Cellular and molecular imaging of CAR-T cell-based immunotherapy

In vivo imaging of nanoparticle-labeled CAR T cells

(2022) Louise Kiru et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Imaging Primer on Chimeric Antigen Receptor T-Cell Therapy for Radiologists

(2022) Patricia M. de Groot et al.   RADIOGRAPHICS

Comparing CAR and TCR engineered T cell performance as a function of tumor cell exposure

(2022) Tassilo L. A. Wachsmann et al.   OncoImmunology

CAR T cell killing requires the IFNγR pathway in solid but not liquid tumours

(2022) Rebecca C. Larson et al.   NATURE

Uncovering the mode of action of engineered T cells in patient cancer organoids

(2022) Johanna F. Dekkers et al.   NATURE BIOTECHNOLOGY

Balancing activation and co-stimulation of CAR tunes signaling dynamics and enhances therapeutic potency

(2022) Yanting Duan et al.   MOLECULAR THERAPY

New insights into CAR T cell-mediated killing of tumor cells

(2022) David Espie et al.   Frontiers in Immunology

Overcoming on-target, off-tumour toxicity of CAR T cell therapy for solid tumours

(2022) Christian L. Flugel et al.   Nature Reviews Clinical Oncology

Engineering chimeric antigen receptor T cells for solid tumour therapy

(2022) Longwei Liu et al.   Clinical and Translational Medicine

Application of CAR-T Cell Therapy beyond Oncology: Autoimmune Diseases and Viral Infections

(2021) Ekaterina Zmievskaya et al.   Biomedicines

IFNg is Critical for CAR T Cell Mediated Myeloid Activation and Induction of Endogenous Immunity

(2021) Darya Alizadeh et al.   Cancer Discovery

CAR T-Cell Therapy: An Update for Radiologists

(2021) Justin G. Yoon et al.   AMERICAN JOURNAL OF ROENTGENOLOGY

Efficient killing of tumor cells by CAR-T cells requires greater number of engaged CARs than TCRs

(2021) Nadia Anikeeva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Comparative analysis of TCR and CAR signaling informs CAR designs with superior antigen sensitivity and in vivo function

(2021) Alexander I. Salter et al.   Science Signaling

Integration of FRET and sequencing to engineer kinase biosensors from mammalian cell libraries

(2021) Longwei Liu et al.   Nature Communications

Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity

(2021) Bettina Weigelin et al.   Nature Communications

CAR Treg: A new approach in the treatment of autoimmune diseases

(2021) Seyedeh Ameneh Beheshti et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Visualizing CAR-T cell Immunotherapy Using 3 Tesla Fluorine-19 MRI

(2021) Veronica P. Dubois et al.   MOLECULAR IMAGING AND BIOLOGY

CAR T-cell Entry into Tumor Islets Is a Two-Step Process Dependent on IFNγ and ICAM-1

(2021) Chahrazade Kantari-Mimoun et al.   Cancer Immunology Research

Feasibility of real-time in vivo 89Zr-DFO-labeled CAR T-cell trafficking using PET imaging

(2020) Suk Hyun Lee et al.   PLoS One

Signaling from T cell receptors (TCRs) and chimeric antigen receptors (CARs) on T cells

(2020) Ling Wu et al.   Cellular & Molecular Immunology

Chimeric antigen receptor signaling: Functional consequences and design implications

(2020) S. E. Lindner et al.   Science Advances

Toward Better Understanding and Management of CAR-T Cell–Associated Toxicity

(2020) Andrea Schmidts et al.   Annual Review of Medicine

Multiple Signaling Roles of CD3ε and Its Application in CAR-T Cell Therapy

(2020) Wei Wu et al.   CELL

Inefficient CAR-proximal signaling blunts antigen sensitivity

(2020) Venugopal Gudipati et al.   NATURE IMMUNOLOGY

A rational mouse model to detect on-target, off-tumor CAR T cell toxicity

(2020) Mauro Castellarin et al.   JCI Insight

The Role of Immunological Synapse in Predicting the Efficacy of Chimeric Antigen Receptor (CAR) Immunotherapy

