Small-molecule inhibitors targeting FOXM1: Current challenges and future perspectives in cancer treatments
出版年份 2023 全文链接
标题
Small-molecule inhibitors targeting FOXM1: Current challenges and future perspectives in cancer treatments
作者
关键词
-
出版物
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
Volume 1878, Issue 6, Pages 189015
出版商
Elsevier BV
发表日期
2023-11-01
DOI
10.1016/j.bbcan.2023.189015
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Improving anti-tumor efficacy of low-dose Vincristine in rhabdomyosarcoma via the combination therapy with FOXM1 inhibitor RCM1
- (2023) Johnny Donovan et al. Frontiers in Oncology
- Effective combination treatments for breast cancer inhibition by FOXM1 inhibitors with other targeted cancer drugs
- (2023) Valeria Sanabria Guillen et al. BREAST CANCER RESEARCH AND TREATMENT
- Favorable outcomes of NPM1mut AML patients are due to transcriptional inactivation of FOXM1, presenting a new target to overcome chemoresistance
- (2023) I. Khan et al. Blood Cancer Journal
- FOXM1 regulates glycolysis and energy production in multiple myeloma
- (2022) Yan Cheng et al. ONCOGENE
- Thiostrepton induces ferroptosis in pancreatic cancer cells through STAT3/GPX4 signalling
- (2022) Weifan Zhang et al. Cell Death & Disease
- Multidrug Resistance in Cancer: Understanding Molecular Mechanisms, Immunoprevention and Therapeutic Approaches
- (2022) Talha Bin Emran et al. Frontiers in Oncology
- Small molecule targeting FOXM1 DNA binding domain exhibits anti-tumor activity in ovarian cancer
- (2022) Zaixin Zhang et al. Cell Death Discovery
- Peptide-based PROTAC degrader of FOXM1 suppresses cancer and decreases GLUT1 and PD-L1 expression
- (2022) Kun Wang et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Endogenous DOPA inhibits melanoma through suppression of CHRM1 signaling
- (2022) Miriam Doepner et al. Science Advances
- FDI-6, a FOXM1 inhibitor, activates the aryl hydrocarbon receptor and suppresses tumorsphere formation
- (2022) Naoya Yamashita et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- FOXM1 and Cancer: Faulty Cellular Signaling Derails Homeostasis
- (2021) Dhanya Kalathil et al. Frontiers in Oncology
- Co-regulation and function of FOXM1/RHNO1 bidirectional genes in cancer
- (2021) Carter J Barger et al. eLife
- The Anticancer Effects of FDI-6, a FOXM1 Inhibitor, on Triple Negative Breast Cancer
- (2021) Karan Ulhaka et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Novel FOXM1 inhibitor identified via gene network analysis induces autophagic FOXM1 degradation to overcome chemoresistance of human cancer cells
- (2021) Mikhail S. Chesnokov et al. Cell Death & Disease
- FOXM1-AKT Positive Regulation Loop Provides Venetoclax Resistance in AML
- (2021) Mikhail S Chesnokov et al. Frontiers in Oncology
- Ursolic Acid Accelerates Paclitaxel-Induced Cell Death in Esophageal Cancer Cells by Suppressing Akt/FOXM1 Signaling Cascade
- (2021) Ruo Yu Meng et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Targeting of the FOXM1 Oncoprotein by E3 Ligase-Assisted Degradation
- (2021) Guoshun Luo et al. JOURNAL OF MEDICINAL CHEMISTRY
- FDI-6 and olaparib synergistically inhibit the growth of pancreatic cancer by repressing BUB1, BRCA1 and CDC25A signaling pathways
- (2021) Shi-Qi Wu et al. PHARMACOLOGICAL RESEARCH
- FDI-6 inhibits the expression and function of FOXM1 to sensitize BRCA-proficient triple-negative breast cancer cells to Olaparib by regulating cell cycle progression and DNA damage repair
- (2021) Shu-Ping Wang et al. Cell Death & Disease
- Transcription Regulation and Genome Rewiring Governing Sensitivity and Resistance to FOXM1 Inhibition in Breast Cancer
- (2021) Yvonne Ziegler et al. Cancers
- FOXM1: a potential therapeutic target in human solid cancers
- (2020) Soheila Borhani et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- FOXM1 regulates leukemia stem cell quiescence and survival in MLL-rearranged AML
- (2020) Yue Sheng et al. Nature Communications
- Genistein inhibits lung cancer cell stem‑like characteristics by modulating MnSOD and FoxM1 expression
- (2020) Zhimin Fu et al. Oncology Letters
- SP1-independent inhibition of FOXM1 by modified thiazolidinediones
- (2020) Seyed Amirhossein Tabatabaei Dakhili et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Predicting FOXM1-Mediated Gene Regulation through the Analysis of Genome-Wide FOXM1 Binding Sites in MCF-7, K562, SK-N-SH, GM12878 and ECC-1 Cell Lines
- (2020) Keunsoo Kang et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Suppression of Tumor Growth, Metastasis, and Signaling Pathways by Reducing FOXM1 Activity in Triple Negative Breast Cancer
- (2020) Parama Dey et al. Cancers
- Pan-Cancer Analyses Reveal Genomic Features of FOXM1 Overexpression in Cancer
- (2019) Carter Barger et al. Cancers
- The FOXM1 inhibitor RCM-1 decreases carcinogenesis and nuclear β-catenin.
