期刊
BIOLOGY DIRECT
卷 18, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s13062-023-00431-4
关键词
Bcl-2 family proteins; Carcinogenesis; Programmed cell death; Oogenesis; Embryogenesis
类别
This mini-review elucidates the functions of Bcl-B in normal conditions and various pathologies, including its regulation of programmed cell death, its oncogene/oncosuppressor activity in tumorigenesis, its impact on drug-acquired resistance, and possible approaches to inhibit Bcl-B.
Bcl-B is a poorly understood protein of the Bcl-2 family that is highly expressed in many healthy tissues and tumor types. Bcl-B is considered an antiapoptotic protein, but many reports have revealed its contradictory roles in different cancer types. In this mini-review, we elucidate the functions of Bcl-B in normal conditions and various pathologies, its regulation of programmed cell death, its oncogene/oncosuppressor activity in tumorigenesis, its impact on drug-acquired resistance, and possible approaches to inhibit Bcl-B.
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