Reparative and Antioxidant Effects of New Analogues of Immunomodulator Thymogen in Experimental Model of Liver Damage

We studied the reparative and antioxidant effects of Thymogen and its new structural analogues obtained by binding amino acid D-Ala to the N- or C-end of the peptide molecule in acute toxic hepatopathy. Intragastric administration of carbon tetrachloride for 5 days caused the development of fat degeneration of hepatocytes, a decrease in catalase activity, and an increase in malondialdehyde concentration. Administration of peptides suppressed oxidative peroxidation and stimulated reparative regeneration of hepatocytes; Thymogen analogues produced more pronounced hepatotropic and antioxidant effects than Thymogen. Inclusion of D-Ala enhanced the effect of Thymogen on the processes of regeneration in hepatocytes and the antioxidant effect under conditions of acute carbon tetrachloride hepatopathy. The highest efficiency was achieved when the amino acid was added to the C-end of the molecule.

Automated summary

The study demonstrates that administration of Thymogen and its new structural analogues can effectively suppress fat degeneration and stimulate regenerative capacity in hepatocytes in acute toxic hepatopathy. These peptides also exhibit antioxidant effects, with the analogues showing stronger hepatotropic and antioxidant effects than Thymogen. The addition of D-Ala enhances the regenerative and antioxidant effects, with the best results achieved when added to the C-end of the molecule.