Article
Materials Science, Multidisciplinary
Cheng Xin, Nan Wang, Yongnan Chen, Binbin He, Qinyang Zhao, Lei Chen, Yufei Tang, Binli Luo, Yongqing Zhao, Xiaokang Yang
Summary: The study found that the morphology of the Ti2Cu phase in TiCu alloy significantly affects biological corrosion and antibacterial properties, with lamellar Ti2Cu phase having a higher galvanic interface and releasing more Cu2+ ions, resulting in a 99.5% antibacterial rate and great potential for medical implant applications.
MATERIALS & DESIGN
(2022)
Article
Materials Science, Multidisciplinary
Lei Shao, Guoliang Xie, Xinhua Liu, Yuan Wu, Jiabin Yu, Kai Feng, Wenli Xue
Summary: The study on Ti-Cu alloys reveals that the formation and distribution of Ti2Cu phase play a crucial role in the combustion process, where the liquid Ti2Cu layer and molten Ti2Cu phase can prevent oxygen diffusion and inhibit burning velocity.
Article
Chemistry, Physical
Jae Won Sim, Jae Hyuk Kim, Chan Hee Park, Jae-Keun Hong, Jong-Taek Yeom, Sang Won Lee
Summary: In this study, the impact of phase conditions on the tensile behaviors of Ti-Cu alloys was investigated. The results showed that the mechanical properties of the alloys were strongly influenced by the Cu content in alpha lath, which depended on the volume of Ti2Cu. A higher volume of Ti2Cu resulted in lower Cu content in alpha lath, leading to higher elongation and lower strength. Additionally, Ti2Cu exhibited superior antibacterial properties compared to Cu-supersaturated alpha lath. This study provides new insights for the design of Ti-Cu alloys as biomaterials.
JOURNAL OF ALLOYS AND COMPOUNDS
(2022)
Article
Materials Science, Multidisciplinary
Hai-Lin Yang, Ling Zou, Akram Nasser Juaim, Chen-Xu Ma, Meng-Zhen Zhu, Fei Xu, Xiao-Na Chen, Yin-Zhou Wang, Xiong-Wen Zhou
Summary: Ti-Cu sintered alloys have been developed for medical implant applications. The alloys exhibited antibacterial activity against Porphyromonas gingivalis and Streptococcus mutans, and the main antibacterial mechanisms were suggested to be the release of copper ions and ROS production. These results demonstrate the potential of Ti-Cu alloys as promising materials for dental and orthopedic implants.
Article
Materials Science, Multidisciplinary
Duo Xu, Zhiyuan Lu, Tianyu Wang, Shudan Wang, Yao Jiang, Zhengyu Xu, Zhenggang Bi, Shuo Geng
Summary: In this study, a new Ti-12Mo-5Cu alloy with good antibacterial properties was prepared by employing Cu and Mo, showing better antibacterial effect and reducing inflammatory reaction and osteomyelitis progression compared to pure Ti. The alloy has great potential for clinical translation due to its great biocompatibility, corrosion resistance, and ability to induce osteogenesis differentiation.
MATERIALS & DESIGN
(2021)
Article
Materials Science, Multidisciplinary
M. Alqattan, Y. Alshammari, F. Yang, L. Peters, L. Bolzoni
Summary: This study successfully developed Ti-Cu-Mn alloys with antibacterial capability through powder metallurgy method, achieving performance comparable to other biomedical Ti alloys. The addition rates of Cu and Mn impact the strength, hardness, and antibacterial capability of the material.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2021)
Article
Materials Science, Biomaterials
Mohammad Alqattan, Linda Peters, Yousef Alshammari, Fei Yang, Leandro Bolzoni
Summary: By adding manganese and copper, new titanium alloys have been developed in this study to reduce manufacturing costs and introduce antibacterial response, leading to enhanced mechanical performance and potential use as permanent medical implants.