- (2019) Samriddhi Shukla et al. MOLECULAR CANCER THERAPEUTICS
- Bortezomib for the Treatment of Hematologic Malignancies: 15 Years Later
- (2019) Pawel Robak et al. Drugs in research & development
- FoxM1 Induced Paclitaxel Resistance via Activation of FoxM1/PHB1/RAF-MEK-ERK Pathway and Enhancement of ABCA2 Transporter
- (2019) Chao Huang et al. Molecular Therapy-Oncolytics
- A Structure-Activity Relationship Study of Forkhead Domain Inhibitors (FDI): the importance of halogen binding interactions
- (2019) Seyed Amirhossein Tabatabaei Dakhili et al. BIOORGANIC CHEMISTRY
- Honokiol is a FOXM1 antagonist
- (2018) Marianna Halasi et al. Cell Death & Disease
- FOXM1 contributes to taxane resistance by regulating UHRF1-controlled cancer cell stemness
- (2018) Bowen Yuan et al. Cell Death & Disease
- FoxM1 repression during human aging leads to mitotic decline and aneuploidy-driven full senescence
- (2018) Joana Catarina Macedo et al. Nature Communications
- MuvB: A Key to Cell Cycle Control in Ovarian Cancer
- (2018) Audra N. Iness et al. Frontiers in Oncology
- Regulation of the master regulator FOXM1 in cancer
- (2018) Guo-Bin Liao et al. Cell Communication and Signaling
- A novel peptide, 9R-P201, strongly inhibits the viability, proliferation and migration of liver cancer HepG2 cells and induces apoptosis by down-regulation of FoxM1 expression
- (2017) Zhenfei Bi et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Role of FoxM1 in the Progression and Epithelial to Mesenchymal Transition of Gastrointestinal Cancer
- (2017) Jing Zhang et al. Recent Patents on Anti-Cancer Drug Discovery
- The FOXM1 inhibitor RCM-1 suppresses goblet cell metaplasia and prevents IL-13 and STAT6 signaling in allergen-exposed mice
- (2017) Lifeng Sun et al. Science Signaling
- Prognostic value of FOXM1 in solid tumors: a systematic review and meta-analysis
- (2017) Lijun Li et al. Oncotarget
- Transcriptional landscape of human cancers
- (2017) Mengyuan Li et al. Oncotarget
- The molecular mechanisms of chemoresistance in cancers
- (2017) Hua-Chuan Zheng Oncotarget
- The FOXM1 inhibitor RCM-1 suppresses goblet cell metaplasia and prevents IL-13 and STAT6 signaling in allergen-exposed mice
- (2017) Lifeng Sun et al. Science Signaling
- Suppression of FOXM1 Transcriptional Activities via a Single-Stranded DNA Aptamer Generated by SELEX
- (2017) Qin Xiang et al. Scientific Reports
- A lignan induces lysosomal dependent degradation of FoxM1 protein to suppress β-catenin nuclear translocation
- (2017) Guang-zhi Dong et al. Scientific Reports
- FoxM1 inhibition enhances chemosensitivity of docetaxel-resistant A549 cells to docetaxel via activation of JNK/mitochondrial pathway
- (2016) Ke Wang et al. ACTA BIOCHIMICA ET BIOPHYSICA SINICA
- Combine and conquer: challenges for targeted therapy combinations in early phase trials
- (2016) Juanita S. Lopez et al. Nature Reviews Clinical Oncology
- A novel FOXM1 isoform, FOXM1D, promotes epithelial–mesenchymal transition and metastasis through ROCKs activation in colorectal cancer
- (2016) X Zhang et al. ONCOGENE
- In silico investigation of FOXM1 binding and novel inhibitors in epithelial ovarian cancer
- (2015) Yi Chen et al. BIOORGANIC & MEDICINAL CHEMISTRY
- A Novel Function of Molecular Chaperone HSP70
- (2015) Marianna Halasi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Thiostrepton interacts covalently with Rpt subunits of the 19S proteasome and proteasome substrates
