Article
Pharmacology & Pharmacy
Pei Ma, Rong Zhang, Lijia Xu, Haibo Liu, Peigen Xiao
Summary: This study utilized network pharmacology to investigate the potential molecular mechanism and new therapeutic opportunities of Coreopsis tinctoria. The results showed that it may have neuroprotective effects by targeting multiple key factors related to apoptosis, particularly through the BCL-2 and AKT signaling pathways. This study provides a theoretical basis for further research on the neuroprotective effects of Coreopsis tinctoria.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Qiu-Xu Chen, Ling Zhou, Tao Long, Da-Lian Qin, Yi-Ling Wang, Yun Ye, Xiao-Gang Zhou, Jian-Ming Wu, An-Guo Wu
Summary: The study shows that galangin has the potential to treat Parkinson's disease by inhibiting neuronal degeneration through activation of the Nrf2/Keap1 signaling pathway and alleviating oxidative damage.
Article
Neurosciences
Hongyan Pei, Heping Shen, Jinhao Bi, Zhongmei He, Liping Zhai
Summary: This study investigates the effects and target of gastrodin (GAS) for treating depression using network pharmacology combined with experimentation. The results show that GAS improves depression-like behaviors and nerve cell injury in CUMS mice by inhibiting Caspase-3-mediated apoptosis. This is achieved through the binding of GAS to Caspase-3 at SER25, inhibiting its maturation and activation.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Multidisciplinary Sciences
Mengyuan Zhang, Haoran Zheng, Jiale He, Mei Zhang
Summary: This study investigates the mechanisms of action of paeoniflorin in Alzheimer's disease (AD) through network pharmacology and experimental validation. It is found that paeoniflorin alleviates cognitive impairment in AD by regulating oxidative stress and neuroinflammation.
Article
Chemistry, Multidisciplinary
Sabine Willems, Julian A. Marschner, Whitney Kilu, Giuseppe Faudone, Romy Busch, Silke Duensing-Kropp, Jan Heering, Daniel Merk
Summary: The ligand-sensing transcription factor Nurr1 emerges as a promising therapeutic target for neurodegenerative pathologies. Statins can modulate the activity of Nurr1, demonstrating clinically relevant neuroprotective effects.
Article
Immunology
Yubiao Zhang, Wenyi Jin, Junwen Chen, Sixing Wei, WenXiang Cai, YuJian Zhong, Yan Zhou, Hao Peng
Summary: This study demonstrates that GAS mitigates aging and mitochondrial damage in chondrocytes of osteoarthritis (OA) by regulating the phosphorylation of the PI3K-AKT pathway via SIRT3. GAS reduced senescence and improved mitochondrial functions in OA chondrocytes. Furthermore, GAS ameliorated pathological changes related to aging, increased SIRT3 expression, and protected the extracellular matrix in an OA rat model.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Qianmei Hu, Jixiang Wang, Maida Irshad, Siyu Mao, Hongting Chen, Yujiao Song, Xuan Xu, Xing Feng
Summary: Mitochondria play a central role in the pathogenesis of Alzheimer's disease, and this study provides evidence for the neuroprotective effects of a compound called biatractylolide (BD) in this disease. Based on a pharmacological model and in vitro experiments, it was demonstrated that BD can inhibit oxidative stress and protect against cell death induced by A beta in neuronal cells. This study offers a theoretical basis for the development of BD as a potential anti-Alzheimer's drug.
