Article
Biochemistry & Molecular Biology
Li-Hua Su, Wen-Jing Ma, Yun-Bao Ma, Tian-Ze Li, Chang-An Geng, Wei Dong, Xiao-Feng He, Ji-Jun Chen
Summary: Bioassay-guided investigation of Artemisia princeps led to the discovery of 13 novel sesquiterpenoid dimers (artemiprinolides A-M) and 11 known ones. Their structures were determined through spectroscopic analysis and their absolute configurations were confirmed by X-ray diffraction and ECD calculations. The isolated dimers exhibited cytotoxicity against several hepatoma cell lines, with compounds 1 and 16 showing the most potent activity. Compound 1 was further found to inhibit cell migration, induce cell cycle arrest, and promote apoptosis.
Article
Chemistry, Multidisciplinary
Wei Dong, Wen-Jing Ma, Yun-Bao Ma, Feng-Jiao Li, Tian-Ze Li, Yong-Cui Wang, Xiao-Feng He, Chang-An Geng, Xue-Mei Zhang, Ji-Jun Chen
Summary: Seventeen new guaiane-type sesquiterpenoid dimers (GSDs) were isolated from Artemisia zhongdianensis. Among them, artemzhongdianolide B9 (9) exhibited the strongest inhibitory effect on hepatoma cells and could suppress HepG2 cells by affecting the p38MAPK signaling pathway.
CHINESE JOURNAL OF CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Lihua Su, Xintian Zhang, Yunbao Ma, Changan Geng, Xiaoyan Huang, Jing Hu, Tianze Li, Shuang Tang, Cheng Shen, Zhen Gao, Xuemei Zhang, Ji-Jun Chen
Summary: In this study, 18 new guaianolide dimers were isolated from the EtOAc fraction of Artemisia atrovirens, with 19 compounds demonstrating cytotoxicity against human hepatoma cell lines. Compound 12 showed the most promising activity against three hepatoma cell lines, suggesting potential therapeutic value.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Chemistry, Multidisciplinary
Li-Hua Su, Wen-Jing Ma, Yun-Bao Ma, Tian-Ze Li, Chang-An Geng, Wei Dong, Xiao-Feng He, Xue-Mei Zhang, Ji-Jun Chen
Summary: In this study, six new compounds were isolated from Artemisia princeps and identified using comprehensive spectral data and calculation. Compounds 1-3 represented a novel type of germacrane-guaiane hetero-dimeric adducts, while compounds 4-6 were eudesmane-guaiane hetero-coupled sesquiterpenoid dimers. These compounds were found to have cytotoxic effects on hepatoma cell lines, with compound 1 showing significant cytotoxicity and inducing apoptosis in HepG2 cells.
CHINESE JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Zhengguang Shao, Lizhi Li, Yongzhe Zheng, Qi Gong, Chang-Qiang Ke, Sheng Yao, Haiyan Zhang, Chunping Tang, Yang Ye
Summary: Eight new sesquiterpenoid dimers were isolated from Artemisia atrovirens, and their structures and absolute configurations were determined through spectroscopic analysis and TDDFT ECD calculation. Compound 8 exhibited anti-inflammatory effect at low concentration.
Article
Biochemistry & Molecular Biology
Wei Dong, Tian-Ze Li, Xiao-Yan Huang, Xiao-Feng He, Chang-An Geng, Xue-Mei Zhang, Ji-Jun Chen
Summary: The ethanol extract of Artemisia zhongdianensis and its acetic acid ethyl ester fraction showed cytotoxicity against hepatic stellate cell line LX2. 21 new guaianolide dimers were isolated from the active fractions, and these compounds exhibited significant cytotoxicity against HSC-LX2 and inhibited the deposition of collagen, hyaluronic acid, and laminin.
BIOORGANIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Xiao-Feng He, Qi-Hao Li, Tian-Ze Li, Yun-Bao Ma, Wei Dong, Ke-Xin Yang, Chang-An Geng, Hao-Wei Zhang, Yuan Wang, Ji-Jun Chen
Summary: Four novel cadinane sesquiterpenoid dimers, Artemeriopolides A-D (1-4), were isolated from Artemisia eriopoda, which contain rare 2-oxaspiro[4.6]undecan-1,7-dione, 2-oxaspiro[4.5]decan-1-one, and 2-oxaspiro[5.5]undecan-1-one ring systems. The structures and absolute configurations were determined by spectral data, ECD calculations, and X-ray crystallography analyses. Compound 1 showed the highest antihepatoma cytotoxicity against HepG2, Huh7, and SK-Hep-1 cells with IC50 values of 33.6, 59.9, and 56.9 muM, respectively. Furthermore, artemeriopolide A (1) inhibited cell migration and invasion, induced G0/G1 cell cycle arrest, and promoted cell apoptosis.
