Article
Thermodynamics
Muhammad Suleman, Samia Riaz, Rashid Jalil
Summary: Magnetic nanoparticles-induced hyperthermia can heat tumors to 41-43 degrees Celsius, destroying cancer cells while keeping normal cells unharmed. This review discusses the basic physical mechanisms, recent advances in mathematical modeling, integration with other therapies, challenges, and future directions of hyperthermia.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2021)
Article
Oncology
H. Petra Kok, Johannes Crezee
Summary: Adapt2Heat is a flexible and intuitive tool for on-line adaptive hyperthermia treatment planning. It provides visualization and optimization features that can enhance the quality of hyperthermia treatment in many locoregional applications.
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2022)
Article
Oncology
H. Petra Kok, Johannes Crezee
Summary: This study developed a temperature-based re-optimization strategy and compared its predicted effectiveness with clinically applied protocol/experience-based steering. The results showed that the re-optimization strategy effectively suppressed hot spots without affecting tumor temperatures, similar to clinical steering. Implementing these strategies can significantly improve the overall treatment quality within hyperthermia centers.
Review
Immunology
Yi Zhang, Zheng Li, Ying Huang, Bingwen Zou, Yong Xu
Summary: Combining tumor immunotherapy with nanoparticle-based hyperthermia has been found to enhance cancer treatment effectiveness. Tumor immunotherapy activates the immune system to attack cancer cells, while nanoparticle-based hyperthermia selectively kills cells by raising the temperature of tumor cells. The combination of both approaches can amplify anti-tumor responses, improve outcomes, and reduce side effects.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Astrid van der Horst, H. Petra Kok, Johannes Crezee
Summary: This study investigated the impact of variations in gastrointestinal gas on temperature distributions during simulated hyperthermia treatment in pancreatic cancer patients. The results showed that increasing gastrointestinal gas volume led to significant differences in tumor temperature. The risk for gastrointestinal gas-associated treatment-limiting hot spots appeared low, while high-temperature regions in normal tissues were mainly located anteriorly.
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2021)
Review
Pharmacology & Pharmacy
Alfonso Toro-Cordova, Monserrat Llaguno-Munive, Rafael Jurado, Patricia Garcia-Lopez
Summary: Cancer is a major global public health problem, and developing new treatment strategies and diagnostic tools is crucial. Magnetoliposomes, as a promising therapeutic approach, can target drug delivery to diseased tissues and enhance treatment effectiveness by producing hyperthermia.
Review
Biochemistry & Molecular Biology
Francesco Claps, Nicola Pavan, Luca Ongaro, Domenico Tierno, Gabriele Grassi, Carlo Trombetta, Gabriele Tulone, Alchiede Simonato, Riccardo Bartoletti, Laura S. Mertens, Bas W. G. van Rhijn, Maria Carmen Mir, Bruna Scaggiante
Summary: Urothelial carcinoma is a common type of cancer, with bladder carcinoma being the most prevalent form. For non-muscle-invasive bladder cancer that does not respond to BCG treatment, radical cystectomy is currently the standard treatment. However, this surgery carries high risks and impacts the patient's quality of life, highlighting the need for alternative bladder-preserving therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Margarethus M. Paulides, Dario B. Rodrigues, Gennaro G. Bellizzi, Kemal Sumser, Sergio Curto, Esra Neufeld, Hazael Montanaro, H. Petra Kok, Hana Dobsicek Trefna
Summary: The success of cancer hyperthermia treatment relies on achieving optimal temperatures in tumor and healthy tissues. Computational simulations play a crucial role in hyperthermia treatment planning and in silico studies for developing new devices and approaches. This paper proposes benchmarks and guidelines to standardize hyperthermia treatment, aiming to facilitate method comparison, code verification, and clinical relevancy.
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2021)
Article
Multidisciplinary Sciences
Ryan Tsz-Hei Tse, Hongda Zhao, Christine Yim-Ping Wong, Angel Wing-Yan Kong, Ronald Cheong-Kin Chan, Ka-Fai To, Chi-Fai Ng, Jeremy Yuen-Chun Teoh
Summary: The study demonstrates that intra-operative and post-operative environments can impact bladder cancer recurrence, with sterile water and MMC showing increased cytotoxicity to cancer cells in hyperthermic conditions.
SCIENTIFIC REPORTS
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Siao Lei, Jie He, Pengli Gao, Yueqi Wang, Hui Hui, Yu An, Jie Tian
Summary: This article introduces the fundamentals and applications of magnetic particle imaging (MPI) and magnetic fluid hyperthermia (MFH), as well as their potential in the treatment of cancer. Furthermore, the challenges and prospects of MPI-MFH are discussed.
MOLECULAR IMAGING AND BIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Pooja Jain, Himanshu Kathuria, Munira Momin
Summary: Bladder cancer is the 10th most common malignancy worldwide with a 5-year survival rate of 75%, but 70% of the cases develop chemoresistance and progress to the muscle invasive stage. Nanotechnology has shown promise in targeted drug delivery to bladder cancer cells, offering potential for better treatment management.
PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Chemistry, Analytical
Gulsah Yildiz, Halimcan Yasar, Ibrahim Enes Uslu, Yusuf Demirel, Mehmet Nuri Akinci, Tuba Yilmaz, Ibrahim Akduman
Summary: This paper proposes an antenna excitation optimization scheme applicable to various configurations and investigates it using CNN-based approaches. The results demonstrate that this method outperforms traditional lookup table methods. The proposed deep-learning-based optimization technique holds great application potential in microwave hyperthermia.
Review
Chemistry, Multidisciplinary
Julian Palzer, Lea Eckstein, Ioana Slabu, Oliver Reisen, Ulf P. Neumann, Anjali A. Roeth
Summary: Iron oxide nanoparticle-based hyperthermia is a promising emerging field in cancer treatment, primarily achieved through magnetic fluid hyperthermia and photothermal therapy. Both methods show potential as tools in cancer treatment and are explored for gastrointestinal malignancies.
Article
Computer Science, Interdisciplinary Applications
Roberto Montes-Robles, Hazael Montanaro, Myles Capstick, Javier Ibanez-Civera, Rafael Masot-Peris, Eduardo Garcia-Breijo, Nicolas Laguarda-Miro, Ramon Martinez-Manez
Summary: The study aims to provide a virtual scenario for the development of an optimized multi-site injection plan for personalized magnetic nanoparticle-mediated hyperthermia. By simulating the impact of magnetic nanoparticles in different environments, the results show that this method can minimize the effect on healthy tissues.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2022)
Article
Oncology
Iva VilasBoas-Ribeiro, Martine Franckena, Gerard C. van Rhoon, Juan A. Hernandez-Tamames, Margarethus M. Paulides
Summary: The purpose of this study was to investigate the differences between planning and treatment positions, their impact on the accuracy of HTP predictions, and the relevance of including true treatment anatomy and position in HTP based on MR images. The results showed that including accurate treatment position and anatomy improved the accuracy of HTP predictions.
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2023)
Article
Oncology
Daphne Schouten, Rob van Os, Anneke M. Westermann, Hans Crezee, Geertjan van Tienhoven, Willemijn M. Kolff, Adriaan D. Bins
Summary: Adding cisplatin to reirradiation and hyperthermia does not show potential benefit in patients with recurrent breast cancer in previously irradiated areas. Most patients can achieve local control regardless of cisplatin use.
Review
Oncology
Marloes IJff, Johannes Crezee, Arlene L. Oei, Lukas J. A. Stalpers, Henrike Westerveld
Summary: This article provides an overview of the biological rationale and clinical effectiveness of hyperthermia as a radiosensitizer in the treatment of cervical cancer. Hyperthermia is particularly effective in hypoxic and nutrient deprived areas of the tumor and is well tolerated. Patients who are contraindicated for cisplatin should be referred to a hyperthermia center for thermoradiation.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2022)
Article
Biochemistry & Molecular Biology
Roxan F. C. P. A. Helderman, Mauricio Tobon Restrepo, Hans M. Rodermond, Gregor G. W. van Bochove, Daan R. Loke, Nicolaas A. P. Franken, H. Petra Kok, Pieter J. Tanis, Johannes Crezee, Arlene L. Oei
Summary: Ultrasound is a reliable non-invasive method to detect and quantify the growth of intraperitoneal tumor nodules in a rat model.
Article
Oncology
H. P. Kok, G. C. van Rhoon, T. D. Herrera, J. Overgaard, J. Crezee
Summary: Biological modeling for hyperthermia combined with radiotherapy has made significant progress. It can predict the effectiveness of different treatment strategies and provide theoretical evaluation for individual patients and patient cohorts. With the improvement of related model parameters, biological modeling is expected to play a greater role in optimizing combined treatments, clinical protocols, and guiding clinical studies.
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2022)
Article
Oncology
H. Petra Kok, Timoteo D. Herrera, Johannes Crezee
Summary: This study found that the radiosensitization effect of hyperthermia can be quantified as an enhanced equivalent radiation dose (EQDRT), and the effect is related to the achieved temperature and time interval between radiation therapy and hyperthermia. Higher temperature and shorter time interval result in greater enhancement of EQDRT.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Article
Oncology
Adela Ademaj, Paraskevi D. Veltsista, Dietmar Marder, Roger A. Haelg, Emsad Puric, Thomas B. Brunner, Hans Crezee, Dorota Gabrys, Martine Franckena, Cihan Gani, Michael R. Horsman, Robert Krempien, Lars H. Lindner, Sergio Maluta, Markus Notter, Griseldis Petzold, Sultan Abdel-Rahman, Antonella Richetti, Andreas R. Thomsen, Pelagia Tsoutsou, Rainer Fietkau, Oliver J. Ott, Pirus Ghadjar, Oliver Riesterer
Summary: There is significant heterogeneity among European clinical centers in the practice of hyperthermia, including the indications treated and the recording of thermometric parameters. More evidence from clinical studies is needed to standardize hyperthermia practice.
