Article
Chemistry, Inorganic & Nuclear
Johannes Karges, Ryjul W. Stokes, Seth M. Cohen
Summary: The research presents a conjugate consisting of a metalloenzyme inhibitor and a Ru(ii) polypyridine complex, which can release the inhibitor upon light exposure. This prodrug design helps achieve spatial and temporal control over treatment, offering a new approach for designing prodrugs of metalloenzyme inhibitors.
DALTON TRANSACTIONS
(2021)
Article
Chemistry, Inorganic & Nuclear
Stephen Mensah, Joseph D. Rosenthal, Mamta Dagar, Tyson Brown, Jonathan J. Mills, Christopher G. Hamaker, Gregory M. Ferrence, Michael I. Webb
Summary: The evolution of high virulence bacterial strains has led to the development of novel therapeutic agents. Metal-based therapeutics, with their structural variability and unique modes of action, show great promise. This study focused on the preparation and evaluation of ruthenium(ii)-arene complexes containing Schiff base ligands with an attached ferrocene, and identified a complex with prominent activity against clinically relevant bacterial strains.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Medicinal
Yishen Liu, Qianqian Li, Meijia Gu, Disheng Lu, Xiaoxing Xiong, Zhiyun Zhang, Yanna Pan, Yuqin Liao, Qihang Ding, Wanxia Gong, Dean Shuailin Chen, Mengting Guan, Junzhu Wu, Zhiquan Tian, Hai Deng, Lijuan Gu, Xuechuan Hong, Yuling Xiao
Summary: The clinical success of cisplatin paved the way for the application of metallodrugs. This study successfully transformed an electron acceptor into a novel NIR-II fluorophore with potential for cancer treatment. The modified fluorophore showed enhanced photothermal conversion efficiency and targeting ability for tumor cells, making it a promising theranostic platform.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Moideen Musthafa, Ramaiah Konakanchi, Rakesh Ganguly, Chandrasekar Balachandran, Shin Aoki, Anandaram Sreekanth
Summary: A series of aroyl selenourea ligands and their Ru(II) complexes were synthesized and characterized, with the molecular structures confirmed by single XRD crystal method. The cytotoxic study revealed that complexes 1 and 2 showed promising cytotoxic activity against HeLa S3 cells, while the in vitro DNA interaction studies indicated an intercalative mode of binding in the order of 1 > 2 > 3.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Chemistry, Multidisciplinary
Sean J. Steinke, Sayak Gupta, Eric J. Piechota, Curtis E. Moore, Jeremy J. Kodanko, Claudia Turro
Summary: This paper reports two new tris-heteroleptic Ru(II) complexes with triphenylphosphine coordination, which show suitable photochemical properties for photochemotherapeutic applications. The study reveals that under visible light irradiation, the complexes exhibit increased activity due to the photoinduced substitution reaction of PPh3 ligand in the excited state. These complexes represent a new design motif for the selective release of PPh3 and CH3CN for use in photochemotherapy.
Article
Chemistry, Inorganic & Nuclear
Kasturi Ganguli, Natalia Belkova, Sabuj Kundu
Summary: In this study, new ligands containing an indolyl fragment and phenanthroline, as well as their corresponding Ru(ii) complexes, were synthesized and characterized. The catalytic activity of these cyclometalated (NNC)Ru(ii) complexes towards the beta-methylation of alcohols using methanol as the reagent was investigated. The results showed that these complexes exhibited superior reactivity compared to various (NNN)Ru(ii) complexes. They selectively methylated a wide range of primary, secondary, and aliphatic straight chain alcohols. This methodology was also applied to the methylation of natural products and the gram scale synthesis of beta-methylated alcohols.
