期刊
CHEMICAL COMMUNICATIONS
卷 51, 期 47, 页码 9651-9654出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc02807h
关键词
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资金
- Carlsberg Foundation
- Lundbeck foundation
- Aarhus University
Two decarboxylative methods providing access to N-alkylated alpha-trihalomethylated heterocyclic amines have been developed. A batch protocol in which methyl trifluoroacetate acts both as a methylating reagent and subsequently as a nucleophilic trifluoromethyl anion precursor upon its addition to (iso)quinoline derivatives. Next, a telescoped continuous flow process, forming the corresponding alpha-trichloromethylated heterocyclic amines, utilizing a similar decarboxylation of trichloroacetic acid, was developed and taken to scale-up.
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