Article
Cell Biology
Fangfang Duan, Jianpei Li, Jiajia Huang, Xin Hua, Chenge Song, Li Wang, Xiwen Bi, Wen Xia, Zhongyu Yuan
Summary: This study aimed to investigate the relationship between serum copper levels and early-stage triple-negative breast cancer (TNBC), and establish a predictive model based on serum copper levels for individualized survival predictions. The results showed that high serum copper levels were significantly associated with worse DFS and OS, and the prognostic models based on serum copper demonstrated excellent discrimination and predictive calibration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Haojia Li, Kaustav Bera, Paula Toro, PingFu Fu, Zelin Zhang, Cheng Lu, Michael Feldman, Shridar Ganesan, Lori J. Goldstein, Nancy E. Davidson, Akisha Glasgow, Aparna Harbhajanka, Hannah Gilmore, Anant Madabhushi
Summary: Our study demonstrates that collagen fiber organization is associated with breast cancer prognosis, and using H&E image analysis can serve as a potential prognostic biomarker for early stage ER+ IBC without the need for special staining or microscopy techniques.
Article
Medicine, Research & Experimental
Mohamed El-Tanani, Angela Platt-Higgins, Hamdi Nsairat, Ismail I. Matalka, Khaled Abdul-Aziz Ahmed, Shu-Dong Zhang, Walhan Alshaer, Abdalla Awidi, Kyle B. Matchett, Alaa A. Aljabali, Vijay Mishra, Angel Serrano-Aroca, Murtaza M. Tambuwala, Philip S. Rudland
Summary: This research finds that the expression of Ran is associated with survival, metastasis, and relapse in breast cancer patients, suggesting it as a unique biomarker for prognosis and diagnosis.
Article
Oncology
Paolo Tarantino, Qingchun Jin, Nabihah Tayob, Rinath M. Jeselsohn, Stuart J. Schnitt, Julie Vincuilla, Tonia Parker, Svitlana Tyekucheva, Tianyu Li, Nancy U. Lin, Melissa E. Hughes, Anna C. Weiss, Tari A. King, Elizabeth A. Mittendorf, Giuseppe Curigliano, Sara M. Tolaney
Summary: This study investigated whether low ERBB2 expression is associated with distinct clinicopathologic characteristics and prognosis among patients with hormone receptor-positive and triple-negative breast cancer. The results did not support the interpretation of ERBB2-low breast cancer as a distinct biologic subtype. ERBB2-low expression was positively associated with the level of ER expression, suggesting confounding effects in prognostic analyses of ERBB2-low expression.
Review
Cell Biology
Katerina Vlataki, Sevastiani Antonouli, Christina Kalyvioti, Evangeli Lampri, Sevasti Kamina, Davide Mauri, Haralampos V. Harissis, Angeliki Magklara
Summary: Liquid biopsies involve analyzing tumor-derived biological material in body fluids, primarily blood, to provide valuable clinical information for cancer management. They are non-invasive and can overcome limitations of tissue biopsy, aiding in making therapeutic decisions. Recent studies have shown the potential clinical utility of detecting circulating tumor DNA (ctDNA) in improving patient prognosis and monitoring therapy response, particularly in metastatic cancers. Technological advancements now allow accurate identification of ctDNA in early-stage cancers despite low levels in the bloodstream.
Article
Oncology
Aparna Gunda, Chetana Basavaraj, Chandra Prakash Serkad, Manjula Adinarayan, Ramu Kolli, Mallikarjuna Siraganahalli Eshwaraiah, Cristina Saura, Fiorella Ruiz, Patricia Gomez, Vicente Peg, Jose Jimenez, Susanne Sprung, Heidi Fiegl, Christine Brunner, Daniel Egle, Gs Bhattacharyya, Manjiri M. Bakre
Summary: The first blinded validation of CanAssist Breast (CAB) in a multi-country European patient cohort demonstrated its ability to accurately predict recurrence risk in early-stage breast cancer patients and its similar performance in Indian and European cohorts.
Article
Medical Laboratory Technology
Tony Loughman, Stephen Barron, Chan-Ju Angel Wang, Peter Dynoodt, Bozena Fender, Cesar Lopez-Ruiz, Sharon Stapleton, Aurelie Fabre, Cecily Quinn, Bjorn Nodin, Karin Jirstrom, Fatemeh Razmara, Anthony O'Grady, Anne-Marie Baird, Steven G. Gray, Ana Freixo, Cathy B. Moelans, Paul J. van Diest, Michael J. Duffy, Desmond O'Leary, John Crown, Adrian P. Bracken, William M. Gallagher
Summary: This study describes the analytical performance characteristics of the OncoMasTR multigene prognostic test for early-stage breast cancer. The test shows high precision, reproducibility, and suitability for decentralized use in molecular pathology laboratories.
