Article
Clinical Neurology
Virginia D. Buckles, Chengjie Xiong, Randall J. Bateman, Jason Hassenstab, Ricardo Allegri, Sarah B. Berman, Jasmeer P. Chhatwal, Adrian Danek, Anne M. Fagan, Bernardino Ghetti, Alison Goate, Neill Graff-Radford, Mathias Jucker, Johannes Levin, Daniel S. Marcus, Colin L. Masters, Lena McCue, Eric McDade, Hiroshi Mori, Krista L. Moulder, James M. Noble, Katrina Paumier, Oliver Preische, John M. Ringman, Nick C. Fox, Stephen Salloway, Peter R. Schofield, Ralph Martins, Jonathan Voglein, John C. Morris
Summary: As prevention trials progress with ADAD participants, it is important to understand similarities and differences with sporadic LOAD to ensure generalizability of findings. Cognitive trajectories of ADAD MCs were compared to autopsy-confirmed LOAD individuals, showing differences in rates of decline between the two groups. While both groups showed declining cognitive performance, ADAD MCs declined more rapidly post-symptom onset, indicating common AD pathologies but with some distinct differences.
ALZHEIMERS & DEMENTIA
(2022)
Review
Nutrition & Dietetics
Piotr Londzin, Milena Zamora, Beata Kakol, Aleksandra Taborek, Joanna Folwarczna
Summary: Caffeine may have beneficial effects against Alzheimer's disease and related cognitive impairment, but the results of studies are inconclusive, and further research is needed to elucidate the role of caffeine in cognition and possibly AD risk.
Article
Clinical Neurology
David D. Ward, Lindsay M. K. Wallace, Kenneth Rockwood
Summary: This study aimed to investigate the association between health-deficit accumulation and the risks of MCI and dementia independently of the APOE genotype; the results showed that an increasing frailty index was associated with a higher risk of developing MCI and dementia, regardless of the presence of the APOE e4 allele.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2021)
Article
Chemistry, Multidisciplinary
Yanyan Liu, Xuan Zhang, Lili Zhang, Hongmei Zhu, Jiurong Chen, Ziyuan Lin, Bin Zhou, Shanling Liu, He Wang, Huaqin Sun
Summary: This study revealed differences in protein expression and biological processes between genders in individuals with Down syndrome, providing insights for personalized detection and treatment.
Article
Clinical Neurology
Winston Chiong, Benjamin David Tolchin, Richard J. Bonnie, Katharina M. Busl, Salvador Cruz-Flores, Leon G. Epstein, Ericka P. Greene, Judy Illes, Matthew Kirschen, Daniel G. Larriviere, Sneha Mantri, Michael A. Rubin, Barney J. Stern, Lynne P. Taylor
Summary: Alzheimer's disease is a feared and stigmatized condition that has a significant impact on patients, families, and society as a whole. There is an urgent need for further research in effective treatments for AD, and patients require more support from clinicians and communities, with trust being a fundamental aspect of this support.
Article
Clinical Neurology
Johannes Levin, Jonathan Voglein, Yakeel T. Quiroz, Randall J. Bateman, Valentina Ghisays, Francisco Lopera, Eric McDade, Eric Reiman, Pierre N. Tariot, John C. Morris
Summary: The amyloid cascade hypothesis for Alzheimer's disease has faced challenges due to inconsistent clinical benefits of drugs targeting amyloid beta peptide. It is important to conduct intervention studies in cognitively unimpaired individuals at risk for dementia to further evaluate the hypothesis.
ALZHEIMERS & DEMENTIA
(2022)
Article
Immunology
Sarah A. Cooley, Brittany Nelson, Anna Boerwinkle, Kevin E. Yarasheski, Kris M. Kirmess, Matthew R. Meyer, Suzanne E. Schindler, John C. Morris, Anne Fagan, Beau M. Ances, Jane A. O'Halloran
Summary: The plasma amyloid-beta (A beta) 42/A beta 40 ratio, a blood-based biomarker for brain amyloid in Alzheimer disease, is not abnormal in older cognitively normal or cognitively impaired people with HIV.
CLINICAL INFECTIOUS DISEASES
(2023)
Review
Environmental Sciences
Roshni Patel, Michael Aschner
Summary: Alzheimer's disease affects neuron function and is caused by elevated levels of heavy metals such as lead, zinc, and copper. Both copper and Alzheimer's disease target specific areas in the brain, impacting motor skills and critical thinking. Studies have shown a relationship between copper ion concentration and the formation of amyloid-beta plaques, furthering neurodegeneration.
