Review
Chemistry, Inorganic & Nuclear
Zoufeng Xu, Zhigang Wang, Zhiqin Deng, Guangyu Zhu
Summary: Platinum-based anticancer drugs have been widely used in clinical practice for over 40 years, with a focus on developing platinum(IV) prodrugs based on traditional platinum(II) anticancer drugs. Recent progress in the field includes synthesizing platinum(IV) prodrugs with new oxidizing reagents, understanding the hydrolysis and stability of platinum(IV) complexes, and exploring reduction processes to achieve controllable intracellular reduction of platinum(IV) prodrugs. This review aims to enhance researchers' understanding of platinum(IV) anticancer prodrugs and inspire new strategies, ideas, and applications in metal-based drugs.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Chemistry, Multidisciplinary
Qiyuan Zhou, Shu Chen, Zoufeng Xu, Gongyuan Liu, Shuyuan Zhang, Zhigang Wang, Man-Kit Tse, Shek-Man Yiu, Guangyu Zhu
Summary: This study reports the synthesis of Pt-IV complexes bearing axial pyridines through ligand exchange reactions. It was discovered that these axial pyridines can be quickly released after reduction, indicating their potential as axial leaving groups. Two multitargeted Pt-IV prodrugs containing bioactive pyridinyl ligands, a PARP inhibitor and an EGFR tyrosine kinase inhibitor, were successfully obtained using this method. These conjugates show great potential for overcoming drug resistance, with the latter inhibiting the growth of Pt-resistant tumor in vivo. This research expands the synthetic methods for Pt-IV prodrugs and increases the range of bioactive axial ligands that can be conjugated to a Pt-IV center.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Inorganic & Nuclear
Jiafan Lin, Jishuai Zhang, Ziqi Ma, Xiaoqin Wu, Fuyi Wang, Yao Zhao, Kui Wu, Yi Liu
Summary: The interaction between a photoactivatable Pt(iv) prodrug and human telomeric DNA was studied. Two major mono-platinated DNA adducts were detected, with trans-[Pt-II(N-3)(py)(2)](+) and trans-[Pt-II(py)(2)](2+) as the bound Pt moieties. The platination sites were found to be G(6) and A(3) in one adduct, and a potential intrastrand crosslink was speculated after G(4) and G(6) in the other adduct. Minor platinated adducts and oxidized DNA adducts were also observed. These results provide valuable chemical information about the photoreaction between photoactivatable Pt(iv) anticancer prodrugs and human telomeric DNA.
DALTON TRANSACTIONS
(2023)
Review
Chemistry, Multidisciplinary
Shunzhe Zheng, Guanting Li, Jianbin Shi, Xinying Liu, Meng Li, Zhonggui He, Chutong Tian, Ken-ichiro Kamei
Summary: Due to the severe dose-dependent toxicity and drug resistance, platinum (Pt)-based chemotherapy has limitations. Pt(IV) prodrug nanotherapeutics have emerged as a promising approach to improve the antitumor performance of Pt drugs. This article summarizes the latest advances in Pt(IV) prodrug nano-therapeutics, including their potential for overcoming biological barriers and their synergistic effects with other therapies.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Engineering, Biomedical
Xiaohui Xiao, Yupeng Wang, Jieyao Chen, Peng Qin, Peiyao Chen, Dongfang Zhou, Yue Pan
Summary: This study presents a self-targeting nano-assembly strategy based on platinum(IV)-lactose amphiphilic prodrug for synergistic and safe chemoradiotherapy of hepatocellular carcinoma (HCC). The nano-assembly targets HCC cells and releases cisplatin to induce DNA damage and cell apoptosis. Under X-ray irradiation, the assembly enhances the cell-killing effect of radiotherapy.
Review
Chemistry, Multidisciplinary
Johannes Karges
Summary: Platinum(II) complexes are widely used in chemotherapy, but are associated with severe side effects and poor tumor selectivity. To address this issue, platinum(IV) molecular prodrugs and nanoparticle formulations that can be activated into therapeutically active analogs through specific triggers have been explored. This article critically reviews the mechanisms for activating platinum(IV) prodrugs using chemical and photophysical triggers.
Article
Pharmacology & Pharmacy
Theresa Mendrina, Isabella Poetsch, Hemma Schueffl, Dina Baier, Christine Pirker, Alexander Ries, Bernhard K. K. Keppler, Christian R. R. Kowol, Dan Gibson, Michael Grusch, Walter Berger, Petra Heffeter
Summary: Platinum compounds are effective treatment options for various cancer types, but their use is limited by side effects and drug resistance. A new multi-targeted platinum(IV) prodrug, cisPt(PhB)(2), has shown promising anticancer activity and the ability to overcome drug resistance mechanisms. The drug's mode of action is influenced by cellular fatty acid metabolism and mitochondrial activity. Specifically, it is more effective against cisplatin-resistant cancer cells with Warburg-like properties. This orally applicable prodrug has the potential to improve cancer treatment outcomes.
Article
Chemistry, Inorganic & Nuclear
Juan Sanchez-Camacho, Sonia Infante-Tadeo, Ana C. Carrasco, Stefano Scoditti, A'lvaro Martinez, Fabienne Barroso-Bujans, Emilia Sicilia, Ana M. Pizarro, Luca Salassa
Summary: In this study, two new asymmetric Pt(IV) derivatives were designed and synthesized, which could be effectively activated into toxic Pt(II) species by incubation with nicotinamide adenine dinucleotide, sodium ascorbate, and glutathione in the dark and under light irradiation. One of the derivatives displayed enhanced toxicity in MDA-MB-231 breast cancer cells preincubated with ascorbate, suggesting selective triggering of oxaliplatin generation through redox activation. Covalent binding of the flavin to the Pt complex was shown to be pivotal for this effect.
INORGANIC CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Giulia D. S. Ferretti, Julia Quarti, Gileno dos Santos, Luciana P. Rangel, Jerson L. Silva
Summary: p53 is a mutated tumor suppressor protein that often aggregates and promotes cancer growth. Studying new molecules and therapeutic targets that disrupt p53 aggregates is a promising strategy against cancer. This review classifies anticancer molecules into four categories and highlights the role of autophagy in degrading aggregated p53.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Inorganic & Nuclear
Ran Zhang, Yueyue Zhang, Liumei Tang, Yixing Xu, Hao Li, Xueping Jiang, Xiangdong Xin, Zhongzheng Gui
Summary: A series of Pt(IV) prodrugs containing a microtubule inhibitor paclitaxel were synthesized and evaluated for their antitumor activity. One of the prodrugs, named Ptxplatin, effectively entered cancer cells and induced DNA damage, cell cycle arrest, and inhibition of cell migration. Furthermore, Ptxplatin caused mitochondrial dysfunction and triggered endoplasmic reticulum stress, ultimately leading to cancer cell death.
INORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Chemistry, Multidisciplinary
Hemma Schueffl, Sarah Theiner, Gerrit Hermann, Josef Mayr, Philipp Fronik, Diana Groza, Sushilla van Schonhooven, Luis Galvez, Nadine S. Sommerfeld, Arno Schintlmeister, Siegfried Reipert, Michael Wagner, Robert M. Mader, Gunda Koellensperger, Bernhard K. Keppler, Walter Berger, Christian R. Kowol, Anton Legin, Petra Heffeter
Summary: The platinum (IV) prodrug, which binds to albumin, enhances the efficacy of oxaliplatin therapy by facilitating tumor-specific release and accumulation, resulting in prolonged terminal excretion half-life and increased effective platinum dose. This innovative approach shows significant anticancer activity against colon tumors in vivo and should be further developed for clinical trials.
