Article
Biochemistry & Molecular Biology
Glauber Da Costa, Moyses F. A. Neto, Alicia K. P. Da Silva, Ester M. F. De Sa, Luanne C. F. Cancela, Jeanina S. Vega, Cassio M. Lobato, Juliana P. Zuliani, Jose M. Espejo-Roman, Joaquin M. Campos, Franco H. A. Leite, Cleydson B. R. Santos
Summary: This study aimed to develop new insecticides against Aedes aegypti, the main vector for several viral diseases. Through computational methods and screening, five compounds with potential insecticidal activity were identified. These compounds were found to be dual inhibitors of chitin synthase and juvenile hormonal protein, making them potential candidates for controlling Aedes aegypti mosquitoes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Rasel Ahmed Khan, Rajib Hossain, Abolghasem Siyadatpanah, Khattab Al-Khafaji, Abul Bashar Ripon Khalipha, Dipta Dey, Umma Hafsa Asha, Partha Biswas, Abu Saim Mohammad Saikat, Hadi Ahmadi Chenari, Polrat Wilairatana, Muhammad Torequl Islam
Summary: Dengue fever is a dangerous endemic disease caused by the dengue virus, resulting in millions of deaths worldwide. Some derivatives of diterpenoids exhibit anti-dengue viral properties. In silico studies showed that certain compounds have good binding affinities to viral proteins, suggesting their potential as anti-dengue medications.
Article
Biology
Antony Stalin, Appadurai Daniel Reegan, Munusamy Rajiv Gandhi, R. R. Saravanan, Kedike Balakrishna, Abd El-Latif Hesham, Savarimuthu Ignacimuthu, Ying Zhang
Summary: Embelin and its derivatives, 6-bromoembelin and vilangin, showed strong mosquitocidal activities against larvae and pupae of Aedes aegypti and Culex quinquefasciatus. Among them, vilangin exhibited the highest larvicidal activity. The histopathological results revealed that vilangin caused significant damage to the midgut of mosquito larvae and impaired the peritrophic membrane. The molecular docking and molecular dynamics studies further demonstrated the effectiveness of vilangin in inhibiting acetylcholinesterase activity.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Alex Bruno Lobato Rodrigues, Rosany Lopes Martins, Erica de Menezes Rabelo, Jonathan Lopes de Matos, Lizandra Lima Santos, Lethicia Barreto Brandao, Renata do Socorro Barbosa Chaves, Anderson Luiz Pena da Costa, Cleidjane Gomes Faustino, Dayse Maria da Cunha Sa, Ana Luzia Ferreira Farias, Patrick de Castrio Cantuaria, Sheylla Susan Moreira da Silva de Almeida
Summary: This study evaluated the insecticidal potential of Ayapana triplinervis essential oil nano-emulsions and found that they have a high lethality against Aedes aegypti adults. Additionally, the nano-emulsions showed low acute dermal toxicity in mice.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Article
Plant Sciences
Jaqueline C. M. Borges, Khalid Haddi, Wilson R. Valbon, Lara T. M. Costa, Sergio D. Ascencio, Gil R. Santos, Ilsamar M. Soares, Robson S. Barbosa, Kelvinson F. Viana, Eder A. P. Silva, Wellington S. Moura, Bruno S. Andrade, Eugenio E. Oliveira, Raimundo W. S. Aguiar
Summary: The use of formulations containing botanical products for controlling insects that vector human and animal diseases has increased in recent years. Plant extracts seem to offer fewer risks to the environment and to human health without reducing the application strategy's efficacy when compared to synthetic and conventional insecticides and repellents. In this study, the potential of extracts obtained from a specific plant as a tool to be integrated into the management of one of the principal vectors for the transmission of arborviruses in humans was evaluated. The larvicidal and repellence performance against adult mosquitoes and potential undesired effects on non-target organisms were assessed.
