期刊
MATURITAS
卷 93, 期 -, 页码 28-33出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.maturitas.2016.06.002
关键词
Ageing; Carnosine; Inflammation; Oxidative stress; Advanced glycation end products; Signalling pathways
资金
- Monash Graduate Scholarship
- Monash International Postgraduate Scholarship
- Australian National Health and Medical Research Council
- National Heart Foundation Future Leader Fellowship
- Royal Australasian College of Physicians
- Foundation for High Blood Pressure Research
The causes of ageing are usually regarded as multifactorial; thus effective regulation might be achieved by intervention at multiple sites. It has been suggested that the endogenous dipeptide carnosine, also available as a food supplement, possesses anti-ageing activity and may achieve its reported age-alleviating effects via a number of mechanisms. Carnosine's possible anti-ageing mechanisms are therefore discussed; the evidence suggests that inhibition of the mechanistic target of rapamycin and carbonyl scavenging may be involved. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
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