Colibactin biosynthesis and biological activity depend on the rare aminomalonyl polyketide precursor

Critical Intermediates Reveal New Biosynthetic Events in the Enigmatic Colibactin Pathway

(2015) Zhong-Rui Li et al.   CHEMBIOCHEM

The colibactin warhead crosslinks DNA

(2015) Maria I. Vizcaino et al.   Nature Chemistry

Correction to Isolation of a Metabolite from the pks Island Provides Insights into Colibactin Biosynthesis and Activity

(2015) Carolyn A. Brotherton et al.   ORGANIC LETTERS

Two more pieces of the colibactin genotoxin puzzle from Escherichia coli show incorporation of an unusual 1-aminocyclopropanecarboxylic acid moiety

(2015) Xiaoying Bian et al.   Chemical Science

Gut Symbionts from Distinct Hosts Exhibit Genotoxic Activity via Divergent Colibactin Biosynthesis Pathways

(2014) Philipp Engel et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Bacterial genotoxin colibactin promotes colon tumour growth by inducing a senescence-associated secretory phenotype

(2014) Antony Cougnoux et al.   GUT

Comparative Metabolomics and Structural Characterizations Illuminate Colibactin Pathway-Dependent Small Molecules

(2014) Maria I. Vizcaino et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Colon cancer-associated B2Escherichia colicolonize gut mucosa and promote cell proliferation

(2014) Jennifer Raisch   WORLD JOURNAL OF GASTROENTEROLOGY

In Vivo Evidence for a Prodrug Activation Mechanism during Colibactin Maturation

(2013) Xiaoying Bian et al.   CHEMBIOCHEM

The genusPseudovibriocontains metabolically versatile bacteria adapted for symbiosis

(2013) Vladimir Bondarev et al.   ENVIRONMENTAL MICROBIOLOGY

A Prodrug Resistance Mechanism Is Involved in Colibactin Biosynthesis and Cytotoxicity

(2013) Carolyn A. Brotherton et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Escherichia coli Producing Colibactin Triggers Premature and Transmissible Senescence in Mammalian Cells

(2013) Thomas Secher et al.   PLoS One

Interplay between Siderophores and Colibactin Genotoxin Biosynthetic Pathways in Escherichia coli

(2013) Patricia Martin et al.   PLoS Pathogens

Analysis of Structure–Function Relationships in the Colibactin-Maturating Enzyme ClbP

(2012) Antony Cougnoux et al.   JOURNAL OF MOLECULAR BIOLOGY

Molecular Insights into the Biosynthesis of Guadinomine: A Type III Secretion System Inhibitor

(2012) Tracy C. Holmes et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A natural prodrug activation mechanism in nonribosomal peptide synthesis

(2011) Daniela Reimer et al.   Nature Chemical Biology

Recognition of (2S)-Aminomalonyl-Acyl Carrier Protein (ACP) and (2R)-Hydroxymalonyl-ACP by Acyltransferases in Zwittermicin A Biosynthesis

(2010) Yolande A. Chan et al.   BIOCHEMISTRY

Escherichia coli induces DNA damage in vivo and triggers genomic instability in mammalian cells

(2010) G. Cuevas-Ramos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adenylation Enzyme Characterization Using γ -18O4-ATP Pyrophosphate Exchange

(2009) Vanessa V. Phelan et al.   CHEMISTRY & BIOLOGY

Genetic Structure and Distribution of the Colibactin Genomic Island among Members of the Family Enterobacteriaceae

(2009) J. Putze et al.   INFECTION AND IMMUNITY

Characterization of the Complete Zwittermicin A Biosynthesis Gene Cluster from Bacillus cereus

(2008) B. M. Kevany et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Molecular Epidemiology and Phylogenetic Distribution of the Escherichia coli pks Genomic Island

(2008) J. R. Johnson et al.   JOURNAL OF CLINICAL MICROBIOLOGY