ORGANIC CHEMISTRY FRONTIERS
(2023)
Article
Chemistry, Organic
Chong Shang, Xiao-Yan Huang, Yuan Wang, Wei Dong, Xiao-Feng He, Tian-Ze Li, Ji-Jun Chen
Summary: Artemongolides A-E and F, a unique class of diseco-guaianolides, were isolated from the whole plant of Artemisia mongolica. Their structures were determined through spectroscopic analyses and the absolute configurations of compounds A and F were confirmed by X-ray crystallography. Compound A showed cytotoxic activity against HSC-LX2 cells and inhibited the deposition of human collagen type I, hyaluronic acid, and laminin.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Ziwei Zhu, Ablajan Turak, Haji Akber Aisa
Summary: This study isolated several sesquiterpene lactones from Artemisia mongolica, a type of plant. The structures of these compounds were identified through various analytical techniques, including NMR and X-ray crystallography. Some of the compounds also exhibited anti-inflammatory and antitumor activities.
Article
Chemistry, Multidisciplinary
Li-Hua Su, Tian-Ze Li, Yun-Bao Ma, Chang-An Geng, Xiao-Yan Huang, Xin Zhang, Zhen Gao, Ji-Jun Chen
Summary: Inspired by sesquiterpenoid dimers, 12 new compounds were isolated from Artemisia atrovirens, with compounds 4, 6, 7, and 10 showing moderate cytotoxicity against HepG2, SMMC-7721, and Huh7 cell lines, while compounds 5 and 11 exhibited antihepatoma activity equivalent to sorafenib.
CHINESE JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Applied
Gui-Min Xue, Jin-Feng Xue, Chen-Guang Zhao, Zhen-Zhu Zhao, Yan-Jun Sun, Kun Du, Han-Wei Li, Wei-Sheng Feng
Summary: Investigation into the chemical diversity of Artemisia argyi resulted in the discovery of two new and four known sesquiterpenoids. The structures of the new compounds were determined through extensive spectroscopic data and their absolute configurations were elucidated. All compounds showed inhibitory activity against NO production, with IC50 values ranging from 1.91 to 36.52 μM.
NATURAL PRODUCT RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Jixin Li, Zhirong Cui, Yongyi Li, Chunhua Han, Yanqiu Zhang, Pengfei Tang, Letian Cui, Hao Zhang, Jun Luo, Lingyi Kong
Summary: Guided by the MS/MS molecular networks strategy, chlospicenes A and B, the first example of cyclopropane moiety cracked lindenane sesquiterpene Michael addition dimers, along with their biogenetic analogues, were targetedly discovered from the roots of Chloranthus henryi. The structures and absolute configurations of these compounds were characterized by NMR, ECD, and X-ray diffraction analysis. The plausible biogenic pathway speculation suggested that cyclopropylcarbinyl rearrangement may play a dominant role in the key crack of the cyclopropane moiety. Additionally, compounds 1 and 2 exhibited significant anti-nonalcoholic steatohepatitis (NASH) activity in FFA-induced HepG2 cells by reducing intracellular lipid accumulation.
CHINESE CHEMICAL LETTERS
(2022)
Article
Biochemistry & Molecular Biology
Ablajan Turak, Haji Akber Aisa
Summary: Eleven undescribed oxygen heterocyclic Diels-Alder-Type sesquiterpenoid dimers were isolated from the seeds of Vernonia anthelmintica. The structures of them were determined by NMR experiments and HRESIMS. Vernodalidimer K and Q exhibited significant cytotoxic activity against HCT-15 cell line.
Article
Plant Sciences
Ziwei Zhu, Ablajan Turak, Deng Zang, Haji Akber Aisa
Summary: A phytochemical investigation of Artemisia mongolica resulted in the discovery of two new crotonic acid esters, 7E-Hexene-5-ly-[6'-O-(2E-butyryl alkenyl)]-O-fl-D-Glucopyranoside (1) and 7-methyl-pentane-5-ly-[6'-O-(2E-butyryl alkenyl)]-O-fl-D-Glucopyranoside (2), along with nine known compounds. Compound 1 showed significant improvement in relative tyrosinase activity and relative melanin content. These compounds were first reported from A. mongolica.
PHYTOCHEMISTRY LETTERS
(2023)
Article
Chemistry, Medicinal
Xing Wang, Chunping Tang, Suoriya Meng, Bixi Tang, Yi Zang, Chang-Qiang Ke, Sheng Yao, Jia Li, Yang Ye
Summary: Ten undescribed noreudesmane-type sesquiterpenoids, including eight 12,13-dinoreudesmanes and a pair of 11,12,13-trinoreudesmane epimers, were isolated from Artemisia hedinii. Their structures were determined through extensive spectroscopic analysis, and their anti-inflammatory activities were evaluated in murine macrophages RAW264.7 cells, showing significant inhibition of LPS-induced CCL2 mRNA expression in a dose-dependent manner.
