Article
Biochemistry & Molecular Biology
Juliana Ferreira Boelter, Solange Cristina Garcia, Gabriela Goethel, Mariele Feiffer Charao, Livia Marchi de Melo, Adriano Brandelli
Summary: This study investigated the potential in vivo toxicity of nanoliposomes encapsulating the antimicrobial peptide nisin using the nematode Caenorhabditis elegans as an alternative model. The results showed that nisin and liposomes had low toxicity to C. elegans, suggesting that liposome encapsulation can be considered a non-toxic delivery system for nisin.
Article
Chemistry, Multidisciplinary
Jinju Cai, Jingru Shi, Chen Chen, Mengping He, Zhiqiang Wang, Yuan Liu
Summary: SFAs substantially enhance the antibacterial activity against mcr-positive bacteria, inhibit biofilm formation and eliminate matured biofilms, prevent the spread of mobile colistin resistance, and exhibit excellent therapeutic effect in animal infection models.
Article
Pharmacology & Pharmacy
Jingru Shi, Chen Chen, Dejuan Wang, Ziwen Tong, Zhiqiang Wang, Yuan Liu
Summary: The study demonstrated that peptide WW307 displayed potent antibacterial activity against MDR bacteria, especially MRSA and Gram-negative pathogens carrying bla(NDM-5), mcr-1 or tet(X4). Additionally, WW307 showed great biofilm inhibition and eradication activity. Safety and stability experiments also indicated that WW307 had potential as a candidate for combating MDR pathogens.
Article
Microbiology
Di Zhang, Jingyi Chen, Qian Jing, Zheng Chen, Azeem Ullah, Longguang Jiang, Ke Zheng, Cai Yuan, Mingdong Huang
Summary: A new antibiotic peptide, PcG(3)K(5)(RW)(3), has been identified to show increased antimicrobial efficacy against both Gram-positive and Gram-negative bacteria. Furthermore, the peptide demonstrates potent antimicrobial effect upon red light illumination and is safe for mammalian cells, promoting wound healing in a mouse infection model.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tomasz Szostek, Daniel Szulczyk, Jolanta Szymanska-Majchrzak, Michal Kolinski, Sebastian Kmiecik, Dagmara Otto-Slusarczyk, Aleksandra Zawodnik, Eliza Rajkowska, Kinga Chaniewicz, Marta Struga, Piotr Roszkowski
Summary: Sixteen new Ciprofloxacin derivatives were designed and synthesized, and their antimicrobial and cytotoxic activities were evaluated. Derivative 12 exhibited the highest antimicrobial activity and showed good activity against cancer cells without cytotoxicity to normal cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Environmental
Libing Chu, Jianlong Wang, Shijun He, Chuanhong Chen, Laszlo Wojnarovits, Erzsebet Takacs
Summary: The study investigated the treatment of pharmaceutical wastewater from an erythromycin production factory by gamma irradiation. Results showed a high removal efficiency of antibiotics and antimicrobial resistance genes, with the addition of peroxymonosulfate further enhancing erythromycin removal at lower doses of irradiation. Ionizing radiation-coupled technique shows promise in reducing antibiotics, ARGs, and antimicrobial activity in pharmaceutical wastewater.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Biotechnology & Applied Microbiology
Gil Sander Prospero Gama, Alexandre Santos Pimenta, Francisco Marlon Carneiro Feijo, Caio Sergio Santos, Bruno Caio Chaves Fernandes, Moacir Franco de Oliveira, Elias Costa de Souza, Thays V. C. Monteiro, Maira Fasciotti, Tatiane Kelly Barbosa de Azevedo, Rafael Rodolfo de Melo, Ananias Francisco Dias Junior
Summary: The antibacterial and antifungal action of two types of wood vinegar (Eucalyptus urograndis and Bambusa vulgaris) was evaluated, and their chemical profiles were determined. Both types of wood vinegar exhibited significant antimicrobial activity, with the bamboo vinegar being more effective. GC/MS analysis showed that the chemical compositions of the two wood vinegars were similar but with some significant differences.
WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Swagatam Barman, Sudip Mukherjee, Logia Jolly, Cassandra Troiano, Alessandro Grottesi, Debajyoti Basak, Paolo Calligari, Brinta Bhattacharjee, Gianfranco Bocchinfuso, Lorenzo Stella, Jayanta Haldar
Summary: New isoamphipathic antibacterial molecules with positional isomerism were designed and showed good antibacterial activity with low toxicity towards mammalian cells. The ortho isomer, IAM-1, exhibited strong selective activity towards bacterial membranes. Furthermore, IAM-1 demonstrated efficacy against dormant bacteria and mature biofilms, as well as moderate in vivo activity against MRSA wound infection with no detectable dermal toxicity.
Article
Immunology
Winston E. Anthony, Carey-Ann D. Burnham, Gautam Dantas, Jennie H. Kwon
Summary: This review discusses the gut as a reservoir for antimicrobial resistance and pathogen colonization, with a focus on beta-lactam and plasmid-mediated quinolone resistance. It also explores the use of functional metagenomics and long-read sequencing technologies to detect and understand antimicrobial resistance genes within the gut microbiome, as well as the potential for future microbiome-directed methods for detecting and preventing infections.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Multidisciplinary Sciences
Tokuhiro Matsubara, Shuichi Maki, Yukiko Toshimori
Summary: The new disinfectant demonstrated strong bactericidal and virucidal activities, quickly inactivating all microorganisms except enterovirus. Within 5 min of exposure to the disinfectant, infectivity of 12 microbial strains was eliminated. The disinfectant showed minimal acute cytotoxicity in vitro and all volunteers tested negative in the human open patch test.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Dmitriy Korolev, Michael Shumilo, Galina Shulmeyster, Alexander Krutikov, Alexey Golovkin, Alexander Mishanin, Anna Spiridonova, Olga Kulagina, Michael Galagudza
Summary: The overuse of antibiotics has led to the emergence of resistant bacteria. Silver nanoparticles are a good alternative with antibacterial activity against various bacteria, including multidrug-resistant strains. Combining them with known antibiotics shows a synergistic effect, enhancing the antimicrobial activity. This study focused on synthesizing conjugates of silver nanoparticles with lincomycin and cefazolin, and evaluating their physicochemical properties, cytotoxicity, and synergism of antimicrobial activity. The obtained samples demonstrated 50% antimicrobial activity, making them suitable for topical drug preparations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Karol Sklodowski, Sylwia Joanna Chmielewska-Deptula, Ewelina Piktel, Przemyslaw Wolak, Tomasz Wollny, Robert Bucki
Summary: Antimicrobial resistance is a global problem that requires new approaches to combat infections caused by antibiotic resistant bacteria. Nanomedicine has potential in delivering drugs and targeting specific cells, such as pathogenic microbes. Metallic nanoparticles and nanosystems offer unique properties, including the ability to overcome microbial resistance, enhance antimicrobial activity, reduce toxicity, and reduce dosage. This review discusses the synergistic interactions, core structure, and combination therapy of metallic nanoparticles, as well as their biocompatibility, toxicity control, resistance induction, and effects on the host microbiome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Microbiology
Ronan A. Murphy, Matthew Coates, Sophia Thrane, Akshay Sabnis, James Harrison, Silke Schelenz, Andrew M. Edwards, Thomas Vorup-Jensen, Jane C. Davies
Summary: Pseudomonas aeruginosa is a common pathogen causing lung infections in people with cystic fibrosis. Glatiramer acetate, a drug used in multiple sclerosis treatment, has shown potential antipseudomonal activity. This study demonstrates that glatiramer acetate improves the efficacy of tobramycin, an antibiotic, against P. aeruginosa. It disrupts the bacterial cell wall and enhances the permeability of P. aeruginosa, allowing tobramycin to work more effectively. This research suggests that glatiramer acetate could be repurposed as an antibiotic resistance breaker for P. aeruginosa.
MICROBIOLOGY SPECTRUM
(2022)
Article
Chemistry, Physical
B. Gandhi, M. Jhansi, S. S. Deshpande, T. Vinay, S. Misra, Shiva Shanker Kaki
Summary: A series of 1,3,4-oxadiazole based 1-monoacylglycerol derivatives were synthesized and evaluated for their antimicrobial and anticancer activity. The derivatives showed noticeable inhibition on selected bacterial and fungal strains as well as broad spectrum cytotoxicity against various cell lines. These lipidic oxadiazole derivatives hold potential as promising antitumor agents and further studies can be conducted to design analogs with improved therapeutic effects.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Biochemistry & Molecular Biology
A. Norrie Pearce, Dan Chen, Liam R. Edmeades, Melissa M. Cadelis, Azza Troudi, Jean Michel Brunel, Marie-Lise Bourguet-Kondracki, Brent R. Copp
Summary: Evaluation of succinylprimaquine-polyamine conjugates identified two derivatives with intrinsic antimicrobial activity against Staphylococcus aureus and Cryptococcus neoformans. In the presence of doxycycline, these compounds also showed potent antibiotic adjuvant properties against Pseudomonas aeruginosa. Further studies explored the structure-activity relationship to enhance antimicrobial properties against P. aeruginosa.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Physical
Zibo Li, Qian Liu, Qiang Li, Mingdong Dong
Summary: This study investigates the lubrication effect of hydrated halogen anions on positively charged surfaces using atomic force microscopy and friction force microscopy. The results show that the mechanical properties of the hydration layers depend on the concentration of electrolyte solutions, and the friction coefficient and friction dissipation are significantly lower at low concentrations. Superlubricity can be achieved in low concentration electrolyte solution. These findings provide insights into the origins of hydration lubrication.
