Article
Multidisciplinary Sciences
Gyorgy Sinkovits, Janos Schnur, Lisa Hurler, Petra Kiszel, Zita Z. Prohaszka, Pal Sik, Erika Kajdacsi, Laszlo Cervenak, Veronika Maraczi, Mate David, Borbala Zsigmond, Eva Rimanoczy, Csaba Bereczki, Loek Willems, Erik J. M. Toonen, Zoltan Prohaszka
Summary: Multisystem inflammatory syndrome in children (MIS-C) is a rare and life-threatening complication of SARS-CoV-2 infection. This syndrome is characterized by high fever, inflammation, and shock-like symptoms. Activation of immune cells and inflammation markers play a crucial role in the pathogenesis, and treatment with intravenous immunoglobulin leads to improvement of the disease. Complement system activation is closely related to the disease activity and its reduction is associated with rapid improvement after treatment.
SCIENTIFIC REPORTS
(2022)
Review
Medicine, General & Internal
Elvis Hysa, Carlo Alberto Cutolo, Emanuele Gotelli, Greta Pacini, Carlotta Schenone, Elke O. Kreps, Vanessa Smith, Maurizio Cutolo
Summary: This review explores the pathophysiology of uveitis associated with SIRDs, with a focus on the epidemiology of uveitis among different SIRDs. Behcet's disease, spondyloarthritides, and sarcoidosis are highlighted for their significant impact.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Rheumatology
Achilleas Floudas, Nuno Neto, Carl Orr, Mary Canavan, Phil Gallagher, Conor Hurson, Michael G. Monaghan, Sunil Nagpar, Ronan H. Mullan, Douglas J. Veale, Ursula Fearon
Summary: This study investigates pathogenic and protective polyfunctional T-cell responses in patients with rheumatoid arthritis (RA), individuals at risk (IAR), and healthy controls (HC) synovial tissue biopsies, identifying a novel population of pathogenic polyfunctional T-cells enriched in RA joints prior to clinical inflammation. Results show increased plasticity of Tfh cells and CD4 T-cell polyfunctionality in RA patients, with enrichment of memory Treg cell responses. The switch from potentially protective to pathogenic T-cell polyfunctionality prior to clinical inflammation highlights a potential therapeutic intervention opportunity in RA.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Review
Medicine, Research & Experimental
Naoual El Menyiy, Aicha El Allam, Sara Aboulaghras, Imane Jaouadi, Saad Bakrim, Nasreddine El Omari, Mohammad Ali Shariati, Alevtin Miftakhutdinov, Polrat Wilairatana, Mohammad S. Mubarak, Abdelhakim Bouyahya
Summary: Autoimmune diseases are caused by the overactivity of the immune system towards self-constituents. Natural compounds derived from medicinal plants have shown potential in modulating the inflammatory responses of these diseases, presenting a promising approach for treatment and prevention.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Rheumatology
Meredyth G. Ll Wilkinson, Dale Moulding, Thomas C. R. McDonnell, Michael Orford, Chris Wincup, Joanna Y. J. Ting, Georg W. Otto, Restuadi Restuadi, Daniel Kelberman, Charalampia Papadopoulou, Sergi Castellano, Simon Eaton, Claire T. Deakin, Elizabeth C. Rosser, Lucy R. Wedderburn
Summary: This study identifies a novel pathway in which altered mitochondrial biology in CD14+ monocytes of Juvenile dermatomyositis (JDM) patients leads to the production of oxidized mitochondrial DNA (oxmtDNA) and stimulates the expression of interferon (IFN) type 1 signature genes. Targeting this pathway has therapeutic potential in JDM and other IFN type 1-driven autoimmune diseases.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Engineering, Environmental
Ruo-Di Zhang, Cong Chen, Peng Wang, Yang Fang, Ling-Qiong Jiang, Xi Fang, Yan Zhao, Jing Ni, De-Guang Wang, Hai-Feng Pan
Summary: Auto-inflammatory and autoimmune diseases of the musculoskeletal system are characterized by severe erosion of joints and connective tissues, leading to chronic inflammation and damage. Genetic and environmental risk factors have been identified, and recent studies suggest that air pollution exposure may play a role in the development and occurrence of these diseases. Air pollution can induce oxidative stress, inflammation, epigenetic modifications, and mitochondrial dysfunction, primarily affecting the lungs and subsequently influencing immune and inflammatory responses. This review explores the association between air pollution and specific musculoskeletal diseases, such as osteoarthritis, rheumatoid arthritis, spondyloarthritis, and juvenile idiopathic arthritis, and aims to provide a comprehensive understanding of the mechanisms involved. The findings may contribute to the formulation of effective public health policies to mitigate the adverse health effects of air pollutants.
ENVIRONMENTAL GEOCHEMISTRY AND HEALTH
(2023)
Article
Pharmacology & Pharmacy
Vijay Kanoje, Dilip Pandey, Akshaya Wagh, Sukanya Patra, Ajit Kumar Marisetti, Madhusudhan Reddy, Charudatt Samant, Nilesh Mahajan, Milind Gholve, Sudeep Sabde, Sneha Trivedi, Trupti Bhankhede, Vinod Patil, Prashant Nigade, Dipak Modi, Maneesh Mehta, Prajakta Ahirrao, Swathi Tota, Bidyut Nanda, Shashikant Pawar, Anuradha Polawar, Kaustubh Tamane, Sandip Kuldharan, Gururaj Vishwase, Nirmal Jana, Sachin J. Mahangare, Prashant Vidhate, Dipak Lagad, Jayasagar Gundu, Samiron Phukan, Manojkumar Shukla, Lakshmi Narasimham, Kumar V. S. Nemmani, Mandar Bhonde, Sharad Sharma, Rajender K. Kamboj, Venkata P. Palle
Summary: This study describes the in vitro and in vivo activity and drug-like properties of the PI3K delta specific inhibitor LL-00071210 in rheumatoid arthritis models. LL-00071210 shows excellent selectivity and stability, demonstrating potential as a clinical drug for the treatment of autoimmune diseases.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Immunology
Jingfeng Yu, Sihan Sheng, Xiaosu Zou, Zhengwu Shen
Summary: A novel artemisinin derivative (compound 4) showed strong immunosuppressive activity. Various methods were used to evaluate its immunosuppressive activity and mechanism of action. The results suggest that it has potential application as an anti-inflammatory bowel disease drug.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Nutrition & Dietetics
Xingyu Han, Ayda-Ayleen Ordouie, Renate Schmelz, Thomas Hummel
Summary: This study found that patients with inflammatory bowel disease (IBD) often have decreased olfactory function, mainly manifested as increased olfactory threshold. The olfactory threshold is correlated with clinical disease activity and BMI. Importantly, treatment with TNF-alpha inhibitors may improve olfactory function in IBD patients.
Article
Rheumatology
Edward Chia-Cheng Lai, Ya-Chun Huang, Tzu-Chi Liao, Meng-Yu Weng
Summary: This study found that primary Sjogren's syndrome, SLE, SSc, and SV are associated with an increased risk of premature coronary artery disease.
Article
Immunology
Azam Safary, Kamal Esalatmanesh, Amir Taher Eftekharsadat, Mohammad -Reza Jafari Nakjavani, Alireza Khabbazi
Summary: Vaccination against COVID-19 is important for achieving herd immunity and controlling the pandemic. However, a small number of people may develop autoimmune rheumatic diseases (ARDs) as a rare adverse reaction to the vaccines. This study identifies individuals who developed de-novo ARDs after COVID-19 vaccination, with a higher prevalence among those who received the AstraZeneca vaccine. Prompt diagnosis and treatment can prevent irreversible organ damage.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Rheumatology
George E. Fragoulis, Elena Nikiphorou, Mrinalini Dey, Sizheng Steven Zhao, Delphine Sophie Courvoisier, Laurent Arnaud, Fabiola Atzeni, Georg M. N. Behrens, Johannes W. J. Bijlsma, Peter Boehm, Costas A. Constantinou, Silvia Garcia-Diaz, Meliha Crnkic Kapetanovic, Kim Lauper, Mariana Luis, Jacques Morel, Gyoergy Nagy, Eva Poleverino, Jef van Rompay, Marco Sebastiani, Anja Strangfeld, Annette de Thurah, James Galloway, Kimme L. Hyrich
Summary: This study aims to develop recommendations for screening and prevention of chronic and opportunistic infections in patients with autoimmune inflammatory rheumatic diseases (AIIRD). Four overarching principles and eight specific recommendations were formulated through international collaboration. These recommendations provide guidance for clinical practice to reduce the burden of opportunistic infections in AIIRD patients.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Medicine, Research & Experimental
Teodora Isac, Sebastian Isac, Razvan Rababoc, Mihail Cotorogea, Laura Iliescu
Summary: Inflammatory liver diseases have a significant socio-economic impact and are multifactorial and wide-spread. Early identification of inflammatory hepatic lesions and the development of new epigenetic therapies are important strategies. The main types of inflammatory liver diseases are alcoholic and non-alcoholic fatty liver disease, autoimmune hepatitis, viral hepatitis, and Wilson disease. Epigenetic processes such as DNA methylation/demethylation, histone covalent changes, and microRNA synthesis play a modulatory role in disease progression and response to treatment. Epigenetic therapy offers a new perspective considering the limitations of conventional strategies.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Rheumatology
