Article
Biochemistry & Molecular Biology
Viktoriya Shishkina, Andrey Kostin, Artem Volodkin, Vera Samoilova, Igor Buchwalow, Markus Tiemann, Dmitri Atiakshin
Summary: This study analyzed the skin dermis of C57BL/6J mice after a long stay in space flight and found that weightlessness resulted in an increase in type III collagen-rich fibers and a decrease in co-localization of mast cells with fibroblasts and impregnated fibers. The potential molecular and cellular mechanisms for the changes in fibrillogenesis activity and the decrease in fibrous structures with a predominant content of type-I collagen under zero-gravity conditions are discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell & Tissue Engineering
Faiza Farhan, Manjari Trivedi, Priscilla Di Wu, Wei Cui
Summary: This study found that HLCs cultured with collagen showed increased albumin and alpha-1 anti-trypsin expression, reduced AFP, and higher urea secretion compared to HLCs cultured with Matrigel. However, collagen-cultured HLCs exhibited lower CYP3A4 activity and glycogen storage than Matrigel-cultured HLCs. The functional differences in HLCs between collagen and Matrigel cultures resemble hepatic zonation in the liver lobules.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Biophysics
Hamed Hatami-Marbini, Milad Rohanifar
Summary: This study investigates the influence of axial prestress on the nonlinear mechanical response of random fiber networks, considering different material models and microstructural properties. Important conclusions are made, including the effects of tensile and compressive prestress strains on the initial network shear stiffness, as well as the influence of geometric disorder and randomness in fiber stiffness on the mechanical response.
BIOPHYSICAL JOURNAL
(2021)
Article
Multidisciplinary Sciences
Neel Nissen, Stephanie Kehlet, Mogens K. Boisen, Maria Liljefors, Christina Jensen, Astrid Z. Johansen, Julia S. Johansen, Janine T. Erler, Morten Karsdal, Joachim H. Mortensen, Anette Hoye, Nicholas Willumsen
Summary: Collagen biomarkers, particularly PRO-C3 and PRO-C6, were significantly associated with shorter overall survival (OS) in patients with metastatic colorectal cancer (mCRC). High baseline levels of these biomarkers were predictive of poor treatment response. Combining all collagen biomarkers improved prognostic capacity, supporting the importance of collagen and cancer-associated fibroblast (CAF) biology in colorectal cancer (CRC).
SCIENTIFIC REPORTS
(2021)
Review
Oncology
Ashley M. Fuller, Tzipora S. Karin Eisinger-Mathason
Summary: This review discusses the diversity of collagen molecules in tumor tissue and the relationship between collagen heterogeneity and the inconsistent efficacy of collagen-targeting therapies.
Article
Engineering, Biomedical
Menekse Ermis, Natashya Falcone, Natan Roberto De Barros, Marvin Mecwan, Reihaneh Haghniaz, Auveen Choroomi, Mahsa Monirizad, Yeji Lee, Jihyeon Song, Hyun-Jong Cho, Yangzhi Zhu, Heemin Kang, Mehmet R. Dokmeci, Ali Khademhosseini, Junmin Lee, Han -Jun Kim
Summary: The tumor microenvironment, particularly the matrix component, plays a crucial role in the progression and therapeutic responsiveness of PDAC. By engineering hyaluronic acid and gelatin-based hydrogels to mimic desmoplastic matrices, a multicellular pancreatic tumor model is developed that allows for a better understanding and monitoring of PDAC progression, with potential applications in personalized medicine and drug testing.
BIOACTIVE MATERIALS
(2023)
Review
Oncology
Hans Raskov, Shruti Gaggar, Asma Tajik, Adile Orhan, Ismail Gogenur
Summary: During the development of solid cancers, the extracellular matrix (ECM) undergoes significant changes, which play a critical role in promoting cancer cell growth and spread. Investigating the biochemical and biophysical characteristics of ECM during carcinogenesis is crucial for understanding the disease and incorporating ECM profiling into personalized treatment approaches. This review highlights the latest findings in ECM research and potential therapeutic targets.
