Article
Nutrition & Dietetics
Kun Hee Park, Joo-Hyun Hong, Seon-Hee Kim, Jin-Chul Kim, Ki Hyun Kim, Ki-Moon Park
Summary: The fruit of Hippophae rhamnoides has potential therapeutic efficacy for osteoporosis due to its osteogenic differentiation-promoting effect. In vitro and in vivo studies showed that the fruit significantly stimulated the differentiation of mesenchymal stem cells into osteoblasts, increased osteogenic gene expression, and improved bone mineral density in an osteoporosis mouse model.
Article
Biochemistry & Molecular Biology
Yu Han, Chen Yuan, Xiaowei Zhou, Yingjie Han, Yanhao He, Jian Ouyang, Wenna Zhou, Zhenhua Wang, Honglun Wang, Gang Li
Summary: OA, AA, and MA exhibit significant anti-inflammatory effects in vitro, with OA and AA exerting their effects through MAPKs, NF-kappa B, and Nrf2 signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Plant Sciences
Swati Pundir, Prakrati Garg, Ananya Dviwedi, Aaliya Ali, V. K. Kapoor, Deepak Kapoor, Saurabh Kulshrestha, Uma Ranjan Lal, Poonam Negi
Summary: Sea buckthorn is a flowering shrub native to cold temperate regions of Eurasia, primarily found in China. It is widely used in folk medicine for various skin-related issues, with phytochemical studies revealing the presence of a wide variety of bioactive compounds. Pharmacological studies have demonstrated its antibacterial, anti-sebum, antifungal, anti-psoriasis, anti-atopic dermatitis and wound healing activities, making it a valuable ingredient in cosmeceuticals.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Chemistry, Applied
Xingang Lyu, Xiao Wang, Qilei Wang, Xueying Ma, Suolian Chen, Jianbo Xiao
Summary: Encapsulation of sea buckthorn leaf extracts using electrohydrodynamic technology protected polyphenols and flavonoids, enhancing their bioaccessibility in the intestine and preserving their antioxidant activity and inhibition of metabolic syndrome-related enzymes. This innovative method may promote the use of sea buckthorn as a nutritional supplement and expand its commercial applications.
Article
Plant Sciences
Jerzy Zuchowski
Summary: Sea buckthorn, a thorny shrub or small tree, is rich in nutrients and has been extensively studied for its medicinal and cosmetic properties. Over the past decade, significant progress has been made in the research on sea buckthorn, including the discovery of new compounds and in-depth investigation of its pharmacological properties.
PHYTOCHEMISTRY REVIEWS
(2023)
Article
Plant Sciences
Anita Zapalowska, Natalia Matlok, Milosz Zardzewialy, Tomasz Piechowiak, Maciej Balawejder
Summary: The ozone treatment significantly affected the quality of sea buckthorn berries, particularly in terms of volatile compounds and mechanical properties, extending the plant's storage life.
Article
Genetics & Heredity
Xiaomei Luo, Juncheng Liu, Zhoujian He
Summary: Oligo-FISH probes were used to detect the chromosomes of Hippophae rhamnoides taxa and distinguish different taxa. The study provides important data for chromosome identification, classification, and breeding utilization of wild resources of H. rhamnoides.
Article
Biochemistry & Molecular Biology
Changchao Huan, Yao Xu, Wei Zhang, Haochun Pan, Ziyan Zhou, Jingting Yao, Tingting Guo, Bo Ni, Song Gao
Summary: This study found that Hippophae rhamnoides polysaccharides (HRP) can inhibit the infectivity of PRV and reduce infection-induced oxidative stress. Therefore, HRP may be a potential antiviral drug against newly emerging PRV variants.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Green & Sustainable Science & Technology
Mabkhoot Alsaiari, Awais Bokhari, Lai Fatt Chuah, Muhammad Mubashir, Farid A. Harraz, Abdulaziz Ibrahim Almohana, Pau Loke Show, Mukesh Kumar Awasthi, Moustafa A. Rizk
Summary: This research demonstrates the application of hydrodynamic cavitation (HC) technology in the manufacturing of non-edible Hippophae rhamnoides (HiRO) seed oil. It is noted that the HC pilot assembly has not been used in any research pertaining to HiRO triglycerides biodiesel production. Optimizing the system for yield alone can only address one aspect of biodiesel production, and it is necessary to optimize both output and cavitational parameters for maximum efficiency in the transesterification reaction.
