期刊
ACTA HISTOCHEMICA
卷 125, 期 7, 页码 -出版社
ELSEVIER GMBH
DOI: 10.1016/j.acthis.2023.152091
关键词
Giant cells; Giant cell granuloma; Giant cell tumor; Cell-in-cell formation
类别
Cell cannibalism was investigated as a method to predict the clinical behavior of central giant cell granuloma (CGCG). The quantification of cannibal multinucleated giant cells (CMGC) through routine anatomopathological examination can help predict the clinical behavior of CGCG.
Central giant cell granuloma (CGCG) is a benign jaw lesion with variable clinical behavior. Cell cannibalism is a cellular process associated with aggressiveness and invasion in malignant neoplasms. Here, we morphologically investigated cell cannibalism as an auxiliary method to predict CGCG clinical behavior. Cell cannibalism was quantitatively evaluated in 19 cases of peripheral giant cell granuloma (PGCG), 38 cases of CGCG (nonaggressive and aggressive), and 19 cases of giant cell tumor of bone (GCT) stained with hematoxylin and eosin. Ttest was performed to assess the differences between the variables analyzed (p & LE; 0.05). Cell cannibalism was identified in 21% of non-aggressive CGCGs and 68.4% of aggressive CGCGs. A significantly higher amount of cannibal multinucleated giant cells (CMGC) was observed in aggressive CGCG compared to PGCG and nonaggressive CGCG (p = 0.042; p = 0.044, respectively). There were no significant differences in the CMGC index between non-aggressive CGCG and PGCG (p = 0.858) and between aggressive CGCG and GCT (p = 0.069). CGGC cases that exhibited rapid growth and tooth displacement and/or root resorption had a higher amount of CMGC (p = 0.035; p = 0.041, respectively). Cell cannibalism can be identified in CGCG through routine anatomopathological examination. The quantification of CMGC can help to predict the clinical behavior of central giant cell granuloma.
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