Research Progress on the Immune-Inflammatory Mechanisms of Posttraumatic Epilepsy

Microglia play beneficial roles in multiple experimental seizure models

(2023) Synphane Gibbs‐Shelton et al.   GLIA

Maturation, Morphology, and Function: The Decisive Role of Intestinal Flora on Microglia: A Review

(2023) Lichao Liu et al.   Journal of Integrative Neuroscience

Microglia in epilepsy

(2023) Cheng Yu et al.   NEUROBIOLOGY OF DISEASE

Microglia sense and suppress epileptic neuronal hyperexcitability

(2023) Yang Hu et al.   PHARMACOLOGICAL RESEARCH

Susceptibility to epilepsy after traumatic brain injury is associated with preexistent gut microbiome profile

(2022) Jesus‐Servando Medel‐Matus et al.   EPILEPSIA

Gut microbiome effects on neuronal excitability & activity: Implications for epilepsy

(2022) Henry Darch et al.   NEUROBIOLOGY OF DISEASE

Role of HMGB1/TLR4 and IL-1β/IL-1R1 Signaling Pathways in Epilepsy

(2022) Shaohui Zhang et al.   Frontiers in Neurology

Modification of post-traumatic epilepsy by fecal microbiota transfer

(2022) Jesus-Servando Medel-Matus et al.   EPILEPSY & BEHAVIOR

Overview Article Astrocytes as Initiators of Epilepsy

(2022) Lukas Henning et al.   NEUROCHEMICAL RESEARCH

Microglia states and nomenclature: A field at its crossroads

(2022) Rosa C. Paolicelli et al.   NEURON

Astrocytes and Epilepsy

(2021) Devin K. Binder et al.   NEUROCHEMICAL RESEARCH

Post-traumatic seizures and antiepileptic therapy as predictors of the functional outcome in patients with traumatic brain injury

(2021) Valeria Pingue et al.   Scientific Reports

Seizures are a druggable mechanistic link between TBI and subsequent tauopathy

(2021) Hadeel Alyenbaawi et al.   eLife

Reactive astrocyte-driven epileptogenesis is induced by microglia initially activated following status epilepticus

(2021) Fumikazu Sano et al.   JCI Insight

The Role of Neuroinflammation in Post-traumatic Epilepsy

(2021) Lei Sun et al.   Frontiers in Neurology

The gut microbiota as a biomarker in epilepsy

(2021) Emilio Russo   NEUROBIOLOGY OF DISEASE

TLR4 signaling in neurons enhances calcium‐permeable AMPAR currents and drives post‐traumatic epileptogenesis

(2020) Akshata A. Korgaonkar et al.   ANNALS OF NEUROLOGY

Microglial polarization in posttraumatic epilepsy: Potential mechanism and treatment opportunity

(2020) Peravina Therajaran et al.   EPILEPSIA

Modulation of post-traumatic immune response using the IL-1 receptor antagonist anakinra for improved visual outcomes

(2020) Lucy P Evans et al.   JOURNAL OF NEUROTRAUMA

Minocycline prevents neuronal hyperexcitability and neuroinflammation in medial prefrontal cortex, as well as memory impairment caused by repeated toluene inhalation in adolescent rats

(2020) Silvia L. Cruz et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Microglial depletion aggravates the severity of acute and chronic seizures in mice

(2020) Wenning Wu et al.   BRAIN BEHAVIOR AND IMMUNITY

Zebrafish model of posttraumatic epilepsy

(2020) Sung‐Joon Cho et al.   EPILEPSIA

Reactive Glia Inflammatory Signaling Pathways and Epilepsy

(2020) Pascual Sanz et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neuroinflammatory mechanisms of post-traumatic epilepsy

(2020) Sanjib Mukherjee et al.   Journal of Neuroinflammation

Negative feedback control of neuronal activity by microglia

(2020) Ana Badimon et al.   NATURE

The complement C3‐C3aR pathway mediates microglia–astrocyte interaction following status epilepticus

(2020) Yujia Wei et al.   GLIA

Traumatic brain injury in China

(2019) Ji-Yao Jiang et al.   LANCET NEUROLOGY

Interleukin-10 inhibits interleukin-1β production and inflammasome activation of microglia in epileptic seizures

(2019) Yi Sun et al.   Journal of Neuroinflammation

Emerging roles for the intestinal microbiome in epilepsy

(2019) Gregory R. Lum et al.   NEUROBIOLOGY OF DISEASE

Microglia-Triggered Plasticity of Intrinsic Excitability Modulates Psychomotor Behaviors in Acute Cerebellar Inflammation

(2019) Masamichi Yamamoto et al.   Cell Reports

Role of Astrocytes in Post-traumatic Epilepsy

(2019) Songbai Xu et al.   Frontiers in Neurology

Aquaporin-4 Dysregulation in a Controlled Cortical Impact Injury Model of Posttraumatic Epilepsy