Article
Chemistry, Multidisciplinary
Ziwei Su, Xiangxiang Zhang, Weichen Wang, Mingdong Dong, Xiaojun Han
Summary: This study demonstrates an efficient way to build self-powered artificial cells containing thylakoids that convert light energy into chemical energy to supply ATP. The generated ATP and NADPH can be used in promoting biological enzyme cascade reactions and provide a pathway for building more complex artificial cells.
CHINESE JOURNAL OF CHEMISTRY
(2023)
Article
Engineering, Biomedical
Sofie Husted Laursen, Signe Gellert Hansen, Mehmet Berat Taskin, Menglin Chen, Lise Wogensen, Jens Vinge Nygaard, Susanne Maigaard Axelsen
Summary: This study provides new insights into future pelvic organ prolapse (POP) repair in postmenopausal women by demonstrating the sufficient support and biocompatibility of electrospun polycaprolactone (PCL) meshes coated with stem cells and growth factor in elderly rats in the long term, thus highlighting its potential clinical significance.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2023)
Article
Thermodynamics
Botao Zhang, Shengjie Gong, Shichang Dong, Zhenqin Xiong, Qiang Guo
Summary: Boiling-induced vibration characteristics and mechanisms were investigated in pool boiling experiments. Turbulence and bubble collapse were identified as the two main mechanisms causing vibration. The peak amplitude of the first natural frequency increased with increasing heat flux and decreasing subcooling degree for turbulence-induced vibration. The peak amplitude of the second natural frequency increased with increasing heat flux for a certain subcooled temperature above 10 degrees C, and remained stable for lower subcooled temperatures. The dominant mechanism transitioned from bubble collapse to turbulence with decreasing subcooled temperature for a certain heat flux. The highest root-mean-square (RMS) value of vibration velocity corresponded to an increasing subcooled temperature with increasing heat flux.
APPLIED THERMAL ENGINEERING
(2023)
Article
Engineering, Environmental
Yanping Zhang, Alice Le Friec, Di Sun, Menglin Chen
Summary: The development of flexible electronics with adjustable performance offers a promising approach for treating cardiac diseases, overcoming the limitations of conventional electronic systems due to biomechanical mismatches. By exploring the natural flow behavior of polymer melt in Melt electrowriting (MEW), researchers created a fibrous mesh electrode with a sinusoidal anisotropic structure resembling the collagen fiber architecture in the heart. This anisotropic, stretchable electrode mesh demonstrated the ability to synchronize cardiomyocyte beating through its biomimetic viscoelastic behavior and fine-tuned electrical properties, offering great potential for cardiac repair.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Physical
Zhiqun Xie, Dionysios D. Dionysiou, Shuang Luo, Menglin Chen, Zongsu Wei
Summary: In order to enhance the utilization of peroxymonosulfate (PMS) and the stability of catalyst, a dual-reaction center catalyst Cu-Mg0.388Al2.408O4-BN was developed without expensive rare metals. The presence of Mg resulted in a positively charged surface, which facilitated the adsorption of bisphenol A (BPA) and PMS anions under neutral pH conditions. The formation of an electron-rich Cu center was achieved due to the relatively low electronegativity of Mg and the cation-pi interaction between Cu and boron nitride (BN). The combination of electrostatic attraction and dual-reaction center enabled the rapid degradation of BPA through electron transfer and subsequent activation of PMS.
APPLIED CATALYSIS B-ENVIRONMENTAL
(2023)
Article
Food Science & Technology
Chen Shen, Wenqing Chen, Changzhu Li, Tariq Aziz, Haiying Cui, Lin Lin
Summary: Plant essential oils (EOs) have gained attention for their antibacterial and antifungal activity in food safety. However, their limited solubility and stability hinder their application. Nanoemulsions (NEs) can be used as a solution to enhance the effectiveness of EOs while minimizing the impact on food quality.