Article
Chemistry, Multidisciplinary
Alessandra Barbanente, Valentina Gandin, Chiara Donati, Carmela Ilaria Pierro, Giovanni Natile, Nicola Margiotta
Summary: Platinum-based drugs have been successful in treating solid tumors, but toxicity and resistance limit their outcomes. Natural products, such as 10-HDA found in royal jelly, are being explored as safe and easily available anti-cancer drugs. In this study, the researchers aimed to combine the functionality of 10-HDA with platinum to develop new compounds with potential anti-cancer activity. The synthesized compounds were characterized and tested for their cytotoxicity against human tumor cell lines. The results showed that some of the new compounds exhibited promising activity against specific tumor cell lines.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Stefano Scoditti, Gloria Mazzone, Nico Sanna, Emilia Sicilia
Summary: This study presents an in-depth computational investigation into the ability of a recently proposed multi-action Ru(II)-Pt(IV) conjugate to act as a photosensitizer in photodynamic therapy (PDT) and chemo-therapeutic drugs. The results show that the investigated complex is capable of releasing a light-absorbing chromophore for use in PDT, and it can also generate cytotoxic reactive oxygen species.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Ying Tu, Hao-Ming Li, Meng-Meng Wang, Yan Su, Hong-Ke Liu, Zhi Su
Summary: This study developed a dual-targeted platinum (IV) prodrug Pt-CMN, which significantly enhanced anticancer performance and provided a new strategy for enhancing anticancer effects through subcellular organelle targeting.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2022)
Article
Biophysics
Ping-Hsuan Wu, Pei-Fen Cheng, Watchareeya Kaveevivitchai, Teng-Hao Chen
Summary: Manipulating Fenton chemistry in tumor microenvironment (TME) for the generation of reactive oxygen species is an effective strategy for chemodynamic therapy. Here, a nanozyme MOF-Pt(IV)@GOx was developed by covalently grafting a prodrug of cisplatin (Pt(IV) prodrug) onto a ferric metal-organic framework (MOF) and loading it with a biocatalyst glucose oxidase (GOx). The system achieved synergistic trimodal therapy consisting of ferroptosis, starvation therapy, and chemotherapy, by enhancing GOx loading and chemotherapy, reducing Fe(III) to Fe(II) for Fenton reaction, converting Pt(IV) prodrug to cisplatin, and promoting intracellular acidity and H2O2 supply in TME.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Kwan Ho Ngai, Xinwen Sun, Yinping Wang, Long Lin, Zefeng Chen, Qi Wei, Mingjie Li, Chuhao Luan, Wenjun Zhang, Jianbin Xu, Mingzhu Long
Summary: The precise engineering of monovalent cations in perovskite materials has led to significant improvements in performance and stability for perovskite light-emitting diodes (PeLEDs). However, the specific role of A-site cations in the electroluminescence (EL) performance and degradation mechanism of PeLEDs remains unclear. This study shows that the commonly used methylammonium cation (MA(+)) has a negative effect on the electrochemical reaction at the perovskite-metal oxide interface, resulting in deteriorated EL performance compared to formamidinium cation (FA(+))-based perovskite. Furthermore, the addition of inorganic cesium cation (Cs+) in a small amount of FA(+) improves crystallinity and crystal size, leading to an optimized peak external quantum efficiency of 21.3% and enhanced stability in PeLEDs.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Engineering, Environmental
Jialin Yu, Ke Wang, Shibo Shao, Wei Li, Shangfeng Du, Xianfeng Chen, Cong Chao, Xianfeng Fan
Summary: This paper systematically studied the influence of ionic radius, valence state, surface concentration, and basicity of dopants on the catalytic performance of La2O3 in transesterification of glycerol and dimethyl carbonate. It was found that the ionic radius and valence state of the dopants are the determining factors, while the basic site density is not crucial. Among alkali and alkaline earth metals, 25 mol% Na/La2O3 catalyst achieved the highest glycerol conversion (85%) and glycerol carbonate yield (60%). A plausible mechanism of glycerol and dimethyl carbonate transesterification on Na/La2O3 catalyst has been proposed. This research could help understand the promotional role of alkali metals and alkaline earth metals and guide future design of metal oxide catalysts.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Engineering, Environmental