(2019) Jenny I. Szu et al.   NEUROSCIENCE

Moderate Traumatic Brain Injury Alters the Gastrointestinal Microbiome in a Time-Dependent Manner

(2018) Susannah E. Nicholson et al.   SHOCK

Noninflammatory Changes of Microglia Are Sufficient to Cause Epilepsy

(2018) Xiaofeng Zhao et al.   Cell Reports

Monophosphoryl Lipid A and Pam3Cys Prevent the Increase in Seizure Susceptibility and Epileptogenesis in Rats Undergoing Traumatic Brain Injury

(2018) Soghra Hesam et al.   NEUROCHEMICAL RESEARCH

Selective deletion of glutamine synthetase in the mouse cerebral cortex induces glial dysfunction and vascular impairment that precede epilepsy and neurodegeneration

(2018) Yun Zhou et al.   NEUROCHEMISTRY INTERNATIONAL

Damage-Associated Molecular Patterns in Inflammatory Diseases

(2018) Jong Seong Roh et al.   Immune Network

Inflammation in epileptogenesis after traumatic brain injury

(2017) Kyria M. Webster et al.   Journal of Neuroinflammation

Interleukin-1 Receptor in Seizure Susceptibility after Traumatic Injury to the Pediatric Brain

(2017) Bridgette D. Semple et al.   JOURNAL OF NEUROSCIENCE

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Sodium selenate retards epileptogenesis in acquired epilepsy models reversing changes in protein phosphatase 2A and hyperphosphorylated tau

(2016) Shi-jie Liu et al.   BRAIN

NKCC1 up-regulation contributes to early post-traumatic seizures and increased post-traumatic seizure susceptibility

(2016) Fushun Wang et al.   Brain Structure & Function

Astrocyte roles in traumatic brain injury

(2016) Joshua E. Burda et al.   EXPERIMENTAL NEUROLOGY

Microglial/Macrophage Polarization Dynamics following Traumatic Brain Injury

(2016) Alok Kumar et al.   JOURNAL OF NEUROTRAUMA

Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor

(2016) Veit Rothhammer et al.   NATURE MEDICINE

Crucial role of astrocytes in temporal lobe epilepsy

(2016) C. Steinhäuser et al.   NEUROSCIENCE

IL-1β associations with posttraumatic epilepsy development: A genetics and biomarker cohort study

(2015) Matthew L. Diamond et al.   EPILEPSIA

Host microbiota constantly control maturation and function of microglia in the CNS

(2015) Daniel Erny et al.   NATURE NEUROSCIENCE

Albumin induces excitatory synaptogenesis through astrocytic TGF-β/ALK5 signaling in a model of acquired epilepsy following blood–brain barrier dysfunction

(2015) Itai Weissberg et al.   NEUROBIOLOGY OF DISEASE

Priming the Inflammatory Pump of the CNS after Traumatic Brain Injury

(2015) Kristina G. Witcher et al.   TRENDS IN NEUROSCIENCES

Phagocytosis of Microglia in the Central Nervous System Diseases

(2014) Ruying Fu et al.   MOLECULAR NEUROBIOLOGY

Disulfide-Containing High Mobility Group Box-1 Promotes N-Methyl-d-Aspartate Receptor Function and Excitotoxicity by Activating Toll-Like Receptor 4-Dependent Signaling in Hippocampal Neurons

(2013) Silvia Balosso et al.   ANTIOXIDANTS & REDOX SIGNALING

Progressive Neurodegeneration After Experimental Brain Trauma

(2013) David J. Loane et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Hyperphosphorylated Tau is Implicated in Acquired Epilepsy and Neuropsychiatric Comorbidities

(2013) Ping Zheng et al.   MOLECULAR NEUROBIOLOGY

Factors regulating microglia activation

(2013) Katrin Kierdorf et al.   Frontiers in Cellular Neuroscience

Albumin is taken up by hippocampal NG2 cells and astrocytes and decreases gap junction coupling

(2012) Oliver Braganza et al.   EPILEPSIA

Intravenous multipotent adult progenitor cell therapy after traumatic brain injury: modulation of the resident microglia population

(2012) Peter A Walker et al.   Journal of Neuroinflammation

Incidence of traumatic brain injury in New Zealand: a population-based study

(2012) Valery L Feigin et al.   LANCET NEUROLOGY

Aquaporin-4 Reduces Post-Traumatic Seizure Susceptibility by Promoting Astrocytic Glial Scar Formation in Mice

(2011) Daniel C Lu et al.   JOURNAL OF NEUROTRAUMA

Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures

(2010) Mattia Maroso et al.   NATURE MEDICINE

Epilepsy after head injury: An overview

(2009) Daniel H. Lowenstein   EPILEPSIA

Blood-brain barrier disruption in post-traumatic epilepsy

(2007) O Tomkins et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY