Article
Neurosciences
Iven-Alex von Mucke-Heim, Jan M. Deussing
Summary: Psychiatric disorders are highly burdensome worldwide, with many patients experiencing treatment resistance. Recent research has revealed the importance of neuroimmune systems in mood disorder biology, specifically the dysregulation in neuroimmune cross-talk driven by genetic risk factors and environmental influences. One emerging immune target is purinergic signalling via the P2X7 receptor (P2X7R). However, no clinically meaningful applications have been identified so far, highlighting the need for further research and translation of findings from bench to bedside.
Article
Medicine, General & Internal
Zhu-Qing Zhang, Zhi-Peng Guo, Xue-Yu Lv, Peter Soeroes, Xiao-Xu Wang, Lihong Wang, Chun-Hong Liu
Summary: This article describes a clinical trial that aims to study the efficacy of transcutaneous vagus nerve stimulation (taVNS) in preventing the relapse of major depressive disorder (MDD) and investigate its underlying mechanisms. The trial will randomize 90 participants with recurrent MDD in remission into real or sham taVNS group and evaluate their biopsychosocial factors. The results will contribute to the development of effective methods for preventing MDD relapse.
Article
Psychiatry
Go Okada, Yuki Sakai, Maki Shibakawa, Toshinori Yoshioka, Eri Itai, Hotaka Shinzato, Osamu Yamamoto, Kenichi Kurata, Tatsuji Tamura, Hiroaki Jitsuiki, Hidehisa Yamashita, Akio Mantani, Norio Yokota, Mitsuo Kawato, Yasumasa Okamoto
Summary: This study aims to validate the feasibility and efficacy of diagnostic and stratification markers for major depressive disorder (MDD) through a clinical trial, providing important data for the clinical application of these markers.
Article
Clinical Neurology
Fabiano G. Nery, Jeffrey A. Welge, David Fleck, Wade Weber, Rodrigo Patino, Jeffrey R. Strawn, Caleb M. Adler, Stephen M. Strakowski, Melissa P. DelBello
Summary: To identify biomarkers of prodromal mood disorders, functional brain activation was examined in children and adolescents at familial risk for bipolar disorder. It was found that at-risk youth exhibited reduced activation to emotional distracters in the right ventrolateral prefrontal cortex at baseline. Additionally, increased activation in the right ventrolateral prefrontal cortex, caudate, and putamen at baseline predicted the development of a mood episode in at-risk youth who later experienced such an episode.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Medicine, General & Internal
Julia Boberg, Viktor Kaldo, David Mataix-Cols, James J. Crowley, Bjorn Roelstraete, Matthew Halvorsen, Erik Forsell, Nils H. Isacsson, Patrick F. Sullivan, Cecilia Svanborg, Evelyn H. Andersson, Nils Lindefors, Olly Kravchenko, Manuel Mattheisen, Hilda B. Danielsdottir, Ekaterina Ivanova, Magnus Boman, Lorena Fernandez de la Cruz, John Wallert, Christian Ruck
Summary: MULTI-PSYCH is a research project aimed at improving risk stratification, outcome prediction, and secondary preventive interventions for depression and anxiety disorders through highly structured internet-based cognitive-behaviour therapy (ICBT). The project combines clinical, genetic, and nationwide register data, and includes 2668 patients with depression and anxiety who underwent 12 weeks of ICBT at an internet psychiatry clinic in Stockholm, Sweden.
Article
Computer Science, Interdisciplinary Applications
Wonjun Ko, Wonsik Jung, Eunjin Jeon, Heung-Il Suk
Summary: This paper proposes a novel deep learning framework that effectively handles neuroimaging and genetic data simultaneously, achieving state-of-the-art performance in Alzheimer's disease and mild cognitive impairment identification. Unlike existing methods, the framework learns the relationship between imaging phenotypes and genotypes in a nonlinear way without prior neuroscientific knowledge.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2022)
Article
Behavioral Sciences
Mona Guath, Johan Lundin Kleberg, Jan Weis, Ebba Widegren, Matilda Frick, Stefan Moller, Lisa Klevebrant, Barry Karlsson, David Fallmar, Johanna Martensson, Daniel S. Pine, Karin Brocki, Malin Gingnell, Andreas Frick
Summary: Depressive symptoms are associated with altered pupillary responses during learning and reward prediction as well as with changes in neurometabolite levels. The present pilot study found that pupil dilation during learning was related to depressive symptoms and choline concentrations in the dorsal anterior cingulate cortex (dACC). However, glutamate and GABA were not related to depressive symptoms or pupillary responses.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Adriane E. Napp, Torsten Diekhoff, Olf Stoiber, Judith Enders, Gerd Diederichs, Peter Martus, Marc Dewey
Summary: Self-hypnosis significantly reduced claustrophobia in high-risk patients undergoing MRI scans, leading to a decreased need for sedation and non-sedation coping actions. The majority of patients preferred self-hypnosis for future MRI examinations.
EUROPEAN RADIOLOGY
(2021)
Article
Psychiatry
Ryan Arathimos, Chiara Fabbri, Evangelos Vassos, Katrina A. S. Davis, Oliver Pain, Alexandra Gillett, Jonathan R. Coleman, Ken Hanscombe, Saskia Hagenaars, Bradley Jermy, Anne Corbett, Clive Ballard, Dag Aarsland, Byron Creese, Cathryn M. Lewis
Summary: This study identifies five groups of individuals with homogeneous clinical characteristics based on symptoms of manic and/or irritable mood. The study explores differences between these groups in terms of diagnoses, functional outcomes, and genetic liability. The findings suggest that data-driven investigations of psychopathological symptoms can complement research on clinical diagnoses and contribute to the development of improved classification systems for mood disorders.
BRITISH JOURNAL OF PSYCHIATRY
(2022)
Review
Medicine, General & Internal
Kaloyan Stoychev, Dancho Dilkov, Elahe Naghavi, Zornitsa Kamburova
Summary: This paper reviews all genome-wide association studies conducted in the past ten years, sampling patients with AUD and co-occurring mood or anxiety disorder(s). The results support the significant overlap of genetic factors involved in AUDs and mood and anxiety disorders. Larger samples and re-sequencing approaches will be necessary to disentangle the genetic architecture of dual diagnosis.
Article
Radiology, Nuclear Medicine & Medical Imaging
Wenjin Liu, Xiaoqin Huang, Xuebing Liu, Dakota Ortega, Li Chen, Zhensen Chen, Jie Sun, Lulu Wang, Thomas S. Hatsukami, Chun Yuan, Haige Li, Junwei Yang
Summary: The study found that uncontrolled hypertension is associated with subclinical cerebrovascular injury, affecting both small and medium-to-large arteries. The presence of intracranial plaque, vascular rarefaction, reduced cerebral blood flow, and increased white matter hyperintensity were all correlated with uncontrolled hypertension, particularly with uncontrolled diastolic blood pressure.
EUROPEAN RADIOLOGY
(2021)
Article
Clinical Neurology
Mavis Kusi, Samantha Tze Sum Wong, Chantal M. Percival, Riley Zurrin, Meighen M. Roes, Todd S. Woodward, Vina M. Goghari
Summary: This study investigated abnormalities in functional networks involved in lexical decision in patients with bipolar disorder (BD). The results showed that the BD group performed better than the control group in the lexical decision task, and had higher activation in the response network. This suggests that BD may be associated with sustained activity in the response network, which could contribute to psychomotor dysfunction in BD.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Alejandra Monserrat Rodriguez-Ramirez, Valente Cedillo-Rios, Claudia Becerra-Palars, Fatima Meza-Urzua, Joanna Jimenez-Pavon, Pamela Morales-Cedillo, Maria Margarita Lopez-Titla, Cesar Leonardo Sanchez-Segura, Maria de Lourdes Martinez-Gudino, Hiram Ortega-Ortiz, Beatriz Camarena-Medellin
Summary: Valproate is commonly used to treat bipolar disorder, but long-term full response is reported by only 13% of patients. This study aimed to evaluate the clinical features and prefrontal cortical thickness of long-term treatment response to valproate in bipolar disorder patients. The findings suggest that patients with mixed features have increased odds of achieving full response, and those with full response exhibit better preservation of the right prefrontal cortex.
PSYCHIATRY RESEARCH-NEUROIMAGING
(2021)
Review
Medicine, General & Internal
Jie Li, Feng Zhang, Wenchun Wang, Rizhao Pang, Jiancheng Liu, Qiuhong Man, Anren Zhang
Summary: This study aims to summarize the prevalence and risk factors of anxiety and depression in patients with breast cancer. Data will be analyzed and synthesized from multiple databases in different languages, evaluating heterogeneity and publication bias, and assessing the quality of the systematic review.
Article
Psychiatry
Huaxin Fan, Zhaowen Liu, Xinran Wu, Gechang Yu, Xinrui Gu, Nanyu Kuang, Kai Zhang, Yu Liu, Tianye Jia, Barbara J. Sahakian, Trevor W. Robbins, Gunter Schumann, Wei Cheng, Jianfeng Feng, Benjamin Becker, Jie Zhang
Summary: This study aimed to identify impulsivity-dependent subtypes in preadolescent internalising disorders and investigate their distinct anxiety-impulsivity relationships, neurobiology, genetics, cognition, and clinical trajectories.
BRITISH JOURNAL OF PSYCHIATRY
(2023)
Article
Psychiatry
Marco Antonio Sanabrais-Jimenez, Alejandro Aguilar-Garcia, Sandra Hernandez-Munoz, Emmanuel Sarmiento, Rosa E. Ulloa, Anabel Jimenez-Anguiano, Beatriz Camarena
Summary: The study revealed an association between the low activity genotype and allele of the Val158Met polymorphism of the COMT gene and suicide attempt in Mexican adolescents with major depressive disorder.
NORDIC JOURNAL OF PSYCHIATRY
(2022)
Article
Clinical Neurology
Alejandra Monserrat Rodriguez-Ramirez, Valente Cedillo-Rios, Claudia Becerra-Palars, Fatima Meza-Urzua, Joanna Jimenez-Pavon, Pamela Morales-Cedillo, Maria Margarita Lopez-Titla, Cesar Leonardo Sanchez-Segura, Maria de Lourdes Martinez-Gudino, Hiram Ortega-Ortiz, Beatriz Camarena-Medellin
Summary: Valproate is commonly used to treat bipolar disorder, but long-term full response is reported by only 13% of patients. This study aimed to evaluate the clinical features and prefrontal cortical thickness of long-term treatment response to valproate in bipolar disorder patients. The findings suggest that patients with mixed features have increased odds of achieving full response, and those with full response exhibit better preservation of the right prefrontal cortex.
PSYCHIATRY RESEARCH-NEUROIMAGING
(2021)
Article
Clinical Neurology
Alejandra Monserrat Rodriguez-Ramirez, Maria Teresa Alcantara-Garces, Sergio Hernandez-Jimenez, Ana Cristina Garcia-Ulloa, Denise Arcila-Martinez, Hector Velazquez-Jurado, Rodrigo Eduardo Arizmendi-Rodriguez
Summary: This study evaluated the effects of anxiety disorders on metabolic parameters in patients with type 2 diabetes. It found that patients with anxiety disorders had the worst glycemic control at 3 and 12 months of follow-up. The differences in HbA1c levels between patients with and without anxiety disorders increased over time, and factors such as anxiety symptoms, sex, age, years of diagnosis, and insulin treatment were associated with HbA1c parameters.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2023)
Article
Clinical Neurology
Marco Antonio Sanabrais-Jimenez, Ayerim Alma Esquivel-Lopez, Carlo Esteban Sotelo-Ramirez, Alejandro Aguilar-Garcia, Bruno Ordonez-Martinez, Joanna Jimenez-Pavon, Maria Victoria Madrigal-Lara, Alan Jair Diaz-Vivanco, Beatriz Camarena
Summary: The study found that the gene variants of NR3C1 and NR3C2 interact with childhood trauma, increasing the susceptibility to suicide attempts (SA) in psychiatric patients with a history of CT.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2023)
Article
Clinical Neurology
Carlo E. Sotelo-Ramirez, Beatriz Camarena, Marco Antonio Sanabrais-Jimenez, Julio Uriel Zaragoza-Hoyos, Bruno Ordonez-Martinez, Raul Escamilla-Orozco, Beatriz Gomez-Gonzalez
Summary: This study analyzed the association between TLR1, TLR2, and TLR6 gene polymorphisms and the etiology of schizophrenia. The results showed significant differences in genotype and allele frequencies of these genes between patients and controls, and an interaction between TLR1/rs4833093 and TLR2/rs5743709 genes that increased the risk of developing schizophrenia.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2023)
Article
Clinical Neurology
Maria Teresa Alcantara-Garces, Alejandra Monserrat Rodriguez-Ramirez, Ana Cristina Garcia-Ulloa, Sergio Hernandez-Jimenez
Summary: This study aimed to describe the metabolic status and clinical characteristics associated with NPPD in patients with less than five years of T2D diagnosis and explore the role of age in the presentation of psychiatric comorbidities. The results showed that NPPD were frequent comorbidities in the sample, with younger age, female sex, and personal psychiatric history being the most important factors associated with psychiatric comorbidities. Younger subjects had a higher risk for psychiatric disorders and worse metabolic control.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2022)
Article
Clinical Neurology
Alejandra Monserrat Rodriguez-Ramirez, Fatima Meza-Urzua, Valente Cedillo-Rios, Claudia Becerra-Palars, Joanna Jimenez-Pavon, Ingrid Pamela Morales-Cedillo, Marco Antonio Sanabrais-Jimenez, Sandra Hernandez-Munoz, Beatriz Camarena-Medellin
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2020)