Weihua Wang, Juan Ding, Zhenjie Liu, Yanbin Wei, Wenhua Cheng, Qingcui Liu, Weilu Zhang, XingChao Wang, Wenjun Zhang, Bao Wang, Jiulin Wang, Yudai Huang
Summary: A multifunctional cobweb-like complex binder (TA-PAA) consisting of tapioca (TA) and polyacrylic acid (PAA) is designed and applied as an efficient binder for high capacity and long-term cycle performance SiO anode. The binder addresses the issues of electrode contact failure and capacity decay caused by the volume expansion of silicon-based anodes.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Multidisciplinary Sciences
Zhi-Yan Guo, Rongbo Sun, Zixiang Huang, Xiao Han, Haoran Wang, Cai Chen, Yu-Qin Liu, Xusheng Zheng, Wenjun Zhang, Xun Hong, Wen-Wei Li
Summary: Crystallinity engineering strategy can improve the activity-stability balance of metal oxides in Fenton-like catalysis, leading to higher pollutant degradation efficiency and improved catalyst stability.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Chemistry, Analytical
Zhongjiao Feng, Jiasheng Wu, Weimin Liu, Haohui Ren, Xiuli Zheng, Wenjun Zhang, Chun-Sing Lee, Pengfei Wang
Summary: A Golgi-targeting two-photon fluorescent probe was designed to detect hydrogen peroxide with high sensitivity and selectivity. It can be used for visualization of endogenous/exogenous H2O2 in vitro and in vivo.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Multidisciplinary
Wenhua Cheng, Qingcui Liu, Juan Ding, Xingchao Wang, Lei Wang, Jiulin Wang, Wenjun Zhang, Yudai Huang
Summary: The dilution effect of PO43- on the surface of Li-rich layered oxides (LLOs) inhibits the migration of transition metal (TM) and reduces interfacial side reactions (ISR), resulting in improved cycling stability and enhanced capacity retention of LLOs.
Article
Chemistry, Multidisciplinary
Shuai Jiang, Tongyao Xiao, Cui Xu, Suwen Wang, Hui-Qing Peng, Wenjun Zhang, Bin Liu, Yu-Fei Song
Summary: An engineered heterostructure comprising NiFe-LDH and in situ formed NiFe-HAB coordination polymer has been demonstrated to effectively inhibit the OER activity and promote the MOR activity. The heterostructure exhibits outstanding electrocatalytic capability for methanol oxidation, leading to efficient MOR.
Article
Multidisciplinary Sciences
Gongyuan Liu, Yachao Zhang, Houzong Yao, Zhiqin Deng, Shu Chen, Yue Wang, Wang Peng, Guohan Sun, Man-Kit Tse, Xianfeng Chen, Jianbo Yue, Yung-Kang Peng, Lidai Wang, Guangyu Zhu
Summary: In this work, cyaninplatin, a Pt(IV) anticancer prodrug, is introduced, which can be activated by ultrasound. The sono-activation of cyaninplatin leads to strengthened mitochondrial DNA damage and cell killing efficiency, along with overcoming drug resistance. This study demonstrates the practical utility of ultrasound in activating Pt(IV) anticancer prodrugs for the eradication of deep tumor lesions.
Article
Engineering, Multidisciplinary
Allana Lewis, Fraz Saeed Butt, Xiuming Wei, Nurul A. Mazlan, Zheng Chen, Yaohao Yang, Shuiqing Yang, Norbert Radacsi, Xianfeng Chen, Yi Huang
Summary: The water-organic cosolvent system allows for the fabrication of ZIF with lower chemical consumption and interesting nanostructures and surface properties. Different cosolvents have varying impacts on ZIF nucleation, crystallization, phase transformation, and morphological evolution. A mechanism for ZIF growth in various solvents was proposed, providing important insights for aqueous-based fabrications and the synthesis and structure control/modifications of ZIFs & their composite materials.
RESULTS IN ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Zhenjie Liu, Pingping Chang, Murong Xi, Juan Ding, Xingchao Wang, Jiulin Wang, Wenjun Zhang, Yudai Huang
Summary: Designing efficient catalysts is crucial for the development of electrochemical synthesis technologies. In this study, a novel vacuum induction strategy is used to synthesize a nickel boride/nickel (Ni3B/Ni) heterostructure catalyst for the electrochemical oxidation of methanol. The catalyst exhibits high reactivity, ultra-high selectivity, and ultra-long life. Mechanistic studies suggest that the formation of *CH2O occurs most favorably in the Ni3B/Ni heterostructure.