Article
Multidisciplinary Sciences
Huiqiong Zou, Peipei Hao, Yingying Cao, Li Li, Ruifeng Ding, Xuefeng Bai, Yongzhi Xue
Summary: This study investigated the effect of Hippophae rhamnoides L. (HRP) on the activity of CYP2D6 in rats with BCG-induced immunological liver injury. The results showed that HRP restored the metabolic function of the liver by reversing the downregulation of CYP2D6 through inhibition of NF-kappa B signal transduction and regulation of the cAMP/PKA/CREB/CYP2D6 pathway. HRP could be considered as an alternative clinical drug for treating hepatitis B and other immune-related liver diseases.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Applied
Chen Shen, Teng Wang, Feng Guo, Kunlai Sun, Bin Wang, Jie Wang, Zefeng Zhang, Xing Zhang, Yuqin Zhao, Yin Chen
Summary: A novel heteropolysaccharide fraction (SP0.1-1) was isolated from Sea buckthorn berries, with a specific composition and structure. Supplementing with SP0.1-1 extended fruit flies' lifespan, enhanced antioxidant enzyme activities, and reduced oxidative damage, showing potential for sea buckthorn polysaccharide products development.
CARBOHYDRATE POLYMERS
(2021)
Article
Plant Sciences
Yajing Gu, Xinxin Wang, Fang Liu, Jin Zhang, Xiufang Zhang, Jiping Liu, Sijia Li, Decheng Wang, Hongquan Guan, Diandong Hou
Summary: The present study investigated the effects of total flavonoids of Hippophae rhamnoides (TFH) on MC903-induced atopic dermatitis (AD)-like lesions in mice. TFH showed anti-inflammatory and immunomodulatory effects by regulating Th1/Th2 balance, inhibiting mast cell infiltration, and promoting the expression of filaggrin (FLG). TFH also reduced the expressions of cytokines and signaling proteins related to inflammation and repaired the skin barrier. These findings suggest that TFH may have potential as an external treatment for AD.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Haoyue Wang, Wei Qi, Yuefeng Guo, Yajie Xu
Summary: Stumping promotes fine root growth and physiological recovery in Hippophae rhamnoides, although the specific effects on fine roots and physiological indices are still unknown. This study comprehensively analyzed the changes in root tips, plant growth, and physiological indices after stumping. Differential indices between stumped and non-stumped forests were identified using partial least squares discriminant analysis.
Article
Chemistry, Organic
Elenilson F. da Silva, Krist Helen Antunes Fernandes, Denise Diedrich, Jessica Gotardi, Marcia Silvana Freire Franco, Carlos Henrique Tomich de Paula da Silva, Ana Paula Duarte de Souza, Simone Cristina Baggio Gnoatto
Summary: Respiratory syncytial virus (RSV) is a common cause of acute respiratory infections in infants, and the current treatment drug ribavirin has limitations due to its side effects. This study designed two new anti-RSV drugs and found that compound 8 may be a potential candidate.
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Veterinary Sciences
Rudolf Dupak, Jana Hrnkova, Nikoleta Simonova, Jan Kovac, Eva Ivanisova, Anna Kalafova, Monika Schneidgenova, Marta Soltesova Prnova, Jan Brindza, Katarina Tokarova, Marcela Capcarova
Summary: Sea buckthorn, known for its antioxidant effects, can effectively suppress hyperglycemia, reduce water intake, and lower sorbitol levels in the lens of the eyes in diabetic rats.
RESEARCH IN VETERINARY SCIENCE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Yuseung Yi, Seong-Joo Heo, Jai-Young Koak, Seong-Kyun Kim
Summary: This retrospective clinical study aimed to evaluate the incidence and consequences of mechanical complications in components of internal conical connection implants and analyze the risk indicators. The results showed that molar implant-supported restorations and male patients had a higher risk of mechanical complications. Gold screws had a lower risk of screw loosening but a higher risk of fracture compared to titanium screws. Narrow-diameter implants had a higher risk of fracture.