Article
Biochemistry & Molecular Biology
Ker Shien Tan, Adzzie Shazleen Azman, Pouya Hassandarvish, Zheng Hua Amelia-Yap, Tiong Kai Tan, Van Lun Low
Summary: This study used LC-MS/MS to investigate the protein profile changes in Aedes aegypti larvae and adults treated with lethal concentrations of Streptomyces sp. KSF103 ethyl acetate (EA) extract. The results showed upregulation of proteins associated with metabolism, protein regulation/degradation, energy production, cellular organization and structure, enzyme activity, and calcium ion transport and homeostasis. The study identified ATP synthase, fructose-bisphosphate aldolase (FBA), and ATP citrate synthase as potential protein targets for insecticide development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Lamya Ahmed Al-Keridis, Nael Abutaha, Fahd A. AL-mekhlafi, Ahmed Moustafa Rady, Mohammed S. Al-Khalifa
Summary: Mosquito-borne infections pose a global health threat, and this study used in silico molecular docking to screen potential antiviral and anti-Aedes aegypti compounds from phytochemicals of Phoenix dactylifera. Promising candidates were identified for further investigation.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Article
Multidisciplinary Sciences
Shinji Kasai, Kentaro Itokawa, Nozomi Uemura, Aki Takaoka, Shogo Furutani, Yoshihide Maekawa, Daisuke Kobayashi, Nozomi Imanishi-Kobayashi, Michael Amoa-Bosompem, Katsunori Murota, Yukiko Higa, Hitoshi Kawada, Noboru Minakawa, Tran Chi Cuong, Nguyen Thi Yen, Tran Vu Phong, Sath Keo, Kroesna Kang, Kozue Miura, Lee Ching Ng, Hwa-Jen Teng, Samuel Dadzie, Sri Subekti, Kris Cahyo Mulyatno, Kyoko Sawabe, Takashi Tomita, Osamu Komagata
Summary: Aedes aegypti, the main mosquito vector for dengue and other arboviral infectious diseases, has developed high levels of pyrethroid resistance in populations collected from Vietnam and Cambodia. This resistance could pose a serious threat to the control of dengue fever and other Aedes-borne infectious diseases.
Editorial Material
Biochemistry & Molecular Biology
Andrew S. Paige, Laura B. Duvall
Summary: A new study has discovered a mosquito salivary protein that binds directly to a cuticular partner during biting, leading to reshaping of the mosquito mouthparts, increased salivation and probing, and enhanced blood-feeding efficiency. By impacting mosquito-host interactions, this finding could have implications for pathogen transmission.
Article
Parasitology
Fernanda Hohana Almeida e Sa, Anderson Roberto Nery Silva, Thalyta Julyanne Silva de Oliveira, Amanda Leite Guimaraes, Francisco Roberto de Azevedo, Miriam Brito dos Santos, Aline Taiane de Macedo Pinto, Jair Fernandes Virginio, Edilson Beserra de Alencar de Alencar Filho
Summary: In this study, an in vitro larvicidal activity was discovered in Aedes aegypti mosquitoes for a chalcone compound, which showed high potency with 100% lethality at 2.5 ppm concentration. These findings offer potential for the development of a larvicidal formulation and exploration of new chemical compounds as alternative strategies for controlling the spread of viral diseases.
Article
Multidisciplinary Sciences
Nael Abutaha, Bader O. Almutairi
Summary: The aim of this study was to investigate the bioactive molecules in Dracaena cinnabari extract and evaluate their therapeutic potential using various analysis methods. The results showed the presence of 25 different compounds in the extract, with beta-Sitosterol and stigmasterol identified as the lead compounds. Molecular docking studies indicated a strong binding affinity of these compounds to the dengue virus and Aedes aegypti. Moreover, toxicity prediction suggested the safety of beta-Sitosterol and 4,4'-Dihydroxy-2 methoxydihydrochalcone. Overall, this study highlights the potential of D. cinnabari as a source of promising molecules, although further in vivo and in vitro investigations are needed.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2023)
Article
Chemistry, Physical
Eduard David Simoes Mourao, Thiego Gustavo Cavalcante de Carvalho, Sammya Yasmin Evangelista Mendes de Lima, Edilson Beserra de Alencar Filho
Summary: This study used virtual screening methods to identify molecular scaffolds capable of inhibiting the Sterol Carrier Protein-2 from Aedes aegypti, based on a database of secondary metabolites from the Caatinga biome in Brazil. The biflavonoid loniflavone was identified as the most promising compound for interaction with 1PZ4, with potential implications for further research.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Multidisciplinary Sciences
Talya Shragai, Juliana Perez-Perez, Marcela del Pilar Quimbayo-Forero, Raul Rojo, Laura C. Harrington, Guillermo Rua-Uribe
Summary: Dengue is becoming an increasing global threat in rapidly growing urban areas. This study analyzes nine years of dengue case data in Medellin, Colombia and finds that changes in accessibility and usage of public transit are correlated with changes in the spread and magnitude of localized outbreaks. Locations closer to and with greater utilization of public transit have higher dengue incidence, with a stronger effect observed in lower socioeconomic status areas. These results emphasize the importance of public health services in conjunction with urban growth.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Hitoshi Kawada, Yukiko Higa, Shinji Kasai
Summary: The extensive use of photostable 2nd generation pyrethroids for malaria and dengue vector control has led to widespread pyrethroid resistance in Aedes aegypti in southern Vietnam. The L982W mutation in the voltage-sensitive sodium channel has been identified as a significant cause of high-pyrethroid resistance in Vietnamese Ae. aegypti.