Article
Spectroscopy
Yimin Guo, Weimen Liu, Jie Sha, Xuewei Li, Haohui Ren, Jiasheng Wu, Wenjun Zhang, Chun-Sing Lee, Pengfei Wang
Summary: The development of photosensitizers with subcellular targeting capability has become a focus in photodynamic therapy research. In this study, two coumarin-based photosensitizers (C-S-2 and C-S-3) were designed and synthesized with expanded pi-conjugation, strong electron-donor and acceptor groups, and sulfur substitution strategy. These sulfured-coumarins demonstrated near-infrared emission, lipid droplet-targeting ability, and significant photocytotoxicity under laser irradiation. Specifically, C-S-3 showed better photostability, superior lipid droplet-targeting capability, and stronger photodynamic effect on cancer cells compared to C-S-2.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Materials Science, Biomaterials
Xue Feng, Yuxiang Xue, Sevil Gonca, Kunlang Ji, Mei Zhang, Francisco R. Garcia-Garcia, Quan Li, Yi Huang, Konstantin V. Kamenev, Xianfeng Chen
Summary: The intrinsic pathological characteristics of tumor microenvironments limit the deep penetration of nanomedicines, but magnetophoresis using external magnetic force shows promise in improving their tumor penetration. However, current research mainly focuses on large nanoparticles, neglecting ultrasmall superparamagnetic iron oxide (Fe3O4) nanoparticles.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Review
Materials Science, Multidisciplinary
Minmin Shao, Daniela Lopes, Joana Lopes, Satar Yousefiasl, Ana Macario-Soares, Diana Peixoto, Ines Ferreira-Faria, Francisco Veiga, Joao Conde, Yi Huang, Xianfeng Chen, Ana Claudia Paiva-Santos, Pooyan Makvandi
Summary: Bio-mimicking principles enable the functionalization of nanoparticles by camouflaging their surfaces with biomembranes, providing superior biocompatibility, interfacial features, immune evasion, and active targeting properties. Cell membranes, derived from various optimized cells, have been used as coating materials. The concept has also been applied to subcellular structures, such as extracellular vesicles and intracellular organelles. Specifically, exosomes, nanosized vesicles enriched with proteins, have shown great potential as biological nanocarriers for biomedical applications. This review focuses on the clinical applications of exosome membrane-coated nanosystems in cancer diagnosis and therapy.
Article
Materials Science, Biomaterials
Yanping Wang, Xuewei Li, Weimin Liu, Jie Sha, Zhe Yu, Shuai Wang, Haohui Ren, Wenjun Zhang, Chun-Sing Lee, Pengfei Wang
Summary: This work describes the synthesis and application of a curcumin-based photosensitizer, CN, which can simultaneously target lipid droplets and the endoplasmic reticulum, enhancing the efficiency of photodynamic therapy. CN exhibits longer absorption and emission wavelengths and sensitivity to polarity, leading to excellent photodynamic effects. The phototoxicity of CN results in apoptosis by destroying the endoplasmic reticulum and ferroptosis by oxidizing polyunsaturated fatty acids in lipid droplets.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Chemistry, Physical
Qingcui Liu, Qiaohong Su, Wenhua Cheng, Juan Ding, Wenjun Zhang, Jiulin Wang, Yonggang Wang, Xingchao Wang, Yudai Huang
Summary: In this study, Fe-Mo2C@CN was successfully synthesized by introducing Fe into the Mo-based catalyst, which suppressed the dissolution of Mo and improved the electrocatalytic performance for the oxygen evolution reaction (OER). Experimental and theoretical results revealed the role of Fe and the importance of lattice oxygen in the OER process, providing a theoretical basis for the application of Mo-based catalysts in water splitting.
APPLIED CATALYSIS B-ENVIRONMENTAL
(2024)
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)