STRAHLENTHERAPIE UND ONKOLOGIE
(2023)
Article
Oncology
Akke Bakker, Remko Zweije, H. Petra Kok, Lukas J. A. Stalpers, G. Henrike Westerveld, Karel A. Hinnen, Geertjan van Tienhoven, M. Willemijn Kolff, Hans Crezee
Summary: The study demonstrates similar clinical performance between the hybrid Alba 4D and the AMC-4 locoregional hyperthermia systems, indicating comparable treatment outcomes for patients.
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2022)
Article
Oncology
Iris S. G. Brummelhuis, Johannes Crezee, J. Alfred Witjes
Summary: This study investigated the effect of higher thermal dose on clinical outcomes in nonmuscle invasive bladder cancer (NMIBC) patients and found no significant association between thermal dose and NMIBC outcome. However, the occurrence of bladder spasms had a limiting effect on thermal dose. It is recommended to maintain the treatment temperature above 40.5 degrees Celsius for at least 45 minutes while respecting individual tolerability.
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2023)
Article
Biology
P. Agnass, H. M. Rodermond, E. van Veldhuisen, J. A. Vogel, R. ten Cate, K. P. van Lienden, T. M. van Gulik, N. A. P. Franken, A. L. Oei, H. P. Kok, M. G. Besselink, J. Crezee
Summary: IRE is an effective ablation technique for unresectable cancers. This study investigates the impact of mild and moderate hyperthermia on the electroporation effect and establishes a cell viability model. The results indicate that higher temperatures enhance cell ablation and the cell viability model successfully predicts temperature-dependent outcomes.
JOURNAL OF THERMAL BIOLOGY
(2023)
Article
Oncology
Daan R. Loke, H. Petra Kok, Roxan F. C. P. A. Helderman, Nicolaas A. P. Franken, Arlene L. Oei, Jurriaan B. Tuynman, Remko Zweije, Jan Sijbrands, Pieter J. Tanis, Johannes Crezee
Summary: In this study, a 3D-printed anatomically correct phantom of a female peritoneum was used to validate the thermal module of a treatment planning software. The software, based on OpenFoam, helps understand and map thermal heterogeneities during Hyperthermic IntraPeritoneal Chemotherapy (HIPEC) treatments. The experimental data compared well with simulated temperature distributions, indicating the accuracy of the software.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Roxan F. C. P. A. Helderman, Bella Bokan, Gregor G. W. van Bochove, Hans M. Rodermond, Elsy Thijssen, Wouter Marchal, Arezo Torang, Daan R. Loke, Nicolaas A. P. Franken, H. Petra Kok, Pieter J. Tanis, Johannes Crezee, Arlene L. Oei
Summary: In patients with limited peritoneal metastasis from colorectal cancer, cytoreductive surgery followed by hyperthermic intraperitoneal chemotherapy is a potentially curative treatment option. This study investigated the impact of treatment temperature and duration on the effectiveness of oxaliplatin and mitomycin C in preclinical models, and found that higher temperatures and longer treatment durations resulted in improved efficacy and reduced toxicity.
FRONTIERS IN ONCOLOGY
(2023)
Article
Computer Science, Interdisciplinary Applications
Jort A. Groen, Johannes Crezee, Hanneke W. M. van Laarhoven, Maarten F. Bijlsma, H. Petra Kok
Summary: Uncertainties in tissue and perfusion property values have a significant impact on hyperthermia treatment planning, and the PCE-based analysis helps identify major uncertainties, assess their impact, and judge the reliability of treatment plans.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2023)
Article
Oncology
Daan R. Loeke, H. Petra Kok, Roxan F. C. P. A. Helderman, Bella Bokan, Nicolaas A. P. Franken, Arlene L. Oei, Jurriaan B. Tuynman, Pieter J. Tanis, Johannes Crezee
Summary: This study compares the impact of different treatment strategies on temperature and drug distributions and evaluates the effects using simulation results and clinical data. The study finds that treatment strategy has a significant influence on the distributions, additional inflow catheters can improve thermal distributions, and different heating strategies can optimize the effectiveness and reduce the risk of thermal damage.
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2023)
Article
Surgery
E. S. Zwanenburg, D. D. Wisselink, C. E. L. Klaver, A. R. M. Brandt, A. J. A. Bremers, J. W. A. Burger, W. M. U. van Grevenstein, P. H. J. Hemmer, I. H. J. T. de Hingh, N. F. M. Kok, M. J. Wiezer, J. B. Tuynman, P. J. Tanis
Summary: This study aimed to evaluate the impact of laparoscopic or open resection on the incidence and severity of adhesions in locally advanced colonic cancer. The results revealed that open surgery was identified as an independent risk factor for adhesions, while intraperitoneal chemotherapy did not increase the occurrence of adhesions.
BRITISH JOURNAL OF SURGERY
(2022)