Felix Kartnig, Daniel Mrak, Elisabeth Simader, Selma Tobudic, Helga Radner, Peter Mandl, Lisa Goeschl, Nikolaus Hommer, Margareta Mayer, Philipp Hofer, Thomas Hummel, Thomas Deimel, Irina Gessl, Antonia Puchner, Andreas Kerschbaumer, Renate Thalhammer, Alessandra Handisurya, Renate Kain, Stefan Winkler, Josef S. Smolen, Karin Stiasny, Thomas Perkmann, Helmuth Haslacher, Judith H. Aberle, Daniel Aletaha, Leonhard X. Heinz, Daniela Sieghart, Michael Bonelli
Summary: This clinical trial evaluated the immunogenicity and safety of a third COVID-19 vaccination in patients with immune-mediated inflammatory diseases (IMIDs). The results showed that the third vaccination had good immunogenicity and safety in these patients, but the effects of immunomodulatory therapy should be considered.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Medicine, General & Internal
Dario Cocito, Erdita Peci, Maria Claudia Torrieri, Marinella Clerico
Summary: The therapeutic administration of subcutaneous immunoglobulin (SCIg) offers various advantages over intravenous immunoglobulin (IVIg) in the treatment of chronic inflammatory demyelinating polyneuropathy (CIDP). SCIg is as effective as IVIg but better tolerated and easier to administer. It is also more convenient and cost-effective, allowing for flexible treatment scheduling at home and improving patients' overall quality of life.
JOURNAL OF CLINICAL MEDICINE
(2023)
Letter
Medicine, General & Internal
Abdolrazagh Hashemi Shahraki, Majid Vahed, Mehdi Mirsaeidi
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2021)
Review
Immunology
Masoud Shamaei, Mehdi Mirsaeidi
Summary: The incidence and prevalence of NTM infections are increasing worldwide, posing a major public health threat. Macrophages play a crucial role in immune responses against NTM, including phagocytosis, antigen presentation, and downstream activation of adaptive immune responses.
INFECTION AND IMMUNITY
(2021)
Article
Cell Biology
Foad Rommasi, Mohammad Javad Nasiri, Mehdi Mirsaeidi
Summary: The novel coronavirus pandemic has posed significant challenges to medical healthcare in the current century. Researchers and medical professionals have been striving to find effective drugs and treatment options to combat COVID-19. This article discusses various medications and their potential mechanisms of action in treating the disease.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Shamila D. Alipoor, Mehdi Mirsaeidi
Summary: The infectivity of SARS-CoV-2 is likely due to its ability to utilize a group of cell surface receptors, including ACE2, as entry sites. However, there may be other receptors and auxiliary membrane proteins involved in the cell entry process. The presence of these receptors may explain certain characteristics of COVID-19 infections, such as asymptomatic hypoxemia. Different variants of SARS-CoV-2 may exhibit varying degrees of binding affinity to these receptors.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Medicine, General & Internal
Malihe Rezaee, Moein Zangiabadian, Amirali Soheili, Tess Moore Calcagno, Maryam Rahmannia, Roshan Dinparastisaleh, Mohammad J. Nasiri, Mehdi Mirsaeidi
Summary: Anti-tumor necrosis factor-alpha agents have been found to be effective in treating refractory sarcoidosis, although studies have shown conflicting results. This systematic meta-analysis confirms the effectiveness of anti-TNF-alpha agents in both pulmonary and extrapulmonary sarcoidosis, with a slightly higher efficacy observed in extrapulmonary sarcoidosis.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Microbiology
Abdolrazagh Hashemi Shahraki, Majid Vahed, Roshan Dinparastisaleh, Mehdi Mirsaeidi
Summary: In this study, we introduce UF_RH5, a novel lytic phage that targets clinically isolated Pseudomonas aeruginosa. It belongs to the Siphovirus morphology family, Septimatrevirus genus, with a 42,566-bp genome and a GC content of 53.60%, encoding 58 proteins. Under electron microscopy, UF_RH5 is observed to have a length of 121 nm and a capsid size of 45 nm.
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2023)
Article
Microbiology
Abdolrazagh Hashemi Shahraki, Majid Vahed, Mehdi Mirsaeidi
Summary: Here, the genome sequence of a new Pseudomonas aeruginosa bacteriophage, UF_RH1, is presented. This lytic phage has a genome size of 42,567 bp and belongs to the Siphoviridae family and Septimatrevirus genus. UF_RH1 shows genetic similarities with Stenotrophomonas phage vB_SmaS-DLP_2.
