Article
Endocrinology & Metabolism
C. Guo, H. Duan, W. Fu, H. He, F. Xie, Z. Yang, M. Zheng, L. Zhang
Summary: The study investigated the key mechanism of DDR mutation in hepatocellular carcinoma, constructed a prognostic signature, and found that the stromal prognostic gene signature was associated with survival outcomes and the immune microenvironment in patients with HCC.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Article
Medicine, Research & Experimental
Jungang Liu, Xiaoliang Huang, Haizhou Liu, Chunyin Wei, Haiming Ru, Haiquan Qin, Hao Lai, Yongsheng Meng, Guo Wu, Weishun Xie, Xianwei Mo, Caroline H. Johnson, Yawei Zhang, Weizhong Tang
Summary: This study revealed that KRAS mutation in CRC is associated with suppressed immune pathways and immune infiltration, with increased Tregs and decreased M1 macrophages and activated CD4 memory T cells. An immune risk model was established to classify CRC patients with distinct clinical outcomes based on gene expression and immune cell abundance.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Zheng Zhou, Yusong Zhou, Dongbo Liu, Qingping Yang, Mengjie Tang, Wei Liu
Summary: This study constructed a prognostic model of cuproptosis-related genes (CRGs) in hepatocellular carcinoma (HCC) and investigated the prognostic and immune relevance of CRGs in HCC. The results suggested that CRGs, especially CDKN2A, may serve as potential prognostic predictors in HCC patients and provide novel insights into cancer therapy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Genetics & Heredity
Min Fu, Qiang Wang, Hanbo Wang, Yun Dai, Jin Wang, Weiting Kang, Zilian Cui, Xunbo Jin
Summary: In this study, a robust immune-related prognostic gene signature for prostate cancer was explored using methods such as WGCNA. Analysis of 259 IRGs identified nine functional modules correlated with biochemical recurrence of prostate cancer and 35 IRGs associated with prognosis, improving the scientific and accurate treatment decisions for clinicians.
FRONTIERS IN GENETICS
(2021)
Review
Genetics & Heredity
Fidelis Charles Bugoye, Rispah Torrorey-Sawe, Richard Biegon, Nazima Dharsee, Fidelice M. S. Mafumiko, Kirtika Patel, Simeon K. Mining
Summary: In recent years, studies have shown that a significant number of men with prostate cancer have genetic defects in the DNA damage repair gene response and mismatch repair genes. Specific gene alterations, such as homologous recombination (HRR) genes and genes for DNA mismatch repair (MMR), are associated with a higher risk and more severe types of prostate cancer. Imbalances in DNA damage repair can lead to mutations, cell death, and compromise tissue homeostasis, potentially impacting tumor immunity and promoting tumor growth. Patients with altered MMR genes may benefit from immunotherapy, highlighting the importance of mutational genetic testing for these treatments. This review summarizes the current knowledge on DDR mechanisms in prostate cancer and discusses the impact on patient management.
FRONTIERS IN GENETICS
(2023)
Article
Cell Biology
Shruti Patrick, Kirti Lathoria, Vaishali Suri, Ellora Sen
Summary: Gliomas with IDH1 mutations are more sensitive to chemotherapy and have lower levels of YAP1. These mutations lead to enhanced DNA damage and reduced FOLR1 expression. Similar observations were made in patient-derived IDH1 mutant glioma tissues. YAP1 and its partner TEAD2 were found to regulate FOLR1 expression. Reduced FOLR1 expression was associated with better patient survival. Depletion of FOLR1 increased the susceptibility of IDH1 wild-type gliomas to temozolomide-induced cell death. IDH1 mutants exhibited reduced levels of pro-inflammatory cytokines IL6 and IL8. YAP1 influenced DNA damage and the regulation of IL6 and IL8. YAP1 expression was associated with immune cell infiltration in gliomas. Simultaneous depletion of YAP1 and FOLR1 could enhance the potency of DNA damaging agents and reduce the release of inflammatory mediators, potentially affecting immune modulation. FOLR1 was identified as a potential prognostic marker for gliomas, predicting responsiveness to temozolomide and other DNA damaging agents.
CELLULAR SIGNALLING
(2023)
Article
Oncology
Junjie Zhao, Chong Li, Qinggang Li, Shen Shen, Xiaobo Hu, Zihui Dong, Yize Zhang, Jiyuan Xing
Summary: This study comprehensively analyzed the features of transcriptional aging-relevant genes in hepatocellular carcinoma (HCC) and identified six aging-related genes that are closely associated with HCC prognosis and immune characteristics. A prognostic prediction model based on these genes demonstrated great predictive ability.
