Homology modeling, virtual screening, molecular docking, and ADME approaches to identify a potent agent targeting NK2R protein

Neurokinin-1 Receptor (NK-1R) Antagonists as a New Strategy to Overcome Cancer Resistance

(2022) Marilina García-Aranda et al.   Cancers

Structural insights into the activation of neurokinin 2 receptor by neurokinin A

(2022) Wenjing Sun et al.   Cell Discovery

Elinzanetant (NT-814), a Neurokinin 1,3 Receptor Antagonist, Reduces Estradiol and Progesterone in Healthy Women

(2021) Steve Pawsey et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Randomized Controlled Trial of Neurokinin 3 Receptor Antagonist Fezolinetant for Treatment of Polycystic Ovary Syndrome

(2021) Graeme L Fraser et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Neurokinin 2 receptor-mediated bladder and colorectal responses in aged spinal cord injured rats

(2021) Lesley Marson et al.   SPINAL CORD

Structures of neurokinin 1 receptor in complex with G q and G s proteins reveal substance P binding mode and unique activation features

(2021) Cristian Thom et al.   Science Advances

Neurokinin-1 antagonist orvepitant for EGFRI-induced pruritus in patients with cancer: a randomised, placebo-controlled phase II trial

(2020) Bruno Vincenzi et al.   BMJ Open

Neurokinin receptor antagonism: a patent review (2014-present)

(2020) Miguel Muñoz et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Pharmacodynamic Activity of the Novel Neurokinin-3 Receptor Antagonist SJX-653 in Healthy Men

(2020) Richard A Anderson et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Human substance P receptor binding mode of the antagonist drug aprepitant by NMR and crystallography

(2019) Shuanghong Chen et al.   Nature Communications

Crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists

(2018) Jendrik Schöppe et al.   Nature Communications

SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules

(2017) Antoine Daina et al.   Scientific Reports

The neurokinin-2 receptor antagonist ibodutant improves overall symptoms, abdominal pain and stool pattern in female patients in a phase II study of diarrhoea-predominant IBS

(2016) J Tack et al.   GUT

3Drefine: an interactive web server for efficient protein structure refinement

(2016) Debswapna Bhattacharya et al.   NUCLEIC ACIDS RESEARCH

Modelling three-dimensional protein structures for applications in drug design

(2013) Tobias Schmidt et al.   DRUG DISCOVERY TODAY

Neuropeptide Signaling Activates Dendritic Cell-Mediated Type 1 Immune Responses through Neurokinin-2 Receptor

(2012) H. Kitamura et al.   JOURNAL OF IMMUNOLOGY

Molecular Modeling of the Peptide Agonist-Binding Site in a Neurokinin-2 Receptor

(2009) Indu R. Chandrashekaran et al.   Journal of Chemical Information and Modeling

Comparative efficacy of maropitant and selected drugs in preventing emesis induced by centrally or peripherally acting emetogens in dogs

(2008) H. S. SEDLACEK et al.   JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS