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CHEMICAL PAPERS
卷 -, 期 -, 页码 -出版社
SPRINGER INT PUBL AG
DOI: 10.1007/s11696-023-03150-2
关键词
Tris(indolyl)methanes; Indoles; Dimethyl carbonate; Copper catalyst; Carbon source
In this study, a copper acetate/tert-butyl hydroperoxide-mediated reaction of N-substituted indoles with dimethyl carbonate was reported, leading to the synthesis of tris(indolyl)methanes through alpha-C-H functionalization of dimethyl carbonate's methoxy group. The central methine carbon in the product is derived from the dimethyl carbonate molecule, which serves as both a substrate and a reaction medium. This process is facilitated by a low-cost and environmentally friendly copper metal catalyst. Notably, this is the first reported synthesis of tris(indolyl)methanes using dimethyl carbonate as a sole carbon source.
Here, we report a copper acetate/tert-butyl hydroperoxide-mediated reaction of N-substituted indoles with dimethyl carbonate under heating to give tris(indolyl)methanes via alpha-C-H functionalization of the methoxy group of dimethyl carbonate. The central methine carbon in the product comes from the dimethyl carbonate molecule, which is used as a substrate as well as a reaction medium. The reaction uses a cheap and environmentally benign copper metal catalyst which makes the process useful. This is the first report of tris(indolyl)methane synthesis using dimethyl carbonate as a single carbon source.
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