- (2015) Cristinel Sandu et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- The prognostic landscape of genes and infiltrating immune cells across human cancers
- (2015) Andrew J Gentles et al. NATURE MEDICINE
- Targeted inhibition of metastatic melanoma through interference with Pin1-FOXM1 signaling
- (2015) F Kruiswijk et al. ONCOGENE
- FOXM1-mediated downregulation of uPA and MMP9 by 3,3′-diindolylmethane inhibits migration and invasion of human colorectal cancer cells
- (2015) HUA JIN et al. ONCOLOGY REPORTS
- 3,3′-Diindolylmethane potentiates paclitaxel-induced antitumor effects on gastric cancer cells through the Akt/FOXM1 signaling cascade
- (2015) HUA JIN et al. ONCOLOGY REPORTS
- Targeting FoxM1 inhibits proliferation, invasion and migration of nasopharyngeal carcinoma through the epithelial-to-mesenchymal transition pathway
- (2015) CHAO YU et al. ONCOLOGY REPORTS
- Inference of transcriptional regulation in cancers
- (2015) Peng Jiang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Genetic determinants of FOXM1 overexpression in epithelial ovarian cancer and functional contribution to cell cycle progression
- (2015) Carter J Barger et al. Oncotarget
- FOXM1 binds directly to non-consensus sequences in the human genome
- (2015) Deborah A. Sanders et al. GENOME BIOLOGY
- FOXM1: An emerging master regulator of DNA damage response and genotoxic agent resistance
- (2014) Stefania Zona et al. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms
- Panepoxydone Targets NF-kB and FOXM1 to Inhibit Proliferation, Induce Apoptosis and Reverse Epithelial to Mesenchymal Transition in Breast Cancer
- (2014) Ritu Arora et al. PLoS One
- Casticin induces breast cancer cell apoptosis by inhibiting the expression of forkhead box protein M1
- (2014) LI-PING LIU et al. Oncology Letters
- Suppression of the FOXM1 transcriptional programme via novel small molecule inhibition
- (2014) Michael V. Gormally et al. Nature Communications
- SPDEF Inhibits Prostate Carcinogenesis by Disrupting a Positive Feedback Loop in Regulation of the Foxm1 Oncogene
- (2014) Xin-Hua Cheng et al. PLoS Genetics
- MELK-Dependent FOXM1 Phosphorylation is Essential for Proliferation of Glioma Stem Cells
- (2013) Kaushal Joshi et al. STEM CELLS
- Casticin induces ovarian cancer cell apoptosis by repressing FoxM1 through the activation of FOXO3a
- (2013) LING JIANG et al. Oncology Letters
- Genome-wide mapping of FOXM1 binding reveals co-binding with estrogen receptor alpha in breast cancer cells
- (2013) Deborah A Sanders et al. GENOME BIOLOGY
- Targeting FOXM1 in cancer
- (2012) Marianna Halasi et al. BIOCHEMICAL PHARMACOLOGY
- Combination with bortezomib enhances the antitumor effects of nanoparticle-encapsulated thiostrepton
- (2012) Ming Wang et al. CANCER BIOLOGY & THERAPY
- Thiostrepton, proteasome inhibitors and FOXM1
- (2012) Andrei L. Gartel CELL CYCLE
- Proteasome Inhibitors: An Expanding Army Attacking a Unique Target
- (2012) Alexei F. Kisselev et al. CHEMISTRY & BIOLOGY
- Overexpression of FoxM1 offers a promising therapeutic target in diffuse large B-cell lymphoma
- (2012) S. Uddin et al. HAEMATOLOGICA
- Aurora B Is Regulated by the Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase (MAPK/ERK) Signaling Pathway and Is a Valuable Potential Target in Melanoma Cells
- (2012) Caroline Bonet et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Forkhead Transcription Factor FOXM1 Controls Cell Cycle-Dependent Gene Expression through an Atypical Chromatin Binding Mechanism
- (2012) X. Chen et al. MOLECULAR AND CELLULAR BIOLOGY
