Article
Nursing
Hedda Bekken Lindberg, Simen A. Steindal, Monica Evelyn Kvande
Summary: The objectives of this study were to explore critical care nurses' experiences of caring for adult patients experiencing iatrogenic opioid withdrawal in the intensive care unit. A qualitative study was conducted, and data were collected through semi-structured interviews. Findings suggest that critical care nurses face challenges in identifying opioid withdrawal and emphasize the need for effective communication and management strategies.
INTENSIVE AND CRITICAL CARE NURSING
(2023)
Article
Pharmacology & Pharmacy
Rebekah A. Eadie, Cathrine A. McKenzie, Daniel J. Hadfield, Nicola J. Kalk, Scott Bolesta, Martin F. Dempster, Daniel F. McAuley, Bronagh Blackwood
Summary: This study investigated the use of opioid, sedative, and preadmission medications in critically ill adults in UK ICUs, and found a high prevalence of medication with potential for iatrogenic withdrawal syndrome. Most ICUs lacked sedation/analgesia policies and did not screen for iatrogenic withdrawal.
INTERNATIONAL JOURNAL OF CLINICAL PHARMACY
(2023)
Review
Respiratory System
Patrice S. Lamey, Dylan M. Landis, Kenneth M. Nugent
Summary: This article reviewed the frequency, characteristics, and treatment of iatrogenic opioid withdrawal syndrome (IOWS) in hospitalized adults. The review found that IOWS occurs in 15 to 40% of ICU patients who required opioid infusions. Treatment approaches included reusing opioids with slower reductions in dosage and using specific drugs to aid in recovery.
JOURNAL OF THORACIC DISEASE
(2022)
Review
Respiratory System
Patrice S. Lamey, Dylan M. Landis, Kenneth M. Nugent
Summary: This review analyzed clinical studies to determine the frequency, characteristics, and treatment of iatrogenic opioid withdrawal syndrome (IOWS) in critically ill adults. The review found that IOWS occurs in 15 to 40% of ICU patients who required opioid infusions, and factors such as weaning rate, duration of infusion, and concomitant benzodiazepine use influenced the development of the syndrome. Treatment approaches included slower reductions in the rate of infusion and the use of an alpha-2 agonist. More research is needed to develop diagnostic tools for IOWS.
JOURNAL OF THORACIC DISEASE
(2022)
Article
Medicine, General & Internal
Leslie W. Young, Songthip T. Ounpraseuth, Stephanie L. Merhar, Zhuopei Hu, Alan E. Simon, Andrew A. Bremer, Jeannette Y. Lee, Abhik Das, Margaret M. Crawford, Rachel G. Greenberg, P. Brian Smith, Brenda B. Poindexter, Rosemary D. Higgins, Michele C. Walsh, Ward Rice, David A. Paul, Jessie R. Maxwell, Sucheta Telang, Camille M. Fung, Tanner Wright, Anne Marie Reynolds, Devon W. Hahn, Julie Ross, Jennifer M. McAllister, Moira Crowley, Sophie K. Shaikh, Karen M. Puopolo, Lori Christ, Jaime Brown, Julie Riccio, Kara Wong Ramsey, Erica F. Braswell, Lauren Tucker, Karen R. McAlmon, Krishna Dummula, Julie Weiner, Jessica R. White, Meghan P. Howell, Sarah Newman, Jessica N. Snowden, Lori A. Devlin
Summary: A study conducted at 26 hospitals in the United States found that the use of the "Eat, Sleep, Console" care approach significantly reduced the time until infants with neonatal opioid withdrawal syndrome were medically ready for discharge, without increasing specified adverse outcomes.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Medicine, General & Internal
Suthinee Taesotikul, Pitchaya Dilokpattanamongkol, Viratch Tangsujaritvijit, Chuthamanee Suthisisang
Summary: This study found that approximately one-fourth of mechanically ventilated patients who received opioid infusion experienced IOWS, especially common in patients undergoing rapid weaning. Monitoring for IOWS is recommended, especially in patients receiving rapid weaning of opioids.
CURRENT MEDICAL RESEARCH AND OPINION
(2021)
Article
Critical Care Medicine
Alexandre Bourdiol, Vincent Legros, Fanny Vardon-Bounes, Thomas Rimmele, Paul Abraham, Clement Hoffmann, Claire Dahyot-Fizelier, Maud Jonas, Pierre Bouju, Cedric Cirenei, Yoann Launey, Gregoire Le Gac, Samia Boubeche, Edouard Lamarche, Olivier Huet, Lucillia Bezu, Julie Darrieussecq, Magdalena Szczot, Agathe Delbove, Johan Schmitt, Sigismond Lasocki, Johann Auchabie, Ludivine Petit, Emmanuelle Kuhn-Bougouin, Karim Asehnoune, Hugo Ingles, Antoine Roquilly, Raphael Cinotti
Summary: This multicenter prospective study investigated the prevalence, risk factors, and medical management of persistent pain symptoms in patients with ICU length of stay >= 48 h. The study found that persistent pain symptoms were frequent in critical illness survivors, but specialized pain management remained infrequent.
