Article
Medicine, General & Internal
Meaghan Clough, Jade Bartholomew, Owen B. White, Joanne Fielding
Summary: Working memory impairments are common in early multiple sclerosis, and the most frequent impairment phenotypes are visual-spatial and auditory. The test of visual-spatial working memory provides the best measure of impairment, while the symbol digit modalities test has limitations in screening cognitive impairment in early MS.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Julia K. Prummer, Veronika M. Stein, Eliane Marti, Andreas Lutterotti, Ilijas Jelcic, Gertraud Schuepbach-Regula, Thorsten Buch, Arianna Maiolini
Summary: Meningoencephalitis of unknown origin (MUO) in dogs, similar to multiple sclerosis (MS) in humans, has a high prevalence of cerebrospinal fluid (CSF)-specific oligoclonal bands (OCBs) indicating an inflammatory B cell response.
Article
Cell Biology
Katharina Lambert, Keagan G. Moo, Azlann Arnett, Gautam Goel, Alex Hu, Kaitlin J. Flynn, Cate Speake, Alice E. Wiedeman, Vivian H. Gersuk, Peter S. Linsley, Carla J. Greenbaum, S. Alice Long, Rebecca Partridge, Jane H. Buckner, Bernard Khor
Summary: By analyzing the immune phenotypes of individuals with Down syndrome, we discovered immune dysregulation features shared with other autoimmune diseases and developed immune clocks to measure immune aging in Down syndrome.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Veterinary Sciences
Elzbieta Giza, Piotr Teodorowski, Stanislaw Winiarczyk, Oliwier Teodorowski, Marcin Kalinowski, Lukasz Adaszek
Summary: This case study examined a Pug dog suspected of having Pug dog encephalitis, suggesting that while genetic testing showed a low risk of developing the disease, caution should still be exercised in diagnosis and breeding. Additionally, the acute onset of seizures in a young Pug dog does not always indicate a poor prognosis.
MEDYCYNA WETERYNARYJNA-VETERINARY MEDICINE-SCIENCE AND PRACTICE
(2021)
Article
Veterinary Sciences
Rebecca Windsor, Samuel Stewart, Jessica Schmidt, Mario Mosqueda, Ignazio Piras, Stefan M. Keller, Briana Steinmetz, Dori L. Borjesson, Matthew Huentelman, Chand Khanna
Summary: This study found that pug dogs at genetic risk for NME might show neurological abnormalities before developing pathognomonic clinical signs. This discovery can aid in early diagnosis and treatment of the disease.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2022)
Article
Clinical Neurology
Johanna Engelhard, Denise M. Oleske, Sarah Schmitting, Karen E. Wells, Saritha Talapala, Luigi M. Barbato
Summary: A recent study conducted in Germany compared the different phenotypes of multiple sclerosis (MS) in terms of prevalence rates, drug treatments, and associated clinical conditions. The study found that the prevalence rates of all MS phenotypes have increased over time, with older patients being more common and a higher proportion of females. The types of treatments prescribed varied between phenotypes, and each phenotype was associated with different clinical conditions.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2022)
Article
Clinical Neurology
Sabrina Haben, Andrea Ciplea, Marianne Tokic, Nina Timmesfeld, Sandra Thiel, Ralf Gold, Annette Magdalene Langer-Gould, Kerstin Hellwig
Summary: This study aimed to assess the association between four different postpartum strategies and relapse risk during the first 6 months postpartum. The results showed that early treatment with natalizumab/fingolimod reduced the hazard of postpartum relapse from month 3, but did not diminish the hazard of early postpartum relapse. Therefore, an early postpartum treatment strategy should be determined well before delivery for women with active multiple sclerosis.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Biology
Stepfanie M. Aguillon, Jennifer Walsh, Irby J. Lovette
Summary: This study identified the genetic basis of six distinct plumage patches in North American woodpeckers, revealing that color differences could be created through selection acting on novel combinations of coloration genes.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2021)
Article
Immunology
Anne Wisgalla, Caren Ramien, Mathias Streitz, Stephan Schlickeiser, Andreea-Roxana Lupu, Anke Diemert, Eva Tolosa, Petra C. Arck, Judith Bellmann-Strobl, Nadja Siebert, Christoph Heesen, Friedemann Paul, Manuel A. Friese, Carmen Infante-Duarte, Stefan M. Gold
Summary: During pregnancy, there are significant shifts in NK cell populations, with an increase in CD56(bright) NK cells and a decrease in CD56(dim) NK cells. These changes occur in both pregnant women with multiple sclerosis and healthy pregnant women, potentially contributing to disease amelioration in multiple sclerosis during pregnancy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Clinical Neurology
Winston Dzau, Sifat Sharmin, Francesco Patti, Guillermo Izquierdo, Sara Eichau, Alexandre Prat, Marc Girard, Pierre Duquette, Marco Onofrj, Alessandra Lugaresi, Serkan Ozakbas, Oliver Gerlach, Cavit Boz, Pierre Grammond, Murat Terzi, Maria Pia Amato, Daniele La Spitaleri, Cristina Ramo-Tello, Davide Maimone, Elisabetta Cartechini, Katherine Buzzard, Olga Skibina, Anneke van der Walt, Helmut Butzkueven, Gerardo Iuliano, Aysun Soysal, Tomas Kalincik
Summary: This study investigated the association between early progression independent of relapse activity (PIRA) and relapse-associated worsening (RAW) with the onset and disability accumulation of secondary progressive multiple sclerosis (SPMS). It found that early PIRA and RAW were associated with increased risk of SPMS, but not with the rate of disability progression during SPMS.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Andrew D. Goodman, Janel K. Fedler, Jon Yankey, Elizabeth A. Klingner, Dixie J. Ecklund, Christopher V. Goebel, Robert A. Bermel, Marianne Chase, Christopher S. Coffey, Eric C. Klawiter, Robert T. Naismith, Robert J. Fox
Summary: The study found that there was a differential treatment effect of ibudilast on brain atrophy rate between primary and secondary progressive multiple sclerosis patients, primarily driven by patients with primary progressive MS. This difference may have been due to faster brain atrophy progression rates in the primary progressive MS patients compared to secondary progressive MS patients.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2021)
Article
Pharmacology & Pharmacy
Stefania Olla, Maristella Steri, Alessia Formato, Michael B. Whalen, Silvia Corbisiero, Cristina Agresti
Summary: Oxidative stress is implicated in the pathogenesis of multiple sclerosis (MS), and identifying drugs that can regulate oxidative homeostasis may offer new treatment options for the disease. This study used an in silico approach to link genome-wide MS associations and molecular QTLs to explore potential drug targets related to oxidative stress pathways. The findings suggest existing drugs could target OS-related molecules regulated by functional MS variants, in addition to approved disease-modifying treatments.
Article
Clinical Neurology
Hengameh Shams, Xiaorong Shao, Adam Santaniello, Gina Kirkish, Adil Harroud, Qin Ma, Noriko Isobe, Catherine Schaefer, Jacob L. McCauley, Bruce A. C. Cree, Alessandro Didonna, Sergio E. Baranzini, Nikolaos A. Patsopoulos, Stephen L. Hauser, Lisa F. Barcellos, Roland G. Henry, Jorge R. Oksenberg
Summary: Polygenic inheritance plays a pivotal role in multiple sclerosis susceptibility. The development of polygenic risk scores (PRS) can assess disease status and severity, providing enhanced risk assessment and radiographic outcomes. This study indicates important associations of PRS with risk assessment and tissue injury outcomes, potentially informing targeted screening and prevention strategies.
Article
Clinical Neurology
Aurora Zanghi, Simonetta Galgani, Paolo Bellantonio, Mauro Zaffaroni, Giovanna Borriello, Matilde Inglese, Silvia Romano, Antonella Conte, Francesco Patti, Maria Trojano, Carlo Avolio, Emanuele D'Amico
Summary: This study investigated the determinants of recovery from first relapse and relapse-associated worsening (RAW) in relapsing-remitting multiple sclerosis patients. Age and pyramidal phenotype were found to be the strongest predictors of recovery and RAW.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Immunology
Erik Ellwardt, Muthuraman Muthuraman, Gabriel Gonzalez-Escamilla, Venkata Chaitanya Chirumamilla, Felix Luessi, Stefan Bittner, Frauke Zipp, Sergiu Groppa, Vinzenz Fleischer
Summary: This study aimed to elucidate the functional connectivity of anxiety-related networks associated with atrophied areas in patients with multiple sclerosis (MS). The findings showed that higher anxiety levels were associated with thinning of the left dorsal prefrontal cortex. Bilateral prefrontal cortex, amygdala, and hippocampus were functionally connected to anxiety-related atrophy maps. There were also reduced information flow between the prefrontal cortex and amygdala at rest, and pathologically increased prefrontal cortex excitability in MS patients compared to controls.
JOURNAL OF NEUROINFLAMMATION
(2022)