In-depth immune profiling reveals advanced B- and T-cell differentiation to be associated with Th1-driven immune dysregulation in common variable immunodeficiency

T-bethighCD21low B cells: the need to unify our understanding of a distinct B cell population in health and disease

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Follicular helper T cell signature of replicative exhaustion, apoptosis, and senescence in common variable immunodeficiency

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Ex vivo effect of JAK inhibition on JAK-STAT1 pathway hyperactivation in patients with dominant-negative STAT3 mutations

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SARS-CoV-2-Specific and Functional Cytotoxic CD8 Cells in Primary Antibody Deficiency: Natural Infection and Response to Vaccine

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Distinct CD8 T Cell Populations with Differential Exhaustion Profiles Associate with Secondary Complications in Common Variable Immunodeficiency

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Elevated CD21low B Cell Frequency Is a Marker of Poor Immunity to Pfizer-BioNTech BNT162b2 mRNA Vaccine Against SARS-CoV-2 in Patients with Common Variable Immunodeficiency

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Lymphocyte alterations in patients with Common Variable Immunodeficiency (CVID) and autoimmune manifestations

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Raised Serum Markers of T Cell Activation and Exhaustion in Granulomatous-Lymphocytic Interstitial Lung Disease in Common Variable Immunodeficiency

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T cell perturbations persist for at least 6 months following hospitalization for COVID-19

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Human T-bet governs the generation of a distinct subset of CD11c high CD21 low B cells

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Characterisation of age‐associated B cells in early drug‐naïve rheumatoid arthritis patients

(2022) Gemma Vidal‐Pedrola et al.   IMMUNOLOGY

The 2022 Update of IUIS Phenotypical Classification for Human Inborn Errors of Immunity

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Distinct inflammation-related proteins associated with T cell immune recovery during chronic HIV-1 infection

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Aging and CMV discordance are associated with increased immune diversity between monozygotic twins

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Hallmarks of T cell aging

(2021) Maria Mittelbrunn et al.   NATURE IMMUNOLOGY

Not-so-opposite ends of the spectrum: CD8+ T cell dysfunction across chronic infection, cancer and autoimmunity

(2021) Jenna L. Collier et al.   NATURE IMMUNOLOGY

Immunogenicity of Anti-SARS-CoV-2 Vaccines in Common Variable Immunodeficiency

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The right time for senescence

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The expansion of human T-bet high CD21 low B cells is T cell dependent

(2021) Baerbel Keller et al.   Science Immunology

Plasma protein profiling reflects Th1-driven immune dysregulation in common variable immunodeficiency

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Functions of Tfh Cells in Common Variable Immunodeficiency

(2020) Corentin Le Saos-Patrinos et al.   Frontiers in Immunology

Heterogeneity of Liver Disease in Common Variable Immunodeficiency Disorders

(2020) Antonio Pecoraro et al.   Frontiers in Immunology

Reduced Ebola vaccine responses in CMV+ young adults is associated with expansion of CD57+KLRG1+ T cells

(2020) Georgina Bowyer et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Sestrins induce natural killer function in senescent-like CD8+ T cells

(2020) Branca I. Pereira et al.   NATURE IMMUNOLOGY

Increased Respiratory Viral Detection and Symptom Burden Among Patients with Primary Antibody Deficiency: Results from the BIPAD Study

(2020) Mark J. Ponsford et al.   Journal of Allergy and Clinical Immunology-In Practice

Targeted Proteomics Reveals Inflammatory Pathways that Classify Immune Dysregulation in Common Variable Immunodeficiency

(2020) Roos-Marijn Berbers et al.   JOURNAL OF CLINICAL IMMUNOLOGY

The senescence-associated secretory phenotype and its regulation

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IFNγ induces epigenetic programming of human T-bethi B cells and promotesTLR7/8 and IL-21 induced differentiation

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Evaluating laboratory criteria for combined immunodeficiency in adult patients diagnosed with common variable immunodeficiency

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The PD-1/PD-L1 Axis and Virus Infections: A Delicate Balance

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Abatacept as a Long-Term Targeted Therapy for LRBA Deficiency

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(2018) Mladen Jergović et al.   EXPERIMENTAL GERONTOLOGY

Regulation and Function of the PD-L1 Checkpoint

(2018) Chong Sun et al.   IMMUNITY

Loss-of-function nuclear factor κB subunit 1 (NFKB1) variants are the most common monogenic cause of common variable immunodeficiency in Europeans

