Editorial Material
Nutrition & Dietetics
Nikolay Mironov, Mainul Haque, Azeddine Atfi, Mohammed S. Razzaque
Summary: Phosphorus is an abundant mineral in the human body, playing a crucial role in glucose metabolism and bone health. High phosphate burden has been linked to increased risk of metabolic syndrome and cardiometabolic disorders, highlighting the importance of further research on phosphate toxicity.
Review
Cell Biology
Hong Yang, Lingling Chen, Qian Sun, Fangyao Yao, Saeed Muhammad, Chao Sun
Summary: This paper summarizes the role of HDAC11 in regulating the progression of obesity-related metabolic disorders, emphasizing its crucial role in the occurrence and development of metabolic diseases.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Xuan Sun, Junfeng Duan, Chenyi Gong, Yuting Feng, Jiaxin Hu, Rong Gu, Biao Xu
Summary: This study suggests that colchicine may have therapeutic potential for dilated cardiomyopathy and other nonischemic heart failure associated with the inflammatory response.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Genetics & Heredity
Aecio A. Braga, Raul H. Bortolin, Magda E. Graciano-Saldarriaga, Thiago D. C. Hirata, Alvaro Cerda, Renata C. C. de Freitas, Hui T. Lin-Wang, Jessica B. Borges, Joao I. D. Franca, Laureane N. Masi, Rui Curi, Tania C. Pithon-Curi, Marcelo F. Sampaio, Lara R. Castro, Gisele M. Bastos, Rosario D. C. Hirata, Mario H. Hirata
Summary: This study aimed to explore the association of circulating miRNAs with obesity, metabolic alterations, and inflammation in patients with MetS. Seven miRNAs were found to be dysregulated in MetS patients, with miR-421 being associated with a high risk of MetS, insulin resistance, and hypertension. Circulating miR-421 may serve as a potential biomarker for insulin resistance, metabolic dysregulation, and inflammatory status in MetS patients.
Article
Microbiology
Celine M. Kisimba, Jack L. Donahue, Krishna Karthik Chivukula, Poorani Subramanian, Shreni D. Mistry, Anna Wolska, Alan T. Remaley, Jack A. Yanovski, Andrew P. Demidowich
Summary: This study found that obesity-induced systemic inflammation plays a substantial role in the development of insulin resistance and type 2 diabetes. Obesity also leads to gut dysbiosis, further contributing to metabolic dysregulation and systemic inflammation. However, it remains unclear how dysregulation of systemic inflammation in obesity affects the gut microbiome.
BIOSCIENCE OF MICROBIOTA FOOD AND HEALTH
(2023)
Article
Agriculture, Multidisciplinary
Shishi Huang, Yuan Zou, Hongbiao Tang, Jingyu Zhuang, Zhiwei Ye, Tao Wei, Junfang Lin, Qianwang Zheng
Summary: This study found that Cordyceps militaris polysaccharides (CMP) can significantly reduce obesity induced by a high-fat diet, improve hyperlipidemia and insulin resistance, and alleviate systemic inflammation. Additionally, CMP can regulate obesity-induced gut dysbiosis by restoring the diversity of gut microbiota and increasing the abundance of short-chain fatty acid-producing bacteria. This study highlights the potential of CMP as a prebiotic agent to protect obese individuals from metabolic disorders and gut dysbiosis.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Medicine, Research & Experimental
Dae Seong Yoon, Su Yeon Cho, Hye Jin Yoon, Sang Ryong Kim, Un Ju Jung
Summary: The study found that PC can reduce white adipose tissue weight, adipocyte size, and plasma leptin levels in mice, along with decreased lipogenic enzyme activity and mRNA expression in adipose tissue. Additionally, PC can lower hepatic lipogenic enzyme activity and gene expression while increasing fatty acid oxidation and gene expression in the liver.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Cardiac & Cardiovascular Systems
Kathleen Pappritz, Jie Lin, Muhammad El-Shafeey, Henry Fechner, Uwe Kuhl, Alessio Alogna, Frank Spillmann, Ahmed Elsanhoury, Rainer Schulz, Carsten Tschope, Sophie Van Linthout
Summary: This study evaluated the potential of colchicine to improve CVB3-induced myocarditis. The results showed that colchicine can alleviate cardiac damage, reduce inflammation, and improve cardiac function. In addition, colchicine can inhibit the NLRP3 inflammasome pathway, reducing cardiac fibrosis and cell apoptosis.
Review
Endocrinology & Metabolism
Dan Wu, Huiying Wang, Lijun Xie, Fang Hu
Summary: The increase in obesity and associated diseases is a major global health problem. The gut microbiota plays a significant role in maintaining energy balance and host immunity. Understanding the relationship between gut microbiota and adipose tissues may provide potential intervention strategies for treating obesity and associated diseases.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Lina Wang, Ping Sun, Yuzhang Wu, Li Wang
Summary: Obesity-induced low-grade chronic inflammation in metabolic tissues is a major factor for various diseases. Tissue-resident macrophages and adaptive CD8(+) T cells play important roles in this process, but further research is needed to understand the mechanisms involved.