Article
Nutrition & Dietetics
Phillipa Darroch, Wendy J. O'Brien, Hajar Mazahery, Carol Wham
Summary: This study aimed to investigate the prevalence of sarcopenia and associated risk factors among older adults in three residential aged care facilities in Auckland, New Zealand. The findings revealed that a majority of residents were malnourished or at risk of malnutrition, and 41% had sarcopenia. Lower body mass index and lower Mini Nutrition Assessment-Short Form score were predictive of sarcopenia.
Article
Medicine, General & Internal
Daina B. Esposito, Krista F. Huybrechts, Martha M. Werler, Loreen Straub, Sonia Hernandez-Diaz, Helen Mogun, Brian T. Bateman
Summary: This study compared the risk of neonatal opioid withdrawal syndrome (NOWS) among neonates exposed to different types of opioids during the last 3 months of pregnancy, finding that strong agonists with long half-lives were associated with a higher risk of NOWS. This information can help healthcare providers make informed decisions when prescribing opioids for pain management in late pregnancy.
Review
Neurosciences
Lisa Isaac, Nynke J. van den Hoogen, Sharifa Habib, Tuan Trang
Summary: The use of opioids in pregnant women may result in neonatal opioid withdrawal syndrome (NOWS). Risk factors and drug exposure dose in neonates affect the incidence and severity of NOWS. Treatment of NOWS relies on clinical assessment and the use of pharmacotherapy tools.
JOURNAL OF NEUROSCIENCE RESEARCH
(2022)
Article
Ophthalmology
Cindy Ung, Yoshihiro Yonekawa, Jennifer F. Waljee, Vidhya Gunaseelan, Yen-Ling Lai, Maria A. Woodward
Summary: In patients who underwent ophthalmic surgery, the rate of new persistent opioid use was 3.4% in those who had prior opioid exposure compared to 0.6% in opioid-naive patients. For patients who had an initial perioperative opioid prescription, a prescription size of 150 morphine milligram equivalents or more was associated with an increased odds of refill.
Article
Medicine, General & Internal
Kunrong Yu, Na Guo, Dingding Zhang, Ying Xia, Yanling Meng, Li Weng, Bin Du
Summary: This study retrospectively analyzed the prevalence and risk factors of feeding intolerance (FI) in 1057 ICU patients receiving early continuous enteral nutrition (EN). The results showed that FI frequently occurs in the early days of ICU stay, particularly in patients undergoing mechanical ventilation (MV) and continuous renal replacement therapy (CRRT).
CHINESE MEDICAL JOURNAL
(2022)
Article
Multidisciplinary Sciences
Jan-Quinten Mol, Julia van Tuijl, Siroon Bekkering, Charlotte D. C. C. van der Heijden, Sander A. J. Damen, Benjamin C. Cossins, Liesbeth van Emst, Tim M. Nielen, Laura Rodwell, Yang Li, Gheorghe A. M. Pop, Mihai G. Netea, Niels van Royen, Niels P. Riksen, Saloua El Messaoudi
Summary: An increasing number of patients develop non-traditional risk factor-induced myocardial infarction, and this study investigated the role of trained immunity in these patients. It was found that monocytes from patients with myocardial infarction had increased cytokine production capacity, particularly interleukin-10, which was associated with specific histone marks. Considering the lack of intervenable risk factors, trained immunity could be a promising target for future therapy.
Article
Emergency Medicine
Sally Mahmoud, Erik Anderson, Aidan Vosooghi, Andrew A. Herring
Summary: This study examined a cohort of patients treated with buprenorphine and phenobarbital or benzodiazepines for concurrent opioid and alcohol withdrawal in the ED. The results showed no serious adverse events related to the medications used for treatment. Further research should focus on optimizing medical therapy and transitioning patients to maintenance treatment for substance use disorders.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Oncology
Takashi Omoto, Junichi Asaka, Satoru Nihei, Kenzo Kudo
Summary: This study aimed to determine the frequency of opioid-induced neurotoxicity (OIN) in cancer patients receiving oral controlled-release oxycodone and to identify risk factors for OIN. It was found that age ≥65 years, total bilirubin ≥1.3 mg/dL, and concomitant use of pregabalin or mirogabalin were independent risk factors for OIN in patients receiving oxycodone.
SUPPORTIVE CARE IN CANCER
(2023)
