Article
Oncology
Masahide Saito, Takafumi Komiyama, Kan Marino, Shinichi Aoki, Mitsuhiko Oguri, Takashi Yamada, Naoki Sano, Hidekazu Suzuki, Koji Ueda, Hiroshi Onishi
Summary: The study aimed to investigate the impact of different MLC speed constraints in VMAT on treatment plan quality, and the results showed that increasing the MLC speed constraint can improve the quality of dose distribution.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2022)
Article
Multidisciplinary Sciences
Sultan Fahad Alhujaili, Feras Alafer, Abdulaziz Saad A. Alshabibi, Ziyad Awadh Alrowaili, Meshari Almeshari, M. A. Al Kafi, A. H. Aldosari, Sami Alshaikh, Belal Moftah
Summary: This study evaluated the implementation of MOSkin detectors for SRS dosimetry of the CyberKnife & REG; system. The performance of MOSkin detectors was assessed using Iris collimators on water-equivalent phantoms. Dosimetric evaluation included measurements of tissue-phantom ratio, output factor, and off-axis ratio. Results showed that MOSkin sensors can accurately reproduce measurements obtained by commercial sensors with an acceptable level of precision.
JOURNAL OF RADIATION RESEARCH AND APPLIED SCIENCES
(2023)
Article
Engineering, Biomedical
Jinghui Wang, Lei Wang, Peter G. Maxim, Billy W. Loo
Summary: An automated optimization strategy was developed for collimator design in small-field radiotherapy systems. Results showed good agreement with the CyberKnife system when prioritizing minimum penumbra, indicating the potential application of this strategy to more complex collimator designs.
PHYSICS IN MEDICINE AND BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Valerie Schmelter, Sarah Heidorn, Alexander Muacevic, Siegfried G. Priglinger, Paul Foerster, Raffael Liegl
Summary: Iris melanoma is a rare form of uveal melanoma, with treatment options including surgical resection, enucleation, or irradiation. This study analyzed the visual outcomes of eight patients with iris melanoma following robotic-assisted CyberKnife treatment, showing that robotic-assisted radiosurgery is a promising non-invasive treatment option.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Tobias Greve, Felix Ehret, Theresa Hofmann, Jun Thorsteinsdottir, Franziska Dorn, Viktor Svigelj, Anita Resman-Gaspersic, Joerg-Christian Tonn, Christian Schichor, Alexander Muacevic
Summary: The study analyzed a large series of cerebral AVMs treated by the frameless CyberKnife stereotactic radiosurgery system. Most AVMs were classified as Spetzler-Martin grade I to III. The occurrence of new neurological deficits after treatment was 5.1%, with almost all patients recovering.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Felix Ehret, Markus Kufeld, Christoph Furweger, Alfred Haidenberger, Paul Windisch, Carolin Senger, Melina Kord, Malte Trager, David Kaul, Christian Schichor, Jorg-Christian Tonn, Alexander Muacevic
Summary: The study reports treatment outcomes of spinal ependymomas using robotic radiosurgery (RRS) from two institutions, showing that RRS is a safe and efficient treatment modality for managing primary and secondary spinal ependymal tumors in patients with multiple lesions and local recurrences.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Tianlong Ji, Yaowen Song, Xinyu Zhao, Yuzi Wang, Guang Li
Summary: The Separate planning approach showed improved treatment efficiency and normal tissue dosimetry compared to the Combined approach. Increasing the number of collimators in the Combined plan led to improvements in some parameters but also increased the normal brain dose.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Carolin Senger, Anne Kluge, Melina Kord, Zoe Zimmermann, Alfredo Conti, Markus Kufeld, Anita Kreimeier, Franziska Loebel, Carmen Stromberger, Volker Budach, Peter Vajkoczy, Gueliz Acker
Summary: This study is the largest published series on robotic radiosurgery for ONSM so far and shows that robotic radiosurgery is a safe and effective treatment. 90.0% of patients had stable or improved visual acuity, and the overall local tumor control rate was 96.0%.