DALTON TRANSACTIONS
(2022)
Review
Chemistry, Multidisciplinary
Gang Zhou, Zhuanzhuan Guo, Xiao Shen
Summary: Oxycarbenes are important intermediates in synthetic chemistry. While the synthetic and catalytic applications of oxycarbenes with Group 6 metals have been well explored, the applications beyond Group 6 Fischer carbene complexes are less studied due to difficulties in controlling their reactivity and the need for a stoichiometric amount of a pre-synthesized Group 6 metal carbene complex. This Minireview summarizes the early applications and recent advances of late-transition-metal oxycarbene complexes, and hopes to inspire further development in this emerging area.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Inorganic & Nuclear
Austin P. Lanquist, Eric J. Piechota, Lanka D. Wickramasinghe, Alexia Marques Silva, Randolph P. Thummel, Claudia Turro
Summary: Two new complexes, [Ru(tpy)(qdppz)](PF6)(2) and [Ru(qdppz)(2)](PF6)(2), were investigated for their potential use as phototherapeutic agents. They exhibit different photophysical properties compared to [Ru(tpy)(2)](2+), with distinct absorption and emission spectra.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Sean J. Steinke, Eric J. Piechota, Lauren M. Loftus, Claudia Turro
Summary: This study investigates the excited states of a series of complexes [Ru(tpy)(L)(CH3CN)]n+ (1-11), and finds that the photoinduced CH3CN dissociation in these complexes occurs from the metal-to-ligand charge transfer (3MLCT) excited state instead of a dissociative triplet ligand field (3LF) state as previously believed. This discovery suggests alternative pathways for ligand photodissociation and has broad implications for the design principles of applications that require ligand photodissociation.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Zhihui Jin, Shuang Qi, Xusheng Guo, Yao Jian, Yuanjun Hou, Chao Li, Xuesong Wang, Qianxiong Zhou
Summary: The simple modification of a pyrene group on the labile ligand in this work gives the resultant complex 1 versatility, such as turn-on fluorescence after photo-dissociation, dual PDT and PACT activity, and a large two-photon absorption cross section.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Yao Jian, Zhihui Jin, Shuang Qi, Xuwen Da, Zhanhua Wang, Xuesong Wang, Qianxiong Zhou
Summary: In this study, a Ru2 drug was constructed that specifically labeled the surface of Gram-positive bacteria through bio-orthogonal click reaction, achieving specific and effective photo-inactivation against Staphylococcus aureus and methicillin-resistant Staphylococcus aureus without affecting mammalian cells.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Debajyoti Saha, Nayim Sepay
Summary: Fluxionality in eta(1)-aromatic carbocyclic-ligated Pd(ii) complexes is maintained when the eta(1)-carbon is replaced with an N atom through hemilabile palladium-carbon eta(1)-pyrrole ligation. A tetra-coordinated neutral chloro-pyrrole-Pd(ii)-pi-allyl complex with dynamic behavior at room temperature was reported and characterized, leading to the formation of a cationic palladium complex upon chlorine abstraction by AgSbF6. Crystallographic characterization showed that the coordination mode of the pyrrole subtly changes in these isostructural complexes with different carbon ligands (sigma or pi).
NEW JOURNAL OF CHEMISTRY
(2021)
Review
Chemistry, Multidisciplinary
Yan-Lin Li, Ai-Juan Li, Sheng-Li Huang, Jagadese J. Vittal, Guo-Yu Yang
Summary: This review focuses on the design and syntheses of Ru(N^N)3 and Ir(C^N)2(X^N) functionalized architectures of metal-organic frameworks (MOFs), covalent-organic frameworks (COFs), metallasupramolecules, organic supramolecules and supramolecular organic frameworks (SOFs), as well as their photocatalytic applications.
CHEMICAL SOCIETY REVIEWS
(2023)
Article
Chemistry, Physical
Igor E. Uflyand, Valerii V. Tkachev, Vladimir A. Zhinzhilo, Ekaterina G. Drogan, Victoria E. Burlakova, Mikhail E. Sokolov, Victor T. Panyushkin, Rosa K. Baimuratova, Gulzhian Dzhardimalieva
Summary: The reaction between copper(II) acrylate and 4 '-phenyl-2,2 ' :6 ' ,2 ''-terpyridine produced a metal containing monomer 1, characterized by a triclinic crystal structure with an ideal tetragonal pyramidal configuration. The thermal decomposition of complex 1 yielded nanomaterials of the Cu@C core shell type, which act as effective antiwear and antifriction additives for lubricating oils.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Inorganic & Nuclear
Robin Vinck, Albert Gandioso, Pierre Burckel, Bruno Saubamea, Kevin Cariou, Gilles Gasser
Summary: Four new ruthenium(II) polypyridyl complexes were synthesized and their properties were studied. It was found that these complexes could self-assemble into nanoparticles and accumulate in lysosomes upon internalization by cells. Conjugation with biotin increased cellular uptake but did not increase phototoxicity. However, these complexes showed high phototoxicity upon irradiation at long wavelengths (645-670 nm) and self-assembling behavior, making them promising for the development of new lysosome-targeted photosensitizers for photodynamic therapy.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Yuki Yamamoto, Miyuto Ota, Shintaro Kodama, Kazuki Michimoto, Akihiro Nomoto, Akiya Ogawa, Mitsunori Furuya, Kiminori Kawakami
Summary: A green method for the oxidation of alcohols to carboxylic acids has been developed using a co-catalytic system based on gold, silver, and copper catalysts. This method selectively oxidizes various primary alcohols to their corresponding carboxylic acids with high yields.
