标题
Antibodies and α-synuclein: What to target against Parkinson's Disease?
作者
关键词
-
出版物
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
Volume -, Issue -, Pages 140943
出版商
Elsevier BV
发表日期
2023-10-01
DOI
10.1016/j.bbapap.2023.140943
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Who Ever Said It Would Be Easy? Reflecting on Two Clinical Trials Targeting α‐Synuclein
- (2023) Poul Henning Jensen et al. MOVEMENT DISORDERS
- Microfluidic antibody affinity profiling of alloantibody-HLA interactions in human serum
- (2023) Matthias M. Schneider et al. BIOSENSORS & BIOELECTRONICS
- Assessment of heterogeneity among participants in the Parkinson's Progression Markers Initiative cohort using α-synuclein seed amplification: a cross-sectional study
- (2023) Andrew Siderowf et al. LANCET NEUROLOGY
- Protocol to determine antibody affinity and concentration in complex solutions using microfluidic antibody affinity profiling
- (2023) Marc Emmenegger et al. STAR Protocols
- Passive Immunization in Alpha-Synuclein Preclinical Animal Models
- (2022) Jonas Folke et al. Biomolecules
- The C-terminal tail of α-synuclein protects against aggregate replication but is critical for oligomerization
- (2022) Azad Farzadfard et al. Communications Biology
- Glycation modulates alpha-synuclein fibrillization kinetics: A sweet spot for inhibition
- (2022) Azad Farzadfard et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Trial of Prasinezumab in Early-Stage Parkinson’s Disease
- (2022) Gennaro Pagano et al. NEW ENGLAND JOURNAL OF MEDICINE
- Trial of Cinpanemab in Early Parkinson’s Disease
- (2022) Anthony E. Lang et al. NEW ENGLAND JOURNAL OF MEDICINE
- EGCG has Dual and Opposing Effects on the N-terminal Region of Self-associating α-synuclein Oligomers
- (2022) Anne Louise Grønnemose et al. JOURNAL OF MOLECULAR BIOLOGY
- Alpha-Synuclein Antibody Characterization: Why Semantics Matters
- (2021) Tiago Fleming Outeiro MOLECULAR NEUROBIOLOGY
- α-Helical peptidic scaffolds to target α-synuclein toxic species with nanomolar affinity
- (2021) Jaime Santos et al. Nature Communications
- Current Therapies in Clinical Trials of Parkinson’s Disease: A 2021 Update
- (2021) E. Maruthi Prasad et al. Pharmaceuticals
- Lipid Peroxidation Products HNE and ONE Promote and Stabilize Alpha-Synuclein Oligomers by Chemical Modifications
- (2021) Camilla Andersen et al. BIOCHEMISTRY
- Neurotoxic or neuroprotective: Post-translational modifications of α-synuclein at the cross-roads of functions
- (2021) Joshna Gadhavi et al. BIOCHIMIE
- Microfluidics and the quantification of biomolecular interactions
- (2021) Daniel E. Otzen et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- Development of a universal nanobody-binding Fab module for fiducial-assisted cryo-EM studies of membrane proteins
- (2021) Joël S. Bloch et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structural and Functional Insights into α-Synuclein Fibril Polymorphism
- (2021) Surabhi Mehra et al. Biomolecules
- Alpha-Synuclein Aggregation in Parkinson's Disease
- (2021) E. Srinivasan et al. Frontiers in Medicine
- Generation of Monoclonal Antibodies against Phosphorylated α-Synuclein at Serine 129: Research Tools for Synucleinopathies
- (2020) Muneera Fayyad et al. NEUROSCIENCE LETTERS
- Accelerated Amyloid Beta Pathogenesis by Bacterial Amyloid FapC
- (2020) Ibrahim Javed et al. Advanced Science
- Kinetic fingerprints differentiate the mechanisms of action of anti-Aβ antibodies
- (2020) Sara Linse et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- How specific are the conformation-specific α-synuclein antibodies? Characterization and validation of 16 α-synuclein conformation-specific antibodies using well-characterized preparations of α-synuclein monomers, fibrils and oligomers with distinct structures and morphology
- (2020) Senthil T. Kumar et al. NEUROBIOLOGY OF DISEASE
- Two conformationally distinct α-synuclein oligomers share common epitopes and the ability to impair long-term potentiation
- (2019) Femke van Diggelen et al. PLoS One
- α-Synuclein misfolding and aggregation: Implications in Parkinson’s disease pathogenesis
- (2019) Surabhi Mehra et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- Antibodies against alpha‐synuclein: tools and therapies
- (2019) Nishant N. Vaikath et al. JOURNAL OF NEUROCHEMISTRY
- Autonomic Dysfunction in α-Synucleinopathies