REGENERATIVE BIOMATERIALS
(2021)
Article
Chemistry, Physical
M. Paul, Y. Alshammari, F. Yang, L. Bolzoni
Summary: This study investigates the processing and properties of Ti-Cu-Nb alloys obtained via powder metallurgy. The studied alloys have a lamellar microstructure, which is refined by the incremental addition of Cu+Nb and a eutectoid substructure is formed for sufficiently high contents of Cu. The resistance to plastic deformation increases monotonically due to the microstructural changes, while the ductility initially increases for small additions of Cu+Nb and subsequently decreases due to the impact of the residual pores.
JOURNAL OF ALLOYS AND COMPOUNDS
(2023)
Article
Materials Science, Multidisciplinary
Dong-Yang Fan, Zhe Yi, Xu Feng, Wen-Zhi Tian, Da-Ke Xu, A. M. Cristino Valentino, Qiang Wang, Hong-Chen Sun
Summary: The study revealed that TC4-5Cu/TC4 alloy exhibited strong bactericidal property against sessile S.tnutans and effective biofilm-restrained ability, with a trend of down-regulation in gene expression.
Article
Materials Science, Multidisciplinary
Jia-Qi Zhang, Shuang Cao, Ying Liu, Mian-Mian Bao, Jing Ren, Sheng-Yi Li, Er-Lin Zhang, Jian-Jie Wang
Summary: Ti-Cu alloys exhibit strong antibacterial properties, high strength, and excellent corrosion resistance, making them suitable for orthopedic and dental implants. This study investigated the tribocorrosion behaviors of Ti-Cu alloys in simulated biological environments and compared them with cp-Ti. The results showed that Ti-Cu alloys had better corrosion resistance and wear resistance, making them potentially valuable for applications requiring wear and corrosion resistance.
Article
Chemistry, Physical
Peng Du, Tao Xiang, Xinxin Yang, Guoqiang Xie
Summary: A porous Cu-bearing Ti-based BMG with high porosity and mechanical characteristics close to bone tissue was developed using the space holder method and SPS technology. The addition of porous structures increased the rate of Cu ion release and significantly improved antibacterial activity, making it a promising substitute for natural bone.
JOURNAL OF ALLOYS AND COMPOUNDS
(2022)
Article
Materials Science, Multidisciplinary
Xiaotong Bao, Talante Juma, Xuan Li, Jili Ding, Xiaobin Liu, Shanshan Liu, Junwen Li, Yongping Cao, Tao Zhang
Summary: In this research, a new series of beta duplex phase Ti50Zr25Nb25-xAgx alloys were prepared by rapid solidification process. The microstructure, mechanical properties, antibacterial properties, ion release behavior, and biocompatibility of the alloys were systematically investigated. The alloys exhibited low Young's modulus, high strength and hardness, and good antibacterial activity and biocompatibility.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2022)
Article
Materials Science, Multidisciplinary
Chao Song, Shuai Ren, Shaohui Li, Shengwei Li, Guijun Liu, Zhihua Nie, Yandong Wang, Daoyong Cong
Summary: This study utilizes strain glass to improve the reversibility of phase transformation. The incorporation of Al into Ti-Zr-Ni-Cu induces strain glass and endows the alloy with reversible phase transformation and ideal superelasticity.
MATERIALS RESEARCH LETTERS
(2023)
Article
Materials Science, Multidisciplinary
Lei Shao, Zhibin Li, Jiabin Yu, Gang Yang, Cheng Zhang, Yu Zou, Jinfeng Huang
Summary: The combustion behavior and mechanism of Ti2AlNb alloy were revealed through Promoted Ignition Combustion (PIC) tests and compared with Ti-6.5Al-3.5Mo-1.5Zr-0.3Si (TC11) alloy. Despite similar ignition temperatures, Ti2AlNb exhibited a faster burning velocity than TC11, attributed to differences in Nb and Mo element enrichment locations, and O phase decomposition in the heat affected zone. The location of alloying elements enrichment and phase transition in the heat affected zone are key factors influencing the burn resistance of Ti2AlNb and TC11 alloys.