ANALYTICAL CELLULAR PATHOLOGY
(2023)
Article
Immunology
Wei Wu, Xin'an Wang, Wei Le, Chang Lu, Haopeng Li, Yaru Zhu, Xi Chen, Wenbin An, Chengdang Xu, Qiang Wu, Licheng Wang
Summary: In this study, the tumor microenvironment and immune cell infiltration were analyzed in patients with prostate cancer. High immune cell infiltration scores were associated with poor prognosis and decreased expression of immune-related genes. The TGF-beta and WNT-beta signaling pathways were enriched in the high infiltration score subgroup, suggesting a potential mechanism for immune suppression in prostate cancer patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Genetics & Heredity
Yucheng Qian, Jingsun Wei, Wei Lu, Fangfang Sun, Maxwell Hwang, Kai Jiang, Dongliang Fu, Xinyi Zhou, Xiangxing Kong, Yingshuang Zhu, Qian Xiao, Yeting Hu, Kefeng Ding
Summary: This study focused on immune-related genes (IRGs) to establish a prognostic model for colorectal cancer patients, providing recommendations for clinical treatment. The 18-IRG signature was identified as an independent prognostic factor for overall survival in CRC patients, reflecting the state of tumor immune microenvironment (TIME) to a certain extent.
FRONTIERS IN GENETICS
(2021)
Article
Multidisciplinary Sciences
Yi Liu, Long Cheng, Chao Li, Chen Zhang, Lei Wang, Jiantao Zhang
Summary: This study investigates the relationship between tumor microenvironment (TME) and colorectal cancer prognosis by analyzing gene expression data. Lower immune scores were significantly associated with malignant progression of CRC. Six prognostic genes related to the CRC microenvironment were identified and validated in independent cohorts, showing significant associations with immune cell infiltration levels. This research may help in discovering new diagnostic and prognostic biomarkers as well as potential treatment targets for colorectal cancer.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Wei Feng, Yongxin Zhang, Wenwei Liu, Xiaofeng Wang, Tianxiang Lei, Yujie Yuan, Zehong Chen, Wu Song
Summary: By analyzing the gene data of colorectal cancer (CRC) patients, we constructed a prognosis model based on immune genes and studied the immune mechanisms and therapeutic sensitivity of CRC. This is of great significance for the diagnosis and treatment of CRC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Genetics & Heredity
Xinghao Wang, Chen Xu, Hongzan Sun
Summary: This study explores the effect of DNA damage repair-related genes on immune function in cervical cancer patients, and establishes a prognosis model based on these genes. The immune score and key genes related to immune cell infiltration are analyzed. The study finds that DNA damage repair-related genes can effectively predict the prognosis in cervical cancer.
FRONTIERS IN GENETICS
(2022)
Article
Genetics & Heredity
Ziyuan Ren, Minghui Hu, Zhonglin Wang, Junpeng Ge, Xiaoyan Zhou, Guoming Zhang, Hongying Zheng
Summary: This study established a 15-gene prognostic signature based on ferroptosis-related genes for lung adenocarcinoma (LUAD) and validated its predictive ability, providing nomograms for clinical reference. Functional analysis revealed associations between ferroptosis and cell cycle, cell metabolism, and immune pathways. Pan-cancer analysis demonstrated the heterogeneity of these genes among different cancer types. Ten genes were identified as potential targets for further research, with KRAS and PGD suggested as novel immunotherapy biomarkers.
FRONTIERS IN GENETICS
(2021)
Article
Immunology
Zidan Zhao, Tsz Kin Mak, Yuntao Shi, Huaping Huang, Mingyu Huo, Changhua Zhang
Summary: In this study, a lncRNA prognostic model related to DNA damage repair was constructed, and it was found that gastric cancer patients in the low-risk group had better overall survival. The study also discovered that patients in the low-risk group who received immunotherapy had a better prognosis. This work provides a foundation for improving the prognosis and response to immunotherapy among patients with gastric cancer.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Genetics & Heredity
Miao Yu, Yi Zhang, Rongchen Mao, Chao Zhu, Ruixue Zhao, Lai Jin
Summary: This study identified eight immune-related hub genes for predicting prognosis in gastric cancer patients, and found that the low-risk subgroup had better immune characteristics and prognosis. The model developed in this study accurately predicted the survival of gastric cancer patients and outperformed other models.