Optimization of a Protein-Targeted Medicine into an RNA-Specific Small Molecule

Pervasive transcriptome interactions of protein-targeted drugs

(2023) Linglan Fang et al.   Nature Chemistry

Transcriptome-Wide Mapping of Small-Molecule RNA-Binding Sites in Cells Informs an Isoform-Specific Degrader of QSOX1 mRNA

(2022) Yuquan Tong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Targeting RNA structures with small molecules

(2022) Jessica L. Childs-Disney et al.   NATURE REVIEWS DRUG DISCOVERY

Reprogramming of Protein-Targeted Small-Molecule Medicines to RNA by Ribonuclease Recruitment

(2021) Peiyuan Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

FGFR Inhibitors in Oncology: Insight on the Management of Toxicities in Clinical Practice

(2021) Anuhya Kommalapati et al.   Cancers

Visualizing a protonated RNA state that modulates microRNA-21 maturation

(2020) Jared T. Baisden et al.   Nature Chemical Biology

Perspectives on targeting RNA with small molecules to capture opportunities at the intersection of chemistry, biology, and medicine

(2019) Matthew D. Disney   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Calculation of accurate interatomic contact surface areas for the quantitative analysis of non-bonded molecular interactions

(2019) Judemir Ribeiro et al.   BIOINFORMATICS

Measuring RNA–Ligand Interactions with Microscale Thermophoresis

(2018) Michelle H. Moon et al.   BIOCHEMISTRY

Receptor tyrosine kinases (RTKs) in breast cancer: signaling, therapeutic implications and challenges

(2018) Ramesh Butti et al.   Molecular Cancer

Mechanisms of receptor tyrosine kinase activation in cancer

(2018) Zhenfang Du et al.   Molecular Cancer

Principles for targeting RNA with drug-like small molecules

(2018) Katherine Deigan Warner et al.   NATURE REVIEWS DRUG DISCOVERY

The ReFRAME library as a comprehensive drug repurposing library and its application to the treatment of cryptosporidiosis

(2018) Jeff Janes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inforna 2.0: A Platform for the Sequence-Based Design of Small Molecules Targeting Structured RNAs

(2016) Matthew D. Disney et al.   ACS Chemical Biology

Small molecules, big targets: drug discovery faces the protein–protein interaction challenge

(2016) Duncan E. Scott et al.   NATURE REVIEWS DRUG DISCOVERY

Structural and dynamic insights into the energetics of activation loop rearrangement in FGFR1 kinase

(2015) Tobias Klein et al.   Nature Communications

The Effect of Mutations on Drug Sensitivity and Kinase Activity of Fibroblast Growth Factor Receptors: A Combined Experimental and Theoretical Study

(2015) Tom D. Bunney et al.   EBioMedicine

Targeting FGFR with Dovitinib (TKI258): Preclinical and Clinical Data in Breast Cancer

(2013) F. Andre et al.   CLINICAL CANCER RESEARCH

MicroRNA-21 targets tumor suppressor genes in invasion and metastasis

(2008) Shuomin Zhu et al.   CELL RESEARCH

Design, Structure−Activity Relationships and in Vivo Characterization of 4-Amino-3-benzimidazol-2-ylhydroquinolin-2-ones: A Novel Class of Receptor Tyrosine Kinase Inhibitors

(2008) Paul A. Renhowe et al.   JOURNAL OF MEDICINAL CHEMISTRY