Article
Chemistry, Organic
Dat Phuc Tran, Yuki Sato, Yuki Yamamoto, Shin-ichi Kawaguchi, Shintaro Kodama, Akihiro Nomoto, Akiya Ogawa
Summary: The study developed a method that can generate pentavalent and trivalent phosphorus-centered radicals simultaneously by homolytic cleavage of the P-V(O)-P-III bond, enabling the phosphinylphosphination of terminal alkynes. This method exhibits high regio- and stereoselectivity and can be applied to a wide range of terminal alkynes.
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Organic
Yuki Yamamoto, Shintaro Kodama, Riku Nishimura, Akihiro Nomoto, Michio Ueshima, Akiya Ogawa
Summary: In this study, a one-pot construction of beta-lactam scaffolds was achieved with excellent cis selectivity. The subsequent hydrolysis of these beta-lactams also yielded corresponding beta-amino acids with high yields and selectivity.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Physical
Akihiro Nomoto, Tomoya Okada, Yuki Yamamoto, Shota Kuroda, Kuniaki Marui, Mika Yamamoto, Hidetaka Tsujimoto, Michio Ueshima, Tamotsu Nishigahana, Keiji Itoh, Gohei Kobata, Shintaro Kodama, Akiya Ogawa
Summary: The synthesis of Acid Blue 7 dye using a catalytic oxidation reaction with polyoxometalate catalyst and hydrogen peroxide in water was evaluated as a viable method to reduce the usage of harmful heavy metal oxidants. The reaction successfully produced Acid Blue 7 from the corresponding leuco acid at 95 degrees C in 45 minutes, demonstrating promising applications for 10 g-scale synthesis.
Article
Chemistry, Physical
Shintaro Kodama, Yuki Yamamoto, Yohsuke Kobiki, Hitomi Matsubara, Cong Chi Tran, Shin-ichi Kawaguchi, Akihiro Nomoto, Akiya Ogawa
Summary: The study showed that the use of different transition metal catalysts can selectively synthesize different products, while also achieving a cascade synthesis from diarylation reactions to quinoxaline compounds.
Article
Chemistry, Organic
Shintaro Kodama, Kazuki Bunno, Akihiro Nomoto, Akiya Ogawa
Summary: 4,4'-Di-tert-butyl-2,2'-bipyridinium trifluoromethanesulfonate was synthesized by reacting 4,4'-Di-tert-butyl-2,2'-bipyridine with scandium(III) trifluoromethanesulfonate in acetonitrile, followed by precipitation with diethyl ether. The structure of the new compound was confirmed using FT-IR, H-1, C-13{H-1}, and F-19{H-1} NMR spectroscopy and CHN elemental analysis, presenting a safe and simple method for obtaining mono-protonated bipyridinium trifluoromethanesulfonate without the direct use of trifluoromethanesulfonic acid.
Article
Biochemistry & Molecular Biology
Yuki Yamamoto, Ryo Tanaka, Shintaro Kodama, Akihiro Nomoto, Akiya Ogawa
Summary: The study achieved the photoinduced bisphosphination of alkynes, resulting in the synthesis of important transition-metal ligands. The optimization of reaction conditions allowed for a wide substrate range and complete regioselective introduction of phosphorus groups.
Article
Biochemistry & Molecular Biology
Yuki Yamamoto, Fumiya Sato, Qiqi Chen, Shintaro Kodama, Akihiro Nomoto, Akiya Ogawa
Summary: This study focuses on the synthesis of diaryl tellurides, particularly unsymmetrical ones, which has been limited due to the instability of the compounds and their intermediates. The researchers investigated a bimolecular homolytic substitution reaction between aryl radicals and diaryl ditellurides, resulting in the selective formation of unsymmetrical diaryl tellurides with high yields. The electronic effects of substituents on both reactants were also studied.
