetes underwent detailed cognitive assessments and 3-Tesla proton MR spectroscopy. The associations of neurotransmitters with type 2 diabetes and cognitive performance were examined using multivariate regression analyses controlling for age, sex, education, BMI, and percentage gray/white matter ratio in spectroscopic voxel.Analysis revealed higher GABA+ levels in participants with type 2 diabetes, in participants with higher fasting blood glucose levels and in participants with higher HbA(1c) levels, and higher GABA+ levels in participants with both high HbA(1c) levels and less cognitive performance.To conclude, participants with type 2 diabetes have alterations in the GABAergic neurotransmitter system, which are related to lower cognitive functioning, and hint at the involvement of an underlying metabolic mechanism.
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