- (2019) José Javier Mendoza-Velásquez et al. Frontiers in Neurology
- α‐synuclein oligomers and fibrils: a spectrum of species, a spectrum of toxicities
- (2019) Parvez Alam et al. JOURNAL OF NEUROCHEMISTRY
- Brain-First versus Gut-First Parkinson’s Disease: A Hypothesis
- (2019) Per Borghammer et al. Journal of Parkinsons Disease
- Optimizing intracellular antibodies (intrabodies/nanobodies) to treat neurodegenerative disorders
- (2019) Anne Messer et al. NEUROBIOLOGY OF DISEASE
- Efficient clearance of Aβ protofibrils in AβPP-transgenic mice treated with a brain-penetrating bifunctional antibody
- (2018) Stina Syvänen et al. Alzheimers Research & Therapy
- Development of an aggregate-selective, human-derived α-synuclein antibody BIIB054 that ameliorates disease phenotypes in Parkinson's disease models
- (2018) Andreas Weihofen et al. NEUROBIOLOGY OF DISEASE
- T cells from patients with Parkinson’s disease recognize α-synuclein peptides
- (2017) David Sulzer et al. NATURE
- Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers
- (2017) Giuliana Fusco et al. SCIENCE
- α-Synuclein Oligomers: A Study in Diversity
- (2016) Femke van Diggelen et al. ISRAEL JOURNAL OF CHEMISTRY
- Molecular mechanisms of protein aggregation from global fitting of kinetic models
- (2016) Georg Meisl et al. Nature Protocols
- Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein
- (2016) Marcus D Tuttle et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Pathological -synuclein transmission initiated by binding lymphocyte-activation gene 3
- (2016) X. Mao et al. SCIENCE
- Antibody-based PET imaging of amyloid beta in mouse models of Alzheimer’s disease
- (2016) Dag Sehlin et al. Nature Communications
- Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein
- (2016) Marcus D Tuttle et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Exposure to the Functional Bacterial Amyloid Protein Curli Enhances Alpha-Synuclein Aggregation in Aged Fischer 344 Rats and Caenorhabditis elegans
- (2016) Shu G. Chen et al. Scientific Reports
- Generation and characterization of novel conformation-specific monoclonal antibodies for α-synuclein pathology
- (2015) Nishant N. Vaikath et al. NEUROBIOLOGY OF DISEASE
- Co-existence of Two Different α-Synuclein Oligomers with Different Core Structures Determined by Hydrogen/Deuterium Exchange Mass Spectrometry
- (2014) Wojciech Paslawski et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- How Epigallocatechin Gallate Can Inhibit α-Synuclein Oligomer Toxicityin Vitro
- (2014) Nikolai Lorenzen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Synucleins Regulate the Kinetics of Synaptic Vesicle Endocytosis
- (2014) K. J. Vargas et al. JOURNAL OF NEUROSCIENCE
- The Role of Stable α-Synuclein Oligomers in the Molecular Events Underlying Amyloid Formation
- (2014) Nikolai Lorenzen et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- ESCRT-mediated Uptake and Degradation of Brain-targeted α-synuclein Single Chain Antibody Attenuates Neuronal Degeneration In Vivo
- (2014) Brian Spencer et al. MOLECULAR THERAPY
- Chaperone-mediated autophagy: roles in disease and aging
- (2013) Ana Maria Cuervo et al. CELL RESEARCH
- Immunotherapy for neurodegenerative diseases: Focus on α-synucleinopathies
- (2013) Elvira Valera et al. PHARMACOLOGY & THERAPEUTICS
- Structural and functional characterization of two alpha-synuclein strains
- (2013) Luc Bousset et al. Nature Communications
- Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia
- (2013) Changyoun Kim et al. Nature Communications
- Fusion to a highly charged proteasomal retargeting sequence increases soluble cytoplasmic expression and efficacy of diverse anti-synuclein intrabodies
- (2012) Shubhada N. Joshi et al. mAbs
- Passive Immunization Reduces Behavioral and Neuropathological Deficits in an Alpha-Synuclein Transgenic Model of Lewy Body Disease
- (2011) Eliezer Masliah et al. PLoS One
- Low-resolution structure of a vesicle disrupting -synuclein oligomer that accumulates during fibrillation
- (2011) L. Giehm et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Physico-chemical determinants of soluble intrabody expression in mammalian cell cytoplasm
- (2010) Erik Kvam et al. PROTEIN ENGINEERING DESIGN & SELECTION
- The Influence of Vesicle Size and Composition on α-Synuclein Structure and Stability
- (2009) Lars Kjaer et al. BIOPHYSICAL JOURNAL
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started