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2023)
Article
Microbiology
Abdolrazagh Hashemi Shahraki, Majid Vahed, Shahla Masood, Mehdi Mirsaeidi
Summary: We present the genome sequence of a lytic phage, UF_RH6, that infects Pseudomonas aeruginosa. This phage was isolated from a respiratory secretion sample obtained from a patient with pulmonary P. aeruginosa. UF_RH6 belongs to the Caudoviricetes family and the Samunavirus genus. The genome of UF_RH6 is 94,715 bp long and encodes 130 proteins.
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2023)
Article
Infectious Diseases
D. Visca, R. Centis, E. Pontali, E. Zampogna, A. -M. Russell, G. B. Migliori, C. Andrejak, M. Aro, H. Bayram, K. Berkani, J. Bruchfeld, J. M. Chakaya, J. Chorostowska-Wynimko, B. Crestani, M. P. Dalcolmo, L. D'Ambrosio, A-T. Dinh-Xuan, S. Duong-Quy, C. Fernandes, J. -M. Garcia-Garcia, A. de Melo Kawassaki, L. Carrozzi, M. A. Martinez-Garcia, P. Carreiro Martins, M. Mirsaeidi, Y. Mohammad, R. N. Naidoo, N. Neuparth, L. Sese, D. R. Silva, I. Solovic, T. M. Sooronbaev, A. Spanevello, N. Sverzellati, L. Tanno, S. Tiberi, T. Vasankari, E. Vasarmidi, M. Vitacca, I. Annesi-Maesano
Summary: This is the first consensus-based set of clinical standards for the diagnosis, treatment, and prevention of post-COVID-19 lung disease. The aim is to improve patient care and quality of life by guiding clinicians, program managers, and public health officers in planning and implementing a pulmonary rehabilitation program to manage post-COVID-19 lung disease.
INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE
(2023)
Article
Medicine, General & Internal
Anne-Marie Rick, Matthew B. Laurens, Ying Huang, Chenchen Yu, Thomas C. S. Martin, Carina A. Rodriguez, Christina A. Rostad, Rebone M. Maboa, Lindsey R. Baden, Hana M. El Sahly, Beatriz Grinsztejn, Glenda E. Gray, Cynthia L. Gay, Peter B. Gilbert, Holly E. Janes, James G. Kublin, Yunda Huang, Brett Leav, Ian Hirsch, Frank Struyf, Lisa M. Dunkle, Kathleen M. Neuzil, Lawrence Corey, Paul A. Goepfert, Stephen R. Walsh, Dean Follmann, Karen L. Kotloff
Summary: This study found that previous infection, hybrid immunity, and vaccination all provide substantial protection against symptomatic and severe COVID-19 during the early Delta period. Hybrid immunity, which combines previous infection with vaccination, is more effective than vaccination alone. Vaccination, previous infection, and hybrid immunity all offer near-complete protection against severe disease.
Review
Respiratory System
Debabrata Bandyopadhyay, Mehdi S. Mirsaeidi
Summary: Sarcoidosis is a multi-system granulomatous disorder with unknown causes. Some patients may develop sarcoidosis-associated pulmonary fibrosis (SAPF), which is a distinct clinical entity. The mechanisms of fibrosis in SAPF are not fully understood. Although risk factors for SAPF development have been identified, accurate prediction of individual patient risk is currently not possible.
EUROPEAN RESPIRATORY REVIEW
(2023)
Article
Respiratory System
Yu-Che Lee, Ko-Yun Chang, Mehdi Mirsaeidi
Summary: Chronic respiratory diseases are a major cause of death globally and have significant impacts on individuals and communities. This study aimed to assess the association between county-level sociodemographic vulnerabilities and chronic respiratory disease mortality in the United States. The results showed significant associations between the social vulnerability index and its subindices with chronic respiratory disease mortality.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2023)
Article
Critical Care Medicine
Mohammad M. Banoei, Roshan Dinparastisaleh, Ali Vaeli Zadeh, Mehdi Mirsaeidi
Summary: The study utilized a SIMPLS-based model to analyze clinical features and comorbidities of COVID-19 patients, identifying important predictors for predicting hospital mortality, such as coronary artery disease and diabetes. By using machine learning methods, clustering analysis was performed to classify high- and low-risk patients among COVID-19 survivors.
Article
Respiratory System
Sara Haddadi, Brian Cody Adkinson, Greg E. Holt, Mehdi Mirsaeidi
Summary: Sarcoidosis is a granulomatous inflammatory disease with unknown etiology that may develop concurrently or following cancer. Early detection of granuloma in mediastinal lymph nodes could indicate undiagnosed lung cancer. Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is the preferred diagnostic modality for lung lesions.
RESPIRATORY MEDICINE CASE REPORTS
(2021)