Editorial Material
Multidisciplinary Sciences
Cassandra Willyard
Summary: Researchers are attempting to develop protection against malaria at every stage of the parasite's life cycle.
Review
Biochemistry & Molecular Biology
Valentina Rangel-Angarita, Stacy A. Malaker
Summary: This review summarizes recent advancements in the study of mucin-domain glycoproteins, highlighting their roles in diseases, challenges, and new opportunities for research in this area.
ACS CHEMICAL BIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Harry V. M. Spiers, Lukas K. J. Stadler, Hugo Smith, Vasilis Kosmoliaptsis
Summary: Extracellular vesicles (EVs) are lipid bilayer-delimited nanoparticles released by cells, carrying a cargo rich in proteins, lipids, DNA, and various RNA species. EVs play a crucial role in physiological and pathological processes by delivering their cargo to recipient cells and inducing downstream signaling. They have shown potential as effective drug delivery systems, particularly in organ transplantation to prevent rejection and mitigate ischemia reperfusion injury.
Review
Pharmacology & Pharmacy
Assaf Ben-Arzi, Rita Ehrlich, Ron Neumann
Summary: The future continuous growth of the global older population increases the burden of retinal diseases worldwide. This review discusses the unmet medical needs, novel modes of drug delivery, and advancements in pharmacodelivery to the retina.
Review
Psychiatry
Dhruva Ithal, Salil K. Sukumaran, Debanjan Bhattacharjee, Alekhya Vemula, Ravi Nadella, Jayant Mahadevan, Reeteka Sud, Biju Viswanath, Meera Purushottam, Sanjeev Jain
Summary: Severe mental illnesses have complex inheritance patterns with both common and rare variants. Some genes affect brain morphology and neuropsychiatric manifestations, while others are linked to various signaling pathways. A 'disease in dish' approach can help further explore fundamental mechanisms.
ASIAN JOURNAL OF PSYCHIATRY
(2021)
Review
Hematology
Ting Li, Arthur Liesz
Summary: Inflammation plays a crucial role in ischemic stroke, both locally in the brain and systemically. New therapeutic strategies targeting inflammation are needed.
THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Computer Science, Hardware & Architecture
Yu Cheng, Bo Yin, Shuai Zhang
Summary: With the growth of mobile technology, wireless networks have become an integral part of everyday life. Deep learning technology shows great potential in wireless network optimization, with data-driven approaches helping to automate network configuration and management.
IEEE WIRELESS COMMUNICATIONS
(2021)
Editorial Material
Biochemistry & Molecular Biology
Lisa F. Stinson, Donna T. Geddes
Summary: Microbial metabolites are transmitted to infants via human milk, impacting early-life programming. The use of metabolomics is advocated to complement current milk microbiome research.
TRENDS IN MICROBIOLOGY
(2022)
Article
Neurosciences
Patrick Friedrich, Stephanie J. Forkel, Celine Amiez, Joshua H. Balsters, Olivier Coulon, Lingzhong Fan, Alexandros Goulas, Fadila Hadj-Bouziane, Erin E. Hecht, Katja Heuer, Tianzi Jiang, Robert D. Latzman, Xiaojin Liu, Kep Kee Loh, Kaustubh R. Patil, Alizee Lopez-Persem, Emmanuel Procyk, Jerome Sallet, Roberto Toro, Sam Vickery, Susanne Weis, Charles R. E. Wilson, Ting Xu, Valerio Zerbi, Simon B. Eickoff, Daniel S. Margulies, Rogier B. Mars, Michel Thiebaut de Schotten
Summary: Evolution strikes a balance between ancestral history and current adaptations in animals. Comparing species can provide insights into evolutionary history, while comparative neuroimaging uses MRI to identify similarities and differences in brain structure and function across species.
Review
Oncology
Matthew J. Lin, Judit Svensson-Arvelund, Gabrielle S. Lubitz, Aurelien Marabelle, Ignacio Melero, Brian D. Brown, Joshua D. Brody
Summary: The article discusses the current status and potential of cancer vaccines, emphasizing the need for accurate immune monitoring of early trials to advance the most promising vaccines. It also classifies cancer vaccines based on the included antigens and their colocalization with antigen-presenting cells, highlighting the challenges and opportunities in advancing these vaccines to the clinic.
Article
Health Care Sciences & Services
Jacob Sunshine
Summary: The widespread adoption of smart speakers has the potential to greatly improve human health. These devices can be used to enhance chronic disease management, identify medical emergencies, monitor behavior changes, reduce isolation, and remotely monitor respiratory diseases.
JMIR MHEALTH AND UHEALTH
(2022)
Editorial Material
Oncology
Xin Li, Deepak Saxena
Summary: The study identifies IL-33, a pro-inflammatory cytokine, as a chemotactic factor released in response to intratumoral mycobiome that attracts type 2 immune cells. Depletion of fungi or deletion of IL-33 significantly decreases pancreatic ductal adenocarcinoma (PDAC) tumor progression and improves survival.
Review
Chemistry, Multidisciplinary
Laura K. Buckton, Marw N. Rahimi, Shelli R. McAlpine
Summary: Developing macrocyclic peptides that can reach intracellular targets is a significant challenge, and current chemical strategies can improve cell permeability, but often at the expense of biological activity.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Review
Endocrinology & Metabolism
Anasuya Das Gupta, Natalia Krawczynska, Erik R. Nelson
Summary: Extracellular vesicles, including exosomes, play important roles in normal physiology and disease states by delivering signals through membrane-bound particles in body fluids. Similar to the endocrine system, the EV system is likely under homeostatic control, making the regulation of their biogenesis and secretion crucial for further exploration.
Review
Medicine, General & Internal
Elisa Damiani, Andrea Carsetti, Erika Casarotta, Roberta Domizi, Claudia Scorcella, Abele Donati, Erica Adrario
Summary: Microcirculatory dysfunction is crucial to the development of tissue dysoxia and organ failure in sepsis. Sublingual videomicroscopy allows real-time assessment of microvascular blood flow, revealing alterations during sepsis and their correlation with poor outcomes. It also highlights the discrepancy between macro-hemodynamic parameters and microvascular perfusion, emphasizing the importance of integrating microvascular monitoring in septic patient management.
FRONTIERS IN MEDICINE
(2023)
