Highly Functional Acyclic Xeno Nucleic Acids

Syntheses of Base-Labile Pseudo-Complementary SNA and l-aTNA Phosphoramidite Monomers

(2023) Fuminori Sato et al.   Journal of Organic Chemistry

Functionalization of acyclic xenonucleic acid with modified nucleobases

(2023) Keiji Murayama et al.   POLYMER JOURNAL

Rapid Chemical Ligation of DNA and Acyclic Threoninol Nucleic Acid (aTNA) for Effective Nonenzymatic Primer Extension

(2023) Hikari Okita et al.   Journal of the American Chemical Society

Xeno nucleic acids (XNAs) having non-ribose scaffolds with unique supramolecular properties

(2022) Hiroyuki Asanuma et al.   CHEMICAL COMMUNICATIONS

Signal Amplification Circuit Composed of Serinol Nucleic Acid for RNA Detection

(2022) Yanglingzhi Chen et al.   CHEMISTRY LETTERS

Orthogonal Amplification Circuits Composed of Acyclic Nucleic Acids Enable RNA Detection

(2022) Yanglingzhi Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Supernatural: Artificial Nucleobases and Backbones to Program Hybridization-Based Assemblies and Circuits

(2022) Miguel López-Tena et al.   BIOCONJUGATE CHEMISTRY

Nonenzymatic polymerase-like template-directed synthesis of acyclic l-threoninol nucleic acid

(2021) Keiji Murayama et al.   Nature Communications

Design and Hybridization Properties of Acyclic Xeno Nucleic Acid Oligomers

(2021) Keiji Murayama et al.   CHEMBIOCHEM

Complete chemical synthesis of long DNA transcriptable in human cells

(2021) Kazuki Yamaoka et al.   CHEMBIOCHEM

Pyrene modified serinol nucleic acid nanostructure converts chirality of threoninol nucleic acids into circularly polarized luminescence signals

(2021) Hiromu Kashida et al.   CHEMISTRY-A EUROPEAN JOURNAL

Incorporation of Pseudo‐complementary Bases 2,6‐Diaminopurine and 2‐Thiouracil into Serinol Nucleic Acid (SNA) to Promote SNA/RNA Hybridization

(2020) Yukiko Kamiya et al.   Chemistry-An Asian Journal

Comparison of multiple factors that impact the efficiency of non‐enzymatic DNA ligation: Key parameters for maximizing ligation rates and yields with carbodiimide activation

(2020) Chiamaka Obianyor et al.   CHEMBIOCHEM

Dual crosslinking photo‐switches for orthogonal photo‐control of hybridization between serinol nucleic acid and RNA

(2020) Yuuhei Yamano et al.   CHEMISTRY-A EUROPEAN JOURNAL

DNA Polymerase Variants with High Processivity and Accuracy for Encoding and Decoding Locked Nucleic Acid Sequences

(2020) Hidekazu Hoshino et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Principles and Applications of Nucleic Acid Strand Displacement Reactions

(2019) Friedrich C. Simmel et al.   CHEMICAL REVIEWS

8-Pyrenylvinyl Adenine Controls Reversible Duplex Formation between Serinol Nucleic Acid and RNA by [2 + 2] Photocycloaddition

(2019) Keiji Murayama et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Highly stable hexitol based XNA aptamers targeting the vascular endothelial growth factor

(2019) Elena Eremeeva et al.   NUCLEIC ACIDS RESEARCH

What Is XNA?

(2019) John C. Chaput et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Invading Escherichia coli Genetics with a Xenobiotic Nucleic Acid Carrying an Acyclic Phosphonate Backbone (ZNA)

(2019) Min Luo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Serinol Nucleic Acid with a Fluorescent Uracil Analog serves as a Quencher‐free Linear Probe

(2019) Keiji Murayama et al.   CHEMBIOCHEM

Bifacial Nucleobases for Hexaplex Formation in Aqueous Solution

(2018) Hiromu Kashida et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Heterochiral DNA Strand-Displacement Circuits

(2017) Adam M. Kabza et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Assembly of a biocompatible triazole-linked gene by one-pot click-DNA ligation

(2017) Mikiembo Kukwikila et al.   Nature Chemistry

DNA sequence–directed shape change of photopatterned hydrogels via high-degree swelling

(2017) Angelo Cangialosi et al.   SCIENCE

D-a TNA Circuit Orthogonal to DNA Can Be Operated by RNA Input via SNA

(2017) Keiji Murayama et al.   ChemistrySelect

Rational design of hybridization chain reaction monomers for robust signal amplification

(2016) Yan Shan Ang et al.   CHEMICAL COMMUNICATIONS

Ultrasensitive Molecular Beacon Designed with Totally Serinol Nucleic Acid (SNA) for Monitoring mRNA in Cells

(2015) Keiji Murayama et al.   CHEMBIOCHEM

Acyclic l-threoninol nucleic acid (l-aTNA) with suitable structural rigidity cross-pairs with DNA and RNA

(2015) Keiji Murayama et al.   CHEMICAL COMMUNICATIONS

Gamma Peptide Nucleic Acids: As Orthogonal Nucleic Acid Recognition Codes for Organizing Molecular Self-Assembly

(2015) Iulia Sacui et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalysts from synthetic genetic polymers

(2014) Alexander I. Taylor et al.   NATURE

Base-Pairing Properties of a Structural Isomer of Glycerol Nucleic Acid

(2013) Phaneendrasai Karri et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Highly Stable Duplex Formation by Artificial Nucleic Acids Acyclic Threoninol Nucleic Acid (aTNA) and Serinol Nucleic Acid (SNA) with Acyclic Scaffolds

(2013) Keiji Murayama et al.   CHEMISTRY-A EUROPEAN JOURNAL

Binding of a Structured d-RNA Molecule by an l-RNA Aptamer

(2013) Jonathan T. Sczepanski et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Design, synthesis, biophysical and primer extension studies of novel acyclic butyl nucleic acid (BuNA)

(2013) Vipin Kumar et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Three-Dimensional Structures Self-Assembled from DNA Bricks

(2012) Y. Ke et al.   SCIENCE

Synthetic Genetic Polymers Capable of Heredity and Evolution

(2012) V. B. Pinheiro et al.   SCIENCE

Control of the Chirality and Helicity of Oligomers of Serinol Nucleic Acid (SNA) by Sequence Design

(2011) Hiromu Kashida et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Neural network computation with DNA strand displacement cascades

(2011) Lulu Qian et al.   NATURE

Efficient enzyme-free copying of all four nucleobases templated by immobilized RNA

(2011) Christopher Deck et al.   Nature Chemistry

Synthesis and Properties of the Simplified Nucleic Acid Glycol Nucleic Acid

(2010) Eric Meggers et al.   ACCOUNTS OF CHEMICAL RESEARCH

Unexpectedly Stable Artificial Duplex from Flexible Acyclic Threoninol

(2010) Hiroyuki Asanuma et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Control of DNA Strand Displacement Kinetics Using Toehold Exchange

(2009) David Yu Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Template-directed synthesis of a genetic polymer in a model protocell

(2008) Sheref S. Mansy et al.   NATURE