(2020) Dongfang Liu et al.   Cell Communication and Signaling

Molecular Imaging of Chimeric Antigen Receptor T Cells by ICOS-ImmunoPET

(2020) Federico Simonetta et al.   CLINICAL CANCER RESEARCH

Multifocal Necrotizing Leukoencephalopathy With Preferential Microglia Toxicity in a Patient Treated With Chimeric Antigen Receptor T-Cells and Review of the Literature

(2020) Daniel F Marker et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Non-invasive monitoring of the kinetic infiltration and therapeutic efficacy of nanoparticle-labeled chimeric antigen receptor T cells in glioblastoma via 7.0-Tesla magnetic resonance imaging

(2020) Tian Xie et al.   CYTOTHERAPY

Engineering and Design of Chimeric Antigen Receptors

(2019) Sonia Guedan et al.   Molecular Therapy-Methods & Clinical Development

Killing Mechanisms of Chimeric Antigen Receptor (CAR) T Cells

(2019) Mohamed-Reda Benmebarek et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

3D model for CAR‐mediated cytotoxicity using patient‐derived colorectal cancer organoids

(2019) Theresa E Schnalzger et al.   EMBO JOURNAL

Single-cell imaging of CAR T cell activity in vivo reveals extensive functional and anatomical heterogeneity

(2019) Marine Cazaux et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Biophysical basis underlying dynamic Lck activation visualized by ZapLck FRET biosensor

(2019) Rongxue Wan et al.   Science Advances

Dynamic Profiling of Antitumor Activity of CAR T Cells Using Micropatterned Tumor Arrays

(2019) Xiao Wang et al.   Advanced Science

Imaging CAR T Cell Trafficking with eDHFR as a PET Reporter Gene

(2019) Mark A. Sellmyer et al.   MOLECULAR THERAPY

Engineering strategies to overcome the current roadblocks in CAR T cell therapy

(2019) Sarwish Rafiq et al.   Nature Reviews Clinical Oncology

Positron emission tomography of adoptively transferred chimeric antigen receptor T cells with Zirconium-89 oxine

(2018) Michael Ryan Weist et al.   JOURNAL OF NUCLEAR MEDICINE

Immunological Synapse Predicts Effectiveness of Chimeric Antigen Receptor Cells

(2018) Wei Xiong et al.   MOLECULAR THERAPY

Chimeric antigen receptor T cells form nonclassical and potent immune synapses driving rapid cytotoxicity

(2018) A. J. Davenport et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CAR T cell immunotherapy for human cancer

(2018) Carl H. June et al.   SCIENCE

TCR Signaling: Mechanisms of Initiation and Propagation

(2018) Adam H. Courtney et al.   TRENDS IN BIOCHEMICAL SCIENCES

Single-fluorophore biosensors for sensitive and multiplexed detection of signalling activities

(2018) Sohum Mehta et al.   NATURE CELL BIOLOGY

Phosphoproteomic analysis of chimeric antigen receptor signaling reveals kinetic and quantitative differences that affect cell function

(2018) Alexander I. Salter et al.   Science Signaling

Teaching an old dog new tricks: next-generation CAR T cells

(2018) Nicholas Tokarew et al.   BRITISH JOURNAL OF CANCER

Chimeric Antigen Receptor Library Screening Using a Novel NF-κB/NFAT Reporter Cell Platform

(2018) Julian Rydzek et al.   MOLECULAR THERAPY

Expanding the Therapeutic Window for CAR T Cell Therapy in Solid Tumors: The Knowns and Unknowns of CAR T Cell Biology

(2018) Keisuke Watanabe et al.   Frontiers in Immunology

Comparison of T Cell Activities Mediated by Human TCRs and CARs That Use the Same Recognition Domains

(2017) Daniel T. Harris et al.   JOURNAL OF IMMUNOLOGY

Quantitative Imaging Approaches to Study the CAR Immunological Synapse

(2017) Malini Mukherjee et al.   MOLECULAR THERAPY

T-cell calcium dynamics visualized in a ratiometric tdTomato-GCaMP6f transgenic reporter mouse

(2017) Tobias X Dong et al.   eLife

Imaging Spatiotemporal Activities of ZAP-70 in Live T Cells Using a FRET-Based Biosensor

(2016) Kaitao Li et al.   ANNALS OF BIOMEDICAL ENGINEERING

Real-Time Analysis of Calcium Signals during the Early Phase of T Cell Activation Using a Genetically Encoded Calcium Biosensor