Article
Engineering, Biomedical
Claire Robertson, Aimy Sebastian, Aubree Hinckley, Naiomy D. Rios-Arce, William F. Hynes, Skye A. Edwards, Wei He, Nicholas R. Hum, Elizabeth K. Wheeler, Gabriela G. Loots, Matthew A. Coleman, Monica L. Moya
Summary: Breast cancers have limited immune activation and expression of immunotherapy markers. The extracellular matrix may contribute to this limitation. Collagen 4 suppresses T cell function, while fibronectin activates T cells.
Article
Engineering, Biomedical
Chunxi Ge, Yiming Li, Fashuai Wu, Peter Ma, Renny T. Franceschi
Summary: Skeletal progenitor cells rely on collagen-binding integrins and discoidin domain receptors (DDR1 and DDR2) as collagen receptors for bone development and regeneration. This study evaluated specific triple helical peptides containing GFOGER and GVMGFO binding domains to stimulate DDR2 and integrin signaling, as well as osteoblast differentiation. The combination of these peptides cooperatively enhanced both DDR2 and focal adhesion kinase (FAK) signaling, leading to increased osteoblast differentiation. This finding suggests that scaffolds containing DDR and integrin-activating peptides could be a new approach for promoting bone regeneration.
ACTA BIOMATERIALIA
(2023)
Article
Biochemistry & Molecular Biology
Ghazi O. Bou Ghanem, Dmitry Koktysh, Robert O. Baratta, Brian J. Del Buono, Eric Schlumpf, Lauren K. Wareham, David J. Calkins
Summary: This study investigates the potential of collagen mimetic peptides (CMPs) in repairing damaged collagen in ocular tissues. The results demonstrate that CMPs can restore the stiffness and structure of collagen in optic nerve head tissues, offering a promising therapeutic avenue for ocular disorders involving collagen remodeling and degradation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Shinichiro F. Ichise, Takaki Koide
Summary: In this study, a collagen-like peptide polymer was developed that can form a gel within 10 minutes. The polymer can be used as a 3D cell scaffold and the formation of the cells' 3D structure can be controlled by introducing collagen-derived bioactive sequences into the peptide sequence.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Electrical & Electronic
Ippei Yagi, Kazuki Koike, Satoshi Uchida
Summary: Fibrosis is a disease characterized by abnormal accumulation of extracellular matrix material, leading to organ failure. This study presents a non-invasive treatment strategy using non-converging ultrasound irradiation to soften fibrotic tissue. The irradiation-induced cavitation caused a decrease in the mechanical strength of fibrotic tissue, possibly due to the fracture of collagen fibers. This method shows potential for treating various fibrotic tissues.
IEEJ TRANSACTIONS ON ELECTRICAL AND ELECTRONIC ENGINEERING
(2023)
Article
Clinical Neurology
Jianhe Zhang, Tengkun Yin, Chenyu Ding, Jianjun Gu, Bin Zhu, Jun Li, Ziqian Chen, Shousen Wang
Summary: The study investigates the relationship between intrasellar pressure and microvascular structure in pituitary adenomas. In the study, it was found that intrasellar pressure showed a double-peak pattern as pituitary adenoma size increased. Certain parameters of the microvascular structure were positively related to intrasellar pressure, indicating an adaptive change in response to ensure sufficient blood supply to the adenoma. Further study is needed to understand the specific mechanism of this phenomenon.