- Casticin induces growth suppression and cell cycle arrest through activation of FOXO3a in hepatocellular carcinoma
- (2012) LIHUA HE et al. ONCOLOGY REPORTS
- Suppression of FOXM1 Sensitizes Human Cancer Cells to Cell Death Induced by DNA-Damage
- (2012) Marianna Halasi et al. PLoS One
- Targeting GRB7/ERK/FOXM1 Signaling Pathway Impairs Aggressiveness of Ovarian Cancer Cells
- (2012) David W. Chan et al. PLoS One
- Novel Interactions between FOXM1 and CDC25A Regulate the Cell Cycle
- (2012) Con Sullivan et al. PLoS One
- 7-difluoromethoxyl-5,4’-di-n-octylgenistein inhibits growth of gastric cancer cells through downregulating forkhead box M1
- (2012) Hong-Lin Xiang WORLD JOURNAL OF GASTROENTEROLOGY
- Genome-Wide Expression Analysis of Middle Eastern Colorectal Cancer Reveals FOXM1 as a Novel Target for Cancer Therapy
- (2011) Shahab Uddin et al. AMERICAN JOURNAL OF PATHOLOGY
- FOXM1: From cancer initiation to progression and treatment
- (2011) Chuay-Yeng Koo et al. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms
- Proteasome inhibitory activity of thiazole antibiotics
- (2011) Bulbul Pandit et al. CANCER BIOLOGY & THERAPY
- A Systematic Screen for CDK4/6 Substrates Links FOXM1 Phosphorylation to Senescence Suppression in Cancer Cells
- (2011) Lars Anders et al. CANCER CELL
- FoxM1 is degraded at mitotic exit in a Cdh1-dependent manner
- (2011) Jamila Laoukili et al. CELL CYCLE
- NFκB inhibition and more: A side-by-side comparison of the inhibitors of IKK and proteasome
- (2011) Eugene S. Kandel CELL CYCLE
- A novel mode of FoxM1 regulation: Positive auto-regulatory loop
- (2011) Marianna Halasi et al. CELL CYCLE
- FoxM1 knockdown sensitizes human cancer cells to proteasome inhibitor-induced apoptosis but not to autophagy
- (2011) Bulbul Pandit et al. CELL CYCLE
- Expression of FoxM1 Is Required for the Proliferation of Medulloblastoma Cells and Indicates Worse Survival of Patients
- (2011) M. Priller et al. CLINICAL CANCER RESEARCH
- Natura-Alpha Targets Forkhead Box M1 and Inhibits Androgen-Dependent and -Independent Prostate Cancer Growth and Invasion
- (2011) Y. Li et al. CLINICAL CANCER RESEARCH
- Integrative genomic profiling reveals conserved genetic mechanisms for tumorigenesis in common entities of non-Hodgkin's lymphoma
- (2011) Michael R. Green et al. GENES CHROMOSOMES & CANCER
- The Role of Proteasome Inhibition in Nonsmall Cell Lung Cancer
- (2011) Mauricio Escobar et al. JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY
- FoxM1 and Its Association with Matrix Metalloproteinases (MMP) Signaling Pathway in Papillary Thyroid Carcinoma
- (2011) Maqbool Ahmed et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Novel Proteasome Inhibitors to Overcome Bortezomib Resistance
- (2011) Amy M. Ruschak et al. JNCI-Journal of the National Cancer Institute
- Micelle-Encapsulated Thiostrepton as an Effective Nanomedicine for Inhibiting Tumor Growth and for Suppressing FOXM1 in Human Xenografts
- (2011) M. Wang et al. MOLECULAR CANCER THERAPEUTICS
- The transcription factor FOXM1 is a cellular target of the natural product thiostrepton
- (2011) Nagaratna S. Hegde et al. Nature Chemistry
- Thiazole Antibiotic Thiostrepton Synergize with Bortezomib to Induce Apoptosis in Cancer Cells
- (2011) Bulbul Pandit et al. PLoS One
- Proteasome inhibitors in cancer therapy
- (2011) Lisa J. Crawford et al. Journal of Cell Communication and Signaling
- Phase 1 Trial of Gemcitabine With Bortezomib in Elderly Patients With Advanced Solid Tumors