(2018) Paul Tuijnenburg et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The T H 1 phenotype of follicular helper T cells indicates an IFN-γ–associated immune dysregulation in patients with CD21low common variable immunodeficiency

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Exaggerated follicular helper T-cell responses in patients with LRBA deficiency caused by failure of CTLA4-mediated regulation

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Beyond migration-Chemokines in lymphocyte priming, differentiation, and modulating effector functions

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IL-21 drives expansion and plasma cell differentiation of autoreactive CD11chiT-bet+ B cells in SLE

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Increase of follicular helper T cells skewed toward a Th1 profile in CVID patients with non-infectious clinical complications

(2018) Delphine Turpin et al.   CLINICAL IMMUNOLOGY

Identification of CVID Patients With Defects in Immune Repertoire Formation or Specification

(2018) Pauline A. van Schouwenburg et al.   Frontiers in Immunology

Ruxolitinib reverses dysregulated T helper cell responses and controls autoimmunity caused by a novel signal transducer and activator of transcription 1 (STAT1) gain-of-function mutation

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International Union of Immunological Societies: 2017 Primary Immunodeficiency Diseases Committee Report on Inborn Errors of Immunity

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Plasmodium DNA-mediated TLR9 activation of T-bet+ B cells contributes to autoimmune anaemia during malaria

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c-Myb Regulates the T-Bet-Dependent Differentiation Program in B Cells to Coordinate Antibody Responses

(2017) Dana Piovesan et al.   Cell Reports

A subset of virus-specific CD161+T cells selectively express the multidrug transporter MDR1 and are resistant to chemotherapy in AML

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OMIP-034: Comprehensive immune phenotyping of human peripheral leukocytes by mass cytometry for monitoring immunomodulatory therapies

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Expansion of inflammatory innate lymphoid cells in patients with common variable immune deficiency

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Common and biased signaling pathways of the chemokine receptor CCR7 elicited by its ligands CCL19 and CCL21 in leukocytes

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Exclusion of Patients with a Severe T-Cell Defect Improves the Definition of Common Variable Immunodeficiency

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Variation in the Human Immune System Is Largely Driven by Non-Heritable Influences

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Primary Immunodeficiency Diseases: an Update on the Classification from the International Union of Immunological Societies Expert Committee for Primary Immunodeficiency 2015

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Cytomegalovirus Infection and Memory T Cell Inflation

(2015) Jihye Kim et al.   Immune Network

Early-onset Evans syndrome, immunodeficiency, and premature immunosenescence associated with tripeptidyl-peptidase II deficiency

(2014) P. Stepensky et al.   BLOOD

Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4

(2014) H. S. Kuehn et al.   SCIENCE

Comparison of Diagnostic Criteria for Common Variable Immunodeficiency Disorder

(2014) Rohan Ameratunga et al.   Frontiers in Immunology

Antibody mediated CDCP1 degradation as mode of action for cancer targeted therapy

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T-helper-1-cell cytokines drive cancer into senescence

(2013) Heidi Braumüller et al.   NATURE

Deleterious Mutations in LRBA Are Associated with a Syndrome of Immune Deficiency and Autoimmunity

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T cell phenotypes in patients with common variable immunodeficiency disorders: associations with clinical phenotypes in comparison with other groups with recurrent infections

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Influence of cytomegalovirus infection on immune cell phenotypes in patients with common variable immunodeficiency

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Morbidity and mortality in common variable immune deficiency over 4 decades

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A B-cell subset uniquely responsive to innate stimuli accumulates in aged mice

(2011) Y. Hao et al.   BLOOD

CD8+ CD28− and CD8+ CD57+ T cells and their role in health and disease

(2011) Marius Strioga et al.   IMMUNOLOGY

Genome-wide association identifies diverse causes of common variable immunodeficiency

(2011) Jordan S. Orange et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Inflammation in common variable immunodeficiency is associated with a distinct CD8+ response to cytomegalovirus

(2011) Sayed Mahdi Marashi et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The Enteropathy Associated With Common Variable Immunodeficiency: The Delineated Frontiers With Celiac Disease

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Complement receptor 2/CD21- human naive B cells contain mostly autoreactive unresponsive clones

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Late‐Onset Combined Immune Deficiency: A Subset of Common Variable Immunodeficiency with Severe T Cell Defect

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Circulating CD21low B cells in common variable immunodeficiency resemble tissue homing, innate-like B cells

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Common variable immunodeficiency disorders: division into distinct clinical phenotypes

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Evidence for HIV-associated B cell exhaustion in a dysfunctional memory B cell compartment in HIV-infected viremic individuals

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