JOURNAL OF PROSTHETIC DENTISTRY
(2023)
Article
Engineering, Electrical & Electronic
Oh-Kee Kwon, Chul-Wook Lee, Ki-Soo Kim
Summary: We present an electroabsorption modulator (EAM)-integrated distributed Bragg reflector laser diode (DBR-LD) with high data rate capabilities and wide wavelength tuning. The chip features low threshold current, large tuning range, and high static extinction ratio. Clear eye openings were observed at different data rates, demonstrating excellent modulation performance.
Article
Chemistry, Medicinal
Hye Ryeong Kim, Jonghwan Kim, Jae Sik Yu, Bum Soo Lee, Ki Hyun Kim, Chung Sub Kim
Summary: Dermabacter vaginalis, isolated from vaginal fluid of a Korean female in 2016, yielded a rare imidazolium metabolite, Dermazolium A. The chemical structures of Dermazolium A and five known metabolites were determined by NMR, HRMS, and MS/MS data analysis. Antibacterial tests revealed that Dermazolium A exhibited mild antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) USA300, Lacticaseibacillus paracasei subsp. paracasei KCTC 3510, and Brevibacterium epidermidis KCTC 3090 with MIC values of 41 μg/mL.
ARCHIVES OF PHARMACAL RESEARCH
(2023)
Article
Agriculture, Dairy & Animal Science
Eun Jin Park, Ba Wool Lee, Byeol Ryu, Hyo Moon Cho, Seong Kyun Kim, Seong-Sik Yoo, Eunhee Kim, Won Keun Oh
Summary: This study aimed to discover an anti-influenza herbal mixture and evaluate its antiviral activity against avian influenza. Three different medicinal plants with distinct medicinal purposes were selected and formulated into a combination, which showed potent inhibitory effects on the virus and reduced mortality and virus titers in chickens infected with avian influenza.
Article
Materials Science, Multidisciplinary
Duy Toan Pham, Thanh Lich Nguyen, Thi Truc Linh Nguyen, Thi Truc Phuong Nguyen, Tuan Kiet Ho, Ngoc Yen Nguyen, Van De Tran, Thi Kim Quy Ha
Summary: Limited studies have explored the use of silk fibroin as an oral drug delivery system. This study developed and characterized polyethylenimine-functionalized fibroin nanoparticles (PEI-FNP) loaded with furosemide for oral application. The PEI-FNP demonstrated improved drug solubility and potential for enhancing the oral bioavailability of furosemide.
JOURNAL OF MATERIALS SCIENCE
(2023)
Article
Plant Sciences
Song Lim Ham, Tae Hyun Lee, Kyung Jun Kim, Jung Ha Kim, Su Jung Hwang, Sun Ho Lee, Jae Sik Yu, Ki Hyun Kim, Hyo-Jong Lee, Wonsik Lee, Chung Sub Kim
Summary: Antibiotic resistance is a critical global health issue, requiring the development of new antibiotics. Researchers have isolated a novel antibacterial metabolite, bacillimidazole G, from a probiotic bacterium. This compound showed potent activity against drug-resistant bacteria, including MRSA, and was also able to enhance the effectiveness of a Gram-negative antibiotic. The researchers proposed a biosynthetic pathway for bacillimidazole G based on various experimental approaches.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Plant Sciences
Chen Huo, Sullim Lee, Min Jeong Yoo, Bum Soo Lee, Yoon Seo Jang, Ho Kyong Kim, Seulah Lee, Han Yong Bae, Ki Hyun Kim
Summary: Kaempferia parviflora, also known as Thai ginseng or black ginger, is a tropical medicinal plant traditionally used for treating various ailments. In this study, we isolated six methoxyflavones from the rhizomes of K. parviflora and found that two of them showed significant anti-melanogenic activity.
Article
Engineering, Biomedical
Joo-Eun Lee, Se Yun Jeong, Zijun Li, Hyun-Yi Kim, Hyun-Woo Kim, Min Jeong Yoo, Hee Joo Jang, Do-Kyun Kim, Namki Cho, Hee Min Yoo, Ki Hyun Kim
Summary: This study reports a screening platform to test the antiviral activity of natural products against SARS-CoV-2 and confirms their efficacy using lung organoids. Flavonoids from the natural product library showed strong antiviral activity against SARS-CoV-2 and did not affect cell viability. The screening platform provides a promising system for discovering novel drugs and potential therapeutics for COVID-19.