Article
Nanoscience & Nanotechnology
Joonoh Moon, Hyo-Haeng Jo, Seong-Jun Park, Sung-Dae Kim, Tae-Ho Lee, Chang-Hoon Lee, Myoung-Gyu Lee, Hyun-Uk Hong, Dong-Woo Suh, Dierk Raabe
Summary: The developed Ti-bearing lightweight steel shows excellent strength and ductility at elevated temperatures, suitable for high-temperature parts with reduced loads. Its ductility at 600 degrees Celsius is at least 2.5 times higher than conventional lightweight steels based on the Fe-Mn-Al system.
MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING
(2021)
Article
Engineering, Biomedical
Mian Chen, Jian Hu, Erlin Zhang, Jiali Hu, Xiaoyan Wang, Gaowu Qin
Summary: The nanostructured TiF(x)/TiO(x) coating on titanium surfaces, known as FOTi, has been shown to exhibit antibacterial properties and bioactivity. In this study, the effects of FOTi samples on macrophage behavior and subsequent immunomodulatory effects on osteogenesis were investigated. The results indicated that FOTi samples stimulated macrophage elongation, promoted proinflammatory cytokine production, and induced macrophage polarization towards the anti-inflammatory M2 phenotype, ultimately enhancing osteogenic differentiation.
BIOMEDICAL MATERIALS
(2021)
Article
Materials Science, Multidisciplinary
Lei Yang, Yunqiu Shi, Liujie Shen, Erlin Zhang, Gaowu Qin, Xiaopeng Lu, Xiaorong Zhou
Summary: The study found that Ag significantly influences the corrosion behavior of Mg-Mn-Ag alloys, enhances cathodic activation, and results in a significant increase in the corrosion rate of the alloy with immersion time.
Article
Materials Science, Multidisciplinary
Diangeng Cai, Xiaotong Zhao, Lei Yang, Renxian Wang, Gaowu Qin, Da-fu Chen, Erlin Zhang
Summary: This study developed a novel near beta-titanium alloy (TNZA) with low elastic modulus and strong antibacterial ability by adding Ag element and proper microstructure controlling. The TNZA alloy exhibited good biocompatibility and strong antibacterial properties, showing potential for clinical application.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2021)
Article
Materials Science, Biomaterials
Shan Fu, Yuan Zhang, Gaowu Qin, Erlin Zhang
Summary: The precipitates in Ti-Ag alloy play a crucial role in antibacterial activity, with the Ag-containing phase being the major controlling factor. Ti-Ag(PM) with micro-size Ti2Ag and Ag-rich phase exhibited high antibacterial activity.
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Article
Materials Science, Multidisciplinary
Shuang Cao, Zi-Ming Zhang, Jia-Qi Zhang, Ren-Xian Wang, Xiao-Yan Wang, Lei Yang, Da-Fu Chen, Gao-Wu Qin, Er-Lin Zhang
Summary: Ti-Cu alloy anodic-oxidized coating enhances corrosion resistance, antibacterial properties and biological compatibility, promoting cell proliferation.
Article
Materials Science, Multidisciplinary
Mian Chen, Xiao-Qiao Wang, Er-Lin Zhang, Yi-Zao Wan, Jian Hu
Summary: This study investigated the different fluorine chemical compositions on titanium surfaces, demonstrating that coatings composed of metal fluorides exhibited superior antibacterial effect and cell compatibility. This provides a new perspective for optimizing surface modification methods of fluorinated biomaterials for biomedical applications.
Article
Materials Science, Multidisciplinary
Yuan Zhang, Shan Fu, Lei Yang, Gaowu Qin, Erlin Zhang
Summary: Ti-Cu alloy was surface modified by an alkali-heat treatment to deposit a TiO2/CuO/Cu2O composite coating. The modified alloy exhibited stronger antibacterial ability and enhanced osteogenic activities.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2022)
Article
Materials Science, Biomaterials
Shan Fu, Xiaotong Zhao, Lei Yang, Gaowu Qin, Erlin Zhang
Summary: This study selected Au element as the alloying element to prepare a new Ti-Au alloy with strong antibacterial property, and investigated the influence of the secondary phase on the antimicrobial properties and mechanism. The results showed that Ti-Au alloys exhibited strong antibacterial rate against S. aureus, and had good cytocompatibility and osteogenic properties.
BIOMATERIALS ADVANCES
(2022)
Article
Materials Science, Multidisciplinary
Hai-Lin Yang, Meng-Zhen Zhu, Jian-Ying Wang, Chen-Xu Ma, Xiong-Wen Zhou, Hai-Xia Xing, Er-Lin Zhang, Shou-Xun Ji
Summary: The study showed that the mechanical and antibacterial properties of Ti-3wt%Cu alloy could be significantly improved by cold rolling and different annealing temperatures. Through adjusting the size and distribution of Ti2Cu phase, a balance between strength and ductility could be achieved, increasing the applicability of the alloy in clinical practice. The combination of excellent mechanical properties and antibacterial properties makes the Ti-3wt%Cu alloy a promising candidate for long-term orthopaedic implant applications.
Article
Materials Science, Multidisciplinary
Lei Yang, Wenqiang Xu, Shouzhen He, Erlin Zhang, Xinxin Zhang, Tao Zhang, Gaowu Qin
Summary: The influence of trace Si on the microstructure and corrosion behavior of as-cast Mg-0.4Mn-xSi alloys has been studied. It was found that the presence of trace Si leads to the formation of MnSi, Mn5Si3, and Mn3Si phases, thereby significantly increasing the corrosion rate of the alloys. During corrosion, rod-like MnxSiy precipitates exhibit stronger cathodic activation behavior compared to block-like precipitates.
Article
Materials Science, Multidisciplinary
Jia-Qi Zhang, Shuang Cao, Ying Liu, Mian-Mian Bao, Jing Ren, Sheng-Yi Li, Er-Lin Zhang, Jian-Jie Wang
Summary: Ti-Cu alloys exhibit strong antibacterial properties, high strength, and excellent corrosion resistance, making them suitable for orthopedic and dental implants. This study investigated the tribocorrosion behaviors of Ti-Cu alloys in simulated biological environments and compared them with cp-Ti. The results showed that Ti-Cu alloys had better corrosion resistance and wear resistance, making them potentially valuable for applications requiring wear and corrosion resistance.
Article
Materials Science, Coatings & Films
Yuan Zhang, Shenshen Cui, Shuang Cao, Lei Yang, Gaowu Qin, Erlin Zhang
Summary: In this study, a nanostructured Ti-Cu alloy surface was fabricated using an alkali-heat treatment, which effectively released copper ions and improved the functionality of human umbilical vein endothelial cells. The modified Ti-Cu alloy showed promising angiogenesis potential and could potentially improve osseointegration.
SURFACE & COATINGS TECHNOLOGY
(2022)
Article
Chemistry, Physical
Shenshen Cui, Shuo Liu, Jingjun Nie, Dafu Chen, Xinbao Wu, Gaowu Qin, Erlin Zhang
Summary: Titanium and titanium alloys have been widely used in the biomedical field due to their excellent physical, chemical, and biological properties. In this study, Ti-15Mo-xAg alloys with low elastic modulus and excellent antibacterial ability were designed and prepared. The microstructure, mechanical properties, antibacterial properties, and cytocompatibility were investigated. The results showed that Ti-15Mo-10Ag alloy exhibited a strong antibacterial rate of 99.5%, good cellular compatibility, and a low elastic modulus of 85 GPa, suggesting that this alloy may be a highly competitive medical material.
JOURNAL OF ALLOYS AND COMPOUNDS
(2022)
Article
Materials Science, Multidisciplinary
Shan Fu, Yuan Zhang, Yi Yang, Xiaomeng Liu, Xinxin Zhang, Lei Yang, Dake Xu, Fuhui Wang, Gaowu Qin, Erlin Zhang
Summary: This study proposes a new antibacterial mechanism, showing that the antibacterial effectiveness of alloys is proportional to the micro-area potential differences on their surface. By designing different alloys to eliminate the antibacterial contribution of copper and silver ions, it was found that high micro-area potential differences lead to the production of reactive oxygen species, resulting in antibacterial effects.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Yuan Zhang, Shenshen Cui, Lei Yang, Gaowu Qin, Yong Han, Erlin Zhang
Summary: Nanostructured surfaces have been considered as an effective strategy to reduce inflammatory response in implanted biomaterials. A TiO2 nanostructured surface doped with CuO and Cu2O on Ti-Cu alloy was shown to have excellent cyto-compatibility and reduce inflammatory response by downregulating mRNA expressions and secretion of proinflammatory cytokines.