(2016) Marie Le Borgne et al.   JOURNAL OF IMMUNOLOGY

Reengineering chimeric antigen receptor T cells for targeted therapy of autoimmune disease

(2016) C. T. Ellebrecht et al.   SCIENCE

Molecular Mechanisms for cAMP-Mediated Immunoregulation in T cells – Role of Anchored Protein Kinase A Signaling Units

(2016) Vanessa L. Wehbi et al.   Frontiers in Immunology

Small-Molecule Two-Photon Probes for Bioimaging Applications

(2015) Hwan Myung Kim et al.   CHEMICAL REVIEWS

Structural interplay between germline interactions and adaptive recognition determines the bandwidth of TCR-peptide-MHC cross-reactivity

(2015) Jarrett J Adams et al.   NATURE IMMUNOLOGY

Synthetic biology in cell-based cancer immunotherapy

(2015) Deboki Chakravarti et al.   TRENDS IN BIOTECHNOLOGY

Antibody-modified T cells: CARs take the front seat for hematologic malignancies

(2014) M. V. Maus et al.   BLOOD

Optimized ratiometric calcium sensors for functional in vivo imaging of neurons and T lymphocytes

(2014) Thomas Thestrup et al.   NATURE METHODS

Efficacy and Toxicity Management of 19-28z CAR T Cell Therapy in B Cell Acute Lymphoblastic Leukemia

(2014) M. L. Davila et al.   Science Translational Medicine

The Immunological Synapse

(2014) M. L. Dustin   Cancer Immunology Research

Deep-tissue photoacoustic tomography of Förster resonance energy transfer

(2013) Yu Wang et al.   JOURNAL OF BIOMEDICAL OPTICS

2-photon imaging of phagocyte-mediated T cell activation in the CNS

(2013) Marija Pesic et al.   JOURNAL OF CLINICAL INVESTIGATION

A combination of fluorescent NFAT and H2B sensors uncovers dynamics of T cell activation in real time during CNS autoimmunity

(2013) Dmitri Lodygin et al.   NATURE MEDICINE

Chimeric Antigen Receptor–Modified T Cells for Acute Lymphoid Leukemia

(2013) Stephan A. Grupp et al.   NEW ENGLAND JOURNAL OF MEDICINE

T Cell Activation Results in Conformational Changes in the Src Family Kinase Lck to Induce Its Activation

(2013) A. Stirnweiss et al.   Science Signaling

Engineered Luciferase Reporter from a Deep Sea Shrimp Utilizing a Novel Imidazopyrazinone Substrate

(2012) Mary P. Hall et al.   ACS Chemical Biology

The molecular determinants of CD8 co-receptor function

(2012) David K. Cole et al.   IMMUNOLOGY

A FRET-Based Biosensor for Imaging SYK Activities in Living Cells

(2011) Xue Xiang et al.   Cellular and Molecular Bioengineering

Treating cancer with genetically engineered T cells

(2011) Tristen S. Park et al.   TRENDS IN BIOTECHNOLOGY

Bioluminescence imaging: progress and applications

(2011) Christian E. Badr et al.   TRENDS IN BIOTECHNOLOGY

Case Report of a Serious Adverse Event Following the Administration of T Cells Transduced With a Chimeric Antigen Receptor Recognizing ERBB2

(2010) Richard A Morgan et al.   MOLECULAR THERAPY

Tyrosine phosphorylation: thirty years and counting

(2009) Tony Hunter   CURRENT OPINION IN CELL BIOLOGY

Construction and Preclinical Evaluation of an Anti-CD19 Chimeric Antigen Receptor

(2009) James N. Kochenderfer et al.   JOURNAL OF IMMUNOTHERAPY

Chimeric Receptors Containing CD137 Signal Transduction Domains Mediate Enhanced Survival of T Cells and Increased Antileukemic Efficacy In Vivo

(2009) Michael C. Milone et al.   MOLECULAR THERAPY

Fluorescence Proteins, Live-Cell Imaging, and Mechanobiology: Seeing Is Believing

(2008) Yingxiao Wang et al.   Annual Review of Biomedical Engineering

Sleeping Beauty Transposon‐mediated Engineering of Human Primary T Cells for Therapy of CD19+ Lymphoid Malignancies

(2008) Xin Huang et al.   MOLECULAR THERAPY