Article
Oncology
Jianping Zhang, Lin Wang, Benhua Xu, Miaoyun Huang, Yuangui Chen, Xiaobo Li
Summary: The study found a significant difference in CT numbers between pre-contrast agent and post-contrast agent scans, but no significant dose difference. It was recommended to use plain CT images to improve the accuracy of CyberKnife brain SRS treatment.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Felix Ehret, Carolin Senger, Markus Kufeld, Christoph Fuerweger, Melina Kord, Alfred Haidenberger, Paul Windisch, Daniel Ruess, David Kaul, Maximilian Ruge, Christian Schichor, Joerg-Christian Tonn, Alexander Muacevic
Summary: Robotic radiosurgery (RRS) is a safe, time-saving, and effective treatment modality for intramedullary metastases, especially for patients with unresectable lesions. Many symptoms improve or remain stable after treatment, and most treated lesions are controlled until death. These findings can guide further palliative care for affected patients.
Article
Oncology
Felix Ehret, Lucas Mose, Markus Kufeld, Christoph Fuerweger, Paul Windisch, Alfred Haidenberger, Christian Schichor, Joerg-Christian Tonn, Alexander Muacevic
Summary: This study investigated the efficacy and safety of single-session robotic radiosurgery for spinal metastasis recurrences occurring in the same initial location due to advancements in medical technology. The results showed that this treatment modality is safe, time-saving, and effective, with outcomes comparable to reirradiated metastases in boundary areas.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, General & Internal
Pritsana Punyawai, Nicha Radomsutthikul, Mantana Dhanachai, Chai Kobkitsuksakul, Ake Hansasuta
Summary: This study reported long-term outcomes of frameless robotic stereotactic radiosurgery for brain arteriovenous malformation at Ramathibodi Hospital. The majority of patients achieved an excellent outcome with minimal adverse effects, despite some cases experiencing AVM rupture or new neurological deficits during the follow-up period.
Article
Multidisciplinary Sciences
Franziska Loebel, Antonio Pontoriero, Anne Kluge, Giuseppe Iati, Gueliz Acker, Markus Kufeld, Alberto Cacciola, Stefano Pergolizzi, Sergio Vinci, Sara Lillo, Ran Xu, Carmen Stromberger, Volker Budach, Peter Vajkoczy, Carolin Senger, Alfredo Conti
Summary: Robotic radiosurgery is an effective approach for treating cerebral arteriovenous malformations (AVMs) of all Spetzler-Martin grades, with satisfactory obliteration rates, low toxicity, and a relatively rare incidence of rebleeding. Embolization before treatment can downstage the lesions and improve treatment outcomes.
Article
Oncology
Melina Kord, Anne Kluge, Markus Kufeld, Goda Kalinauskaite, Franziska Loebel, Carmen Stromberger, Volker Budach, Bernhard Gebauer, Gueliz Acker, Carolin Senger
Summary: Fiducial markers (FM) inserted into tumors increase the precision of irradiation during robotic radiosurgery (RRS). This retrospective study evaluated the clinical complications, marker migration, and motion amplitude of FM implantations by analyzing 288 cancer patients who underwent 357 FM implantations prior to RRS with CyberKnife between 2011 and 2019. Complications were most common in lesions affected by respiratory motion, particularly in pulmonary lesions, and were associated with concurrent biopsy sampling. FM migration was observed after CT-guided and clinical implantations, with the largest motion amplitudes seen in hepatic and lower lung lobe lesions. This study emphasizes the importance of FM placement, especially in lesions with significant motion amplitude.
Article
Oncology
Felix Ehret, Markus Kufeld, Christoph Fuerweger, Alfred Haidenberger, Paul Windisch, Susanne Fichte, Ralph Lehrke, Carolin Senger, David Kaul, Daniel Ruess, Maximilian Ruge, Christian Schichor, Joerg-Christian Tonn, Guenter Stalla, Alexander Muacevic
Summary: In addition to surgery and medication, robotic radiosurgery is an effective and safe treatment option for growth hormone-secreting tumors of the pituitary gland infiltrating surrounding tissue structures, achieving biochemical disease control or remission in most patients with decreasing hormone levels. The treatment also demonstrates favorable risk and safety profiles.