Article
Materials Science, Biomaterials
Mohammadreza Kasravi, Alireza Yaghoobi, Tahereh Tayebi, Mahsa Hojabri, Abdolkarim Talebi Taheri, Fatemeh Shirzad, Bahram Jambar Nooshin, Radman Mazloomnejad, Armin Ahmadi, Fatemeh A. Tehrani, Ghasem Yazdanpanah, Mohammad Hadi Farjoo, Hassan Niknejad
Summary: As a promising approach in translational medicine, the decellularization of discarded livers to produce bioscaffolds that support recellularization has potential in overcoming the limitations of conventional liver transplantation. In this study, the researchers investigated the use of matrix metalloproteinase (MMP) inhibition to preserve the extracellular matrix (ECM) during liver decellularization. The results demonstrated that the application of an MMP inhibitor significantly improved the preservation of ECM components and mechanical properties of the bioscaffolds, which supported cell viability and function in vitro. The study also confirmed that the MMP inhibition led to the inhibition of MMP2 and MMP9, providing a novel method to enhance ECM preservation during liver decellularization.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Mohammadsadegh Nadimifar, Weiguang Jin, Clara Coll-Satue, Gizem Bor, Paul Joseph Kempen, Ali Akbar Moosavi-Movahedi, Leticia Hosta-Rigau
Summary: This study presents a metal-phenolic self-assembly approach that can prepare nanoparticles fully made of hemoglobin. The nanoparticles exhibit good oxygen binding and releasing capabilities.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jyoti Kumari, Roel Hammink, Jochem Baaij, Frank A. D. T. G. Wagener, Paul H. J. Kouwer
Summary: Fibrosis is the formation of fibrous connective tissue in response to injury, leading to organ dysfunction. A novel hybrid hydrogel combining synthetic polyisocyanide with hyaluronic acid has been developed, showing strong antifibrotic properties.
BIOMATERIALS ADVANCES
(2024)
Letter
Materials Science, Biomaterials
Melissa Machado Rodrigues, Cristian Padilha Fontoura, Charlene Silvestrin Celi Garcia, Sandro Tomaz Martins, Joao Antonio Pegas Henriques, Carlos Alejandro Figueroa, Mariana Roesch Ely, Cesar Aguzzoli
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jessica Polak, David Sachs, Nino Scherrer, Adrian Suess, Huan Liu, Mitchell Levesque, Sabine Werner, Edoardo Mazza, Gaetana Restivo, Mirko Meboldt, Costanza Giampietro
Summary: Human skin equivalents (HSEs) play a crucial role in tissue engineering. This study introduces a 3D-printed culture insert to apply a static radial constraint on HSEs and examines its effects on tissue characteristics. The results show that the diameter of the culture insert significantly influences tissue contraction, fibroblast and matrix organization, keratinocyte differentiation, epidermal stratification, and basement membrane formation. This study provides important insights for the design of skin tissue engineering.
BIOMATERIALS ADVANCES
(2024)
Review
Materials Science, Biomaterials
Shiliang Chen, Tianming Du, Hanbing Zhang, Jing Qi, Yanping Zhang, Yongliang Mu, Aike Qiao
Summary: This paper reviewed the primary methods for improving the overall properties of biodegradable zinc stents. It discussed the mechanical properties, degradation behavior, and biocompatibility of various improvement strategies. Alloying was found to be the most common, simple, and effective method for improving mechanical properties. Deformation processing and surface modification further improved the mechanical properties and biological activity of zinc alloys. Meanwhile, structural design could endow stents with special properties. Manufacturing zinc alloys with excellent properties and exploring their interaction mechanism with the human body are areas for future research.
BIOMATERIALS ADVANCES
(2024)