期刊
CARBOHYDRATE POLYMERS
卷 320, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2023.121213
关键词
Alginate; Tissue factor; CaCO 3 mineralization; Hemostasis; Biocompatibility
This study describes a simple mineralization strategy to enhance the hemostatic efficacy of alginate non-woven fabrics. The strategy involves the precipitation of amorphous CaCO3 induced by alginate fibers, along with the encapsulation of tissue factor (TF) for controlled release. The mineralized TF-in-alginate fabrics showed superior hemostatic capability compared to other materials, and comprehensive biocompatibility and mechanical stability evaluations demonstrated their good biosafety.
Uncontrolled hemorrhage remains a leading cause of mortality after trauma. This work describes a facile mineralization strategy for enhancing hemostatic efficacy of alginate non-woven fabrics, involving the precipitation of amorphous CaCO3 induced by alginate fibers, along with Trojan-horse-like tissue factor (TF) encapsulation. The amorphous CaCO3 served as a transient carrier, capable of releasing Ca2+ and TF upon contact with blood. Coagulation test and rat tail cut and hemorrhaging liver models all revealed superior hemostatic capability of mineralized TF-in-alginate fabrics compared to bare fabrics, solely mineralized form, or commercial zeolite-modified gauze, benefiting from the combined hemostatic properties of alginate matrix and released Ca2+ and TF. Meanwhile, comprehensive biocompatibility and mechanical stability evaluations demonstrate the ternary composite's good biosafety. These results along with the extension study with chitosan- and cellulosebased dressings underline the great potential and versatility of polysaccharide-hemostat-mediated CaCO3 mineralization with TF integration for achieving rapid hemorrhage control.
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