Article
Chemistry, Multidisciplinary
Yu Shang, Yingying Chen, Qing Wang, Yuqiu He, Shizhen He, Shanshan Yu, Xiaoqing Liu, Fuan Wang
Summary: This study developed an endogenously and sequentially activated DNA circuit for in vivo imaging of tumor cells with high precision and reliability. The smart DNA circuit, engineered using a specific enzymatic regulation strategy, ensured the specific reaction and sensitive imaging, providing a powerful tool for cancer diagnosis and treatment.
Article
Chemistry, Analytical
Shui Qin Chai, Wen Yi Lv, Jia Hui He, Yuan Fang Li, Hong Yan Zou, Chun Mei Li, Cheng Zhi Huang
Summary: The study introduces a simple dual-amplification strategy for highly sensitive miRNA detection, utilizing CHA and multiple fluorophores on an X-shaped DNA nanostructure.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Guo-Xi Liang, Shu-Ying Ye, Hao-Ming Yu, Kai-Ren Zhao, Peng-Fei Liu, Zhi-Jun Liu, Li Wang
Summary: This study proposes a new Zika virus diagnostic platform that combines a DNA walker structure and a localized catalytic hairpin assembly (LCHA) cascade amplification strategy for fast, low-cost, and accurate diagnosis. The method allows for Zika virus sequence detection down to 20 pM without enzymatic DNA amplification, and can detect the virus directly from serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Multidisciplinary
Yuqiu He, Qing Wang, Chen Hong, Ruomeng Li, Jinhua Shang, Shanshan Yu, Xiaoqing Liu, Fuan Wang
Summary: Synthetic catalytic DNA circuits have potential for sensitive intracellular imaging, but their selectivity and efficiency are limited by off-site signal leakage and inefficient on-site activation. An endogenously activated DNAzyme strategy was integrated with a catalytic DNA circuit for selective and efficient microRNA imaging in vivo. The on-site modulation strategy allows these circuits to be expanded in biological systems.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Huimin Wang, Yuqiu He, Jie Wei, Hong Wang, Kang Ma, Yangjie Zhou, Xiaoqing Liu, Xiang Zhou, Fuan Wang
Summary: This study developed a versatile autocatalytic DNA circuit for high-performance in vivo bioanalysis. The circuit showed sensitive and selective detection of analytes, and enabled robust miRNA imaging in living cells and mice. These findings expand the toolbox for accurate diagnosis and programmable therapeutics.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Biophysics
Ye Zhang, Xiaohe Zhang, Bo Situ, Yuan Wu, Shihua Luo, Lei Zheng, Yurong Qiu
Summary: The study introduced a robust electrochemical biosensor using multifunctional DNA tetrahedrons for exo-miRNA analysis, demonstrating high sensitivity and rapid detection. The platform showed efficient quantification of exo-miRNA and profiling of tumor-associated miRNAs in breast cancer, with high sensitivity for breast tumor diagnosis and early detection.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Biochemistry & Molecular Biology
Shi Chen, Li Xing, Douglas Zhang, Alba Monferrer, Thomas Hermann
Summary: This study reported a method for designing and preparing nano-sandwich composite materials through noncovalent assembly of protein, DNA, and RNA modules, successfully synthesizing the three-dimensional structure of a protein-RNA-DNA complex and providing a new design approach for bottom-up preparation of layered biomaterials.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Shi Chen, Li Xing, Douglas Zhang, Alba Monferrer, Thomas Hermann
Summary: This study reports the successful synthesis of a composite material composed of protein, DNA, and RNA through controlled self-assembly and precise positioning, with the 3D architecture confirmed through fluorescence labeling and cryo-electron microscopy studies. The synthesis strategy for the nano-sandwich composite provides a general blueprint for controlled noncovalent assembly of complex supramolecular architectures.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Nanoscience & Nanotechnology
Chun Hong Li, Wen Yi Lv, Fei Fan Yang, Shu Jun Zhen, Cheng Zhi Huang
Summary: Simultaneous detection and imaging of two miRNAs was achieved using a DTN probe, showing great potential for improving detection accuracy.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Analytical
Linyan Li, Xiaojun Fang, Jingqing Le, Yanhui Zheng, Xiarong Tan, Zhou Jiang, Hongxia Li, Jianguo Xu, Huo Xu
Summary: In this study, a cascade catalytic hairpin assembly (CCHA) method was developed for sensitive and selective detection of miRNA. The method showed high assay sensitivity, excellent sequence specificity, and the ability for intracellular imaging, demonstrating promising potential for biosensing, clinical diagnosis, or prognosis.
Article
Engineering, Biomedical
Jinpeng Han, Yuchen Cui, Zi Gu, Dayong Yang
Summary: The study developed a nanocarrier system that can efficiently release drugs in cells while minimizing side effects, utilizing polyphenol-DNA nanocomplexes. Through programmable assembly and disassembly processes, this method achieves precise release of multiple genes and drugs in cells.
Article
Biophysics
Wen-jing Liu, Lu-yao Wang, Zhimei Sheng, Baogang Zhang, Xiaoran Zou, Chun-yang Zhang
Summary: This study demonstrates the assembly of fluorescence-encoded nanostructures driven by RNA methylation for sensitive detection of the m6A modification writer METTL3/14 complex in human breast tissues. The method achieves good specificity and high sensitivity, allowing screening of METTL3/14 complex inhibitors and quantification of complex activity at the single-cell level. Furthermore, it can differentiate the complex level in breast cancer patient tissues and healthy volunteer tissues.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Chemistry, Analytical
Shengqiang Li, Xu Liu, Shenglin Liu, Mei Guo, Cuiying Liu, Ming Pei
Summary: The study introduces a fluorescence detection strategy based on aptamer recognition and mismatched catalytic hairpin assembly for highly sensitive detection of AFP, which has a wide detection range and high anti-interference ability.
ANALYTICA CHIMICA ACTA
(2021)
Article
Chemistry, Analytical
Li Zou, Xinghui Li, Yufen Lai
Summary: An enzyme-free colorimetric aptasensor was developed for the sensitive detection of kanamycin in complex samples, exhibiting high sensitivity and selectivity with a broad linear range and a limit of detection of 10 pM. The aptasensor integrates target-triggered catalytic hairpin assembly (CHA) amplification with the aggregation of DNA-gold nanoparticle probes, leading to a colorimetric readout that can be visualized by naked eye or measured by UV-vis spectroscopy. The aptasensor also demonstrates excellent applicability for kanamycin detection in complex samples with satisfactory recoveries and results comparable to those of the ELISA method, suggesting great potential applications in various fields.
MICROCHEMICAL JOURNAL
(2021)
Article
Chemistry, Analytical
Yingkai Qin, Shuang Li, Yu Wang, Yuan Peng, Dianpeng Han, Huanying Zhou, Jialei Bai, Shuyue Ren, Sen Li, Ruipeng Chen, Tie Han, Zhixian Gao
Summary: In this study, a biosensor based on fluorescence resonance energy transfer between UCNPs and GO with CHA target recycling and amplification was developed for sensitive detection of FB1. The method exhibited high relevance and low detection limit, and could be applied for the detection of FB1 in corn, oats, and infant supplements. The sensitive detection of FB1 proves the application potential of this method on food safety.
ANALYTICA CHIMICA ACTA
(2022)
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)