- (2010) Satya V. Bommakanti et al. AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS
- Negative regulation of the oncogenic transcription factor FoxM1 by thiazolidinediones and mithramycin
- (2010) Vladimir Petrovic et al. CANCER BIOLOGY & THERAPY
- Novel anticancer compounds induce apoptosis in melanoma cells
- (2010) Uppoor G. Bhat et al. CELL CYCLE
- p53 negatively regulates expression of FoxM1
- (2010) Bulbul Pandit et al. CELL CYCLE
- Thiazole antibiotics against breast cancer
- (2010) Marianna Halasi et al. CELL CYCLE
- A new target for proteasome inhibitors: FoxM1
- (2010) Andrei L Gartel EXPERT OPINION ON INVESTIGATIONAL DRUGS
- 3,3′-diindolylmethane enhances taxotere-induced growth inhibition of breast cancer cells through downregulation of FoxM1
- (2010) Aamir Ahmad et al. INTERNATIONAL JOURNAL OF CANCER
- Older versus younger patients with metastatic adenocarcinoma of the esophagus, gastroesophageal junction, and stomach: A pooled analysis of eight consecutive North Central Cancer Treatment Group (NCCTG) trials
- (2010) Jatoi INTERNATIONAL JOURNAL OF ONCOLOGY
- Ursolic acid induces apoptosis by suppressing the expression of FoxM1 in MCF-7 human breast cancer cells
- (2010) Jing-song Wang et al. MEDICAL ONCOLOGY
- FOXM1 Confers Acquired Cisplatin Resistance in Breast Cancer Cells
- (2010) J. M.-M. Kwok et al. MOLECULAR CANCER RESEARCH
- Structure of the FoxM1 DNA-recognition domain bound to a promoter sequence
- (2010) D. R. Littler et al. NUCLEIC ACIDS RESEARCH
- FOXM1 is a transcriptional target of ERα and has a critical role in breast cancer endocrine sensitivity and resistance
- (2010) J Millour et al. ONCOGENE
- FoxM1 is a Novel Target of a Natural Agent in Pancreatic Cancer
- (2010) Zhiwei Wang et al. PHARMACEUTICAL RESEARCH
- New potential anti-cancer agents synergize with bortezomib and ABT-737 against prostate cancer
- (2010) Bulbul Pandit et al. PROSTATE
- Development and pharmacologic characterization of deoxybromophospha sugar derivatives with antileukemic activity
- (2009) Satoki Nakamura et al. INVESTIGATIONAL NEW DRUGS
- A Conserved Phosphorylation Site within the Forkhead Domain of FoxM1B Is Required for Its Activation by Cyclin-CDK1
- (2009) Yi-Ju Chen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Pro-proliferative FoxM1 is a target of p53-mediated repression
- (2009) A M Barsotti et al. ONCOGENE
- Thiazole Antibiotics Target FoxM1 and Induce Apoptosis in Human Cancer Cells
- (2009) Uppoor G. Bhat et al. PLoS One
- FoxM1 Is a General Target for Proteasome Inhibitors
- (2009) Uppoor G. Bhat et al. PLoS One
- FoxM1 inhibitors as potential anticancer drugs
- (2008) Andrei L Gartel EXPERT OPINION ON THERAPEUTIC TARGETS
- Anaphase-Promoting Complex/Cyclosome-Cdh1-Mediated Proteolysis of the Forkhead Box M1 Transcription Factor Is Critical for Regulated Entry into S Phase
- (2008) H. J. Park et al. MOLECULAR AND CELLULAR BIOLOGY
- Activation of FoxM1 during G2 Requires Cyclin A/Cdk-Dependent Relief of Autorepression by the FoxM1 N-Terminal Domain
- (2008) J. Laoukili et al. MOLECULAR AND CELLULAR BIOLOGY
- Thiostrepton selectively targets breast cancer cells through inhibition of forkhead box M1 expression
- (2008) J. M-M. Kwok et al. MOLECULAR CANCER THERAPEUTICS
- Curcumin in combination with bortezomib synergistically induced apoptosis in human multiple myeloma U266 cells
- (2008) Juwon Park et al. Molecular Oncology
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreDiscover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversation