Article
Gastroenterology & Hepatology
Anthony Lembo, Braden Kuo, Ramesh Boinpally, Ella Li, Madhuja Mallick, Wieslaw Bochenek, Wilmin Bartolini
Summary: The study found that MD-7246 did not relieve abdominal pain in patients with IBS-D, and most other efficacy measures did not show improvement compared to placebo.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Medicine, General & Internal
Sergii Tkach, Andrii Dorofeyev, Iurii Kuzenko, Oksana Sulaieva, Tetyana Falalyeyeva, Nazarii Kobyliak
Summary: This study found that fecal microbiota transplantation (FMT) can significantly improve symptoms in patients with post-infectious irritable bowel syndrome (PI-IBS) and has better safety and tolerability compared to traditional pharmacotherapy.
FRONTIERS IN MEDICINE
(2022)
Article
Nutrition & Dietetics
Chiara Ricci, Fernando Rizzello, Maria Chiara Valerii, Enzo Spisni, Paolo Gionchetti, Silvia Turroni, Marco Candela, Federica D'Amico, Renato Spigarelli, Irene Bellocchio, Giovanni Marasco, Giovanni Barbara
Summary: Geraniol, an acyclic monoterpene alcohol, has demonstrated anti-inflammatory and antimicrobial properties and positive effects on gut microbiota in IBS patients. In this study, IBS patients treated with a low-absorbable geraniol food supplement (LAGS) showed a significant reduction in IBS symptoms severity score compared to placebo. Geraniol administration also resulted in changes in gut microbiota composition, with a decrease in Oscillospira and an increase in Faecalibacterium. The findings suggest that LAGS is effective in treating overall IBS symptoms and improving gut microbiota profile, particularly in the IBS mixed subtype.
Article
Medicine, General & Internal
Haiyan Tian, Jiuqi Wang, Renyi Feng, Rui Zhang, Han Liu, Chi Qin, Lin Meng, Yongkang Chen, Yu Fu, Dongxiao Liang, Xin Yuan, Yanping Zhai, Qingyong Zhu, Lingjing Jin, Junfang Teng, Xuebing Ding, Xuejing Wang
Summary: This clinical trial aimed to investigate the clinical efficacy of fecal microbiota transplantation (FMT) in patients with progressive supranuclear palsy-Richardson's syndrome (PSP-RS). The results showed that compared to the placebo group, FMT treatment significantly improved motor and nonmotor symptoms in PSP-RS patients, as well as reduced intestinal inflammation and enhanced intestinal barrier function.
Article
Cell Biology
Bani Ahluwalia, Cristina Iribarren, Maria K. Magnusson, Johanna Sundin, Egbert Clevers, Otto Savolainen, Alastair B. Ross, Hans Tornblom, Magnus Simren, Lena Ohman
Summary: In this study, a distinct fecal microbiota and metabolite profile associated with bowel habits was found in patients with IBS, with metabolites being the main driver of this separation. Additionally, the intestinal microenvironment profile differed between IBS patients with constipation or diarrhea, but no clustering was detected in subgroups based on symptom severity or anxiety levels. Ingenuity pathway analysis predicted altered amino acid metabolism and several cellular and molecular functions in IBS patients.
Article
Gastroenterology & Hepatology
Anne Abildtrup Rode, Mahtab Chehri, Laura Rindom Krogsgaard, Kristine Klysner Heno, Anna Tolboll Svendsen, Iben Ribberholt, Morten Helms, Jorgen Engberg, Kristian Schonning, Michael Tvede, Christian Ostergaard Andersen, Ulrich Stab Jensen, Andreas Munk Petersen, Peter Bytzer
Summary: In comparison for recurrent Clostridioides difficile infection, the FMT group had a higher cure rate than the vancomycin or rectal bacteriotherapy group. Rectal bacteriotherapy and vancomycin performed similarly, but FMT with 1-3 infusions was superior to both. FMT may also reduce mortality compared to vancomycin.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Microbiology
S. Holster, D. Repsilber, D. Geng, T. Hyotylainen, A. Salonen, C. M. Lindqvist, S. K. Rajan, W. M. de Vos, R. J. Brummer, J. Konig
Summary: The study found that allogenic FMT led to changes in microbial composition in IBS patients for up to six months, affecting functional profiles but not fecal metabolites. In contrast, autologous FMT had no effect on these factors. Correlations between microbial composition and metabolites also suggested disruptions in microbe-metabolite interactions after allogenic FMT compared to autologous FMT.
BENEFICIAL MICROBES
(2021)
Article
Immunology
Jie Wu, Liang Lv, Chunlian Wang
Summary: The meta-analysis examined the efficacy of fecal microbiota transplantation (FMT) in irritable bowel syndrome (IBS) and found inconsistent results. FMT administered via colonoscopy or gastroscope may benefit IBS patients and improve their quality of life. However, the quality of evidence supporting the use of FMT in IBS is very low.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Eamonn M. M. Quigley, Louise Markinson, Alex Stevenson, F. Peter Treasure, Brian E. Lacy
Summary: MRx1234 has the potential to become a novel, safe treatment option for patients with IBS-C or IBS-D, and for those who have mixed symptoms or transition between subtypes.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
Jenny Lovdahl, Hans Tornblom, Gisela Ringstrom, Olafur S. Palsson, Magnus Simren
Summary: This study evaluated and compared the effectiveness of nurse-administered individual and group hypnotherapy for patients with IBS. The results showed that gut-directed hypnotherapy, delivered individually or in groups by nurses, can relieve IBS symptoms, improve psychological symptoms, and enhance quality of life.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Microbiology
Jun-Jie Hou, Xin Wang, Yu-Ming Wang, Bang-Mao Wang
Summary: Irritable bowel syndrome (IBS) is a common functional gastrointestinal disease that is closely associated with abnormal changes in gut microbiota and bile acids (BAs) metabolism. Recent research progress supports the potential of new therapeutic strategies targeting the microbiota-BAs axis for the treatment of IBS-D and other related diseases.
CRITICAL REVIEWS IN MICROBIOLOGY
(2022)
Letter
Gastroenterology & Hepatology
Yuka Ikeda, Kurumi Taniguchi, Haruka Sawamura, Ai Tsuji, Satoru Matsuda
Summary: Irritable bowel syndrome is an important health concern that may be linked to alterations in the microbiota of the gut-brain axis. Dietary intake can contribute to the production of D-amino acids, which play key roles in cellular physiological processes against oxidative stresses. The gut microbiota may have significant effects on emotional stability through the action of D-amino acids.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
David Gunn, Rabia Topan, Lorna Barnard, Ron Fried, Ivana Holloway, Richard Brindle, Maura Corsetti, Mark Scott, Adam Farmer, Kapil Kapur, David Sanders, Maria Eugenicos, Nigel Trudgill, Peter Whorwell, John Mclaughlin, Ayesha Akbar, Lesley Houghton, Phil G. Dinning, Qasim Aziz, Alexander C. Ford, Amanda J. Farrin, Robin Spiller
Summary: Ondansetron improves stool consistency and reduces the number of days with loose stool and urgency, according to a meta-analysis of this and other similar trials.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Engineering, Multidisciplinary
Yang Liu, Xinjie Yu, Leilei Yu, Fengwei Tian, Jianxin Zhao, Hao Zhang, Long Qian, Qun Wang, Zhengqing Xue, Qixiao Zhai, Wei Chen
Summary: This study aimed to investigate the IBS-D-alleviating effects of Lactobacillus plantarum CCFM8610, and the results showed that this probiotic significantly alleviated clinical symptoms and gut microbiota dysbiosis.
Review
Medicine, General & Internal
Sofia D. Shaikh, Natalie Sun, Andrew Canakis, William Y. Park, Horst Christian Weber
Summary: Irritable Bowel Syndrome (IBS) is a functional disorder of the gastrointestinal tract characterized by abdominal pain and altered bowel habits. It has a high prevalence and disease burden, affecting the quality of life, work productivity and healthcare utilization and costs. IBS is associated with various conditions, including psychiatric comorbidities. The pathophysiology involves dysregulation of the brain-gut axis, leading to changes in intestinal motility, gut permeability, visceral hypersensitivity and gut microbiota composition. This article aims to explore the role of gut microbiota in the pathophysiology of IBS, factors influencing the gut microbiome, and the potential of microbiome as a treatment target.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Qin Liu, Joyce Wing Yan Mak, Qi Su, Yun Kit Yeoh, Grace Chung-Yan Lui, Susanna So Shan Ng, Fen Zhang, Amy Y. L. Li, Wenqi Lu, David Shu-Cheong Hui, Paul K. S. Chan, Francis K. L. Chan, Siew C. Ng
Summary: This study investigated the link between gut microbiome composition and post-acute COVID-19 syndrome. The results showed that the gut microbiome of patients with long-term complications of COVID-19 differed significantly from that of non-COVID-19 controls and patients without post-acute COVID-19 syndrome.
Article
Agriculture, Dairy & Animal Science
Hai-Qin Li, Fan-fan Zhang, Longfei Chen, Qun Yang, Yan-Bing Zeng, Jia Tan, Guang-Hua Fu, Qiu-Ling Fu, Rong-Chang Liu, Yu Huang, Qi Su, Mei-Fang Tan, Zhao-Feng Kang
Summary: This study analyzed the infection status of ALV in a flock of Anyi tile-like gray chickens. The results showed a 29% ALV positive rate, with a higher diversity of ALV-J strains within the same flock.
Article
Agriculture, Dairy & Animal Science
Lidan Hou, Qi Su, Yawen Zhang, Dan Liu, Yaqing Mao, Peng Zhao
Summary: This study developed a dot blot assay based on PCR method to improve the detection sensitivity of Fowl adenovirus (FAdV), especially for low titer samples. The assay is suitable for multiple serotypes and shows great potential for daily monitoring.
Article
Microbiology
Qin Liu, Tao Zuo, Wenqi Lu, Yun Kit Yeoh, Qi Su, Zhilu Xu, Whitney Tang, Keli Yang, Fen Zhang, Louis H. S. Lau, Rashid N. S. Lui, Miu Ling Chin, Rity Wong, Chun Pan Cheung, Wenyi Zhu, Paul K. S. Chan, Francis K. L. Chan, Grace C. Lui, Siew C. Ng
Summary: Understanding the changes in virome and bacteriome after FMT is critical for treating MDRO infections. This study revealed significant alterations in the fecal bacterial microbiota and expansion of phages in patients who successfully decolonized CRE after FMT. The findings suggest that transkingdom interactions between the virome and bacteriome communities play a role in the effectiveness of FMT for treating CRE infections.
Letter
Gastroenterology & Hepatology
Qi Su, Raphaela Iris Lau, Qin Liu, Francis Ka Leung Chan, Siew Chien Ng
Article
Veterinary Sciences
Longfei Chen, Qi Su, Yan Li, Jinjin Wang, Yawen Zhang, Shuang Chang, Yixin Wang, Peng Zhao
Summary: Chicken infectious anemia virus (CIAV) can be transmitted by contaminated live vaccines, which may contribute to its epidemic in poultry. This study evaluated the contamination status of CIAV in vaccines and identified a contaminated attenuated vaccine. The whole genome of the contaminant was sequenced and found to have a close evolutionary relationship with a strain isolated from a chicken farm in Turkey.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Review
Gastroenterology & Hepatology
Raphaela Lau, Fen Zhang, Qin Liu, Qi Su, Francis K. L. Chan, Siew C. Ng
Summary: The gastrointestinal tract is involved in COVID-19 and changes in the gut microbiota may be related to disease outcomes and host immune dysregulation. This article discusses the interactions between SARS-CoV-2 infection and the gut microbiota, key microbial changes, and potential modulatory strategies.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Qi Su, Qin Liu, Lin Zhang, Zhilu Xu, Chenyu Liu, Wenqi Lu, Jessica Y. L. Ching, Amy Li, Joyce Wing Yan Mak, Grace Chung Yan Lui, Susanna So Shan Ng, Kai Ming Chow, David S. C. Hui, Paul K. S. Chan, Francis Ka Leung Chan, Siew C. Ng
Summary: This study conducted longitudinal fecal metagenomic profiling on 142 COVID-19 patients and found that antibiotic-naive patients with COVID-19 had significantly increased abundance and types of ARGs at baseline. The expansion of the resistome was mainly driven by tetracycline, vancomycin, and multidrug-resistant genes, and persiste for at least 6 months after clearance of the SARS-CoV-2 virus. Antibiotic treatment further increased the abundance of ARGs, while oral probiotics significantly reduced the ARGs reservoir in the gut microbiota of COVID-19 patients.