BIOMATERIALS RESEARCH
(2023)
Article
Chemistry, Medicinal
Nouran M. Fahmy, Mariam I. Gamal El-Din, Maha M. Salem, Sarah H. Rashedy, Gyu Sung Lee, Yoon Seo Jang, Ki Hyun Kim, Chung Sub Kim, Mohamed El-Shazly, Shaimaa Fayez
Summary: A comprehensive untargeted metabolic profiling of three uninvestigated Red-Sea-derived brown algae led to the identification of over 115 metabolites categorized as various lipids. The algae displayed low-to-moderate antioxidant capacity and high cytotoxic activity against cancer cell lines, particularly MCF-7. The cytotoxicity was selective to cancer cells and induced apoptosis, cell cycle arrest, and inhibition of proliferation through the modulation of p53, PI3K, Akt, and mTOR expression.
Article
Nutrition & Dietetics
Dahae Lee, Seulah Lee, Yoon Seo Jang, Rhim Ryoo, Jung Kyu Kim, Ki Sung Kang, Ki Hyun Kim
Summary: This study investigated the cytotoxicity of the mushroom Calvatia nipponica in human breast cancer cells and identified potential anti-tumor compounds. The results suggest that N,N-dimethyl-anthranilic acid may have anti-breast cancer activity and induce apoptosis through extrinsic and intrinsic signaling pathways.
Article
Plant Sciences
Yoon Seo Jang, Da Eun Lee, Dong U. Ju, Se Yun Jeong, Yoon-Joo Ko, Changhyun Pang, Ki Sung Kang, Hui-Jeong Gwon, Hee Min Yoo, Ki Hyun Kim
Summary: This study isolated five secondary metabolites from Jatropha podagrica leaves and found that compound 4 exhibited the most significant antiviral effect. Furthermore, it showed positive effects on the immune system. These findings suggest that these active compounds could be potential therapeutic agents for SARS-CoV-2 and future pandemics.
Article
Plant Sciences
Chen Huo, Quynh Nhu Nguyen, Akida Alishir, Moon-Jin Ra, Sang-Mi Jung, Jeong-Nam Yu, Hui-Jeong Gwon, Ki Sung Kang, Ki Hyun Kim, Adriana Basile
Summary: Compounds isolated from Ginkgo biloba fruit, including syringin, exhibit estrogen-like effects and have the potential to regulate estrogenic activity during menopause.
Article
Chemistry, Multidisciplinary
Elena Seibel, Soohyun Um, Marie Dayras, Kasun H. Bodawatta, Martinus de Kruijff, Knud A. Jonsson, Michael Poulsen, Ki Hyun Kim, Christine Beemelmanns
Summary: In this study, a targeted beta-amino acid-specific homology-based multi-query search was utilized to identify potential microbial producers of beta-amino acid-containing macrolactams. The variation of biosynthetic gene clusters was explored, ciromicin A was heterologously produced, and new macrotermycin derivatives were identified.
COMMUNICATIONS CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Arjun Prasad Timilsina, Bimal Kumar Raut, Chen Huo, Karan Khadayat, Prakriti Budhathoki, Mandira Ghimire, Rabin Budhathoki, Niraj Aryal, Ki Hyun Kim, Niranjan Parajuli
Summary: Metabolomics and molecular networking approaches have been rapidly advancing in the field of biological sciences, allowing for the systematic identification and characterization of bioactive metabolites in natural products. This study focused on evaluating the potential of four medicinal plants in inhibiting enzymatic activity and annotating secondary metabolites.
Article
Chemistry, Organic
Bum Soo Lee, Su Myung Jung, Rhim Ryoo, Sang Un Choi, Seongpil An, Ki Hyun Kim
Summary: In this study, a new dipeptide compound and three known components were isolated from the poisonous mushroom P. cornu-damae. The dipeptide compound exhibited potential anticancer activity, which is the first of its kind found in P. cornu-damae. These findings provide experimental evidence for the potential of the poisonous mushroom as a source of anticancer agents.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