Article
Biochemistry & Molecular Biology
Vu Thai Hung, Cong Chi Tran, Yuki Yamamoto, Shintaro Kodama, Akihiro Nomoto, Akiya Ogawa
Summary: In this study, the reactivity of organochalcogen compounds towards an alkyl-lead bond compound under light was investigated. It was found that diphenyl diselenide exhibited excellent ability in capturing carbon radicals, resulting in higher yields compared to other organochalcogens like diphenyl disulfide and diphenyl ditelluride.
Article
Chemistry, Multidisciplinary
Yuki Yamamoto, Chihiro Yamakawa, Riku Nishimura, Chun-Ping Dong, Shintaro Kodama, Akihiro Nomoto, Michio Ueshima, Akiya Ogawa
Summary: In this study, a metal-free synthetic method for 2-substituted quinazoline derivatives was developed based on green chemistry principles. The use of a catalytic amount of BF3·Et2O as a Lewis acid successfully led to the efficient oxidative condensation and intramolecular cyclization of amines, resulting in the synthesis of 2-arylquinazolines with high yields and excellent atom economy. Furthermore, a practical gram-scale synthesis method using salicylic acid as an organocatalyst was established, expanding the applicability of the green oxidation method.
FRONTIERS IN CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Yuki Yamamoto, Miyuto Ota, Shintaro Kodama, Michio Ueshima, Akihiro Nomoto, Akiya Ogawa, Mitsunori Furuya, Kiminori Kawakami
Summary: A green method for the oxidation of benzylamines to imines was developed using a novel binary system of Au/C-CuO, which exhibited high yields, excellent durability, and recyclability. The system was also successfully applied to the synthesis of N-containing functional molecules.
Article
Chemistry, Organic
Shintaro Kodama, Vu Thai Hung, Tomokazu Saeki, Kei Mihara, Yuki Yamamoto, Motohiro Sonoda, Akihiro Nomoto, Akiya Ogawa
Summary: The paper presents a rare example of the direct and selective transformation of an alkyneto the corresponding diseleno-substituted alkene. The molecular structure of the synthesized compound was evaluated using X-ray analysis and spectral analyses.
Article
Chemistry, Multidisciplinary
Shintaro Kodama, Terushi Hashiguchi, Akira Okumura, Akihiro Nomoto, Akiya Ogawa
Summary: An octanuclear vanadium(V) oxide cluster complex, [V8O20(4,4'-tBubpy)4], functionalized with 4,4'-di-tert-butyl-2,2'-bipyridine (4,4'-tBubpy) ligands, can be used for visible-light photooxidation of alcohols (ROH) by molecular oxygen. The proposed key catalyst intermediates are heptanuclear oxido(alkoxido)vanadium(V) complexes, [V7O17(OR)(4,4'- tBubpy)3], generated in situ from [V8O20(4,4'-tBubpy)4] and ROH.
Review
Chemistry, Organic
Yuki Yamamoto, Shintaro Kodama, Akihiro Nomoto, Akiya Ogawa
Summary: In recent years, there has been a significant focus on the development of environmentally friendly molecular construction methods, particularly those that involve resource recycling and have high atomic efficiency and low environmental impact. This review highlights the latest innovative and green oxidation systems that use atmospheric oxygen to convert amines into imines, and explores their application in the one-pot/eco-friendly synthesis of pharmaceuticals and functional molecules. Catalytic systems that activate molecular oxygen, including transition metal catalytic systems, photoirradiated catalytic systems, and organocatalytic systems, are categorized and described in detail.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Article
Chemistry, Organic
Akihiro Nomoto, Hiroaki Yamaguchi, Masato Masuda, Keisuke Hyakumura, Shintaro Kodama, Tomohiro Osaki, Yoshiharu Okamoto, Mamoru Tanaka, Hiromi Kataoka, Atsushi Narumi, Tomokazu Yoshimura, Shigenobu Yano, Akiya Ogawa
Summary: A sugar-conjugated chlorin e6 derivative was successfully synthesized on a large scale, providing a new research direction for photodynamic therapy.
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)