Article
Pharmacology & Pharmacy
Jiali Yang, Yunhui Ran, Yonghui Yang, Shuyi Song, Yahong Wu, Yuanming Qi, Yanfeng Gao, Guodong Li
Summary: The study found that 4-HIL can inhibit obesity-related insulin resistance by reducing inflammation and regulating the state of macrophages associated with obesity.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Endocrinology & Metabolism
Sandra C. Naaman, Sherry Shen, Meltem Zeytinoglu, Neil M. Iyengar
Summary: Obesity is associated with an increased risk of postmenopausal, hormone receptor-positive breast cancer. Factors such as altered adipokine balance and chronic inflammation contribute to tumorigenesis.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Fayaz Ahmad Mir, Ehsan Ullah, Raghvendra Mall, Ahmad Iskandarani, Tareq A. Samra, Farhan Cyprian, Aijaz Parray, Meis Alkasem, Ibrahem Abdalhakam, Faisal Farooq, Abdul-Badi Abou-Samra
Summary: This study found differential expression of serum metabolites and pathways between Arabic subjects with obesity and metabolic syndrome compared to subjects with obesity only. Lipids, including sphingomyelin, were significantly decreased in the group with metabolic syndrome. Non-lipid metabolites, such as quinolinate, kynurenine, and tryptophan, were also decreased in the group with metabolic syndrome. Metabolites and pathways associated with chronic inflammation were found to be dysregulated in subjects with metabolic syndrome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Maria Rita Fumagalli, Stella Maria Saro, Matteo Tajana, Stefano Zapperi, Caterina A. M. La Porta
Summary: STELLA is a computational method used to derive the spectrum of metabolites associated with an individual's microbiome. By comparing the results with healthy individuals, individual metabolic alterations can be identified.
Article
Multidisciplinary Sciences
Hyun-Bum Kim, Geun-Jeon Kim, Kyung-do Han, Young-Hoon Joo
Summary: The study found that changes in MetS status were associated with the risk of laryngeal cancer. The group that developed MetS had a higher risk of laryngeal cancer compared to the MetS-free group, with abdominal obesity posing the highest risk among MetS components.
Article
Endocrinology & Metabolism
Andrew P. Demidowich, Jordan A. Levine, Ginikanwa I. Onyekaba, Shahzaib M. Khan, Kong Y. Chen, Sheila M. Brady, Miranda M. Broadney, Jack A. Yanovski
DIABETES OBESITY & METABOLISM
(2019)
Article
Hospitality, Leisure, Sport & Tourism
Keisuke Ejima, Stephanie L. Dickinson, Andrew W. Brown, Jack A. Yanovski, Kathryn A. Kaiser, Kevin D. Hall, Steven B. Heymsfield, David B. Allison
PSYCHOLOGY OF SPORT AND EXERCISE
(2020)
Article
Endocrinology & Metabolism
Andrew P. Demidowich, Jordan A. Levine, Sheila M. Brady, Cheryl D. Johnson, Steven J. Soldin, Jack A. Yanovski
DIABETES OBESITY & METABOLISM
(2020)
Article
Endocrinology & Metabolism
Adrian M. Wong, Tushar P. Patel, Elizabeth K. Altman, Nicol Tugarinov, Giampaolo Trivellin, Jack A. Yanovski
Summary: The Tg(Adipoq-cre)1Evdr mouse has an unknown integration site for the transgene, but it has been found to be located between exons 6 and 7 of Tbx18 on mouse chromosome 9. The study also detected transgene-transgene fusion and used droplet digital polymerase chain reaction to identify the Cre copy number in order to potentially identify homozygous mice.
Article
Endocrinology & Metabolism
Shannon E. Marwitz, Megan Gaines, Sheila M. Brady, Sarah J. Mi, Miranda M. Broadney, Susan Z. Yanovski, Van S. Hubbard, Jack A. Yanovski
ENDOCRINOLOGY AND METABOLISM
(2020)
Article
Neurosciences
Katherine M. Cole, Shau-Ming Wei, Pedro E. Martinez, Tuong-Vi Nguyen, Michael D. Gregory, J. Shane Kippenhan, Philip D. Kohn, Steven J. Soldin, Lynnette K. Nieman, Jack A. Yanovski, Peter J. Schmidt, Karen F. Berman
Summary: This study aims to investigate the impact of increased sex steroid production during puberty on neurodevelopment, and explores the relationships with various endocrine events through longitudinal research, as well as assessing the effects of gonadal development on brain structure and function.
