Review
Public, Environmental & Occupational Health
Ting Zhou, Haijing Guan, Luying Wang, Yao Zhang, Mingjun Rui, Aixia Ma
Summary: The EQ-5D-5L is widely used to measure health-related quality of life in patients with different diseases worldwide. The variation in utility values for the same disease is influenced by patient characteristics, living environment, and the EQ-5D-5L value set.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Medicine, Research & Experimental
Sarah Dewilde, Cynthia Z. Qi, Glenn Phillips, Sergio Iannazzo, Mathieu F. Janssen
Summary: For patients with generalized myasthenia gravis (gMG), the association between symptom severity (measured with MG-ADL) and utility values is unknown. This study analyzed data from the ADAPT trial and found a significant association between MG-ADL scores and utility values in gMG patients. Furthermore, treatment with efgartigimod showed significant improvements in both symptoms and quality of life.
ADVANCES IN THERAPY
(2023)
Article
Public, Environmental & Occupational Health
Samer A. Kharroubi, Dan Kelleher
Summary: Valuation estimates for health based on preference-based measures can be improved by using existing countries' valuation results as informative priors.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Health Care Sciences & Services
Juan Zhu, Xin-Xin Yan, Cheng-Cheng Liu, Hong Wang, Le Wang, Su-Mei Cao, Xian-Zhen Liao, Yun-Feng Xi, Yong Ji, Lin Lei, Hai-Fan Xiao, Hai-Jing Guan, Wen-Qiang Wei, Min Dai, Wanqing Chen, Ju-Fang Shi
Summary: The study found that EQ-5D-5L has better discriminatory power and lower ceiling effect in cancer patients, which may be more suitable for assessing HRQoL.
QUALITY OF LIFE RESEARCH
(2021)
Article
Orthopedics
Helen Hoi Lun Tsang, Carlos King Ho Wong, Prudence Wing Hang Cheung, Chak Sing Lau, Ho Yin Chung, Jason Pui Yin Cheung
Summary: The EQ-5D health measure demonstrates satisfactory responsiveness for assessing changes in SpA disease activity, showing good correlations with BASDAI and BASFI scores.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Multidisciplinary Sciences
Chun-Hsiang Yu, Sheng-Mao Chang, Chih-Hui Hsu, Sheng-Han Tsai, Xin-Min Liao, Chang-Wei Chen, Ching-Hsiung Lin, Jung-Der Wang, Tzuen-Ren Hsiue, Chiung-Zuei Chen
Summary: This study predicts the utility of the European Quality of Life-5 Dimensions (EQ-5D-3L) questionnaire from the chronic obstructive pulmonary disease (COPD) assessment test (CAT) using a multinomial logistic regression (MLR) model and response mapping. The MLR model performs as well as other models in terms of prediction accuracy. Bubble chart analysis suggests that the model developed in this study and the Mean Rank Method (MRM) may be better predictive models.
SCIENTIFIC REPORTS
(2022)
Article
Economics
Mihir Gandhi, Ru San Tan, Shir Lynn Lim, Kim Rand, Carolyn S. P. Lam, Nan Luo, Yin Bun Cheung
Summary: This study aimed to investigate the health preferences of patients with heart disease and develop a value set for the 5-level EQ-5D (EQ-5D-5L) based on these patient preferences. The value set could be used for patient-centric economic evaluation and health-related quality of life assessment for patients with heart disease.
Article
Health Care Sciences & Services
Alex Bato, Valentin Brodszky, L. Hunor Gergely, Krisztian Gaspar, Norbert Wikonkal, Agnes Kinyo, Akos Szabo, Zsuzsanna Beretzky, Andrea Szegedi, Eva Remenyik, Norbert Kiss, Miklos Sardy, Fanni Rencz
Summary: The study aimed to compare the measurement properties of two adult versions of EQ-5D in patients with Hidradenitis suppurativa (HS), with EQ-5D-5L outperforming EQ-5D-3L in terms of feasibility, informativity, and validity for important clinical characteristics. EQ-5D-5L was recommended for assessing HS patients across various settings.