Article
Multidisciplinary Sciences
Zeeshan Zafar, Sidra Fatima, Muhammad Faraz Bhatti, Farooq A. Shah, Zack Saud, Tariq M. Butt
Summary: The olfactory system of An. stephensi plays a crucial role in host-seeking, oviposition, and feeding. This study identified and compared the odorant binding proteins (OBPs) and odorant receptors (ORs) of An. stephensi with other mosquitoes and fruit flies. The results showed a close evolutionary relationship between An. stephensi and An. gambiae, a distant relationship with Ae. aegypti, and no relationship with D. melanogaster.
Article
Energy & Fuels
Selvaraju Sivamani, Prema Binnal, Capili Roy, Amal Al Khaldi, Fatema Al Hamar, J. Prakash Maran, N. Sivarajasekar, G. Rajeshkumar, Naif Abdullah Al-Dhabi, Ponmurugan Karuppiah
Summary: The present study aims to optimize the recovery of pectin from Persea americana peel using statistical and non-statistical methods. The results show that the non-statistical method accurately predicts the pectin recovery. Structural analysis reveals that the recovered pectin from Persea americana peel has good quality and can be used as a food ingredient.
BIOMASS CONVERSION AND BIOREFINERY
(2023)
Article
Pharmacology & Pharmacy
Subramanian Mutheeswaran, Antony Mariappan, Kamaraj Ragavendran, Vedapuri Porchezhiyan, Poovan Elankani, Naif Abdullah Al-Dhabi, Mariadhas Valan Arasu, Savarimuthu Ignacimuthu
Summary: An ethnobotanical survey was conducted in Sathuragiri hills, India, revealing 139 medicinally useful plant species. The study highlighted the importance of Fabaceae, Euphorbiaceae, and Apocynaceae families, which contained numerous important medicinal plants. Dermatological ailments, gastrointestinal problems, joint pain, fever, and poisonous bites were among the important diseases treated by these species. The study emphasized the need for conservation of these medicinal plants and local knowledge.
ADVANCES IN TRADITIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
M. R. Lima Mirabel Louis, Vedham Pushpa Rani, Padma Krishnan, Appadurai Daniel Reegan, Kedike Balakrishna, Savarimuthu Ignacimuthu, Soosaimanickam Maria Packiam, Rajan Maheswaran, Osamu Shirota
Summary: This study presents the larvicidal activities of three active constituents from the methanolic extract of unripe fruit peel of Persea americana against three mosquito species. The three compounds showed the highest larvicidal activity against Anopheles stephensi, and also exhibited certain larvicidal activity against Aedes aegypti and Culex quinquefasciatus.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Kaliannan Durairaj, Balamuralikrishnan Balasubramanian, Vijaya Anand Arumugam, Murugesh Easwaran, Sungkwon Park, Utthapon Issara, Karthika Pushparaj, Naif Abdullah Al-Dhabi, Mariadhas Valan Arasu, Wen-Chao Liu, Amin Mousavi Khaneghah
Summary: The limitations of graft material and surgical sites in bone defects treatment pose a challenge in bone tissue engineering. Phytocompounds have a significant impact on bone metabolism. In this study, a biocompatible hydrogel composed of chitosan and methylcellulose encapsulated with veratric acid was investigated for bone defect treatment. The hydrogel showed compatibility with mesenchymal stem cells and promoted osteogenic differentiation, indicating its potential as a therapeutic alternative for bone regeneration.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Wei Zhao, Lanying Pan, Antony Stalin, Jianwei Xu, Liren Wu, Xianfu Ke, Yuan Chen
Summary: 2-Aminoethoxydiphenyl borate (2-APB), a multitarget compound, acts as an inhibitor of three human K(V)1 channels. The effects of 2-APB on K(V)1.4 channel depend on specific amino acids in the cavity region and N-terminal. This study reveals new molecular targets and provides insights into the diverse bioactivities of 2-APB.
Review
Plant Sciences
Pathalam Ganesan, Rajan Samuel, Subramanian Mutheeswaran, Perumal Pandikumar, Appadurai Daniel Reegan, Adeyemi Oladapo Aremu, Savarimuthu Ignacimuthu
Summary: Mosquitoes act as vectors for various diseases and parasites, and plant compounds are considered advantageous for controlling mosquito populations due to their target specificity and biodegradability. This review critically analyzes plant chemicals with larvicidal efficacy against mosquitoes and discusses their mode of action.