Article
Endocrinology & Metabolism
Ashley H. Shoemaker, Heidi J. Silver, Maciej Buchowski, James C. Slaughter, Jack A. Yanovski, Clinton Elfers, Christian L. Roth, M. Jennifer Abuzzahab
Summary: Treatment with a GLP1RA can decrease food intake but also lead to a disproportionate decrease in total energy expenditure compared to changes in body composition.
INTERNATIONAL JOURNAL OF OBESITY
(2022)
Article
Pediatrics
Crescent B. Martin, Bryan Stierman, Jack A. Yanovski, Craig M. Hales, Neda Sarafrazi, Cynthia L. Ogden
Summary: This study examines the differences in adiposity by race/Hispanic origin among US youth and explores how those differences relate to differences in BMI using the most recent national data, including non-Hispanic Asian youth.
Article
Nutrition & Dietetics
Megan N. Parker, Loie M. Faulkner, Lisa M. Shank, Natasha A. Schvey, Lucy K. Loch, Hannah E. Haynes, Bess F. Bloomer, Nasreen A. Moursi, Syeda Fatima, Jennifer A. Te-Vazquez, Sheila M. Brady, Shanna B. Yang, Sara A. Turner, Marian Tanofsky-Kraff, Jack A. Yanovski
Summary: Pre-meal heart rate variability is positively related to perceived loss-of-control eating during a laboratory meal designed to simulate an episode of loss-of-control eating. However, this association is only significant among participants with recent reported episodes of loss-of-control eating.
Article
Pediatrics
Anna Zenno, Sheila M. Brady, Loie M. Faulkner, Kaitlin L. Ballenger, Syeda Fatima, Jack A. Yanovski
Summary: This study found no significant association between circadian variation in serum leptin concentrations during childhood and long-term changes in adiposity.
Article
Pharmacology & Pharmacy
Julia Lazareva, Sheila M. M. Brady, Jack A. A. Yanovski
Summary: Bardet-Biedl Syndrome (BBS) is a rare ciliopathy with a high incidence of obesity. Setmelanotide, an MC4R agonist, can potentially alleviate obesity and improve comorbid conditions associated with obesity in BBS individuals, although it may have some side effects such as skin darkening.
EXPERT OPINION ON PHARMACOTHERAPY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Olanrewaju A. A. Ogunleye, Harish Raviprakash, Ashlee M. M. Simmons, Rhasaan T. M. Bovell, Pedro E. E. Martinez, Jack A. A. Yanovski, Karen E. F. Berman, Peter J. J. Schmidt, Elizabeth C. C. Jones, Hadi Bagheri, Nadia M. M. Biassou, Li-Yueh Hsu
Summary: In this study, an automated convolutional neural network approach using Dixon-based MRI was proposed to quantify abdominal adipose tissue in children and adolescents. The results showed excellent agreement with the reference measurements and accurate abdominal wall segmentation.
Article
Pediatrics
M. M. Broadney, F. Shareef, S. E. Marwitz, S. M. Brady, S. Z. Yanovski, J. P. DeLany, J. A. Yanovski
Article
Family Studies
Amanda Skoranski, Nichole R. Kelly, Rachel M. Radin, Katherine A. Thompson, Ovidiu Galescu, Andrew P. Demidowich, Sheila M. Brady, Kong Y. Chen, Marian Tanofsky-Kraff, Jack A. Yanovski, Lauren B. Shomaker
JOURNAL OF CHILD AND FAMILY STUDIES
(2018)
Article
Pediatrics
C. S. Suelter, N. Schvey, N. R. Kelly, M. Shanks, K. A. Thompson, R. Mehari, S. Brady, S. Z. Yanovski, C. L. Melby, M. Tanofsky-Kraff, J. A. Yanovski, L. B. Shomaker
Article
Medicine, Research & Experimental
Tong Cheng, Zhusheng Chen, Yibin Qin, Xiang Zhu, Hongsheng Chen, Zhongling Xu, Xiaqing Ma
Summary: Morphine is commonly used and effective for pain relief, but its side effect of itching limits its clinical use. This paper discusses the potential of using esketamine to treat morphine-induced itching.
MEDICAL HYPOTHESES
(2024)
Article
Medicine, Research & Experimental
Sung Eun Lee, Eunjung Park, Ji-yun Kim, HyukHoon Kim
Summary: Hyperbaric oxygen therapy (HBOT) is a potential therapeutic modality that has been recognized for its favorable mechanisms in various diseases, including sepsis-associated encephalopathy (SAE). HBOT has neuroprotective effects through its anti-inflammatory and antiapoptotic effects as well as increased tissue oxygenation capacity. However, there are caveats and limitations in applying HBOT in sepsis.
MEDICAL HYPOTHESES
(2024)