Review
Chemistry, Medicinal
Surapriya Surendranath Prabhu, Aathira Sujathan Nair, Saiprabha Vijayakumar Nirmala
Summary: Mitochondria play a crucial role in energy generation and various cellular functions. Understanding the dysfunction of mitochondria is crucial for therapeutic reasons in cancer and other diseases.
ARCHIVES OF PHARMACAL RESEARCH
(2023)
Article
Cell Biology
Thomas Sell, Christian Klotz, Matthias M. Fischer, Rosario Astaburuaga-Garcia, Susanne Krug, Jarno Drost, Hans Clevers, Christine Sers, Markus Morkel, Nils Bluethgen
Summary: Colorectal cancer progression is closely related to deregulation of intestinal differentiation trajectory. The sequential mutations of APC, KRAS, TP53, and SMAD4 enable oncogenic signaling and establish cancer hallmarks. Mass cytometry of isogenic human colon and patient-derived cancer organoids reveals a differentiation axis from normal to cancer states, shaped by the driver mutations. Cells along this axis can be influenced by subsequent mutations to promote or restrict stem cell properties. Nodes of the cancer cell signaling network remain coupled to the differentiation state. Single-cell RNA sequencing links protein signaling network to transcriptomic states with biological and clinical importance.
JOURNAL OF CELL BIOLOGY
(2023)
Review
Oncology
Jahangir Alam, Md Nazmul Huda, Alan J. Tackett, Sayem Miah
Summary: Signaling pathways play critical roles in executing and controlling important biological processes within cells. Dysregulation of signaling pathways can modulate chromatin modifications, thereby contributing to tumorigenesis and metastasis. Understanding the role of these pathways in disease pathogenesis is crucial for developing targeted therapies.
CANCER AND METASTASIS REVIEWS
(2023)
Review
Biochemistry & Molecular Biology
Mohammad Burhan Uddin, Zhishan Wang, Chengfeng Yang
Summary: m(6)A RNA methylation is a prevalent internal modification in mammalian mRNAs, dysregulation of which is frequently observed in pathological conditions, particularly in cancer. Recent studies have shown that oncogenic signaling pathways in cancer are modulated by m(6)A modifications in target mRNAs and noncoding RNA transcripts.
Article
Biochemistry & Molecular Biology
Yize Li, Eduard Porta-Pardo, Collin Tokheim, Matthew H. Bailey, Tomer M. Yaron, Vasileios Stathias, Yifat Geffen, Kathleen J. Imbach, Song Cao, Shankara Anand, Yo Akiyama, Wenke Liu, Matthew A. Wyczalkowski, Yizhe Song, Erik P. Storrs, Michael C. Wendl, Wubing Zhang, Mustafa Sibai, Victoria Ruiz-Serra, Wen-Wei Liang, Nadezhda Terekhanova, Fernanda Martins Rodrigues, Karl R. Clauser, David I. Heiman, Qing Zhang, Francois Aguet, Anna P. Calinawan, Saravana M. Dhanasekaran, Chet Birger, Shankha Satpathy, Daniel Cui Zhou, Liang-Bo Wang, Jessika Baral, Jared L. Johnson, Emily M. Huntsman, Pietro Pugliese, Antonio Colaprico, Antonio Iavarone, Milan G. Chheda, Christopher J. Ricketts, David Fenyo, Samuel H. Payne, Henry Rodriguez, Ana I. Robles, Michael A. Gillette, Chandan Kumar-Sinha, Alexander J. Lazar, Lewis C. Cantley, Gad Getz, Li Ding
Summary: This study reveals the functional states of cancer drivers and their relationship with cancer development through comprehensive proteogenomic analysis. The study found that mutations and copy-number alterations can affect the rewiring of protein interaction networks, most cancer genes tend to converge towards similar molecular states, and the predicted neoantigen burden is correlated with T cell infiltration, indicating the potential application value of immunotherapy.
Review
Biochemistry & Molecular Biology
Tsutomu Shimura
Summary: Under physiological and stress conditions, mitochondria function as a signaling platform for biological events, transmitting information from the mitochondria to the rest of the cell. Mitochondrial molecules such as ATP, reactive oxygen species, cytochrome C, and damage-associated molecular patterns act as messengers in metabolism, stress response, apoptosis, senescence, and inflammation. This review paper summarizes the mitochondrial signaling in response to DNA damage, as well as the regulation of mitochondrial quality control and the role of mitochondrial dysfunction in radiation-induced carcinogenesis. The analysis of the mitochondrial radiation effect is crucial in assessing radiation risks to human health.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Xiaodan Wang, Jiatong Sun, Tong Xu, Yutian Lei, Meichen Gao, Hongjin Lin
Summary: This study found that Imidacloprid increases reactive oxygen species levels, reduces antioxidant enzymes activity, and activates the MAPK signaling pathway, leading to mitochondrial apoptosis, necroptosis, and immune dysfunction. However, Resveratrol can antagonize the toxic effects of Imidacloprid, reduce oxidative stress levels, inhibit the MAPK signaling pathway, and protect cells from damage.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Wenjia Wang, Desheng Wu, Jinxue Ding, Jinli Wang, Jinwu Meng, Ke Ming, Siya Li, Tianxin Qin, Jiaguo Liu, Danchen Aaron Yang
Summary: The modified rougan decoction (MRGD) compound formula has been shown to have the ability to alleviate liver oxidant injury induced by lipopolysaccharide-enrofloxacin (LPS-ENR) in chickens. Recent research has focused on the impact of mitochondrial dysfunction on various diseases. The study investigated the effects of MRGD on mitochondrial structure and function using LPS-ENR-induced injury models in vivo and in vitro, and further explored its molecular mechanism.