CLINICAL CHEMISTRY
(2022)
Article
Oncology
Alexandre Prieur, Andrew Harper, Momtafin Khan, Berengere Vire, Dominique Joubert, Lea Payen, Karen Kopciuk
Summary: Circulating progastrin or hPG(80) can serve as a potential prognostic biomarker for breast cancer, as it is associated with survival outcomes. This study found that higher levels of hPG(80) at diagnosis are significantly associated with an increased risk of recurrence or death in women with breast cancer.
Article
Immunology
Xin Hua, Fangfang Duan, Wenyu Zhai, Chenge Song, Chang Jiang, Li Wang, Jiajia Huang, Huanxin Lin, Zhongyu Yuan
Summary: The study investigated the prognostic value of baseline inflammatory and nutritional biomarkers in early-stage breast cancer patients and developed the INPS scoring system. Four biomarkers were selected to construct INPS using the LASSO Cox analysis, and a prognostic nomogram incorporating INPS and other clinical factors showed excellent discrimination for overall survival prediction.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Oncology
Noorul Wahab, Michael Toss, Islam M. Miligy, Mostafa Jahanifar, Nehal M. Atallah, Wenqi Lu, Simon Graham, Mohsin Bilal, Abhir Bhalerao, Ayat G. Lashen, Shorouk Makhlouf, Asmaa Y. Ibrahim, David Snead, Fayyaz Minhas, Shan E. Ahmed Raza, Emad Rakha, Nasir Rajpoot
Summary: The study proposes an image-based prognostic marker for breast cancer that uses deep learning to objectively assess tumor heterogeneity. The marker demonstrates the ability to predict both patient survival and distant metastasis in early-stage breast cancer, with comparable accuracy to traditional manual assessment methods.
NPJ PRECISION ONCOLOGY
(2023)
Article
Oncology
Sherene Loi, Roberto Salgado, Sylvia Adams, Giancarlo Pruneri, Prudence A. Francis, Magali Lacroix-Triki, Heikki Joensuu, Maria Vittoria Dieci, Sunil Badve, Sandra Demaria, Robert Gray, Elisabetta Munzone, Damien Drubay, Jerome Lemonnier, Christos Sotiriou, Pirkko Liisa Kellokumpu-Lehtinen, Andrea Vingiani, Kathryn Gray, Fabrice Andre, Carsten Denkert, Martine Piccart, Elvire Roblin, Stefan Michiels
Summary: The importance of integrating biomarkers such as TILs into the TNM staging system for TNBC has been emphasized in the AJCC 8th Edition. Studies show that TILs can significantly influence the traditional pathological staging, suggesting that considering TILs in addition to stage can lead to better outcomes for TNBC patients.
Article
Oncology
Marina Sekacheva, Alexander Boroda, Anastasia Fatyanova, Alexander Rozhkov, Nikolai Bagmet
Summary: The blind clinical study aimed to evaluate the novel in-vitro diagnostic chemiluminescent CLIA-CA-62 assay for early-stage breast cancer detection. The results showed that the overall sensitivity of CLIA-CA-62 for breast cancer was 92% (100% for DCIS), decreasing in invasive stages (Stage I=97%, Stage II=85%, and Stage III=83%). This suggests that CLIA-CA-62 could be a useful supplement to current mammography screening and other imaging methods, improving the diagnostic sensitivity for DCIS and Stage I breast cancer.
FRONTIERS IN ONCOLOGY
(2023)
Review
Oncology
Paulina E. Galavis, Camille Hardy Abeloos, Pine C. Cheng, Christine Hitchen, Allison McCarthy, Juhi M. Purswani, Bhartesh Shah, Sameer Taneja, Naamit K. Gerber
Summary: This paper provides a review on the existing data, delivery techniques, and ongoing research of APBI, aiming to better define patient selection, treatment delivery, dosimetric considerations, and toxicity outcomes.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Xin Hua, Fangfang Duan, Jiajia Huang, Xiwen Bi, Wen Xia, Chenge Song, Li Wang, Chang Jiang, Zhongyu Yuan
Summary: The study found an association between serum iron level and prognosis in patients with early-stage triple-negative breast cancer. Patients with low iron levels had significantly longer disease-free survival and overall survival compared to those with high iron levels. Serum iron level was identified as an independent predictor for patient prognosis. A prognostic nomogram incorporating serum iron level was developed for individualized prognosis predictions and showed good discriminatory ability.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Diogo J. Silva, Goncalo Miranda, Teresina Amaro, Matilde Salgado, Alexandra Mesquita
Summary: Tumor budding (TB) is a dynamic process associated with the epithelial-mesenchymal transition and has been proven to be a significant prognostic biomarker for colorectal cancer. This study aimed to investigate the clinical applicability and prognostic value of TB in patients with early breast cancer (EBC). The results showed a significant association between high TB score and aggressive clinicopathological features, as well as poor prognosis. The findings suggest that TB could serve as a valuable prognostic biomarker for EBC.