Article
Chemistry, Applied
Farzaneh Nasrollahzadeh, Maria Julia Spotti, Kasper Skov, Tizazu Mekonen, Menglin Chen, Mario M. Martinez
Summary: The study investigates the impact of incorporating polar gelatin and non-polar zein on the mechanical properties of high moisture meat analogue prototypes. The addition of these proteins alters the elasticity and tenderness of the extrudates, with different effects observed for soy and mung bean prototypes. The concentration-dependent changes in protein structures and water mobility highlight the potential of multifunctional fillers and top-down/bottom-up approaches for creating plant-based structured foods with meat-like texture.
FOOD HYDROCOLLOIDS
(2023)
Article
Materials Science, Biomaterials
Jordi Amagat, Christoph Alexander Mueller, Bjarke Norrehvedde Jensen, Xuya Xiong, Yingchun Su, Natasja Porskjaer Christensen, Alice Le Friec, Mingdong Dong, Ying Fang, Menglin Chen
Summary: We developed an injectable, nanofibrous 2D flexible hydrogel sheet-based neural stimulation device that can be non-invasively implanted via syringe injection for optoelectrical and biochemical dual stimulation of neurons. The device consists of mechanically reinforced nanofibers loaded with photocatatlytic g-C3N4/GO nanoparticles for blue light stimulation and nerve growth factor (NGF) loaded nanofibers for biochemical stimulation of neural differentiation. This device represents a crucial early step in developing a minimally invasive system for neural stimulation.
BIOMATERIALS ADVANCES
(2023)
Review
Food Science & Technology
Xueli Zhang, Changzhu Li, Wei Hu, Mohamed A. Abdel-Samie, Haiying Cui, Lin Lin
Summary: This review focuses on the applications of tea saponin as a natural surfactant in food, particularly in emulsions, delivery systems, extraction, and fermentation. Tea saponin has shown great potential to replace synthetic surfactants in food applications, which is of significant importance for improving the comprehensive utilization value of Camellia seed residue and promoting the sustainable development of the Camellia industry.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Chemistry, Applied
Haiying Cui, Qun Cheng, Changzhu Li, Myat Noe Khin, Lin Lin
Summary: In recent years, the focus of film construction has been on loading active substances to improve biological activity. However, the potential benefits of establishing a cross-linking reaction between the load materials and the substrate for packaging properties have been overlooked. This study aimed to cross-link a gelatin-based film with kappa-carrageenan and dialdehyde beta-cyclodextrin inclusion (IC/DA-beta-CD), and investigate its functionalities.
FOOD HYDROCOLLOIDS
(2023)
Article
Biochemistry & Molecular Biology
Haiying Cui, Rui Xu, Wei Hu, Changzhu Li, Mohamed A. Abdel-Samie, Lin Lin
Summary: Environmental issues caused by plastic packaging materials have become increasingly serious, leading to extensive research on environmentally friendly active packaging materials. In this study, Litsea cubeba essential oil loaded soy protein isolate nanoparticles (LSNPs) were successfully fabricated with appropriate particle size, high storage stability, and salt solution stability. These LSNPs were then added to lentinan edible films. The results showed that the lentinan film with LSNPs in the volume ratio of 4:1 had excellent physical properties and exhibited antibacterial, oxidation resistance, and thermal stability effects.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Nanoscience & Nanotechnology
Rongrong Wu, Zengkai Wang, Zili Jia, Chenglong Li, Jie Wang, Lei Liu, Mingdong Dong
Summary: This study investigates the cross-fibrillation of A beta peptides and different hIAPP structures. The experimental results show that hIAPP aggregates enhance the fibrillation of A beta, especially hIAPP fibrils. Using quantitative nanomechanical mapping and molecular dynamic simulations, different hybrid amyloid strains can be distinguished based on their mechanical properties and structural transformations.
Article
Multidisciplinary Sciences
Steven J. Roeters, Kris Strunge, Kasper B. Pedersen, Thaddeus W. Golbek, Mikkel Bregnhoj, Yuge Zhang, Yin Wang, Mingdong Dong, Janni Nielsen, Daniel E. Otzen, Birgit Schiott, Tobias Weidner
Summary: This study reports a mechanism explaining why lipid membranes catalyze the formation of harmful aggregates at elevated concentrations.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Applied
Xueli Zhang, Xiaochen Chen, Jinming Dai, Haiying Cui, Lin Lin
Summary: The effects of boiling water treatments on the properties of dragon fruit peel pectin films were investigated in this study. It was found that boiling water treatment significantly impacted the mechanical, color, microstructure, and antioxidant capacity of the films, while the barrier, water sensitivity, and thermal stability were hardly affected.
FOOD HYDROCOLLOIDS
(2024)
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)