Review
Infectious Diseases
Qin Liu, Zhilu Xu, Min Dai, Qi Su, Francis Ka Leung Chan, Siew C. Ng
Summary: This article summarizes our current knowledge of the changes in gut bacteriophage communities during fecal microbiota transplantation (FMT) and their association with FMT outcome. The studies have shown that FMT is associated with donor-specific engraftment of bacteriophages, characterized by increased viral diversity and richness, and the bacteriophage composition resembles the donor's profile after FMT. Limited studies have also indicated that cure after FMT is more likely when an increased fraction of the recipient enteric virome is occupied by donor-derived taxa, including Caudovirales in Clostridioides difficile infection. Additionally, fecal virome transplant involving the transfer of gut virome communities alone may induce phenotypical and microbiome improvement in various diseases.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Multidisciplinary Sciences
Qi Su, Qin Liu, Raphaela Iris Lau, Jingwan Zhang, Zhilu Xu, Yun Kit Yeoh, Thomas W. H. Leung, Whitney Tang, Lin Zhang, Jessie Q. Y. Liang, Yuk Kam Yau, Jiaying Zheng, Chengyu Liu, Mengjing Zhang, Chun Pan Cheung, Jessica Y. L. Ching, Hein M. Tun, Jun Yu, Francis K. L. Chan, Siew C. Ng
Summary: Using fecal metagenomics data from 2,320 individuals, the authors develop a microbiome-based machine learning approach that shows high accuracy in diagnosing multiple diseases, highlighting its potential in improving non-invasive diagnostics and monitoring treatment response.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Qin Liu, Qi Su, Fen Zhang, Hein M. Tun, Joyce Wing Yan Mak, Grace Chung-Yan Lui, Susanna So Shan Ng, Jessica Y. L. Ching, Amy Li, Wenqi Lu, Chenyu Liu, Chun Pan Cheung, David S. C. Hui, Paul K. S. Chan, Francis Ka Leung Chan, Siew C. Ng
Summary: By integrating clinical features and multi-omics data, the authors identified specific gut microbiome patterns associated with disease severity and development of post-acute COVID-19 syndrome. These findings highlight the potential utility of host phenotype and multi-kingdom microbiota profiling as a prognostic tool for patients with COVID-19.
NATURE COMMUNICATIONS
(2022)
Article
Gastroenterology & Hepatology
Qi Su, Hein M. Tun, Qin Liu, Yun Kit Yeoh, Joyce Wing Yan Mak, Francis K. L. Chan, Siew C. Ng
Summary: This study examined the association between gut microbiota and Irritable bowel syndrome (IBS) subtypes, and found that there are distinct differences in microbiota composition among different IBS subtypes. The microbial diversity is significantly reduced in IBS-D and IBS-U, but not in IBS-C. The study also identified microbial signatures associated with depression in IBS patients. Factors such as gender, age, and dietary patterns have significant effects on gut microbiota in different IBS subtypes. These findings emphasize the importance of personalized gut microbiome modulation approaches for optimal therapeutic effects in different subtypes of IBS.
Article
Microbiology
Haiqin Li, Chunhe Wan, Zhangzhang Wang, Jia Tan, Meifang Tan, Yanbing Zeng, Jiangnan Huang, Yu Huang, Qi Su, Zhaofeng Kang, Xiaoquan Guo
Summary: In this study, a duplex TaqMan qPCR method was developed to simultaneously detect duck Tembusu virus (DTMUV) and goose astrovirus genotype 2 (GoAstV-2). The method, based on high conservation observed in the published genomes of these viruses, showed high specificity and lower limits of detection of 100 copies/μL for DTMUV and 10 copies/μL for GoAstV-2. The method provides a valuable tool for clinical diagnosis of mixed infections of these viruses in geese.
FRONTIERS IN MICROBIOLOGY
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Qi Su, Qin Liu, Yun Kit Yeoh, Joyce Wing Yan Mak, Siew C. Ng