WORLD NEUROSURGERY
(2021)
Article
Chemistry, Multidisciplinary
Jordi Gonzalez-Molina, Katharina Miria Kirchhof, Bhavik Rathod, Lidia Moyano-Galceran, Maria Calvo-Noriega, Georgia Kokaraki, Astrid Bjorkoy, Monika Ehnman, Joseph W. Carlson, Kaisa Lehti
Summary: Fibrillar collagens have been found to promote cell proliferation, migration, and survival in various epithelial cancers, but their impact on soft tissue sarcoma behavior is not well understood. However, this study unexpectedly reveals that fibrillar collagen-related gene expression is associated with a favorable prognosis in rhabdomyosarcoma. By using collagen matrices with different stiffness and in vivo-like microarchitectures, the study demonstrates that DDR1 activation induces apoptosis, while integrin beta 1 promotes cell survival in 3D rhabdomyosarcoma cell cultures. Mechanistically, the collagen-induced apoptosis is a result of both DDR1-independent and synergistic DDR1-dependent TRPV4-mediated response to mechanical confinement. These findings suggest that dense microfibrillar collagen-rich microenvironments are detrimental to rhabdomyosarcoma cells through an apoptotic response orchestrated by DDR1 signaling and mechanical confinement, which may explain the preference of rhabdomyosarcoma cells to grow in and metastasize to low fibrillar collagen microenvironments such as the lung.
Article
Biochemistry & Molecular Biology
Tomotaka Kitamura, Masayasu Misu, Masahide Yoshikawa, Yukiteru Ouji
Summary: This study demonstrates that lung-derived matrix sheets (LMSs) can induce differentiation of embryonic stem (ES) cells into lung cells, as indicated by the upregulation of lung-related cell markers.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Cell Biology
Morio Azuma, Alimuddin Tofrizal, Rita Maliza, Khongorzul Batchuluun, Dini Ramadhani, Rahimi Syaidah, Takehiro Tsukada, Ken Fujiwara, Motoshi Kikuchi, Kotaro Horiguchi, Takashi Yashiro
ACTA HISTOCHEMICA ET CYTOCHEMICA
(2015)
Article
Cell Biology
Dini Ramadhani, Alimuddin Tofrizal, Takehiro Tsukada, Takashi Yashiro
ACTA HISTOCHEMICA ET CYTOCHEMICA
(2015)
Article
Biology
Alimuddin Tofrizal, Ken Fujiwara, Morio Azuma, Motoshi Kikuchi, Depicha Jindatip, Takashi Yashiro, Shozo Yamada
MEDICAL MOLECULAR MORPHOLOGY
(2017)
Article
Cell Biology
Takehiro Tsukada, Ken Fujiwara, Kotaro Horiguchi, Mono Azuma, Dini Ramadhani, Alimuddin Tofrizal, Khongorzul Batchuluun, Rita Maliza, Rahimi Syaidah, Motoshi Kikuchi, Takashi Yashiro
ACTA HISTOCHEMICA ET CYTOCHEMICA
(2014)
Article
Cell Biology
Morio Azuma, Takehiro Tsukada, Takeshi Inagaki, Fujianti Casmad, Depicha Jindatip, Alimuddin Tofrizal, Rita Maliza, Khongorzul Batchuluun, Rahimi Syaidah, Nobuhiko Ohno, Ken Fujiwara, Motoshi Kikuchi, Takashi Yashiro
ACTA HISTOCHEMICA ET CYTOCHEMICA
(2018)
Article
Cell Biology
Ken Fujiwara, Rita Maliza, Alimuddin Tofrizal, Khongorzul Batchuluun, Dini Ramadhani, Takehiro Tsukada, Morio Azuma, Kotaro Horiguchi, Motoshi Kikuchi, Takashi Yashiro
CELL AND TISSUE RESEARCH
(2014)
Article
Cell Biology
Ken Fujiwara, Kotaro Horiguchi, Rita Maliza, Alimuddin Tofrizal, Khongorzul Batchuluun, Dini Ramadhani, Rahimi Syaidah, Takehiro Tsukada, Morio Azuma, Motoshi Kikuchi, Takashi Yashiro
CELL AND TISSUE RESEARCH
(2015)
Article
Agriculture, Dairy & Animal Science
Yofa Sukmawati, Dessy Arisanty, Alimuddin Tofrizal, Arni Amir
JOURNAL OF ADVANCED VETERINARY AND ANIMAL RESEARCH
(2019)
Article
Cell Biology
Ken Fujiwara, Megumi Yatabe, Alimuddin Tofrizal, Depicha Jindatip, Takashi Yashiro, Ryozo Nagai
CELL AND TISSUE RESEARCH
(2017)