Article
Neurosciences
Wenxiu Xu, Beida Ren, Zehan Zhang, Congai Chen, Tian Xu, Shuling Liu, Chongyang Ma, Xueqian Wang, Qingguo Wang, Fafeng Cheng
Summary: There is still no effective drug for Alzheimer's disease, but QZZD, derived from a Chinese patent drug, may have protective effects in treating the disease. A study combining network pharmacology analysis and experimental validation showed that QZZD has anti-inflammatory effects and neuroprotective effects through modulating the TNFR1-ERK1/2-NF-kappa Bp65 signaling pathway.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Plant Sciences
Yuanyuan Liang, Lin Wang
Summary: AD is a progressive and complex neurodegenerative disease characterized by dementia. Current treatment strategies for AD are not meeting clinical expectations and more treatment options need to be explored. This review investigates the potential mechanisms of C. tinctorius L. and its active constituents in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Food Science & Technology
Yaping Zhou, Qi Wu, Wen Yu, Fan Ye, Yunyun Cao, Otobong D. Akan, Xiuxiu Wu, Tiantian Xie, Han Lu, Fuliang Cao, Feijun Luo, Qinlu Lin
Summary: This study explores the anti-fatigue mechanism of Gastrodia elata Bl. using an exercise-induced fatigue model and network pharmacology. It was found that Gastrodin had significant anti-fatigue effects, improved biochemical indexes, and influenced various pathways. Oxidation and inflammatory factors played a crucial role in the anti-fatigue mechanism, and Gastrodin promoted Nrf2 pathway activation while inhibiting the expression of inflammatory factors. This study provides important insights for the development of Gastrodin-functional foods or anti-fatigue drugs.
Review
Biochemistry & Molecular Biology
Katarzyna Socala, Aleksandra Szopa, Anna Serefko, Ewa Poleszak, Piotr Wlaz
Summary: Coffee contains various bioactive components that are beneficial for human health, such as caffeine, polyphenols, and alkaloids. Research suggests that regular coffee consumption can reduce the risk of cardiovascular diseases, type 2 diabetes, obesity, and certain types of cancer, while also potentially lowering the risk of neurodegenerative conditions like Alzheimer's and Parkinson's diseases. Further studies are needed to fully understand the mechanisms behind these effects and the therapeutic applications of coffee bioactive components.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, Research & Experimental
Jianguo Lin, Qingqing Wang, Simin Zhou, Siyu Xu, Kuiwu Yao
Summary: Ligusticum chuanxiong Hort, also known as Chuanxiong in China, is a widely used medicinal herb with a long history. One of its active components, Tetramethylpyrazine (TMP), has shown to possess various pharmacological properties and has been used in the treatment of cardiovascular, nervous, and digestive system conditions, as well as cancer. TMP exerts its effects through multiple physiological functions and bidirectional regulation of multiple targets and signal pathways.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Pharmacology & Pharmacy
Xiaoya Li, Changxin Sun, Jingyi Zhang, Lanqing Hu, Zongliang Yu, Xiaonan Zhang, Zeping Wang, Jiye Chen, Min Wu, Longtao Liu
Summary: This review evaluates the pharmacological effects and potential mechanisms of paeoniflorin in the treatment of cardiovascular diseases, aiming to advance its further development and application. Paeoniflorin can protect the cardiovascular system by regulating glucose and lipid metabolism, exerting anti-inflammatory, anti-oxidative stress, and anti-arteriosclerotic activities, improving cardiac function, and inhibiting cardiac remodeling. However, further studies on its bioavailability, toxicology, safety, and clinical efficacy are needed.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Youdan Liang, Xiaolin Dai, Yi Cao, Xian Wang, Jing Lu, Long Xie, Kai Liu, Xiaofang Li
Summary: The global epidemic of diabetes has led to increased pressure on public health, necessitating the development of new effective anti-diabetes strategies. Trigonelline, the main component of fenugreek, has been proven to have therapeutic effects on diabetes and its complications. The mechanisms by which trigonelline ameliorates diabetes include modulation of insulin secretion, reduction of oxidative stress, and improvement of glucose tolerance and insulin resistance. Additionally, trigonelline has been reported to possess neuroprotective properties against neurologic diseases such as Alzheimer's disease, Parkinson's disease, stroke, and depression. Comprehensive clinical trials are needed to evaluate the potential therapeutic effects of trigonelline.
Article
Chemistry, Medicinal
Ye Chang, Li-Li Lou, Xin Zhang, Jiao-Yang Hou, Guo-Dong Yao, Xiao-Xiao Huang, Shao-Jiang Song, Bin Lin, Ming Bai
Summary: Four new terpenoids and eleven known compounds were isolated from Solanum lyratum. Some of these compounds demonstrated neuroprotective effects. Enrichment analysis using Gene Ontology and Kyoto Encyclopedia of Genes and Genomes revealed the potential targets and signaling pathways of these active compounds in intervening Alzheimer's disease.