Article
Clinical Neurology
Sanjiban Chakrabarty, Periyasamy Govindaraj, Bindu Parayil Sankaran, Madhu Nagappa, Shama Prasada Kabekkodu, Pradyumna Jayaram, Sandeep Mallya, Sekar Deepha, J. N. Jessiena Ponmalar, Hanumanthapura R. Arivinda, Angamuthu Kanikannan Meena, Rajan Kumar Jha, Sanjib Sinha, Narayanappa Gayathri, Arun B. Taly, Kumarasamy Thangaraj, Kapaettu Satyamoorthy
Summary: The study conducted comprehensive clinical, pathological, biochemical, and genetic analysis on 11 patients with MELAS syndrome, revealing the classical pathogenic mutation m.3243A > G and mutations in nuclear genes associated with MELAS clinical manifestations.
JOURNAL OF NEUROLOGY
(2021)
Article
Oncology
Lisa Hunihan, Dejian Zhao, Heather Lazowski, Man Li, Yuping Qian, Laura Abriola, Yulia V. Surovtseva, Viswanathan Muthusamy, Lynn T. Tanoue, Bonnie E. Gould Rothberg, Kurt A. Schalper, Roy S. Herbst, Frederick H. Wilson
Summary: In this study, genomic characterization of lung adenocarcinoma (LUAD) identified known oncogenic drivers in 98% of tumors from patients with minimal smoking history, and a novel gene rearrangement was discovered in one tumor. The study demonstrated that these gene fusions increased cellular levels of active GTP-RAS, induced cellular transformation, and promoted tumor formation, suggesting RAF-MEK-ERK inhibition as a potential treatment strategy for tumors harboring these alterations.
CLINICAL CANCER RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Wei Yang, Yu Wang, Yiming Hao, Ziyuan Wang, Jie Liu, Jing Wang
Summary: This study demonstrates the cytoprotective effects of piceatannol in attenuating oxidative damage and neurocyte apoptosis, as well as improving mitochondrial function. Piceatannol enhances neuronal protection through the SIRT3/FOXO3a signaling pathway.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Review
Cell Biology
Anabela Ferreira, Flavia Pereira, Celso Reis, Maria Jose Oliveira, Maria Joao Sousa, Ana Preto
Summary: KRAS mutations play a crucial role in promoting cancer cell proliferation, inducing autophagy, and suppressing apoptosis, leading to drug resistance and poor prognosis.
Article
Oncology
Janine M. DeBlasi, Aimee Falzone, Samantha Caldwell, Nicolas Prieto-Farigua, Justin R. Prigge, Edward E. Schmidt, Iok In Christine Chio, Florian A. Karreth, Gina M. DeNicola
Summary: Mutations in the KEAP1-NRF2 pathway are common in NSCLC and contribute to therapy resistance and poor outcomes. The impact of KEAP1 and NRF2 mutations on lung tumor initiation and progression was comprehensively investigated using mouse models. The study revealed the context-dependence and activity threshold for NRF2 in the lung tumorigenic process.
Article
Biochemical Research Methods
Carlos A. Garcia-Prieto, Francisco Martinez-Jimenez, Alfonso Valencia, Eduard Porta-Pardo
Summary: This study highlights the significant impact of variant calling decisions on key analyses of cancer genomic data, such as the identification of cancer driver genes, quantification of mutational signatures, and detection of clinically actionable variants. The choice of somatic variant caller or strategy to combine them can lead to important differences in results, potentially impacting treatment decisions for patients. The widely used Consensus of three calling strategy may result in the loss of important cancer driver genes and actionable mutations, emphasizing the importance of careful consideration in variant calling for critical analyses of tumor sequencing data.
Article
Plant Sciences
Lara Duerr, Tanja Hell, Maciej Dobrzynski, Alberto Mattei, Anika John, Nathanja Augsburger, Gloria Bradanini, Jakob K. Reinhardt, Florian Rossberg, Milos Drobnjakovic, Mahabir P. Gupta, Matthias Hamburger, Olivier Pertz, Eliane Garo
Summary: This study identified natural products that can inhibit oncogenic signaling in melanoma through a combination of techniques.
JOURNAL OF NATURAL PRODUCTS
(2022)