QUALITY OF LIFE RESEARCH
(2021)
Article
Medicine, General & Internal
Nikolaos Kontodimopoulos, Eleni Stamatopoulou, Sousana Gazi, Dimitra Moschou, Michail Krikelis, Michael A. Talias
Summary: This study compared the utilities of EQ-5D-3L, EQ-5D-5L, and SF-6D in patients with different musculoskeletal disorders, and classified them according to disease severity. The results showed higher agreement between EQ-5D-5L and SF-6D, compared to EQ-5D-3L and SF-6D. These discrepancies could have implications on economic evaluations.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Health Care Sciences & Services
Jie Jiang, Yanming Hong, Tiantian Zhang, Zhihao Yang, Tengfei Lin, Zhuoru Liang, Peiyao Lu, Lishun Liu, Binyan Wang, Yongmei Xu, Nan Luo
Summary: This study compared the measurement properties of EQ-5D-3L and EQ-5D-5L in hypertensive patients in rural China. The results showed that the 5L version had a lower ceiling effect and higher informativity compared to the 3L version, with good agreement between the two.
QUALITY OF LIFE RESEARCH
(2021)
Article
Medicine, General & Internal
Christine Marie Baeko Halling, Claire Gudex, Anders Perner, Cathrine Elgaard Jensen, Dorte Gyrd-Hansen
Summary: This study aims to model EQ-5D-5L valuations based on preferences elicited from ICU patients and compare them with preferences of the general population, as well as investigate the heterogeneity in ICU patients' preferences.
Article
Economics
Fanni Rencz, Valentin Brodszky, Mathieu F. Janssen
Summary: This study compares measurement properties of EQ-5D-5L, PROMIS-29+2, and PROMIS-GH-10, and provides comparative evidence for the choice of instruments in population health surveys and cost-utility analyses. Results show that most PROMIS items have enhanced distributional characteristics and good convergent validity with EQ-5D-5L. EQ-5D-5L utilities are higher than PROPr utilities.
Article
Economics
Kamilla Koszoru, Krisztina Hajdu, Valentin Brodszky, Alex Bato, L. Hunor Gergely, Aniko Kovacs, Zsuzsanna Beretzky, Miklos Sardy, Andrea Szegedi, Fanni Rencz
Summary: In adult patients with AD, EQ-5D-5L demonstrated superiority over EQ-5D-3L in terms of ceiling effects, informativity, and convergent validity. Therefore, we recommend the use of EQ-5D-5L to measure health outcomes in clinical settings and for QALY calculations in AD.
EUROPEAN JOURNAL OF HEALTH ECONOMICS
(2023)
Article
Health Care Sciences & Services
Titi Sahidah Fitriana, Fredrick Dermawan Purba, Rina Rahmatika, Riski Muhaimin, Nur Melani Sari, Gouke Bonsel, Elly Stolk, Jan J. Busschbach
Summary: This study compared the measurement properties and responsiveness of EQ-5D-Y-3L and EQ-5D-Y-5L in pediatric patients. The results showed that the feasibility, convergent validity, and disease-specific measures were similar between the two versions, but EQ-5D-Y-5L had better test-retest reliability and sensitivity for detecting health changes.
HEALTH AND QUALITY OF LIFE OUTCOMES
(2021)
Review
Economics
Alexandra J. L. M. Geraerds, Gouke J. Bonsel, Mathieu F. Janssen, Aureliano Paolo Finch, Suzanne Polinder, Juanita A. Haagsma
Summary: The research has found that a range of potentially suitable bolt-on dimensions have been investigated using diverse methods. It is necessary to establish guidelines to standardize the wording of the bolt-on dimension and response options, evaluate the minimal important gain of the bolt-on, and facilitate quality assessment of bolt-on studies. These guidelines will help in decision-making on whether to implement a bolt-on dimension to the EQ-5D.
Article
Public, Environmental & Occupational Health
Simon McNamara, Aki Tsuchiya, John Holmes
Summary: The study found that the UK public is more averse to health inequalities between socioeconomic groups than between neutrally labelled groups, and more willing to prioritize neutrally labelled groups with lower lifetime health. Participant rationales suggest that this divergence is partly driven by factors other than health, such as financial inequality between socioeconomic groups.
SOCIAL SCIENCE & MEDICINE
(2021)
Article
Economics
Brendan Mulhern, Richard Norman, John Brazier
Summary: This study aimed to estimate an SF-6Dv2 value set for Australia using an international protocol, compare Australian and UK values, and understand heterogeneity. The model including Design 1 data and moderating interaction was chosen for the Australian value set, allowing the SF-6Dv2 to be used in health technology assessment decision making in Australia.
Article
Urology & Nephrology
James Fotheringham, Enric Vilar, Tarun Bansal, Paul Laboi, Andrew Davenport, Louese Dunn, Arne Risa Hole
Summary: This study quantified the relative importance and acceptability of longer and more frequent hemodialysis sessions to patients. The findings showed that longer and more frequent sessions were associated with improved survival, quality of life, reduced need for fluid restriction, and avoidance of access complications. Younger age, fatigue, previous experience of access complications, absence of heart failure, and shorter travel time to the dialysis center were associated with a preference for more frequent sessions. These results highlight the need for further research on the clinical effectiveness of these intensive regimens and consideration of patient choice in dialysis selection.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2022)
Article
Dentistry, Oral Surgery & Medicine
Ruvini M. Hettiarachchi, Sanjeewa Kularatna, Joshua Byrnes, Gang Chen, Brendan Mulhern, Paul A. Scuffham
Summary: The study aimed to develop a new PBM classification system for the most prevalent childhood oral health condition, dental caries, comprising five items with a four-level response scale each, to be used in economic evaluations of dental caries health interventions.
JOURNAL OF PUBLIC HEALTH DENTISTRY
(2022)
Article
Economics
Donna Rowen, Nyantara Wickramasekera, Arne Risa Hole, Anju Keetharuth, Allan Wailoo
Summary: This article investigates public preferences regarding factors that influence the choice to make clinical negligence claims against a national healthcare system. The results suggest that the actions of the healthcare system after a patient safety incident and characteristics of the claims process have a larger impact on the probability of making a claim for milder incidents.
Article
Public, Environmental & Occupational Health
Anne Spencer, Oliver Rivero-Arias, Ruth Wong, Aki Tsuchiya, Han Bleichrodt, Rhiannon Tudor Edwards, Richard Norman, Andrew Lloyd, Philip Clarke
Summary: This article provides a historical overview of the development of quality adjusted life year (QALY) and highlights the impact of two seminal papers. It discusses the history and theoretical work of QALY, reviews the methodological debates surrounding it over the past 50 years, and examines how QALY has addressed challenges. Additionally, it presents the thoughts of experts in the field of health economics on future research and policy use of QALY.
SOCIAL SCIENCE & MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Donna Rowen, Philip A. A. Powell, Arne Risa Hole, Maria-Jose Aragon, Adriana Castelli, Rowena Jacobs
Summary: This study uses a discrete choice experiment to determine the relative importance of different aspects of mental healthcare quality to different stakeholders. The results show that being treated with dignity and respect is highly important across all stakeholders. A coordinated approach is important to all stakeholders, while communication is more important to healthcare professionals and service users, and ease of access is more important to the general population.