Article
Clinical Neurology
Zahra Shirzadi, Wai-Ying W. Yau, Stephanie A. Schultz, Aaron P. Schultz, Matthew R. Scott, Maged Goubran, Parisa Mojiri-Forooshani, Nelly Joseph-Mathurin, Kejal Kantarci, Greg Preboske, Marieke J. H. Wermer, Clifford Jack, Tammie Benzinger, Kevin Taddei, Hamid R. Sohrabi, Reisa A. Sperling, Keith A. Johnson, Randall J. Bateman, Ralph N. Martins, Steven M. Greenberg, Jasmeer P. Chhatwal
Summary: This study found that white matter injury appears and progresses in D-CAA patients before the onset of cerebral microbleeds, indicating that white matter disruption measures may serve as valuable biomarkers for the progression of D-CAA.
ANNALS OF NEUROLOGY
(2022)
Article
Multidisciplinary Sciences
Zhen-Kai Ngian, Yow-Yong Tan, Ching-Thong Choo, Wei-Qi Lin, Chao-Yong Leow, Shan-Jie Mah, Mitchell Kim-Peng Lai, Christopher Li-Hsian Chen, Chin-Tong Ong
Summary: The retention of intron 11 of the Tau gene in Alzheimer's disease (AD) leads to the production of truncated Tau11i protein, which is enriched in the brains of AD patients and exhibits biochemical properties resembling pathological Tau species. Therefore, the retention of intron 11 of the Tau gene might be an early biomarker of AD pathology.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Neurosciences
Caterina Di Lauro, Carolina Bianchi, Alvaro Sebastian-Serrano, Lucia Soria-Tobar, Beatriz Alvarez-Castelao, Annette Nicke, Miguel Diaz-Hernandez
Summary: The upregulation of P2X7 in patients with tauopathies and a tauopathy mouse model suggests its involvement in neuroinflammation and potential as a target for treating tauopathies. Pharmacological or genetic blockade of P2X7 in P301S mice reversed microglial activation, reduced intraneuronal phosphorylated Tau levels, and improved cellular survival, motor and memory deficits, and anxiolytic profile. Conversely, overexpression of P2X7 worsened Tau-induced toxicity and exacerbated motor and memory deficits in P301S mice.
PROGRESS IN NEUROBIOLOGY
(2022)
Article
Clinical Neurology
Victor Montal, Eduard Vilaplana, Jordi Pegueroles, Alexandre Bejanin, Daniel Alcolea, Maria Carmona-Iragui, Jordi Clarimon, Johannes Levin, Carlos Cruchaga, Neill R. Graff-Radford, James M. Noble, Jae-Hong Lee, Ricardo Allegri, Celeste M. Karch, Christoph Laske, Peter R. Schofield, Stephen Salloway, Beau Ances, Tammie Benzinger, Eric McDale, Randall Bateman, Rafael Blesa, Raquel Sanchez-Valle, Alberto Lleo, Juan Fortea
Summary: The study suggests a biphasic trajectory for brain structural changes in early preclinical Alzheimer's disease, with increases in cortical thickness and decreases in cortical diffusivity followed by cortical thinning and cortical diffusivity increases in later stages. The timing of these changes aligns with the start of tau biomarker alterations.
ALZHEIMERS & DEMENTIA
(2021)
Article
Engineering, Biomedical
Claudia Corbo, Andrew A. Li, Hossein Poustchi, Gha Young Lee, Sabrina Stacks, Roberto Molinaro, Philip Ma, Theo Platt, Shahed Behzadi, Robert Langer, Vivek Farias, Omid C. Farokhzad
Summary: As the population affected by Alzheimer's disease grows, there is a need for a noninvasive and accurate diagnostic tool, which may be achieved through the unique properties of nanoparticles. Research shows that disease-specific protein coronas formed around nanoparticles can successfully identify subtle changes in plasma protein patterns and detect AD with high specificity and sensitivity. This promising, noninvasive technology has implications for early detection and intervention in AD and other diseases.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Clinical Neurology
Daniel Vasquez, Melissa Sierra Castrillon, Manuela Gomez Vega, Clara Gomez Henck, David Aguillon, Elkin Garcia-Cifuentes, Alberto Jaramillo-Jimenez, Juan Esteban Velez, Lucia Madrigal, Francisco Lopera
Summary: This study investigated the association between quality of life scores and clinical and sociodemographic variables in patients with the PSEN1-E280A mutation, finding that factors related to loss of functionality and independence had a greater impact on quality of life.
NEUROLOGICAL SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Simon M. Bell, Katy Barnes, Matteo De Marco, Pamela J. Shaw, Laura Ferraiuolo, Daniel J. Blackburn, Annalena Venneri, Heather Mortiboys
Summary: Alzheimer's disease is the most common cause of dementia globally, characterized by amyloid beta and tau protein accumulation with currently no approved treatment. In addition to protein aggregation, other pathological changes and early alterations in mitochondrial function are present. Mitochondrial dysfunction caused by amyloid and tau may serve as potential biomarkers for early detection of AD, but further research with larger patient cohorts is needed for clinical application.