SOUTH AFRICAN JOURNAL OF BOTANY
(2023)
Article
Environmental Sciences
Rengasamy Sathya, Mariadhas Valan Arasu, Naif Abdullah Al-Dhabi, Ponnuswamy Vijayaraghavan, Soundharrajan Ilavenil, T. S. Rejiniemon
Summary: Water is vital for all living things on earth, and protecting water from pollution has become an essential need due to rapid urbanization and industrialization. Traditional methods of water treatment have drawbacks, but biological methods have gained more attention in recent years. This paper aims to review the role of bio-remedies in wastewater treatment, along with their advantages and limitations.
Article
Entomology
Muzafar Riyaz, Rauf Ahmad Shah, Ignacimuthu Savarimuthu, Sivasankaran Kuppusamy
Summary: This study sequenced the mitogenomes of two species from the family Erebidae and found that despite different lengths, their gene orders were identical, and both genomes contained 13 protein-coding genes, 22 tRNA genes, 2 rRNA genes, and an A+T-rich region. Phylogenomic analysis revealed that the superfamily Noctuoidea has a well-supported monophyletic relationship with Notodontidae, Erebidae, Nolidae, Euteliidae, and Noctuidae, and L. dorsigera should be classified within the subfamily Toxocampinae instead of Erebinae.
EUROPEAN JOURNAL OF ENTOMOLOGY
(2023)
Article
Plant Sciences
S. Antony Ceasar, S. Ignacimuthu
Summary: Genome editing tools based on CRISPR/Cas system have the potential to solve agricultural issues and improve food production. The use of genetic engineering in agriculture has allowed for the introduction of specific traits in crops, while CRISPR/Cas system offers a more precise technique for targeted modification of genes in the host plant genome. The delivery of CRISPR reagents has the potential to overcome limitations with traditional transformation methods and produce transgene-free plants. The CRISPR/Cas system is expected to play a key role in future crop breeding.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Review
Infectious Diseases
Juhi Puthukulangara Jaison, Balamuralikrishnan Balasubramanian, Jaya Gangwar, Nilina James, Manikantan Pappuswamy, Arumugam Vijaya Anand, Naif Abdullah Al-Dhabi, Mariadhas Valan Arasu, Wen-Chao Liu, Joseph Kadanthottu Sebastian
Summary: The Asteraceae family, with its rich phytochemicals, is widely used for traditional and medicinal purposes. These plants have found applications in various biological fields and nanotechnology. The synthesized nanoparticles from Asteraceae plants are stable, inexpensive, non-toxic, and eco-friendly, and have extensive applications in antibacterial, antifungal, antioxidant, anticancer, antidiabetic, and photocatalytic activities. This review provides an opportunity to understand the recent trend in green synthesis of advanced nanoparticles and discusses the extraction methods, synthesis, characterization, and potential applications of Asteraceae-mediated nanoparticles for human welfare. Constraints and future prospects for green synthesis of nanoparticles from Asteraceae family are summarized.
Article
Biochemistry & Molecular Biology
Rauf Ahmad Shah, Muzafar Riyaz, Savarimuthu Ignacimuthu, Kuppusamy Sivasankaran
Summary: In this study, the complete mitogenomes of Sympis rufibasis, Lacera noctilio, Oxyodes scrobiculata, Mocis undata, and Artena dotata were newly sequenced using next-generation sequencing methods. The analysis of these mitogenomes revealed a common gene order and characteristics unique to Noctuoidea moths. Additionally, the phylogenetic analyses provided insights into the tribe and subfamily relationships within the Erebidae.
BIOCHEMICAL GENETICS
(2023)
Article
Biochemistry & Molecular Biology
Jintao Wang, Huan Liu, Zhuolin Sun, Xinyi Zou, Zixuan Zhang, Xiaofeng Wei, Lanying Pan, Antony Stalin, Wei Zhao, Yuan Chen
Summary: In this study, the TWIK1 current was increased by using a high concentration of ammonium solution. The inhibitory effect of magnolol on TWIK1 was observed, and it was found that G229 and T225 on the P2-pore helix play an important role in TWIK1 inhibition.
Correction
Plant Sciences
Yingying Tan, Zhihong Huang, Yingying Liu, Xiaojiaoyang Li, Antony Stalin, Xiaotian Fan, Zhishan Wu, Chao Wu, Shan Lu, Fanqin Zhang, Meilin Chen, Jiaqi Huang, Guoliang Cheng, Bing Li, Siyu Guo, Yu Yang, Shuofeng Zhang, Jiarui Wu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)