SOCIAL SCIENCE & MEDICINE
(2022)
Article
Economics
Julie Ratcliffe, Siobhan Bourke, Jinhu Li, Brendan Mulhern, Claire Hutchinson, Jyoti Khadka, Rachel Milte, Emily Lancsar
Summary: This study evaluates the classification system for the Quality-of-Life Aged Care Consumers (QOL-ACC) instrument using a discrete choice experiment. The results show that utility increases with survival duration and decreases with higher levels of quality-of-life impairment. A value set for quality assessment and calculation of quality-adjusted life-years was generated.
Article
Public, Environmental & Occupational Health
Jack Elliott, Aki Tsuchiya
Summary: This study examines the impact of health problems on health state valuation and finds that individuals with serious health problems may have different opinions on the value of health states compared to the rest of the population, which has normative implications for the choice of values.
SOCIAL SCIENCE & MEDICINE
(2022)
Article
Economics
Kathleen Manipis, Brendan Mulhern, Philip Haywood, Rosalie Viney, Stephen Goodall
Summary: Lost productivity is a significant cost associated with foodborne illness. A study was conducted to examine preferences for avoiding different illnesses and to estimate the effect of work ability, paid sick leave, and health-related quality of life on willingness-to-pay (WTP). The results showed that factors such as work ability and paid sick leave influenced the WTP to avoid both acute and chronic conditions.
EUROPEAN JOURNAL OF HEALTH ECONOMICS
(2023)
Article
Health Care Sciences & Services
Sanjeewa Kularatna, Gang Chen, Richard Norman, Clara Mukuria, Donna Rowen, Sameera Senanayake, Ruvini Hettiarachchi, Brendan Mulhern, Katie Fozzard, William Parsonage, Steven M. MacPhail
Summary: A population utility value set for the MacNew-7D heart disease-specific instrument was developed using discrete choice experiments. The study found that this value set is likely suitable for estimating quality-adjusted life years derived from the MacNew heart disease health-related quality-of-life questionnaire.
QUALITY OF LIFE RESEARCH
(2023)
Article
Health Care Sciences & Services
Lidia Engel, David G. T. Whitehurst, Juanita Haagsma, M. F. Janssen, Brendan Mulhern
Summary: This study compared the EQ-5D-5L pain/discomfort dimension with other pain and discomfort items collected in the Australian psychometric study. The results showed that a higher proportion of respondents reported impairment on pain severity and discomfort severity items compared to EQ-5D-5L pain/discomfort. The correlation and predictive ability were strongest for pain severity and weakest for discomfort frequency.
QUALITY OF LIFE RESEARCH
(2023)
Article
Health Care Sciences & Services
Brendan J. Mulhern, Tianxin Pan, Richard Norman, An Tran-Duy, Janel Hanmer, Rosalie Viney, Nancy J. Devlin
Summary: This study aims to assess the measurement relationship between EQ-5D-5L, PROMIS-29, and PROPr. The findings suggest a high correlation between the measurement dimensions of these instruments, but PROMIS-29 assesses additional health concepts not covered by EQ-5D. Both instruments are able to detect differences between those with and without a condition, but PROPr can more precisely detect varying levels of self-reported health.
QUALITY OF LIFE RESEARCH
(2023)
Article
Health Care Sciences & Services
Ruvini M. Hettiarachchi, Sanjeewa Kularatna, Joshua Byrnes, Brendan Mulhern, Gang Chen, Paul A. Scuffham
Summary: This study aims to generate an Australian-specific utility algorithm for the Dental Caries Utility Index (DCUI). An online survey was conducted using a representative sample of the Australian general population. The findings suggest that the mapping approach is more suitable for anchoring the DCUI, allowing for utility value calculations in economic evaluations of dental caries interventions targeted for adolescents.
MEDICAL DECISION MAKING
(2023)
Article
Economics
Renee Jones, Rachel O'Loughlin, Xiuqin Xiong, Mina Bahrampour, Nancy Devlin, Harriet Hiscock, Gang Chen, Brendan Mulhern, Kim Dalziel
Summary: This study compares the psychometric performance of common generic paediatric health-related quality-of-life instrument descriptive systems by child age, report type, and health status.